Harran Üniversitesi Tıp Fakültesi Dergisi最新文献

{"title":"Mandibular Bir Varyasyon Olan Temporal Krestal Kanalın Cinsiyete Göre KIBT ile Değerlendirilmesi","authors":"Mehmet Emin Doğan, Menduh Sercan Kaya","doi":"10.35440/hutfd.1400335","DOIUrl":"https://doi.org/10.35440/hutfd.1400335","url":null,"abstract":"Abstract \u0000Objective: The aim of this study was to evaluate the presence of temporal crest canal in a group of Turkish population according to gender using cone beam computed tomography (CBCT).\u0000Materials and Methods: CIBT images of 515 individuals were retrospectively analysed. Twenty-seven of these images were excluded because they did not meet the study criteria. All images were analysed in multiplanar planes. The presence of temporal crest canal was recorded according to age and gender. Data were analysed with Statistical Package for the Social Sciences (SPSS) version 25. Pearson Chi-Square test was used to evaluate the relationship between categorical variables.\u0000Results: 488 KIBT images were analysed and 2.6% of the total temporal crest canal was detected. Right temporal crest canal rate was 1.2% and left temporal crest canal rate was 1.4%. The rate of temporal crest canal was 1.4% in males and 1.2% in females. There was no statistically significant difference in the rate of presence of right and left temporal crest canal in males and females (p > 0.05).\u0000Conclusion: CIBT is an important radiological method for the detection of temporal crest canal. The rate of presence of temporal crest canal did not show a significant difference between genders.","PeriodicalId":502461,"journal":{"name":"Harran Üniversitesi Tıp Fakültesi Dergisi","volume":"183 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140456645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Ultrasonography and Computed Tomography in the Diagnosis of Acute Appendicitis","authors":"Mehmet Gümer, Fırat Erkmen, Emre Karaca, Reşit Çi̇ftçi̇","doi":"10.35440/hutfd.1410081","DOIUrl":"https://doi.org/10.35440/hutfd.1410081","url":null,"abstract":"Background: Acute appendicitis is the acute inflammation of the appendix vermiformis and is one of the leading emergency intra-abdominal surgeries. In the study; To investigate the effectiveness of preoperative USG and CT in the diagnosis of acute appendicitis.\u0000Materials and Methods: The records of 332 patients who underwent appendectomy between March 2018 and March 2023 were retrospectively examined. Gender, age, USG and CT reports and patho-logy results of the patients were recorded. Sensitivity, specificity, positive predictive value and negative predictive values of USG and CT in the diagnosis of acute appendicitis were calculated separately.\u0000Results: The pathology result was reported as acute appendicitis in 312 of the patients, and was evaluated as normal in 20 of them. The pathology result of 254 of 261 patients, whose CT results were evaluated as compatible with acute appendicitis, was reported as acute appendicitis. In 7 patients, it was found to be normal appendicitis. Of 28 patients whose CT results were incompatible with acute appendicitis, the pathology result was positive in 18 and negative in 10. Pathology results of 96 patients whose USG results were compatible with acute appendicitis; Acute appendicitis was found in 90 patients and normal appendix in 6 patients. Pathology results of 41 patients whose USG results were evaluated as negative; It was reported to be compatible with acute appendicitis in 36 cases and normal in 5 cases.\u0000Conclusions: In our study, both the sensitivity and specificity of CT were found to be superior to USG, consistent with the literature. Researching IT effectiveness; We think that prospective studies com-paring teleradiology reports and the reports of radiologists working in hospitals would be useful.","PeriodicalId":502461,"journal":{"name":"Harran Üniversitesi Tıp Fakültesi Dergisi","volume":"12 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140458773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical, Demographic and Electrophysiological Characteristics of Motor Neuron Patients: A Single Centre Experience","authors":"D. Ağırcan","doi":"10.35440/hutfd.1412294","DOIUrl":"https://doi.org/10.35440/hutfd.1412294","url":null,"abstract":"Amaç: Motor nöron hastalığı (MNH) üst ve/veya alt motor nöronların dejenerasyonu ile seyreden progresif nörolojik bozukluklardır. Şanlıurfa ilinde üniversite hastanemize başvuran MNH hastalarının klinik, demografik ve elektrofizyolojik özelliklerinin incelenmesini amaçladık.\u0000Gereç ve Yöntem: 2018-2023 yılları arasında Nöroloji ve Nöromusküler polikliniklerinde ve Elektronörofizyoloji laboratuvarında MNH tanısı konarak takip edilen 190 hastanın dosyaları elektronik ortamda retrospektif olarak incelendi. Hastaların yaş, cinsiyet, başvuru şikâyeti, muayene bulgusu, aile öyküsü ve elektrofizyolojik özellikleri kayıt altına alındı.\u0000Bulgular: Amyotrofik lateral skleroz (ALS) hastalarının 22’ si kadın, 32’ si erkekti. 15 hastanın başlangıç semptomu bulber iken, 39’ unun spinal başlangıçlıydı. 17 hastanın ilk semptomu alt ekstremiteden, 22’ sinin üst ekstremiteden başlamıştı. 36 hastanın ulnar sinir distal motor latansları (DML) median sinir DML’den kısayken, bu hastaların 24’ünde ulnar sinir birleşik kas aksiyon potansiyeli (BKAP) median sinir BKAP’larından yüksek bulundu. 3 Herediter Spastik Paraparezi hastamızın 1’i komplike tipteydi. Poliomiyelit sekeli nedeniyle Elektromiyografi (EMG)’si yapılan hastaların tibialis anterior kası 55 hastada bilateral, 7 hastada tek taraflı etkilenmişti. 2 hastada ileti hızında yavaşlama saptanırken farklı 2 hastada median sinirde tuzak nöropati izlendi. 6 post polio sendromu hastamızın yaş ortalaması 54.25+8.057’ idi. Hirayama Sendromu tanılı hastalarımızın 1’i kadın, 3’ü erkekti. 3 Hastamiz 20-30 yaş arasındayken, 1 hastamiz 58 yaşındaydı. 1 hastamızın servikal görüntülemesinde C6-7 düzeyinde miyelomalazi saptandı. 2 hastanın semptomu olmadığı halde iki yanlı tutulumu varken diğer 2 hastada tek taraflı tutulum vardı. \u0000Sonuç: Hekimlerin MNH’nın belirti, bulgu ve risk faktörlerini bilmeleri erken tanı koyabilmeleri açısından önemlidir.","PeriodicalId":502461,"journal":{"name":"Harran Üniversitesi Tıp Fakültesi Dergisi","volume":"77 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140459899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is Submucosal Lipomatosis of the Appendix Vermiformis Really a Rare Entity?","authors":"Gizem AY HALDIZ","doi":"10.35440/hutfd.1383433","DOIUrl":"https://doi.org/10.35440/hutfd.1383433","url":null,"abstract":"Background: Acute appendicitis (AA) is the most common surgical emergency in patients who visit the emergency department with abdominal pain. In some of the patients who were operated with a prediagnosis of AA, lymphoid hyperplasia, fecalitis, enterobius vermicularis, carcinoid tumor, or adenoma are determined without transmural inflammation in microscopic examination of the appendix. 'Submucosal lipomatosis' is also another entity that has been rarely reported in appendix localization. In this study, we aimed to determine the frequency and severity of submucosal fatty tissue (SFT) in appendectomy specimens and identify risk factors.\u0000Materials and Methods: 293 appendectomy specimens were evaluated retrospectively. The amounts of SFT (A0: None, A1: Isolated adipocytes (Mild), A2: Small adipocyte groups (Moderate), A3: Prominent adipocyte groups (Marked), A4: Severe adipocyte groups that narrow the lumen (Severe)) and the groups that were created according to the amounts of SFT (Group 1: Cases with A1,2,3,4, group 2: Cases with A2,3,4, group 3: Cases with A3,4) were determined in hematoxylin-eosin sections.\u0000Results: \u000091.47% of the cases had any amount of SFT. Amounts of SFT were mild in 23.89%, moderate in 46.76%, marked in 18.09%, and severe in 2.73%. All of the cases without SFT were in pediatric age. When the amount of SFT increased, the mean age and adult rate increased regularly (p<0.05). As 68% of the cases without SFT were female, male predominance was observed in cases with SFT. When the amount of SFT increased, male rate increased regularly (p<0.05). AA wasn’t determined in 26,28% of the cases. The AA rate in the group without SFT (20%) was marked lower than group 1 (78,73%), group 2 (82,32%), and group 3 (83,87%) (p<0.05). The most prominent increase in AA rate was between the group without SFT and group 1 which was the most sensitive group to the amount of SFT. When group 1,2,3 were compared, no significant increase in the AA ratio was found. \u0000Conclusions: The presence of SFT in the appendix is a common condition. Age increase and male gender are risk factors for the accumulation of SFT. Due to SFT accumulation increases the risk of AA, it would be logical to classify it as mild/moderate/marked/severe, and accept it as 'Submucosal lipomatosis'.","PeriodicalId":502461,"journal":{"name":"Harran Üniversitesi Tıp Fakültesi Dergisi","volume":"33 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140487740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"İndirekt Hiperbilirubinemi Tanısı ile Takip Edilen Bebeklerin Değerlendirilmesi","authors":"Abit Demi̇r, Hüseyin Gümüş, Mehmet Turğut","doi":"10.35440/hutfd.1410801","DOIUrl":"https://doi.org/10.35440/hutfd.1410801","url":null,"abstract":"Amaç: İndirekt hiperbilirubinemi tanısıyla yatırılan yenidoğanların klinik ve demografik özellikleri, risk faktörleri ve tedavi yöntemlerinin araştırılması amaçlandı.\u0000Materyal ve Metod: Yenidoğan yoğun bakım ünitesine yatırılan 615 sarılıklı yenidoğan bebeğin demografik özellikleri, laboatuvar verileri ve yenidoğan sarılığı açısından risk faktörleri retrospektif olarak incelendi.\u0000Bulgular: Bebeklerin 340 (% 55,3)' ı kız, 275 (% 44, 7)' i erkek, 532 (% 86,50)' si matür, 80 (% 13)'i prematür ve 3 (% 0,50)'ü ise postmatür idi. Doğum ağırlıkları; 3185 gr ± 0, 50, 3200 (1300-5000) arasında idi. Olgularda en sık sarılık nedeni, Fizyolojik sarılık / Nedeni tespit edilemeyen sarılıklar iken, en az oranda tespit edilen sarılık nedeni ise intrakranial kanama ve konjenital santral sinir sistemi anomalileri idi. \u0000Tedavide, bebeklerin 406 (% 66,0)’sına sadece fototerapi, 35 (% 5,7)’ine ise kan değişimi de yapıldı. Diğer 174 olguya (% 28,3) fototerapi ile birlikte primer hastalığa bağlı olarak antibiyotik, sodium L-tiroksin ve/veya intravenöz sıvı tedavisi de verildi. Olguların 13 (% 2,1)'ünde rebound sarılık, 3 (% 0,5)'ünde geçici hipokalsemi, 1 (% 0,2)' inde anemi ve 1 (% 0,2)' inde ise ishal gelişti. 7 (% 1, 1) olgu altta yatan neden bağlı olarak ex oldu. 1 (% 0,2) bebekte kernikterus gelişirken, 607 (% 98,7) olgu şifa ile taburcu edildi.\u0000Sonuç: Hiperbilirubinemi, yenidoğan döneminde sık görülmektedir. Mortalite ve morbidite engellenmesinde hiperbilirubinemi tedavisinin zamanlaması son derece önemlidir.","PeriodicalId":502461,"journal":{"name":"Harran Üniversitesi Tıp Fakültesi Dergisi","volume":"308 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140501053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kahramanmaraş Merkezli Depremler Sonrası Depremzedelerin Anksiyete Durumunun Uyku Problemleri, Bel ve Boyun Ağrısı ile İlişkisi","authors":"Demet GÖZAÇAN KARABULUT, Hatice Yildirim, Gönül Elpeze, Çağtay Maden","doi":"10.35440/hutfd.1385631","DOIUrl":"https://doi.org/10.35440/hutfd.1385631","url":null,"abstract":"Background: This study aims to examine the relationship between the post-earthquake anxiety status of victims of the Kahramanmaraş-centered earthquake and sleep problems, low back and neck pain. \u0000Materials and Methods: Individuals with a mean age of 27.9±9.1 years who experienced the Kahramanmaraş-centered earthquake were included in the study. The individuals included in the study was evaluated with the Beck Anxiety Inventory (BAI), the Oswestry Disability Index (ODI), the Neck Disability Index (NDI), and the Pittsburgh Sleep Quality Index (PSQI). \u0000Results: Of the participants, 67% were determined to have mild, moderate, and severe anxiety, and all of them had poor sleep quality (6.9±3.8). While the mean PSQI score of 57% of the participants sheltered in their own homes was 5 and above, this rate was 75% for those sheltered outside their homes. Of the individuals sheltered in their own homes, 27% and 37% of those sheltered outside their own homes had the ODI score percentages above 20%. A statistically moderate correlation was determined between the BAI score and the ODI score, the NDI score, and the PSQI score (r=0.511, r=0.604, r=0.539, respectively).\u0000Conclusions: Post-earthquake anxiety was revealed to be associated with sleep problems and low back and neck pain. Considering the relationship between the presence of anxiety, sleep problems, low back and neck pain in the support approaches to be adopted toward earthquake victims, approaches involving these parameters should be planned.","PeriodicalId":502461,"journal":{"name":"Harran Üniversitesi Tıp Fakültesi Dergisi","volume":"62 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140511312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Clinical Syndrome: Median Arcuate Ligament Syndrome","authors":"Mehmet Berhuni̇, Hüseyin Yönder, H. Elkan, A. Özgönül","doi":"10.35440/hutfd.1386917","DOIUrl":"https://doi.org/10.35440/hutfd.1386917","url":null,"abstract":"Özet\u0000Amaç\u0000Median Arkuat Ligament Sendromu (MALS), toplumda 2/100000 oranıyla oldukça nadir gözlenen bir klinik durumdur. Bu nedenle MALS olguları geç tanı alan olgulardır.\u0000Bu yazıda, kliniğimizde MALS tanısı alan ve cerrahi tedavi uygulanan beş hastanın bulgularının literatür bilgileri eşliğinde sunulması amaçlanmıştır.\u0000Materyal ve Metod\u0000Kliniğimizde Ocak 2021-Aralık 2022 tarihleri arasında MALS tanısı alan ve cerrahi tedavi uygulanan beş hastanın dosyası retrospektif olarak incelenmiş ve veriler elde edilmiştir.\u0000Bulgular\u0000MALS tanısı ile cerrahi tedavi alan beş hasta saptandı. Hastaların üçü kadın, ikisi erkekti. Hastaların tamamında yemeklerden sonra artan karın ağrısı ve kilo kaybı şikayeti mevcuttu. Cerrahi tedavi sonrası ortalama ±13,2 (3-24 ay) aylık takiplerinde hastaların kilo aldıkları gözlendi. Ayrıca klinik şikayetlerinin de geçtiği saptandı.\u0000Sonuç\u0000MALS nadir görülen bir hastalık olsa da tanı ve tedavideki gecikme, hastaların kronik şikayetleri nedeniyle sağlık sistemi üzerinde yarattıkları iş gücü kaybı ve artan maliyetler nedeniyle önemlidir. Basıya neden olan fibröz bandın cerrahi tedavi ile eksizyonu, şikayetlerin giderilmesinde oldukça efektiftir.","PeriodicalId":502461,"journal":{"name":"Harran Üniversitesi Tıp Fakültesi Dergisi","volume":"16 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140512526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The State of Practicing Traditional Methods and Their Effects on Individuals With Cutaneous Leishmaniasis in Turkey","authors":"Sena Maci̇t, Selma Kahraman","doi":"10.35440/hutfd.1389983","DOIUrl":"https://doi.org/10.35440/hutfd.1389983","url":null,"abstract":"Background: The aim of this study was to investigate the state of traditional methods used by individuals with cutaneous leishmaniasis (CL) disease and the effects of traditional methods on their health.\u0000Materials and Methods: This was a descriptive study. The sample for this study consisted of 232 cutaneous leishmaniasis patients. The research was conducted in the Oriental Sore Treatment Center between January 01, 2020, and March 01, 2021.The research data were collected with a survey. The descriptive statistics were eval-uated with the chi-square test and phi (Φ) and Cramer’s V parameters. A p-value of less than .05 was considered statistically significant.\u0000Results: It was observed that 96 people participating in the survey who received treatment with the diagnosis of CL were children and 136 people were adults. It was determined that one of the family members of each patient had previous CL with a rate of 44.9% and that 8.1% of the patients themselves had CL before. While the traditional method is not used in pediatric patients with CL, it was determined that 44.1% of adult patients used the traditional method for securing their disease. Patients using traditional methods mostly (48.3%) bought ready-made ointments from herbalists and applied them to the wounds. 66.7% of the patients suffered from the traditional method they applied. While 10.8% of patients aged 45 years and younger, 74.6% of patients over 45 years of age used traditional methods (p<0.05), and it was observed that there was a negative moderate relationship between age and traditional method usage (Φ =-0,64). While 89.5% of illiterate patients used tra-ditional methods, 13.6% of patients with secondary school or higher education were detected to use traditional methods (p<0,05, V=0,57). Patients with facial wounds preferred to use traditional methods more (p<0,05, V=0,25).\u0000Conclusions: This study showed that cutaneous leishmaniasis is still an important public health problem in Şanlıurfa Province in Turkey, and that traditional methods have negative effects on adult patients.\u0000Key Words: Cutaneous Leishmaniasis, Şark Çıbanı, Traditional Method, Health, Effect","PeriodicalId":502461,"journal":{"name":"Harran Üniversitesi Tıp Fakültesi Dergisi","volume":"61 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140513255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sistemik Antimon ile Tedavi Edilen Kutanöz Leishmaniasis Tanılı Hastaların Klinik Özellikleri ve Tedavi Yanıtları","authors":"Nebiye YENTUR DONİ, İsa An","doi":"10.35440/hutfd.1404486","DOIUrl":"https://doi.org/10.35440/hutfd.1404486","url":null,"abstract":"Amaç: Kutanöz leishmaniasis (KL) Leishmania genusuna ait protozoan parazitlerin neden olduğu bir cilt hastalığıdır. KL tedavisi için en sık tercih edilen tedavi seçeneği beş değerli antimon bileşikleridir. Bu çalışmanın amacı sistemik antimon ile tedavi edilen KL tanılı hastaların klinik özellikleri ve tedavi yanıtlarını araştırmaktır. Materyal- metot: Bu retrospektif çalışmaya deri ve zührevi hastalıkları kliniğimizde Mayıs 2018 – Mayıs 2020 tarihleri arasında KL tanısı konulan ve sistemik antimon ile tedavi edilen 52 hasta dahil edildi. Hastaların dosyalarında kayıtlı olan klinik ve demografik özellikleri incelendi. Sistemik antimon (intramüsküler meglumin antimonat (IM MA)) 20 mg/kg /gün dozunda 21 gün boyunca uygulandı. Tedavi yanıtı 12. haftada değerlendirildi. Bulgular: Çalışmamızdaki hastaların 30(%57.7)’u kadın ve 22(%42.3)’si erkek idi. Hastaların ortalama yaşı 26.5±14.23 yıl idi. Lezyonlar en sık yüz bölgesinde yerleşmekteydi ve en sık nodüloülseratif tip lezyonlar görüldü. KL tanısı 48 (%92.3) hastada kutanöz smearde ve 4(%7.7) hastada lezyonlu derinin histopatolojik incelenmesinde amastigotların görülmesi ile konuldu. IM MA tedavisi alan hastalar tedavi yanıtı açısından 12. haftada değerlendirildiğinde 50(%96.1) hastada lezyonlarda tam klinik iyileşme, 2(%3.9) hastada ise kısmi klinik iyileşme görüldü. Sonuç: Sonuç olarak çalışmamızdaki veriler ülkemizde daha önce yayınlanan KL ile ilgili klinik ve demografik veriler ile benzerdi.","PeriodicalId":502461,"journal":{"name":"Harran Üniversitesi Tıp Fakültesi Dergisi","volume":"73 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139150111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Yüksek Yağlı Bir Diyetle Beslenen BALB/C Farelerde Kefir Tüketiminin Lipid Metabolizması ve Adipokin Hormonlar Üzerine Etkileri","authors":"Seren Orhan, Hülya Çi̇çek, Mustafa Örkmez, Mehmet Akif Bozdayi, Efsane Yavuz, Davut Sinan Kaplan, Ahmet Sarper Bozkurt","doi":"10.35440/hutfd.1371056","DOIUrl":"https://doi.org/10.35440/hutfd.1371056","url":null,"abstract":"Background: The imbalance in pro-inflammatory and anti-inflammatory hormones secreted by the increase in fat tissue causes chronic inflammation in the fat tissue. It is thought that this chronic inflammation causes metabolic complications result-ing from obesity. Kefir is a type of probiotic that has recently attracted attention in the fight against obesity. This study aimed to examine the effects of kefir consumption on lipid profile and Adiponectin, Leptin, Resistin and Irisin/FNDC5 in the high fat diet fed BALB/C mouse model. Materials and Methods: BALB/C strain male mice were divided into three groups: control group (n = 10), high fat diet (HFD) (n = 10) and HFD + Kefir (n = 10). Mice were fed specific dietary patterns for eight weeks. The control group was given standard pellet feed. The HFD group was given a high-fat diet containing 52% fat. In addition to the high-fat feed, 15 ml/kg kefir was given to the HFD+Kefir group via oral gavage. Lipid profile was measured on an autoanalyzer using commercial kits. Leptin, Adiponectin, Resistin and Irisin/FNDC5 levels were measured by enzyme-linked immunosorbent assay (ELISA) using commer-cially available kits. Results: As a result of the experiment, there was no difference between the live weight gains of the groups. Epididymal fat weights in the HFD and HFD+Kefir groups were found to be statistically significantly higher than the control group. There was no significant difference between the epididymal fat weights of the HFD and HFD+Kefir groups HDL Cholesterol (HDL-C), LDL Cholesterol (LDL-C) values in the HFD and HFD+Kefir groups were found to be statistically significantly higher than the control group. No statistically significant difference was detected between the HFD+Kefir group and the HFD group in terms of HDL-C, LDL-C values. There was no difference between groups in triglyceride values. Adiponectin and Irisin/FNDC5 values of the HFD+Kefir group were found to be statistically significantly lower than the other groups. There was no statistically significant difference between the control group and the HFD group in terms of Adiponectin and Irisin/FNDC5 values. There was no significant difference between the groups in Leptin and Resistin values. Conclusions: It was thought that kefir may have metabolic effects through adipokines in the high-fat diet nutrition model, and it would be useful to support this with human studies.","PeriodicalId":502461,"journal":{"name":"Harran Üniversitesi Tıp Fakültesi Dergisi","volume":"59 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139155941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}