Journal of Clinical Endocrinology & Metabolism最新文献

{"title":"Sex Differences in the Association Between Thyroid Hormone Sensitivity and Cardiovascular-Kidney-Metabolic Syndrome.","authors":"Lanxuan Jiang, Liyuan Zhou, Jia Liu, Ying Wang, Guang Wang","doi":"10.1210/clinem/dgaf059","DOIUrl":"https://doi.org/10.1210/clinem/dgaf059","url":null,"abstract":"<p><strong>Background: </strong>The relationship between thyroid hormone sensitivity and cardiovascular-kidney-metabolic (CKM) syndrome remains unclear. This study aims to investigate the association between thyroid hormone sensitivity and the early-stage of CKM syndrome, with a specific focus on the moderating effects of sex and age.</p><p><strong>Methods: </strong>A total of 8,391 euthyroid participants were enrolled in this cross-sectional study. Data on metabolic parameters and thyroid hormone levels were collected. Thyroid hormone sensitivity indices-thyroid feedback quantile index (TFQI), thyroid-stimulating hormone index (TSHI), TT4 resistance index (TT4RI), and free thyroxine to free triiodothyronine ratio were calculated. Logistic regression models and restricted cubic spline regression (RCS) were used to analyze the association between thyroid hormone sensitivity and stage 2 of CKM syndrome stratified by sex and age.</p><p><strong>Results: </strong>In men, the higher TFQI, TSHI, and TT4RI values were significantly associated with increased risks of stage 2 of CKM. In women, these associations were weaker but still present, particularly for TSHI. RCS analysis also showed that the risk of CKM tended to increase with decreasing thyroid hormone sensitivity in men. However, these associations in women were not as significant as in men. Age-stratified analysis revealed that older men (>50 years) showed a stronger correlation between thyroid hormone sensitivity and CKM syndrome compared to women.</p><p><strong>Conclusion: </strong>This study demonstrated that impaired thyroid hormone sensitivity is significantly associated with the early-stage of CKM syndrome, particularly in older men. These findings provide the evidence of the importance of thyroid hormone sensitivity in CKM syndrome, especially in men over the age of 50.</p>","PeriodicalId":50238,"journal":{"name":"Journal of Clinical Endocrinology & Metabolism","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143124076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Hepatic Glycogen on Nocturnal Gluconeogenesis in Type 2 Diabetes Mellitus.","authors":"Uma S Unni, Fernando Bril, John P Mugler, Rickey E Carter, Ananda Basu, Rita Basu","doi":"10.1210/clinem/dgaf044","DOIUrl":"https://doi.org/10.1210/clinem/dgaf044","url":null,"abstract":"<p><strong>Background: </strong>Higher gluconeogenesis (GNG) contributes to higher nocturnal endogenous glucose production (EGP) in type 2 diabetes (T2D). Studies using 13C Magnetic Resonance Spectroscopy (MRS) have confirmed lower hepatic glycogen content in T2D than in subjects without diabetes (ND).</p><p><strong>Objective: </strong>We determined the role of glycogen loading vs non-glycogen loading on contribution of GNG to nocturnal EGP in T2D.</p><p><strong>Methods: </strong>14 T2D and 15 matched ND subjects were studied on two occasions, with glycogen loaded (GL: 60% carbohydrate) vs non-glycogen loaded (NGL: 40% carbohydrate) isocaloric meals for 3 days, in random order in the overnight state. [6,6-2H2] Glucose was infused to measure EGP, deuterium labelled water was used to measure GNG and 13C MRS scans were performed in fed and fasted state to measure hepatic glycogen content.</p><p><strong>Results: </strong>Hepatic glycogen content and nocturnal EGP were higher (p<0.05) in GL vs NGL in both cohorts. % GNG to EGP averaged ∼50% in ND throughout the night after both meals. In contrast, % GNG to nocturnal EGP in T2D was lower with GL vs NGL and matched the pattern observed in ND with GL lowering overnight rates of GNG in T2D.</p><p><strong>Conclusion: </strong>Selective targeting of GNG at night with appropriate medications could reduce nocturnal and early morning fasting hyperglycemia and hepatic insulin resistance in people with T2D.</p>","PeriodicalId":50238,"journal":{"name":"Journal of Clinical Endocrinology & Metabolism","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143191140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting Preeclampsia in Gestational Diabetes Mellitus using the sFlt-1/PlGF Ratio.","authors":"Sarah Brittany Noonan, Shaun Patrick Brennecke, Gabriel Davis Jones","doi":"10.1210/clinem/dgaf069","DOIUrl":"https://doi.org/10.1210/clinem/dgaf069","url":null,"abstract":"<p><strong>Context: </strong>The sFlt-1/PlGF ratio blood test can aid the prediction of preeclampsia (PE) in advance of a clinical diagnosis. Gestational diabetes mellitus (GDM) predisposes to PE, but may influence levels of these biomarkers independently of PE.</p><p><strong>Objective: </strong>To determine whether the sFlt-1/PlGF ratio retains its clinical utility to predict PE in patients with GDM.</p><p><strong>Design: </strong>Retrospective analysis of sFlt-1/PlGF ratio and associated clinical outcome data acquired between September 2016 and September 2022.</p><p><strong>Setting: </strong>The Royal Women's Hospital, Melbourne, Australia.</p><p><strong>Patients: </strong>1,416 sFlt-1/PlGF ratio results from pregnant women with and without GDM, and with and without PE, referred for sFlt-1/PlGF testing.</p><p><strong>Intervention: </strong>N/A.</p><p><strong>Main outcome measure: </strong>sFlt-1, PlGF and sFlt-1/PlGF ratio test results in relation to PE and GDM.</p><p><strong>Results: </strong>There were no significant differences in the AUC, specificity, sensitivity, PPV or NPV between the PE + No GDM and PE + GDM groups in both the 0-7 and 8-14 day before delivery categories. In the 0-7 day category the PE + No GDM group had a AUC of 0.82 (95% CI: 0.79-0.87), sensitivity of 85.3% (95% CI: 80.8% - 89.1%), NPV of 92.7% (95% CI: 90.5% - 94.5%), and the PE + GDM group had an AUC of 0.87 (95% CI: 0.82-0.93), sensitivity of 89.4% (95% CI: 76.9% - 96.5%) and NPV of 94.8% (95% CI: 88.7% - 97.7%).</p><p><strong>Conclusions: </strong>The results of this investigation indicate that whilst GDM may lead to changes in the sFlt-1/PlGF ratio, the sFlt-1/PlGF ratio test retains its clinical utility in predicting PE onset.</p>","PeriodicalId":50238,"journal":{"name":"Journal of Clinical Endocrinology & Metabolism","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143191138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chimeric CYP21A1P/CYP21A2 Genes in 21-Hydroxylase Deficiency Detected by Long-Read Sequencing and Phenotypes Correlation.","authors":"Xiaoxia Zhang, Yinjie Gao, Lin Lu, Yaqing Cao, Wei Zhang, Xueyan Wu, Anli Tong, Shi Chen, Xi Wang, Jiangfeng Mao, Min Nie","doi":"10.1210/clinem/dgae819","DOIUrl":"https://doi.org/10.1210/clinem/dgae819","url":null,"abstract":"<p><strong>Context: </strong>21-Hydroxylase deficiency (21-OHD) is caused by pathogenic variants in CYP21A2. High homology between CYP21A2 and its pseudogene CYP21A1P causes mismatches, leading to deletions and CYP21A1P/CYP21A2 chimeras.</p><p><strong>Objective: </strong>To detect chimeric CYP21A1P/CYP21A2 in 21-OHD patients using long-read sequencing (LRS) and analyze genotype-phenotype correlations.</p><p><strong>Methods: </strong>From 2015 to 2023, 869 21-OHD patients were enrolled at Peking Union Medical College Hospital, with 113 identified harboring CYP21A2 large deletion. Long-range PCR and LRS were used to identify the types of CYP21A1P/CYP21A2 chimeric. Haplotype analysis explored founder effects, and in vitro assays assessed the functional impact of novel mutations. Clinical data were retrospectively collected and patients were classified into 4 groups based on genotypes and residual enzyme activity to study genotype-phenotype correlations.</p><p><strong>Results: </strong>Ten types of chimeric CYP21A1P/CYP21A2 genes were identified across 119 alleles, including a novel type, CH-10. The most common, CH-1, accounted for 50.4% of all types. Haplotype analysis of 24 SNPs within CYP21A1P/CYP21A2 CH-1 revealed 25 haplotypes, with haplotype 11 being the most prevalent. Variants p.L100P and p.L301V of CYP21A2 showed enzyme activities of 1.36 ± 0.44% or 1.63 ± 0.19% for 17-hydroxyprogesterone to 11-deoxycortisol, and 1.36 ± 0.58% or 3.99 ± 1.09% for progesterone to 11-deoxycorticosterone, respectively, linked to the simple virilizing type. Genotype-phenotype consistency rates were 78.6% to 84% across the 4 groups.</p><p><strong>Conclusion: </strong>LRS is a comprehensive genetic testing method for 21-OHD patients, effectively detecting both CYP21A2 gene variants and CYP21A1P/CYP21A2 chimeric gene types. This study expands the CYP21A2 variant spectrum by identifying a novel chimera. Haplotype analysis revealed diverse haplotypes for each chimeric gene type, suggesting the absence of a common founder effect. The strong genotype-phenotype correlation aids genetic counseling and supports personalized treatment.</p>","PeriodicalId":50238,"journal":{"name":"Journal of Clinical Endocrinology & Metabolism","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143191134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body-weight Cycling and Risk of Diabetic Kidney Disease in People With Type 1 Diabetes in the DCCT/EDIC Population.","authors":"Marion Camoin, Kamel Mohammedi, Pierre-Jean Saulnier, Samy Hadjadj, Jean-François Gautier, Jean-Pierre Riveline, Nicolas Venteclef, Louis Potier, Gilberto Velho","doi":"10.1210/clinem/dgae852","DOIUrl":"https://doi.org/10.1210/clinem/dgae852","url":null,"abstract":"<p><strong>Context: </strong>Intraindividual body-weight variability or cycling is associated with increased risk of chronic kidney disease (CKD) in the general population.</p><p><strong>Objective: </strong>We conducted a retrospective analysis of data from the Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) studies to assess association between body-weight cycling and the risk of renal events in type 1 diabetes.</p><p><strong>Methods: </strong>Four indices of intraindividual body-weight variability were calculated for 1432 participants of DCCT/EDIC taking into account body-weight measurements during the DCCT follow-up (6 ± 2 years). Variability independent of the mean (VIM) was the main index. Six criteria of progression to CKD were studied during DCCT/EDIC follow-up (21 ± 4 years). Hazard ratio (HR) with 95% confidence interval (CI) were computed in Cox analyses for 1 SD of the indices expressed as Z-score.</p><p><strong>Results: </strong>A high VIM was significantly associated with the incidence of a 40% decline in eGFR from baseline values (HR, 1.25; 95% CI, 1.09-1.41; P = .001), doubling of baseline serum creatinine (HR, 1.34; 95% CI, 1.13-1.57; P = .001), CKD stage 3 (HR, 1.36; 95% CI, 1.12-1.63; P = .002), and with a decline in eGFR > 3 mL/min/m2 per year (all analyses adjusted for CKD risk factors at baseline and follow-up, and use of nephroprotective drugs). VIM was also associated with the incidence of moderately and severely increased albuminuria, but associations did not remain significant following adjustment for follow-up covariates. Similar results were observed for the other indices of body-weight cycling.</p><p><strong>Conclusion: </strong>Body-weight cycling is significantly associated with an increased risk of kidney events in people with type 1 diabetes, regardless of body mass index and traditional risk factors.</p>","PeriodicalId":50238,"journal":{"name":"Journal of Clinical Endocrinology & Metabolism","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143191131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive Risk Stratification Score in Middle-aged and Older Adults with Type 2 Diabetes: a Cross-Sectional Study.","authors":"Jinghua Zhang, Wilson Wai San Tam, Jinhua Lu, Junjie Chen, Joji Kusuyama, Yanhong Dong, Xin Yi Yap, Wentao Zhou, Na Wang, Hui Nan Yeo, Frena Jia Sy Lee, Vivien Xi Wu","doi":"10.1210/clinem/dgaf063","DOIUrl":"https://doi.org/10.1210/clinem/dgaf063","url":null,"abstract":"<p><strong>Context: </strong>Cognitive impairment (CI) affects approximately 45% of middle-aged and older adults with Type 2 Diabetes Mellitus (T2DM) globally. Although formal comprehensive neuropsychological tests are the gold standard for diagnosing CI, they are often time-intensive and may not be feasible in primary care.</p><p><strong>Objective: </strong>This study aimed to develop and validate a novel Risk Stratification Score (RSS) to rapidly and comprehensively predict CI risk among middle-aged and older adults with T2DM, offering a streamlined alternative in clinical practice.</p><p><strong>Methods: </strong>A cross-sectional study was conducted from July 2023 to February 2024 in a primary care polyclinic in Singapore's western region. Participants aged between 40 and 85 diagnosed with T2DM (n=150) were included in a convenience sampling. The primary outcome was CI status and assessed using formal neuropsychological tests, which including Montreal Cognitive Assessment (MoCA).</p><p><strong>Results: </strong>CI was identified in 49.3% of participants (n=74). The RSS, incorporating the MoCA, Diastolic Blood Pressure (DBP), and Short Physical Performance Battery (SPPB), demonstrated excellent discrimination, achieving an area under the ROC curve of 0.802 (p < 0.001). With an optimal cutoff of 0.3, the model showed a sensitivity of 63.5% and specificity of 86.8%, effectively differentiating high- and low-risk CI groups.</p><p><strong>Conclusion: </strong>RSS in clinical practice, exemplified by the Integrated Metabolic Cognitive Risk Stratification Pathway (imCRSP), is a promising tool for rapid CI risk assessment in primary care. Its robust predictive accuracy and ease of use support its application for early intervention in middle-aged and older adults with T2DM. Future studies should validate its use longitudinally and across diverse populations to enhance generalizability.</p>","PeriodicalId":50238,"journal":{"name":"Journal of Clinical Endocrinology & Metabolism","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143124072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LMNA Gene Variations in PCOS: A Persistent Genetic Clue.","authors":"Gustavo Arantes Rosa Maciel, Ismael Dale Cotrim Guerreiro da Silva, Edmund Chada Baracat","doi":"10.1210/clinem/dgaf072","DOIUrl":"https://doi.org/10.1210/clinem/dgaf072","url":null,"abstract":"","PeriodicalId":50238,"journal":{"name":"Journal of Clinical Endocrinology & Metabolism","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143124074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential mechanism associated with post-heart transplantation diabetes mellitus in Chinese patients.","authors":"Xiao Huang, Qiling Xu, Linhua Chen, Li Liu, Ying Zhou, Hong Zhou, Yu Zhang","doi":"10.1210/clinem/dgaf071","DOIUrl":"https://doi.org/10.1210/clinem/dgaf071","url":null,"abstract":"<p><strong>Background: </strong>Post-transplantation diabetes mellitus (PTDM) is a common metabolic complication following heart transplantation, which not only leads to elevated microvascular morbidity, but also seriously affects graft function and recipient survival. However, the specific metabolites and underlying mechanisms are not yet fully understood.</p><p><strong>Methods: </strong>A total of 106 adult heart transplant recipients (56 PTDM and 50 non-PTDM) who followed for more than one year were enrolled in the study. The untargeted metabolomics was performed by ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). The demographic, clinical data and drug information were collected at the time of sample collection.</p><p><strong>Results: </strong>PTDM patients were older (p=0.003), with higher BMI (p=0.010), higher triglyceride levels (TG, p=0.007), and a higher prevalence of hypertension (p=0.001) than non-PTDM. A total of 1174 metabolites were detected, of which 99 metabolites showed significantly differentially abundant (VIP>1, p<0.05, FC>1.5 or <0.67). KEGG functional enrichment analysis showed these differently expressed metabolites could be further enriched in ABC transporter, carbon metabolism, retrograde endocannabinoid signaling, phospholipase D signaling pathway. Compared with non-PTDM group, glutamate, diacylglycerol (DAG) and D-sorbitol were significantly changed in PTDM through metabolomics.</p><p><strong>Conclusions: </strong>These findings may provide a novel understanding of the pathological mechanism of PTDM and could be utilized to predict the development and progression of PTDM.</p>","PeriodicalId":50238,"journal":{"name":"Journal of Clinical Endocrinology & Metabolism","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TP53 Alterations Associate with Poor Response to Lenvatinib in Patients with Advanced Thyroid Cancer.","authors":"Valentina Cirello, Carla Colombo, Delfina Tosi, Alessandro Manzo, Maria Orietta Borghi, Umberto Gianelli, Giacomo Gazzano, Stefano Ferrero, Gianlorenzo Dionigi, Luca Persani, Laura Fugazzola","doi":"10.1210/clinem/dgaf056","DOIUrl":"https://doi.org/10.1210/clinem/dgaf056","url":null,"abstract":"<p><strong>Context: </strong>No data are available about the possible association of TP53 mutations and the response to multikinase inhibitors (MKIs) in thyroid cancer (TC).</p><p><strong>Objective: </strong>We evaluated the impact of TP53 mutations on the response to lenvatinib (LEN) in advanced TCs and in in vitro models.</p><p><strong>Patients and interventions: </strong>We investigated the molecular profile, including TP53 mutations, of 30 tumor tissues from patients treated with LEN, and tested p53 status by immunohistochemistry. These data were compared with clinical-pathological features, and tumor response to LEN. The response to LEN was also evaluated in TP53-defective and TP53-proficient TC cell lines.</p><p><strong>Results: </strong>TP53 mutations significantly correlated with a poor response to LEN (p=0.005). TP53 mutated patients had a shorter progression-free survival (PFS) (p<0.0001) and overall survival (OS) rates (p=0.0007). Accordingly, patients harbouring altered nuclear p53 protein expression had shorter PFS and OS (p=0.0001 and p=0.0056, respectively). These data were confirmed in a validation cohort. In accordance with clinical data, TC cell lines with p53 alterations had low or null sensitivity, while those TP53 wild type showed different degrees of sensitivity, primarily due to the increased number of tumor cells in G1 phase, consistent with the cytostatic effect of LEN.</p><p><strong>Conclusions: </strong>We show for the first time in advanced TC that the presence of TP53 alterations is a predictor of poor response to LEN treatment and associates to worse PFS and OS rates. The evaluation of TP53 mutations/p53 expression might be included into the patient/tumor characterization to be done before starting an MKI treatment.</p>","PeriodicalId":50238,"journal":{"name":"Journal of Clinical Endocrinology & Metabolism","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor from Lin et al.: \"Testosterone Treatment, Weight Loss, and Health-related Quality of Life and Psychosocial Function in Men: A 2-year Randomized Controlled Trial\".","authors":"Kuo-Jen Lin, I-Hung Shao, Yu-Hsiang Lin","doi":"10.1210/clinem/dgaf066","DOIUrl":"https://doi.org/10.1210/clinem/dgaf066","url":null,"abstract":"","PeriodicalId":50238,"journal":{"name":"Journal of Clinical Endocrinology & Metabolism","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}