Journal of Clinical Endocrinology & Metabolism最新文献

Relationship Between Extracellular Water to Total Body Water Ratio and Severe Diabetic Retinopathy in Type 2 Diabetes. 2 型糖尿病患者细胞外水分与全身水分比率与严重糖尿病视网膜病变之间的关系。

IF 5 2区医学

Journal of Clinical Endocrinology & Metabolism Pub Date : 2025-06-17 DOI: 10.1210/clinem/dgae768

Nao Kajitani, Hironobu Umakoshi, Yusuke Kajitani, Hiroki Kaneko, Chitose Matsuzaki, Yasutaka Miyachi, Ryuichi Sakamoto, Yoshihiro Ogawa

{"title":"Relationship Between Extracellular Water to Total Body Water Ratio and Severe Diabetic Retinopathy in Type 2 Diabetes.","authors":"Nao Kajitani, Hironobu Umakoshi, Yusuke Kajitani, Hiroki Kaneko, Chitose Matsuzaki, Yasutaka Miyachi, Ryuichi Sakamoto, Yoshihiro Ogawa","doi":"10.1210/clinem/dgae768","DOIUrl":"10.1210/clinem/dgae768","url":null,"abstract":"Context: Diabetic retinopathy (DR) is a common microvascular complication of diabetes, and identifying the risk factors for severe DR is important.Objective: We aimed to investigate the relationship between severe DR and the extracellular water to total body water ratio (ET ratio).Methods: Retrospective cross-sectional study at the Department of Endocrinology, Metabolism, and Diabetes, Kyushu University Hospital. A total of 205 adults with type 2 diabetes (T2D) were included. The patients were divided into 2 groups: nonproliferative DR (non-PDR; n = 161, 126 with no DR and 35 with simple DR) and proliferative DR (PDR; n = 44, 18 with preproliferative DR and 26 with PDR). The ET ratio was measured using bioelectrical impedance analysis.Results: The ET ratio was significantly higher in the PDR group than in the non-PDR group (0.390 vs 0.398; P < .0001). Multivariate logistic regression analysis showed that the ET ratio was significantly associated with PDR, independent of known risk factors for DR progression. In the subgroup analysis by age, multivariate logistic regression analysis revealed a significant association between the ET ratio and PDR, independent of known risk factors for DR progression in patients younger than 60 years. However, in patients 60 years and older, only the urinary albumin to creatinine ratio (UACR) showed a significant association with PDR in a model using the UACR and the ET ratio.Conclusion: In patients with T2D younger than 60 years, the ET ratio may be a useful indicator for identifying severe DR.","PeriodicalId":50238,"journal":{"name":"Journal of Clinical Endocrinology & Metabolism","volume":" ","pages":"e2248-e2255"},"PeriodicalIF":5.0,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142559187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to Letter to the Editor From Zhang et al: "Cabozantinib Plus Ipilimumab/Nivolumab in Patients with Previously Treated Advanced Differentiated Thyroid Cancer". 回复Zhang等人致编辑的信：卡博赞替尼联合伊匹单抗/纳武单抗治疗晚期分化型甲状腺癌。

IF 5 2区医学

Journal of Clinical Endocrinology & Metabolism Pub Date : 2025-06-17 DOI: 10.1210/clinem/dgaf221

Bhavana Konda, Eric J Sherman, Erminia Massarelli, Jorge Nieva, Jameel Muzaffar, John C Morris, Mabel Ryder, Alan L Ho, Mark Agulnik, Lai Wei, Demond Handley, Catherine Moses, Rajani Jacob, John Wright, Howard Streicher, William Carson, Manisha H Shah

引用次数: 0

Effects of a Carbohydrate-Restricted Diet on β-Cell Response in Adults With Type 2 Diabetes. 限制碳水化合物饮食对 2 型糖尿病成人 β 细胞反应的影响。

IF 5 2区医学

Journal of Clinical Endocrinology & Metabolism Pub Date : 2025-06-17 DOI: 10.1210/clinem/dgae670

Barbara A Gower, Amy M Goss, Marian L Yurchishin, Sarah E Deemer, Bhuvana Sunil, William T Garvey

{"title":"Effects of a Carbohydrate-Restricted Diet on β-Cell Response in Adults With Type 2 Diabetes.","authors":"Barbara A Gower, Amy M Goss, Marian L Yurchishin, Sarah E Deemer, Bhuvana Sunil, William T Garvey","doi":"10.1210/clinem/dgae670","DOIUrl":"10.1210/clinem/dgae670","url":null,"abstract":"Context: β-Cell response to glucose is compromised in individuals with type 2 diabetes (T2D), possibly due in part to excessive carbohydrate consumption.Objective: This study was conducted to determine if a eucaloric carbohydrate-restricted (CR) diet (∼9% energy from carbohydrate, 65% energy from fat), compared to a eucaloric higher carbohydrate (HC) diet (∼55% energy from carbohydrate, 20% energy from fat), would improve β-cell response to glucose in participants with T2D.Methods: Participants were 57 African American and European American adults with T2D not using insulin. Medications were discontinued 1 to 2 weeks prior to baseline testing. A hyperglycemic clamp was used to assess the acute (first-phase) and maximal (arginine-stimulated) C-peptide response to glucose at baseline and after 12 weeks of controlled diet therapy (all food provided). An oral glucose tolerance test (OGTT) was used to assess the disposition index (DI).Results: At 12 weeks, a statistically significant effect of diet was observed on acute C-peptide response (2-fold greater with the CR diet; P < .01). For maximal C-peptide, a significant effect of diet was observed (22% greater with the CR diet; P < .05), as was a significant diet-by-race interaction (P < .05), indicating that the diet effect was specific to European Americans (48% greater with the CR diet; P < .01). OGTT results showed a significant effect of diet on DI at 12 weeks (32% greater with the CR diet; P < .05).Conclusion: These results suggest that a eucaloric CR diet has beneficial effects on β-cell function in patients with mild T2D.","PeriodicalId":50238,"journal":{"name":"Journal of Clinical Endocrinology & Metabolism","volume":" ","pages":"1811-1817"},"PeriodicalIF":5.0,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12187186/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142512182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of Maternal Short Sleep Duration With Neurodevelopmental Delay in Offspring: A Prospective Cohort Study. 母亲睡眠时间短与后代神经发育迟缓的关系：一项前瞻性队列研究

IF 5 2区医学

Journal of Clinical Endocrinology & Metabolism Pub Date : 2025-06-17 DOI: 10.1210/clinem/dgae569

Lei Zhang, Hai-Xia Wang, Wen-Xiang Li, Yuan-Yuan Zhu, Rui-Rui Ma, Yu-Hong Wang, Yu Zhang, Dao-Min Zhu, Peng Zhu

{"title":"Association of Maternal Short Sleep Duration With Neurodevelopmental Delay in Offspring: A Prospective Cohort Study.","authors":"Lei Zhang, Hai-Xia Wang, Wen-Xiang Li, Yuan-Yuan Zhu, Rui-Rui Ma, Yu-Hong Wang, Yu Zhang, Dao-Min Zhu, Peng Zhu","doi":"10.1210/clinem/dgae569","DOIUrl":"10.1210/clinem/dgae569","url":null,"abstract":"Context: To investigate how short sleep duration (SSD) during pregnancy is related to neurodevelopmental delays in offspring, we aimed to inform pregnancy sleep guidelines and promote maternal health and child development.Objective: To identify the associations between SSD during pregnancy and offspring neurodevelopmental delay and to determine whether fetal glucose metabolism plays a role in SSD and neurodevelopmental delays.Methods: This cohort study followed 7059 mother-child pairs from the Maternal & Infants Health in Hefei cohort, and collected sleep data during pregnancy via the Pittsburgh Sleep Quality Index at weeks 24 to 28 and 32 to 36. Neurodevelopmental outcomes from 6 to 36 months postpartum were assessed via the Denver Developmental Screening Test-II and the Gesell Development Diagnosis Scale. Cox proportional hazard regression was used to analyze the link between maternal SSD and neurodevelopmental delay risk. Mediation analysis was used to evaluate the role of cord blood serum C-peptide levels. Three hospitals and children's health centers in Hefei were involved.Results: The stratified analysis revealed a significant association between mothers with SSD during midpregnancy and neurodevelopmental delay in boys (adjusted HR 2.05, 95% CI 1.29, 3.25). Cord blood marker analysis revealed a positive relationship between cord blood serum C-peptide levels and neurodevelopmental delay in offspring (RR 0.04, 95% CI 0.00, 0.08). The proportion of the association between SSD and neurodevelopmental delay mediated by cord blood C-peptide was 11.05%.Conclusion: Maternal SSD during pregnancy was continuously associated with an increased incidence of neurodevelopmental delay with sex differences among offspring. This association may be mediated in part by increased higher levels of cord C-peptide.","PeriodicalId":50238,"journal":{"name":"Journal of Clinical Endocrinology & Metabolism","volume":" ","pages":"2016-2023"},"PeriodicalIF":5.0,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142331506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum 25-Hydroxyvitamin D, Genetic Susceptibility, and Abdominal Aortic Aneurysm Risk. 血清 25-羟维生素 D、遗传易感性和腹主动脉瘤风险。

IF 5 2区医学

Journal of Clinical Endocrinology & Metabolism Pub Date : 2025-06-17 DOI: 10.1210/clinem/dgae692

Yanjun Zhang, Chun Zhou, Ziliang Ye, Mengyi Liu, Panpan He, Sisi Yang, Yuanyuan Zhang, Xiaoqin Gan, Xianhui Qin

{"title":"Serum 25-Hydroxyvitamin D, Genetic Susceptibility, and Abdominal Aortic Aneurysm Risk.","authors":"Yanjun Zhang, Chun Zhou, Ziliang Ye, Mengyi Liu, Panpan He, Sisi Yang, Yuanyuan Zhang, Xiaoqin Gan, Xianhui Qin","doi":"10.1210/clinem/dgae692","DOIUrl":"10.1210/clinem/dgae692","url":null,"abstract":"Context: The association of serum 25-hydroxyvitamin D [25(OH)D] and genetic polymorphisms of the vitamin D receptor (VDR), and the vitamin D binding protein (VDBP) with incident abdominal aortic aneurysm (AAA) remains uncertain.Objective: To investigate whether serum 25(OH)D, genetic polymorphisms of VDR and VDBP, genetic susceptibility to AAA, and the interactions among these factors influence the risk of incident AAA.Methods: This retrospective UK Biobank cohort study included 447 529 participants without a diagnosis of prevalent aortic aneurysm or aortic dissection at baseline. Association between serum 25(OH)D concentration and incident AAA was assessed.Results: During a median follow-up of 12.5 years, 2042 participants developed incident AAA. A significant inverse association between serum 25(OH)D and incident AAA was observed (per SD increment, hazard ratio [HR], 0.92; 95% CI, 0.88-0.96), which was particularly pronounced in older individuals and those without diabetes (both P for interaction < .05). Compared to participants with serum 25(OH)D ≥ 50 nmol/L, those with serum 25(OH)D between 25 and < 50 nmol/L and those with < 25 nmol/L exhibited a significant higher risk of incident AAA. In the 371 621 participants with genetics assessment, individuals carrying AA alleles of ApaI single nucleotide polymorphism had significantly increased risk of incident AAA compared to those carrying CC alleles (HR, 1.16; 95% CI, 1.02-1.32). The inverse association between serum 25(OH)D and incident AAA was stronger in individuals with intermediate or high genetic risk for AAA (P for interaction = .048).Conclusion: There was a significant inverse association between serum 25(OH)D and AAA incidence, particularly among individuals with higher genetic risk for AAA, older age, and without diabetics.","PeriodicalId":50238,"journal":{"name":"Journal of Clinical Endocrinology & Metabolism","volume":" ","pages":"1989-1996"},"PeriodicalIF":5.0,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142373432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to: "Adult Height Following Prepubertal Treatment With Antiandrogen, Aromatase Inhibitor, and Reduced Hydrocortisone in CAH". 更正：“青春期前使用抗雄激素、芳香酶抑制剂和氢化可的松治疗CAH后的成人身高”。

IF 5 2区医学

Journal of Clinical Endocrinology & Metabolism Pub Date : 2025-06-17 DOI: 10.1210/clinem/dgaf244

引用次数: 0

Activin Actions in Adipocytes. 脂肪细胞的激活作用。

IF 5 2区医学

Journal of Clinical Endocrinology & Metabolism Pub Date : 2025-06-17 DOI: 10.1210/clinem/dgaf233

Luisina Ongaro, Daniel Jay Bernard

引用次数: 0

Correction to: "Basal and Stimulated Inhibin B in Pubertal Disorders". 修正：“青春期障碍中的基础抑制素B和受激抑制素B”。

IF 5 2区医学

Journal of Clinical Endocrinology & Metabolism Pub Date : 2025-06-17 DOI: 10.1210/clinem/dgaf264

引用次数: 0

Associations of Serum Testosterone and SHBG With Incident Fractures in Middle-aged to Older Men. 血清睾酮和性激素结合球蛋白与中老年男性骨折发病率的关系。

IF 5 2区医学

Journal of Clinical Endocrinology & Metabolism Pub Date : 2025-06-17 DOI: 10.1210/clinem/dgae703

Louise Grahnemo, Ross J Marriott, Kevin Murray, Lauren T Tyack, Maria Nethander, Alvin M Matsumoto, Eric S Orwoll, Dirk Vanderschueren, Bu B Yeap, Claes Ohlsson

{"title":"Associations of Serum Testosterone and SHBG With Incident Fractures in Middle-aged to Older Men.","authors":"Louise Grahnemo, Ross J Marriott, Kevin Murray, Lauren T Tyack, Maria Nethander, Alvin M Matsumoto, Eric S Orwoll, Dirk Vanderschueren, Bu B Yeap, Claes Ohlsson","doi":"10.1210/clinem/dgae703","DOIUrl":"10.1210/clinem/dgae703","url":null,"abstract":"Context: As men age, circulating testosterone (T) decreases, circulating SHBG increases, and the risk of fracture increases. It is unclear if circulating T, independently of comorbidities, is associated with fracture risk in men.Objectives: To determine associations for T and SHBG with incident fractures in men.Methods: We utilized the large (n = 205 973 participants, 11 088 any fracture cases, 1680 hip fracture cases, 1366 forearm fracture cases) and well-characterized UK Biobank cohort. Associations were modeled using Cox regressions, adjusting for multiple comorbidities/covariates, imputing for missing information, and assessing nonlinearity using cubic splines.Results: For T, not considering SHBG, there was a nonlinear association with hip but not forearm fractures, with the lowest risk in the second quintile. However, in models adjusted for SHBG or using calculated free T, lower T was associated with a higher risk for fractures at all evaluated bone sites. Lower SHBG was strongly associated with a lower risk of hip and forearm fractures (Q1 vs Q5, hip 0.55, 0.47-0.65; forearm 0.62, 0.52-0.74).Conclusion: Low circulating SHBG is strongly associated with a low risk of fracture at all evaluated bone sites, while the associations of circulating T with fracture risk are of lesser magnitude, nonlinear, inconsistent among fracture site, and affected by adjustment for SHBG. These findings demonstrate that circulating SHBG, rather than T, is a major independent biomarker of fracture risk in men. Consequently, both total T and SHBG should be assessed when examining the relationship of endogenous T concentrations with fractures in middle-aged to older men.","PeriodicalId":50238,"journal":{"name":"Journal of Clinical Endocrinology & Metabolism","volume":" ","pages":"1964-1973"},"PeriodicalIF":5.0,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12187124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142382253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aldosterone and Diabetes Risk: An Association in Need of Mechanistic Insights. 醛固酮与糖尿病风险：一种需要从机制上深入了解的关联。

IF 5 2区医学

Journal of Clinical Endocrinology & Metabolism Pub Date : 2025-06-17 DOI: 10.1210/clinem/dgae662

Justin B Echouffo-Tcheugui, Sam Dagogo-Jack

引用次数: 0