Sex Differences in the Association Between Thyroid Hormone Sensitivity and Cardiovascular-Kidney-Metabolic Syndrome.

IF 5.1 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Lanxuan Jiang, Liyuan Zhou, Jia Liu, Ying Wang, Guang Wang
{"title":"Sex Differences in the Association Between Thyroid Hormone Sensitivity and Cardiovascular-Kidney-Metabolic Syndrome.","authors":"Lanxuan Jiang, Liyuan Zhou, Jia Liu, Ying Wang, Guang Wang","doi":"10.1210/clinem/dgaf059","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The relationship between thyroid hormone sensitivity and cardiovascular-kidney-metabolic (CKM) syndrome remains unclear. This study aims to investigate the association between thyroid hormone sensitivity and the early-stage of CKM syndrome, with a specific focus on the moderating effects of sex and age.</p><p><strong>Methods: </strong>A total of 8391 euthyroid participants were enrolled in this cross-sectional study. Data on metabolic parameters and thyroid hormone levels were collected. Thyroid hormone sensitivity indices-thyroid feedback quantile index (TFQI), thyroid-stimulating hormone index (TSHI), thyrotrophic thyroxine resistance index (TT4RI), and free T3 to free T4 ratio were calculated. Logistic regression models and restricted cubic spline regression (RCS) were used to analyze the association between thyroid hormone sensitivity and stage 2 of CKM syndrome stratified by sex and age.</p><p><strong>Results: </strong>In men, the higher TFQI, TSHI, and TT4RI values were significantly associated with increased risks of stage 2 of CKM syndrome. In women, these associations were weaker but still present, particularly for TSHI. RCS analysis also showed that the risk of CKM syndrome tended to increase with decreasing thyroid hormone sensitivity in men. However, these associations in women were not as significant as in men. Age-stratified analysis revealed that older men (>50 years) showed a stronger correlation between thyroid hormone sensitivity and CKM syndrome compared to women.</p><p><strong>Conclusion: </strong>This study demonstrated that impaired thyroid hormone sensitivity was significantly associated with the early-stage of CKM syndrome, particularly in older men. These findings provide the evidence of the importance of thyroid hormone sensitivity in CKM syndrome, especially in men over the age of 50.</p>","PeriodicalId":50238,"journal":{"name":"Journal of Clinical Endocrinology & Metabolism","volume":" ","pages":"e3303-e3312"},"PeriodicalIF":5.1000,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Clinical Endocrinology & Metabolism","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1210/clinem/dgaf059","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 0

Abstract

Background: The relationship between thyroid hormone sensitivity and cardiovascular-kidney-metabolic (CKM) syndrome remains unclear. This study aims to investigate the association between thyroid hormone sensitivity and the early-stage of CKM syndrome, with a specific focus on the moderating effects of sex and age.

Methods: A total of 8391 euthyroid participants were enrolled in this cross-sectional study. Data on metabolic parameters and thyroid hormone levels were collected. Thyroid hormone sensitivity indices-thyroid feedback quantile index (TFQI), thyroid-stimulating hormone index (TSHI), thyrotrophic thyroxine resistance index (TT4RI), and free T3 to free T4 ratio were calculated. Logistic regression models and restricted cubic spline regression (RCS) were used to analyze the association between thyroid hormone sensitivity and stage 2 of CKM syndrome stratified by sex and age.

Results: In men, the higher TFQI, TSHI, and TT4RI values were significantly associated with increased risks of stage 2 of CKM syndrome. In women, these associations were weaker but still present, particularly for TSHI. RCS analysis also showed that the risk of CKM syndrome tended to increase with decreasing thyroid hormone sensitivity in men. However, these associations in women were not as significant as in men. Age-stratified analysis revealed that older men (>50 years) showed a stronger correlation between thyroid hormone sensitivity and CKM syndrome compared to women.

Conclusion: This study demonstrated that impaired thyroid hormone sensitivity was significantly associated with the early-stage of CKM syndrome, particularly in older men. These findings provide the evidence of the importance of thyroid hormone sensitivity in CKM syndrome, especially in men over the age of 50.

甲状腺激素敏感性与心血管-肾脏-代谢综合征之间的性别差异
背景:甲状腺激素敏感性与心血管肾代谢综合征(CKM)的关系尚不清楚。本研究旨在探讨甲状腺激素敏感性与早期CKM综合征之间的关系,并特别关注性别和年龄的调节作用。方法:共有8391名甲状腺功能正常的参与者参加了这项横断面研究。收集代谢参数和甲状腺激素水平数据。计算甲状腺激素敏感性指数-甲状腺反馈分位数指数(TFQI)、促甲状腺激素指数(TSHI)、TT4抵抗指数(TT4RI)、游离甲状腺素与游离三碘甲状腺原氨酸比值。采用Logistic回归模型和限制性三次样条回归(RCS)分析按性别和年龄分层的甲状腺激素敏感性与CKM综合征2期的关系。结果:在男性中,较高的TFQI、TSHI和TT4RI值与CKM 2期风险增加显著相关。在女性中,这些关联较弱,但仍然存在,特别是在TSHI中。RCS分析还显示,CKM的风险随着男性甲状腺激素敏感性的降低而增加。然而,这些关联在女性中并不像在男性中那么显著。年龄分层分析显示,与女性相比,年龄较大的男性(50岁以下)甲状腺激素敏感性与CKM综合征之间的相关性更强。结论:本研究表明,甲状腺激素敏感性受损与早期CKM综合征显著相关,尤其是老年男性。这些发现为甲状腺激素敏感性在CKM综合征中的重要性提供了证据,特别是在50岁以上的男性中。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Journal of Clinical Endocrinology & Metabolism
Journal of Clinical Endocrinology & Metabolism 医学-内分泌学与代谢
CiteScore
11.40
自引率
5.20%
发文量
673
审稿时长
1 months
期刊介绍: The Journal of Clinical Endocrinology & Metabolism is the world"s leading peer-reviewed journal for endocrine clinical research and cutting edge clinical practice reviews. Each issue provides the latest in-depth coverage of new developments enhancing our understanding, diagnosis and treatment of endocrine and metabolic disorders. Regular features of special interest to endocrine consultants include clinical trials, clinical reviews, clinical practice guidelines, case seminars, and controversies in clinical endocrinology, as well as original reports of the most important advances in patient-oriented endocrine and metabolic research. According to the latest Thomson Reuters Journal Citation Report, JCE&M articles were cited 64,185 times in 2008.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信