Journal of Bioethical Inquiry最新文献

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Eight Strategies to Engineer Acceptance of Human Germline Modifications. 设计人类基因修饰的八大策略
IF 1.8 3区 哲学
Journal of Bioethical Inquiry Pub Date : 2024-03-01 Epub Date: 2023-07-31 DOI: 10.1007/s11673-023-10266-3
Shoaib Khan, Katherine Drabiak
{"title":"Eight Strategies to Engineer Acceptance of Human Germline Modifications.","authors":"Shoaib Khan, Katherine Drabiak","doi":"10.1007/s11673-023-10266-3","DOIUrl":"10.1007/s11673-023-10266-3","url":null,"abstract":"<p><p>Until recently, scientific consensus held firm that genetically manipulated embryos created through methods including Mitochondrial Replacement Therapy or human germline genome editing should not be used to initiate a pregnancy. In countries that have relevant laws pertaining to heritable human germline modifications, the vast majority prohibit or restrict this practice. In the last several years, scholars have observed a transformation of scientific and policy restrictions with insistent calls for creating a regulatory pathway. Multiple stakeholders highlight the role of social consensus and public engagement for governance of heritable human germline modifications. However, in the drive to gain public acceptance and lift restrictions, some proponents provide distorted or misleading narratives designed to influence public perception and incrementally shift the consensus. This article describes eight discrete strategies that proponents employ to influence framing, sway public opinion, and revise policymaking of human germline modifications in a manner that undermines honest engagement.</p>","PeriodicalId":50252,"journal":{"name":"Journal of Bioethical Inquiry","volume":" ","pages":"81-94"},"PeriodicalIF":1.8,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10256151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ethics and Health Security in the Australian COVID-19 Context: A Critical Interpretive Literature Review. 澳大利亚新冠肺炎背景下的伦理与健康安全:批判性解释性文献综述。
IF 1.8 3区 哲学
Journal of Bioethical Inquiry Pub Date : 2024-03-01 Epub Date: 2023-11-08 DOI: 10.1007/s11673-023-10255-6
Anson Fehross, Kari Pahlman, Diego S Silva
{"title":"Ethics and Health Security in the Australian COVID-19 Context: A Critical Interpretive Literature Review.","authors":"Anson Fehross, Kari Pahlman, Diego S Silva","doi":"10.1007/s11673-023-10255-6","DOIUrl":"10.1007/s11673-023-10255-6","url":null,"abstract":"<p><p>Background The concept of \"health security\" is often used to motivate public health responses, yet the ethical values that underpin this concept remain largely unexamined. The recent Australian responses to COVID-19 serve as an important case study by which we can analyse the pre-existing literature to see what ethical values shaped, and continue to shape, Australia's response. Methods We conducted a critical interpretive literature review of academic and grey literatures within key databases, resulting in 2,220 sources. After screening for duplicates and relevance, we analysed ninety-six sources. Results First, risk and uncertainty are a leading focus, with a heavy concentration on risks to life and health. Second, free movement, safety, and security were recurringly emphasized, albeit narrowly focused upon the safety of the population. Third, legitimacy was a recurring theme, and it is here that discussions of \"health security\" figured highly. Conclusion Discussions of harm from government and associated official bodies fail to adequately distinguish between various senses of harm. Moreover, while the literature often discusses the balancing of rights, the steps involved in the weighing of these rights is rarely adequately explained and defended. We suggest that decision-makers should endeavour to clearly identify and defend the values undergirding their decisions in the public sphere.</p>","PeriodicalId":50252,"journal":{"name":"Journal of Bioethical Inquiry","volume":" ","pages":"131-150"},"PeriodicalIF":1.8,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11052779/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71488239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CRISPR: Beyond the Excitement. CRISPR:超越兴奋。
IF 1.8 3区 哲学
Journal of Bioethical Inquiry Pub Date : 2024-03-01 Epub Date: 2024-01-23 DOI: 10.1007/s11673-023-10295-y
Khaled Moustafa
{"title":"CRISPR: Beyond the Excitement.","authors":"Khaled Moustafa","doi":"10.1007/s11673-023-10295-y","DOIUrl":"10.1007/s11673-023-10295-y","url":null,"abstract":"","PeriodicalId":50252,"journal":{"name":"Journal of Bioethical Inquiry","volume":" ","pages":"7-9"},"PeriodicalIF":1.8,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139521085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Case for Human Challenge Trials in COVID-19. 在 COVID-19 中进行人体挑战试验的案例。
IF 1.8 3区 哲学
Journal of Bioethical Inquiry Pub Date : 2024-03-01 Epub Date: 2023-09-18 DOI: 10.1007/s11673-023-10309-9
George P Drewett
{"title":"The Case for Human Challenge Trials in COVID-19.","authors":"George P Drewett","doi":"10.1007/s11673-023-10309-9","DOIUrl":"10.1007/s11673-023-10309-9","url":null,"abstract":"<p><p>The COVID-19 pandemic has necessitated rapid research to aid in the understanding of the disease and the development of novel therapeutics. One option is to conduct controlled human infection trials (CHITs). In this article I examine the history of deliberate human infection and CHITs and their utilization prior to the COVID-19 pandemic, key ethical considerations of CHITs in the COVID-19 setting, an analysis of the World Health Organization's (WHO) Key criteria for the ethical acceptability of COVID-19 human challenge studies, and a review of the two COVID-19 CHITs that have already commenced, their compliance with the WHO criteria and other ethical considerations.</p>","PeriodicalId":50252,"journal":{"name":"Journal of Bioethical Inquiry","volume":" ","pages":"151-165"},"PeriodicalIF":1.8,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10290406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Brain-Computer Interfaces, Completely Locked-In State in Neurodegenerative Diseases, and End-of-Life Decisions. 脑机接口、神经退行性疾病的完全锁定状态和生命终结决策。
IF 1.8 3区 哲学
Journal of Bioethical Inquiry Pub Date : 2024-03-01 Epub Date: 2023-07-19 DOI: 10.1007/s11673-023-10256-5
Christopher Poppe, Bernice S Elger
{"title":"Brain-Computer Interfaces, Completely Locked-In State in Neurodegenerative Diseases, and End-of-Life Decisions.","authors":"Christopher Poppe, Bernice S Elger","doi":"10.1007/s11673-023-10256-5","DOIUrl":"10.1007/s11673-023-10256-5","url":null,"abstract":"<p><p>In the future, policies surrounding end-of-life decisions will be faced with the question of whether competent people in a completely locked-in state should be enabled to make end-of-life decisions via brain-computer interfaces (BCI). This article raises ethical issues with acting through BCIs in the context of these decisions, specifically self-administration requirements within assisted suicide policies. We argue that enabling patients to end their life even once they have entered completely locked-in state might, paradoxically, prolong and uphold their quality of life.</p>","PeriodicalId":50252,"journal":{"name":"Journal of Bioethical Inquiry","volume":" ","pages":"19-27"},"PeriodicalIF":1.8,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11052847/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10208920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Flesh Without Blood: The Public Health Benefits of Lab-Grown Meat. 没有血的肉实验室培育肉类对公众健康的益处》。
IF 1.8 3区 哲学
Journal of Bioethical Inquiry Pub Date : 2024-03-01 Epub Date: 2023-09-01 DOI: 10.1007/s11673-023-10254-7
Jonny Anomaly, Heather Browning, Diana Fleischman, Walter Veit
{"title":"Flesh Without Blood: The Public Health Benefits of Lab-Grown Meat.","authors":"Jonny Anomaly, Heather Browning, Diana Fleischman, Walter Veit","doi":"10.1007/s11673-023-10254-7","DOIUrl":"10.1007/s11673-023-10254-7","url":null,"abstract":"<p><p>Synthetic meat made from animal cells will transform how we eat. It will reduce suffering by eliminating the need to raise and slaughter animals. But it will also have big public health benefits if it becomes widely consumed. In this paper, we discuss how \"clean meat\" can reduce the risks associated with intensive animal farming, including antibiotic resistance, environmental pollution, and zoonotic viral diseases like influenza and coronavirus. Since the most common objection to clean meat is that some people find it \"disgusting\" or \"unnatural,\" we explore the psychology of disgust to find possible counter-measures. We argue that the public health benefits of clean meat give us strong moral reasons to promote its development and consumption in a way that the public is likely to support. We end by depicting the change from farmed animals to clean meat as a collective action problem and suggest that social norms rather than coercive laws should be employed to solve the problem.</p>","PeriodicalId":50252,"journal":{"name":"Journal of Bioethical Inquiry","volume":" ","pages":"167-175"},"PeriodicalIF":1.8,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11052809/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10484793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Ethical Examination of Donor Anonymity and a Defence of a Legal Ban on Anonymous Donation and the Establishment of a Central Register. 对匿名捐赠的伦理审查,以及为禁止匿名捐赠的法律禁令和建立中央登记册辩护。
IF 1.8 3区 哲学
Journal of Bioethical Inquiry Pub Date : 2024-03-01 Epub Date: 2023-09-18 DOI: 10.1007/s11673-023-10265-4
Xavier Symons, Henry Kha
{"title":"An Ethical Examination of Donor Anonymity and a Defence of a Legal Ban on Anonymous Donation and the Establishment of a Central Register.","authors":"Xavier Symons, Henry Kha","doi":"10.1007/s11673-023-10265-4","DOIUrl":"10.1007/s11673-023-10265-4","url":null,"abstract":"<p><p>Many if not most sperm donors in the early years of IVF donated under conditions of anonymity. There is, however, a growing awareness of the ethical cost of withholding identifying parental information from donor children. Today, anonymous donation is illegal in many jurisdictions, and some jurisdictions have gone as far as retrospectively invalidating contracts whereby donors were guaranteed anonymity. This article provides a critical evaluation of the ethics and legality of anonymous donation. We defend Australian and British legislation that has outlawed donor anonymity, and we argue for the establishment of a central registry that provides donor children with the ability to easily and reliably access identifying information about their donor parents.</p>","PeriodicalId":50252,"journal":{"name":"Journal of Bioethical Inquiry","volume":" ","pages":"105-115"},"PeriodicalIF":1.8,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10340600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Physician-Assisted Suicide Pathway in Italy: Ethical Assessment and Safeguard Approaches. 意大利医生协助自杀途径:伦理评估和保障方法。
IF 1.8 3区 哲学
Journal of Bioethical Inquiry Pub Date : 2024-03-01 Epub Date: 2023-10-13 DOI: 10.1007/s11673-023-10302-2
Luciana Riva
{"title":"The Physician-Assisted Suicide Pathway in Italy: Ethical Assessment and Safeguard Approaches.","authors":"Luciana Riva","doi":"10.1007/s11673-023-10302-2","DOIUrl":"10.1007/s11673-023-10302-2","url":null,"abstract":"<p><p>Although in Italy there is currently no effective law on physician-assisted suicide or euthanasia, Decision No. 242 issued by the Italian Constitutional Court on September 25, 2019 established that an individual who, under specific circumstances, has facilitated the implementation of an independent and freely-formed resolve to commit suicide by another individual is exempt from criminal liability. Following this ruling, some citizens have submitted requests for assisted suicide to the public health system, generating a situation of great uncertainty in the application processes. As a matter of fact, shared and defined procedures are lacking as Decision 242/2019 merely added some principles on which the legislature will have to base its future intervention. This paper analyses the advisory role that the Decision attributes to territorial ethics committees with the aim of stimulating discussions on their role in oversight mechanisms. The proposed conclusion is that the envisaged role does not appear consistent with the functions of these bodies and is ultimately substantially undefined and unjustified.</p>","PeriodicalId":50252,"journal":{"name":"Journal of Bioethical Inquiry","volume":" ","pages":"185-192"},"PeriodicalIF":1.8,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11052828/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41219107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Mixed-Methods Study Exploring Colombian Adolescents' Access to Sexual and Reproductive Health Services: The Need for a Relational Autonomy Approach. 哥伦比亚青少年获得性健康和生殖健康服务的混合方法研究:采用关系自主方法的必要性》。
IF 1.8 3区 哲学
Journal of Bioethical Inquiry Pub Date : 2024-03-01 Epub Date: 2024-03-26 DOI: 10.1007/s11673-024-10356-w
J Brisson, V Ravitsky, B Williams-Jones
{"title":"A Mixed-Methods Study Exploring Colombian Adolescents' Access to Sexual and Reproductive Health Services: The Need for a Relational Autonomy Approach.","authors":"J Brisson, V Ravitsky, B Williams-Jones","doi":"10.1007/s11673-024-10356-w","DOIUrl":"10.1007/s11673-024-10356-w","url":null,"abstract":"<p><p>This study's objective was to understand Colombian adolescents' experiences and preferences regarding access to sexual and reproductive health services (SRHS), either alone or accompanied. A mixed-method approach was used, involving a survey of 812 participants aged eleven to twenty-four years old and forty-five semi-structured interviews with participants aged fourteen to twenty-three. Previous research shows that adolescents prefer privacy when accessing SRHS and often do not want their parents involved. Such findings align with the longstanding tendency to frame the ethical principle of autonomy as based on independence in decision-making. However, the present study shows that such a conceptualization and application of autonomy does not adequately explain Colombian adolescent participants' preferences regarding access to SRHS. Participants shared a variety of preferences to access SRHS, with the majority of participants attaching great importance to having their parents involved, to varying degrees. What emerges is a more complex and non-homogenous conceptualization of autonomy that is not inherently grounded in independence from parental involvement in access to care. We thus argue that when developing policies involving adolescents, policymakers and health professionals should adopt a nuanced \"relational autonomy\" approach to better respect the myriad of preferences that Colombian (and other) adolescents may have regarding their access to SRHS.</p>","PeriodicalId":50252,"journal":{"name":"Journal of Bioethical Inquiry","volume":" ","pages":"193-208"},"PeriodicalIF":1.8,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140295076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reconceiving Reproduction: Removing "Rearing" From the Definition-and What This Means for ART. 重新认识生殖:将“养育”从定义中删除,以及这对ART意味着什么。
IF 1.8 3区 哲学
Journal of Bioethical Inquiry Pub Date : 2024-03-01 Epub Date: 2023-10-13 DOI: 10.1007/s11673-023-10281-4
Georgina Antonia Hall
{"title":"Reconceiving Reproduction: Removing \"Rearing\" From the Definition-and What This Means for ART.","authors":"Georgina Antonia Hall","doi":"10.1007/s11673-023-10281-4","DOIUrl":"10.1007/s11673-023-10281-4","url":null,"abstract":"<p><p>The predominant position in the reproductive rights literature argues that access to assisted reproductive technologies (ART) forms part of an individual's right to reproduce. On this reasoning, refusal of treatment by clinicians (via provision) violates a hopeful parent's reproductive right and discriminates against the infertile. I reject these views and suggest they wrongly contort what reproductive freedom entitles individuals to do and demand of others. I suggest these views find their origin, at least in part, in the way we define \"reproduction\" itself. This paper critically analyses two widely accepted definitions of human reproduction and demonstrates that both are fundamentally flawed. While the process of reproduction includes the biological acts of begetting and bearing a child, I argue that it does not extend to include rearing. This reworked definition has little impact in the realm of sexual reproduction. However, it has significant ethical implications for the formulation and assignment of reproductive rights and responsibilities in the non-sexual realm in two important ways. First, a claim to access ART where one has an intention to rear a child (but does not beget or bear) cannot be grounded in reproductive rights. Second, lacking an intention to rear does not extinguish the reproductive rights and responsibilities for those who collaborate in the process. I conclude that clinicians collaborate in non-sexual reproduction at the point of triggering conception (begetting) and therefore have the right to refuse to be involved in non-sexual reproduction, in some instances, as do all reproductive collaborators.</p>","PeriodicalId":50252,"journal":{"name":"Journal of Bioethical Inquiry","volume":" ","pages":"117-129"},"PeriodicalIF":1.8,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11052855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41219076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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