Journal of Clinical Sleep Medicine最新文献

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Sleep-related painful erection: the first case in a child. 与睡眠有关的勃起疼痛:第一例儿童。
IF 2.9 3区 医学
Journal of Clinical Sleep Medicine Pub Date : 2025-08-01 DOI: 10.5664/jcsm.11700
Giuseppe Tiralongo, Donata De Stefano, Claudia Volponi, Alessandra Voci, Martina Proietti Checchi, Massimiliano Valeriani, Oliviero Bruni, Romina Moavero
{"title":"Sleep-related painful erection: the first case in a child.","authors":"Giuseppe Tiralongo, Donata De Stefano, Claudia Volponi, Alessandra Voci, Martina Proietti Checchi, Massimiliano Valeriani, Oliviero Bruni, Romina Moavero","doi":"10.5664/jcsm.11700","DOIUrl":"10.5664/jcsm.11700","url":null,"abstract":"<p><p>Sleep-related painful erections are a rare sleep disorder characterized by recurrent nocturnal painful penile erections, typically occurring during rapid eye movement sleep, without associated pain during daytime erections. Although approximately 100 cases have been described in adult males, there are no reports of sleep-related painful erections in childhood. We present the case of a male infant born at 36 weeks' gestation, who began experiencing sleep-related painful erections and nocturnal awakenings in his first year of life. Despite a family history of autoimmune diseases and restless legs syndrome, initial medical evaluations-including cystoscopy, ultrasound, and somatosensory evoked potentials-showed no abnormalities. Treatments with niaprazine and diazepam were ineffective, prompting a referral to our sleep center. A video-polysomnography revealed sleep fragmentation associated with erections, primarily during rapid eye movement sleep. Biochemical tests and a brain magnetic resonance imaging ruled out hormonal and neurological abnormalities. Treatment with L-5-hydroxytryptophan, initiated due to the presence of arousal disorders, appeared to provide clinical benefit, suggesting that sleep-related painful erections, at least in this case, could be considered a peculiar form of parasomnia. At a 4-month follow-up, the child demonstrated overall improvement. While sleep terrors and somniloquy persisted at a reduced frequency, the painful erections decreased in both frequency and intensity, indicating a potential, although unconfirmed, benefit from the treatment. It is also possible that reassurance played a key role in the overall improvement, as has been noted in adult populations.</p><p><strong>Citation: </strong>Tiralongo G, De Stefano D, Volponi C, et al. Sleep-related painful erection: the first case in a child. <i>J Clin Sleep Med</i>. 2025;21(8):1491-1494.</p>","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":" ","pages":"1491-1494"},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12320673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A familial case of congenital central hypoventilation syndrome due to a combination of polyalanine repeat mutation and novel nonpolyalanine repeat mutation. 家族性PARM合并新型NPARM致先天性中枢性低通气综合征1例。
IF 2.9 3区 医学
Journal of Clinical Sleep Medicine Pub Date : 2025-08-01 DOI: 10.5664/jcsm.11702
Kanako Omata, Takahiro Shindo, Mika Nagao, Yoshiyuki Namai
{"title":"A familial case of congenital central hypoventilation syndrome due to a combination of polyalanine repeat mutation and novel nonpolyalanine repeat mutation.","authors":"Kanako Omata, Takahiro Shindo, Mika Nagao, Yoshiyuki Namai","doi":"10.5664/jcsm.11702","DOIUrl":"10.5664/jcsm.11702","url":null,"abstract":"<p><p>Congenital central hypoventilation syndrome is a rare disorder characterized by alveolar hypoventilation and autonomic dysregulation caused by mutations in the paired-like homeobox 2b gene. Among these mutations, the co-occurrence of 2 paired-like homeobox 2b mutations is very rare. Herein, we report a case involving 3 individuals from a 2-generation family, each carrying a heterozygous paired-like homeobox 2b 20/25 polyalanine repeat mutation and a novel nonpolyalanine repeat mutation, c.531C>G, on the same allele with variable phenotypes. Although many patients with 20/25 polyalanine repeat mutation are reported to exhibit normal psychomotor development, 1 individual presented with a significantly more severe psychomotor developmental delay. Determining whether the neurodevelopmental deficits in patients with congenital central hypoventilation syndrome stem from the underlying disease or hypoxic encephalopathy due to insufficient respiratory management is challenging. To understand the potential impact of the novel nonpolyalanine repeat mutation on phenotype, further research is necessary.</p><p><strong>Citation: </strong>Omata K, Shindo T, Nagao M, Namai Y. A familial case of congenital central hypoventilation syndrome due to a combination of polyalanine repeat mutation and novel nonpolyalanine repeat mutation. <i>J Clin Sleep Med</i>. 2025;21(8):1495-1497.</p>","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":" ","pages":"1495-1497"},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12320679/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Images: A disorder-specific CPAP compliance pattern. 图像:疾病特异性CPAP依从性模式。
IF 2.9 3区 医学
Journal of Clinical Sleep Medicine Pub Date : 2025-08-01 DOI: 10.5664/jcsm.11842
Arne Peeters, Simon Horckmans, Dries Testelmans, Bertien Buyse, Alexandros Kalkanis
{"title":"Images: A disorder-specific CPAP compliance pattern.","authors":"Arne Peeters, Simon Horckmans, Dries Testelmans, Bertien Buyse, Alexandros Kalkanis","doi":"10.5664/jcsm.11842","DOIUrl":"https://doi.org/10.5664/jcsm.11842","url":null,"abstract":"<p><p>A patient, previously diagnosed with moderate obstructive sleep apnea and treated with continuous positive airway pressure, was seen for her yearly routine follow-up. A CPAP compliance report of the previous year revealed a periodic usage with almost stable monthly fluctuation between proper and poor adherence. The patient declared compliant usage when sleeping. The patients sleep habits, such as usual bedtime and start of CPAP treatment, had not changed during the monthly variations. What disorder can be explanatory for this CPAP compliance pattern?</p>","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144762155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effectiveness of nonpharmacological sleep interventions in pregnancy: a systematic review and meta-analysis. 妊娠期非药物睡眠干预的有效性:一项系统综述和荟萃分析。
IF 2.9 3区 医学
Journal of Clinical Sleep Medicine Pub Date : 2025-08-01 DOI: 10.5664/jcsm.11696
Pei Chen, Yueying Wang, Jinjin Yuan, Ghada Bourjeily, Chang G Park, Bingqian Zhu, Bilgay Izci-Balserak
{"title":"Effectiveness of nonpharmacological sleep interventions in pregnancy: a systematic review and meta-analysis.","authors":"Pei Chen, Yueying Wang, Jinjin Yuan, Ghada Bourjeily, Chang G Park, Bingqian Zhu, Bilgay Izci-Balserak","doi":"10.5664/jcsm.11696","DOIUrl":"10.5664/jcsm.11696","url":null,"abstract":"<p><strong>Study objectives: </strong>Sleep problems are common during pregnancy. Maintaining good sleep is critical to maternal and fetal health. The objective of this study was to evaluate the effectiveness of nonpharmacological interventions in improving sleep quality and duration during pregnancy, using objective and self-reported sleep measures.</p><p><strong>Methods: </strong>This meta-analysis was conducted ensuring adherence with the preferred reporting items for systematic reviews and meta-analysis guidelines. We systematically searched 5 major electronic databases, PubMed, Cumulative Index to Nursing and Allied Health Literature, Embase, Web of Science, and Cochrane. Only randomized-control trials of nonpharmacological interventions to improve sleep in pregnancy were included. We used random or fixed effect models and pooled estimates as standardized mean differences with 95% confidence intervals. Funnel plots and sensitivity analysis were used to assess publication bias and result robustness.</p><p><strong>Results: </strong>A total of 31 studies (n = 3,307) were included. Meta-analysis revealed that nonpharmacological interventions significantly improved self-reported overall sleep quality (standardized mean difference = -0.99; 95% confidence interval = -1.40, -0.58; I<sup>2</sup> = 96.3%). Subgroup analysis indicated that interventions initiated in late pregnancy (standardized mean difference = -0.88; 95% confidence interval = -1.16, -0.60; I<sup>2</sup> = 85.6%) or spanning different pregnancy stages were effective (standardized mean difference = -1.10; 95% confidence interval = -1.97, -0.24; I<sup>2</sup> = 98.1%). However, these interventions did not significantly affect sleep duration or efficiency, whether self-reported or objectively measured.</p><p><strong>Conclusions: </strong>Nonpharmacological interventions can improve self-reported sleep quality in pregnant females. Clinicians can tailor interventions based on pregnancy period and individual needs to manage their sleep disturbances.</p><p><strong>Citation: </strong>Chen P, Wang Y, Yuan J, et al. Effectiveness of nonpharmacological sleep interventions in pregnancy: a systematic review and meta-analysis. <i>J Clin Sleep Med</i>. 2025;21(8):1463-1476.</p>","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":" ","pages":"1463-1476"},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12320690/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How do you Zzz during pregnancy? A brief review of Z-drug use and management of insomnia during pregnancy. 怀孕期间你是怎么打瞌睡的?妊娠期z -药物的使用及失眠的处理综述。
IF 2.9 3区 医学
Journal of Clinical Sleep Medicine Pub Date : 2025-08-01 DOI: 10.5664/jcsm.11740
Xinhang Tu, Mithri R Junna, Bhanu Prakash Kolla
{"title":"How do you Zzz during pregnancy? A brief review of Z-drug use and management of insomnia during pregnancy.","authors":"Xinhang Tu, Mithri R Junna, Bhanu Prakash Kolla","doi":"10.5664/jcsm.11740","DOIUrl":"10.5664/jcsm.11740","url":null,"abstract":"<p><p>Sleep disturbance is highly prevalent during pregnancy, and there are no guidelines clearly appraising pharmacological treatment for insomnia during pregnancy. Furthermore, the data on the efficacy and safety of nonbenzodiazepine benzodiazepine receptor agonists in pregnant patients are inconclusive. We present a case of insomnia during pregnancy that was managed with doxylamine and zolpidem and discuss the current evidence examining the efficacy and potential adverse effects of treatment with a focus on the nonbenzodiazepine benzodiazepine receptor agonists in the management of insomnia during pregnancy.</p><p><strong>Citation: </strong>Tu X, Junna MR, Kolla BP. How do you Zzz during pregnancy? A brief review of Z-drug use and management of insomnia during pregnancy. <i>J Clin Sleep Med</i>. 2025;21(8):1499-1502.</p>","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":" ","pages":"1499-1502"},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12320687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ventilatory response to hypoxia is more crucial than hypercapnia in the mechanism of opioid-related central sleep apnea. 在阿片类药物相关的中枢性睡眠呼吸暂停机制中,低氧通气反应比高碳酸血症更为重要。
IF 2.9 3区 医学
Journal of Clinical Sleep Medicine Pub Date : 2025-08-01 DOI: 10.5664/jcsm.11840
David Wang, Brendon J Yee, Frances Chung, Ronald R Grunstein
{"title":"Ventilatory response to hypoxia is more crucial than hypercapnia in the mechanism of opioid-related central sleep apnea.","authors":"David Wang, Brendon J Yee, Frances Chung, Ronald R Grunstein","doi":"10.5664/jcsm.11840","DOIUrl":"https://doi.org/10.5664/jcsm.11840","url":null,"abstract":"","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144762157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of adenoid hypertrophy in obstructive sleep apnea outcomes post-mandibular distraction osteogenesis in patients with craniofacial microsomia. 腺样体肥大在颅面小症患者下颌牵张成骨后阻塞性睡眠呼吸暂停结果中的作用。
IF 2.9 3区 医学
Journal of Clinical Sleep Medicine Pub Date : 2025-08-01 DOI: 10.5664/jcsm.11826
Yingxiang Liang, Wenjie Cheng, Kaiyi Shu, Lunkun Ma, Cheng Ke, Xi Xu, Shanbaga Zhao, Lei Li, Zhiyong Zhang, Wei Liu
{"title":"The role of adenoid hypertrophy in obstructive sleep apnea outcomes post-mandibular distraction osteogenesis in patients with craniofacial microsomia.","authors":"Yingxiang Liang, Wenjie Cheng, Kaiyi Shu, Lunkun Ma, Cheng Ke, Xi Xu, Shanbaga Zhao, Lei Li, Zhiyong Zhang, Wei Liu","doi":"10.5664/jcsm.11826","DOIUrl":"https://doi.org/10.5664/jcsm.11826","url":null,"abstract":"<p><strong>Study objectives: </strong>Mandibular distraction osteogenesis (MDO) is recommended for children with craniofacial microsomia (CFM) and obstructive sleep apnea (OSA). However, its efficacy remains limited, with success rates of 36.4%-60%. The role of adenoid hypertrophy (AH) in persistent OSA post-MDO has not been been fully investigated. This study aimed to evaluate the role of AH in influencing MDO outcomes and to explore its contribution to the pathophysiology and treatment of OSA in patients with CFM.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 72 patients with CFM undergoing MDO. Preoperative adenoid size was assessed using adenoid/nasopharyngeal (A/N) ratios from cranial CT scans. Polysomnographic data, including pre- and postoperative obstructive apnea-hypopnea index (OAHI), were analyzed. Patients were classified into effective and ineffective groups based on postoperative OSA improvement. Statistical correlations between A/N ratios, OSA severity, Pruzansky-Kaban classification and treatment outcomes were examined.</p><p><strong>Results: </strong>AH prevalence among patients with CFM with OSA was 61.1%. A/N ratios correlated with postoperative OAHI (r = 0.261, p = 0.027), but not with preoperative OAHI. The ineffective group had higher A/N ratios than the effective group (0.69 ± 0.13 vs. 0.64 ± 0.12). Overall MDO effectiveness rate was 47.22%, with greater improvement observed in patients with severe OSA. No significant association was found between the Pruzansky-Kaban classification and either OSA severity or MDO treatment outcomes.</p><p><strong>Conclusions: </strong>Adenoid hypertrophy plays a significant role in persistent OSA post-MDO, particularly in mild to moderate cases. Routine preoperative assessment of AH, combined with targeted interventions such as adenoidectomy when indicated, may improve treatment outcomes. These findings underscore the importance of addressing both skeletal and soft tissue factors in the comprehensive management of OSA in patients with CFM.</p>","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144762156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Accuracy and acceptability of home sleep apnea testing with electroencephalography compared to in-lab polysomnography for the diagnosis of obstructive sleep apnea in children. 家庭睡眠呼吸暂停测试与实验室多导睡眠图诊断儿童阻塞性睡眠呼吸暂停的准确性和可接受性比较
IF 2.9 3区 医学
Journal of Clinical Sleep Medicine Pub Date : 2025-08-01 DOI: 10.5664/jcsm.11654
Darko Stefanovski, Mahalakshmi Somayaji, Michelle Ward, Jennifer Falvo, Mary Anne Cornaglia, Ignacio E Tapia, Yaelis Roman, Melissa Xanthopoulos, Christopher M Cielos
{"title":"Accuracy and acceptability of home sleep apnea testing with electroencephalography compared to in-lab polysomnography for the diagnosis of obstructive sleep apnea in children.","authors":"Darko Stefanovski, Mahalakshmi Somayaji, Michelle Ward, Jennifer Falvo, Mary Anne Cornaglia, Ignacio E Tapia, Yaelis Roman, Melissa Xanthopoulos, Christopher M Cielos","doi":"10.5664/jcsm.11654","DOIUrl":"10.5664/jcsm.11654","url":null,"abstract":"<p><strong>Study objectives: </strong>In-laboratory polysomnography is recommended for the evaluation of obstructive sleep apnea (OSA) in children, but availability is limited. We hypothesized that home sleep apnea testing including electroencephalogram (HSAT with EEG) could accurately detect OSA in children and be an alternative to polysomnography.</p><p><strong>Methods: </strong>Children clinically referred for polysomnography underwent testing with the HSAT with EEG device twice: once in their home as well as concurrently with in-lab polysomnography (portable lab testing). HSAT with EEG and portable lab testing were compared to reference polysomnography for OSA diagnosis using an obstructive apnea-hypopnea index (OAHI) > 2 events/h. OAHI cutoffs of 1 and 5 events/h were explored. The diagnostic accuracy was further analyzed using the area under the receiver operating characteristic curve.</p><p><strong>Results: </strong>All 15 participants, median (range) age 8.1 (2.9-17.1) years, completed in-lab testing and HSAT with EEG. OSA was identified by polysomnography in 7 (47%) participants. HSAT with EEG correctly identified OSA status from polysomnography in 14 (93%) participants. OAHI was similar between polysomnography (1.7 [0-26] events/h) and portable lab testing (1.6 [0.3-24.4]) and HSAT with EEG (1.8 [0.3-23]), <i>P</i> = .98. HSAT with EEG OAHI showed strong correlation with polysomnography OAHI (Spearman's <i>r</i> = .8, <i>P</i> = .0001). Area under the receiver operating characteristic curve referenced with polysomnography was excellent using OAHI threshold values of 1, 2, and 5 compared with portable lab testing (area under the receiver operating characteristic curve = 0.96, 0.96, and 1, respectively) and HSAT with EEG (area under the receiver operating characteristic curve = 0.79, 0.95, and 0.98 respectively).</p><p><strong>Conclusions: </strong>HSAT with EEG was accurate compared to polysomnography for the diagnosis of pediatric OSA. Electroencephalography may improve the diagnostic accuracy of HSAT in children, particularly for mild OSA and younger children.</p><p><strong>Citation: </strong>Stefanovski D, Somayaji M, Ward M, et al. Accuracy and acceptability of home sleep apnea testing with electroencephalography compared to in-lab polysomnography for the diagnosis of obstructive sleep apnea in children. <i>J Clin Sleep Med</i>. 2025;21(8):1341-1348.</p>","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":" ","pages":"1341-1348"},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12320684/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of side effects of different mandibular advancement devices for patients with obstructive sleep apnea: a systematic review and meta-analysis. 不同下颌推进装置治疗阻塞性睡眠呼吸暂停患者的副作用比较:系统回顾和荟萃分析。
IF 2.9 3区 医学
Journal of Clinical Sleep Medicine Pub Date : 2025-08-01 DOI: 10.5664/jcsm.11712
Xi Wang, Hui Chen, Shaohua Ge, Kaan Orhan, Paul van der Stelt, Xie-Qi Shi
{"title":"Comparison of side effects of different mandibular advancement devices for patients with obstructive sleep apnea: a systematic review and meta-analysis.","authors":"Xi Wang, Hui Chen, Shaohua Ge, Kaan Orhan, Paul van der Stelt, Xie-Qi Shi","doi":"10.5664/jcsm.11712","DOIUrl":"10.5664/jcsm.11712","url":null,"abstract":"<p><strong>Study objectives: </strong>Mandibular advancement devices (MADs) are widely used as noncontinuous positive airway pressure treatment options for obstructive sleep apnea, but they are associated with some side effects. To figure out the side effects related to MAD design and aid clinical decision-making, this systematic review compares the types and severity of side effects caused by both the adjustable and the nonadjustable MADs.</p><p><strong>Methods: </strong>Three databases were searched until May 2024 and 26 relevant studies were eligible for inclusion. The side effects examined include dentoskeletal changes and issues related to the temporomandibular joint, masticatory muscles, or periodontium.</p><p><strong>Results: </strong>Compared with adjustable MADs (overjet: mean difference [MD]: 0.98, 95% CI: 0.66-1.30; overbite: MD: 0.99, 95% CI: 0.67-1.30), nonadjustable MADs show less change in overjet (MD: 0.88, 95% CI: 0.49-1.28) and overbite (MD: 0.79, 95% CI: 0.32-1.26). Adjustable MADs have less impact on temporomandibular joint and masticatory muscles than nonadjustable MADs. However, there were no significant differences in sella-nasion-A point (MD: 0.10, 95% CI: -0.36 to 0.56), sella-nasion-B point (MD: 0.19, 95% CI: -0.28 to 0.67), or A-nasion-B point (MD: -0.14, 95% CI: -0.42 to 0.15) after treatment of either type of MAD. There were no signs of periodontitis or bone resorption observed after treatment with adjustable MAD.</p><p><strong>Conclusions: </strong>The findings provide valuable information for clinicians in selecting an appropriate MAD. However, given the limitations of the current evidence, there is no single superior custom MAD design in terms of side effects at present.</p><p><strong>Citation: </strong>Wang X, Chen H, Ge S, Orhan K, van der Stelt P, Shi X-Q. Comparison of side effects of different mandibular advancement devices for patients with obstructive sleep apnea: a systematic review and meta-analysis. <i>J Clin Sleep Med.</i> 2025;21(8):1477-1486.</p>","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":" ","pages":"1477-1486"},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12320689/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative effectiveness of non-pharmacological interventions on postpartum maternal sleep quality: a systematic review and network meta-analysis. 非药物干预对产后产妇睡眠质量的比较效果:系统综述和网络荟萃分析。
IF 2.9 3区 医学
Journal of Clinical Sleep Medicine Pub Date : 2025-08-01 DOI: 10.5664/jcsm.11814
Cai Thi Thuy Nguyen, Hsiao-Yean Chiu, Marianne Lin-Lewry, Bei Bei, Shao-Yu Tsai, Shu-Yu Kuo
{"title":"Comparative effectiveness of non-pharmacological interventions on postpartum maternal sleep quality: a systematic review and network meta-analysis.","authors":"Cai Thi Thuy Nguyen, Hsiao-Yean Chiu, Marianne Lin-Lewry, Bei Bei, Shao-Yu Tsai, Shu-Yu Kuo","doi":"10.5664/jcsm.11814","DOIUrl":"https://doi.org/10.5664/jcsm.11814","url":null,"abstract":"<p><strong>Study objectives: </strong>Poor sleep quality is prevalent among postpartum women and can negatively impair maternal and family health. Non-pharmacological interventions are preferred approaches over pharmaceutical methods for improving postpartum sleep, though their comparative effects remain unclear. This study aimed to systematically compare and rank the effects of various non-pharmacological interventions on maternal sleep quality at different postpartum stages.</p><p><strong>Methods: </strong>A systematic review and network meta-analysis was conducted. Electronic databases were systematically searched from their inception to July 2024. Randomized controlled trials of non-pharmacological interventions for postpartum sleep were included. Random-effects network meta-analyses were adopted.</p><p><strong>Results: </strong>In total, 19 randomized controlled trials involving 1826 participants examined 13 non-pharmacological interventions for postpartum sleep quality. Foot reflexology demonstrated the largest effect size (standardized mean difference [SMD] = -3.5), followed by progressive muscle relaxation (SMD = -3.2), and massage (SMD = -2.0) compared to usual care during the first three months postpartum. Cognitive behavioral therapy for insomnia (CBTi; SMD = -1.7) and light-dark therapy (SMD = -1.3) are effective during 4-12 months postpartum.</p><p><strong>Conclusions: </strong>Non-pharmacological interventions effectively improve postpartum sleep, with foot reflexology being the most effective in early postpartum period and CBTi optimal for 4-12 months. Health professionals can incorporate these promising interventions into postpartum sleep care. Future research evaluating the direct comparisons of non-pharmacological interventions for postpartum sleep is warranted.</p><p><strong>Systematic review registration: </strong>Registry: PROSPERO; Identifier: CRD42022335715.</p>","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144762153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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