非肥胖女性的热量限制、月经周期和睡眠。

IF 5.1 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Anne E Kim, Skand Shekhar, Katie R Hirsch, Bona P Purse, John A McGrath, Theodore T Zava, Abbie E Smith-Ryan, Janet E Hall
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引用次数: 0

摘要

简介:短期热量限制是女性的常见做法,可能减轻肥胖女性的睡眠呼吸暂停。我们研究了饮食限制对睡眠的影响及其与月经周期中非肥胖女性生殖激素的相互作用。方法:17名无肥胖的健康女性,年龄23.6±2.3岁(平均±SD),在两个月经周期的EFP中分别采用中性和亏能性饮食(NEA±0%和DEA -55%)。每天收集活动数据和尿LH、雌酮-3-葡萄糖醛酸(E1G)、妊娠二醇-3-葡萄糖醛酸(PDG)。在每次饮食的第5天采集血中食欲素和瘦素。研究人员分析了睡眠与月经周期、饮食和激素的关系。结果:DEA和月经周期独立影响睡眠后觉醒(WASO;p=0.004, p=0.007,分别为日粮和周期阶段)和觉醒次数(NOA;p=0.03, p=0.0006),黄体晚期(LLP)睡眠中断最严重。睡眠效率(SE)较低,觉醒持续时间(DOA)较长,与饮食限制有关。Orexin与WASO (p=0.02)、睡眠破碎指数(p=0.001)、NOA (p=0.009)呈正相关,与SE呈负相关(p=0.02)。PDG增加与WASO相关(结论:短期适度的热量限制会单独扰乱睡眠,并加剧整个月经周期中健康、无肥胖的年轻女性的睡眠变化)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Caloric Restriction, the Menstrual Cycle, and Sleep in Women Without Obesity.

Introduction: Short-term caloric restriction is a common practice even in lean and underweight women. We studied the impact of dietary restriction on sleep and its interplay with reproductive hormones across the menstrual cycle in women without obesity.

Methods: Seventeen healthy women without obesity, aged 23.6 ± 2.3 years (mean ± SD) underwent a neutral (± 0%) and deficient energy availability diet (-55%) in the early follicular phase of 2 menstrual cycles. Actigraphic data and urinary LH, estrone-3-glucuronide (E1G), and pregnanediol-3-glucuronide (PDG) were collected daily. Blood orexin and leptin were collected on the fifth day of each diet. Sleep was analyzed in relation to menstrual cycle phase, diet, and hormones.

Results: Decreased energy availability and menstrual cycle phase independently affected wake after sleep onset (WASO; P = .004, P = .007 for diet and cycle phase, respectively) and number of awakenings (NOA; P = .03, P = .0006, respectively) with the greatest sleep disruption in the late luteal phase. Sleep efficiency (SE) was lower and duration of awakenings was longer in association with dietary restriction. Orexin was positively associated with WASO (P = .02), the sleep fragmentation index (P = .001), and NOA (P = .009) and inversely related to SE (P = .02). Increasing PDG was associated with WASO (P < .05) and duration of awakenings (P < .05) and inversely associated with SE (P < .01). Increasing E1G was positively associated with WASO (P < .05) and NOA (P < .01).

Conclusion: Short-term modest caloric restriction independently disrupts sleep and exacerbates changes in sleep that occur across the menstrual cycle in healthy, young women without obesity.

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来源期刊
Journal of Clinical Endocrinology & Metabolism
Journal of Clinical Endocrinology & Metabolism 医学-内分泌学与代谢
CiteScore
11.40
自引率
5.20%
发文量
673
审稿时长
1 months
期刊介绍: The Journal of Clinical Endocrinology & Metabolism is the world"s leading peer-reviewed journal for endocrine clinical research and cutting edge clinical practice reviews. Each issue provides the latest in-depth coverage of new developments enhancing our understanding, diagnosis and treatment of endocrine and metabolic disorders. Regular features of special interest to endocrine consultants include clinical trials, clinical reviews, clinical practice guidelines, case seminars, and controversies in clinical endocrinology, as well as original reports of the most important advances in patient-oriented endocrine and metabolic research. According to the latest Thomson Reuters Journal Citation Report, JCE&M articles were cited 64,185 times in 2008.
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