Dahee Wi, Tonya M Palermo, Anne Stevens, Teresa M Ward
{"title":"Sleep deficiency and symptoms of pain, fatigue, and depressed mood in youth with and without childhood systemic lupus erythematosus.","authors":"Dahee Wi, Tonya M Palermo, Anne Stevens, Teresa M Ward","doi":"10.5664/jcsm.11210","DOIUrl":"10.5664/jcsm.11210","url":null,"abstract":"<p><strong>Study objectives: </strong>We undertook a study to describe and compare sleep deficiency and symptoms of pain, fatigue, and depressed mood in youth with childhood systemic lupus erythematosus (cSLE) to a healthy comparison group of youth and test the associations between sleep and symptoms of pain, fatigue, and depressed mood in youth with cSLE.</p><p><strong>Methods: </strong>Forty-three youth (23 youth with cSLE; 20 age- and sex-matched healthy youth) wore actigraphs and completed sleep diaries for 10 days and completed self-report questionnaires on sleep quality, pain, fatigue, and depressed mood.</p><p><strong>Results: </strong>On average, both groups had a total sleep time of less than 7 hours. Youth with cSLE had worse sleep efficiency (73.3%) and sleep regularity index scores (55.4) compared to the healthy comparison group of youth (79.2% and 60.1, respectively). Youth with cSLE had worse pain (<i>P</i> = .03) and fatigue (<i>P</i> = .004) compared to the healthy comparison group. Negative associations were found among self-reported sleep quality, sleep satisfaction, and symptoms of pain, fatigue, and depressed mood in youth with cSLE and wake after sleep onset was positively associated with fatigue.</p><p><strong>Conclusions: </strong>Poor sleep efficiency and sleep irregularity accompanied by symptoms of pain, fatigue, and depressed mood was prevalent in youth with cSLE. Youth with lupus should be encouraged to maintain a regular sleep schedule. Because this is the first study to incorporate objective sleep and sleep regularity measures in youth with cSLE, additional studies with objective and self-reported sleep measures are needed to replicate our findings.</p><p><strong>Citation: </strong>Wi D, Palermo TM, Stevens A, Ward TM. Sleep deficiency and symptoms of pain, fatigue, and depressed mood in youth with and without childhood systemic lupus erythematosus. <i>J Clin Sleep Med.</i> 2024;20(10):1607-1614.</p>","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":" ","pages":"1607-1614"},"PeriodicalIF":3.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11446131/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140912892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xin Chen, Timo Leppänen, Samu Kainulainen, Timothy P Howarth, Arie Oksenberg, Juha Töyräs, Philip I Terrill, Henri Korkalainen
{"title":"Sleep stage continuity is associated with objective daytime sleepiness in patients with suspected obstructive sleep apnea.","authors":"Xin Chen, Timo Leppänen, Samu Kainulainen, Timothy P Howarth, Arie Oksenberg, Juha Töyräs, Philip I Terrill, Henri Korkalainen","doi":"10.5664/jcsm.11198","DOIUrl":"10.5664/jcsm.11198","url":null,"abstract":"<p><strong>Study objectives: </strong>Excessive daytime sleepiness (EDS) in patients with obstructive sleep apnea is poorly explained by standard clinical sleep architecture metrics. We hypothesized that reduced sleep stage continuity mediates this connection independently from standard sleep architecture metrics.</p><p><strong>Methods: </strong>A total of 1,907 patients with suspected obstructive sleep apnea with daytime sleepiness complaints underwent in-lab diagnostic polysomnography and next-day Multiple Sleep Latency Test. Sleep architecture was evaluated with novel sleep-stage continuity quantifications (mean sleep stage duration and probability of remaining in each sleep stage), and conventional metrics (total non-rapid eye movement stages 1, 2, 3 (N1, N2, N3) and rapid eye movement times; and sleep onset latency). Multivariate analyses were utilized to identify variables associated with moderate EDS (5 ≤ mean daytime sleep latency ≤ 10 minutes) and severe EDS (mean daytime sleep latency < 5 minutes).</p><p><strong>Results: </strong>Compared to those without EDS, participants with severe EDS had lower N3 sleep continuity (mean N3 period duration 10.4 vs 13.7 minutes, <i>P</i> < .05), less N3 time (53.8 vs 76.5 minutes, <i>P</i> < .05), greater total sleep time (374.0 vs 352.5 minutes, <i>P</i> < .05), and greater N2 time (227.5 vs 186.8 minutes, <i>P</i> < .05). After adjusting for standard sleep architecture metrics using multivariate logistic regression, decreased mean wake and N3 period duration, and the decreased probability of remaining in N2 and N3 sleep remained significantly associated with severe EDS, while the decreased probability of remaining in wake and N2 sleep were associated with moderate EDS.</p><p><strong>Conclusions: </strong>Patients with obstructive sleep apnea and EDS experience lower sleep continuity, noticeable especially during N3 sleep and wake. Sleep-stage continuity quantifications assist in characterizing the sleep architecture and are associated with objective daytime sleepiness highlighting the need for more detailed evaluations of sleep quality.</p><p><strong>Citation: </strong>Chen X, Leppänen T, Kainulainen S, et al. Sleep stage continuity is associated with objective daytime sleepiness in patients with suspected obstructive sleep apnea. <i>J Clin Sleep Med</i>. 2024;20(10):1595-1606.</p>","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":" ","pages":"1595-1606"},"PeriodicalIF":3.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11446124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140900181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ahmed S BaHammam, Mohammed A Al-Abri, Rusdi Abd Rashid, Babak Amra, Khaled Al Oweidat, Joey W Y Chan, Ning-Hung Chen, Naricha Chirakalwasan, Rodolfo V Dizon, Ravi Gupta, Sy Duong-Quy, Fang Han, Seung Bong Hong, Zhang Jihui, Haitham Jahrami, Mouhamad Ghyath Jamil, Ki-Young Jung, Hiroshi Kadotani, Leong Chai Leow, Pei-Lin Lee, WonChul Shin, Liyue Xu, Yun Kwok Wing, Yuichi Inoue
{"title":"Mapping the landscape of sleep medicine training across Asia.","authors":"Ahmed S BaHammam, Mohammed A Al-Abri, Rusdi Abd Rashid, Babak Amra, Khaled Al Oweidat, Joey W Y Chan, Ning-Hung Chen, Naricha Chirakalwasan, Rodolfo V Dizon, Ravi Gupta, Sy Duong-Quy, Fang Han, Seung Bong Hong, Zhang Jihui, Haitham Jahrami, Mouhamad Ghyath Jamil, Ki-Young Jung, Hiroshi Kadotani, Leong Chai Leow, Pei-Lin Lee, WonChul Shin, Liyue Xu, Yun Kwok Wing, Yuichi Inoue","doi":"10.5664/jcsm.11240","DOIUrl":"10.5664/jcsm.11240","url":null,"abstract":"<p><strong>Study objectives: </strong>This study assessed the current state of sleep medicine accreditation and training in Asia by conducting a comprehensive survey across 29 Asian countries and regions facilitated by the Asian Society of Sleep Medicine to identify existing gaps and provide recommendations for future enhancements.</p><p><strong>Methods: </strong>The Asian Society of Sleep Medicine Education Task Force Committee designed a survey to gather data on accreditation, education, and training standards in sleep medicine, including information on challenges in enhancing education in the field.</p><p><strong>Results: </strong>With an 86% (25 countries/regions) response rate, the survey showed that sleep medicine is recognized as an independent specialty in just 9 countries/regions (36% of the countries/regions surveyed). Ten countries/regions have established sleep medicine training programs, with Japan and Saudi Arabia offering it as a distinct specialty. Significant disparities in training and accreditation standards were identified, with many countries/regions lacking formalized training and practice guidelines. The survey also revealed that most local sleep societies across Asia support the development of an Asian Sleep Medicine Training Curriculum led by the Asian Society of Sleep Medicine. However, several barriers significantly impede the establishment and development of sleep medicine training programs, including the scarcity of trained specialists and technologists and the absence of national accreditation for sleep medicine.</p><p><strong>Conclusions: </strong>The survey highlights the need for standardized sleep medicine training and accreditation across Asia. Developing an Asian Sleep Medicine Training Curriculum and promoting Asian Society of Sleep Medicine accreditation guidelines are key recommendations. Implementing these strategies is essential for advancing sleep medicine as a widely recognized discipline throughout Asia.</p><p><strong>Citation: </strong>BaHammam AS, Al-Abri MA, Abd Rashid R, et al. Mapping the landscape of sleep medicine training across Asia. <i>J Clin Sleep Med</i>. 2024;20(10):1647-1656.</p>","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":" ","pages":"1647-1656"},"PeriodicalIF":3.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11446127/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141421611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jeremy Landeo-Gutierrez, Julie Ryu, Kelan Tantisira, Rakesh Bhattacharjee
{"title":"Ethnic/racial and sex disparities in obstructive sleep apnea among adolescents in southern California.","authors":"Jeremy Landeo-Gutierrez, Julie Ryu, Kelan Tantisira, Rakesh Bhattacharjee","doi":"10.5664/jcsm.11238","DOIUrl":"10.5664/jcsm.11238","url":null,"abstract":"<p><strong>Study objectives: </strong>Pediatric obstructive sleep apnea (OSA) is common; however, inclusion of adolescents and especially those of ethnic/racial minorities in research is scarce. We hypothesized that ethnic/racial minority adolescents undergoing polysomnography have higher prevalence and more severe OSA compared to those who are non-Hispanic (NH) White.</p><p><strong>Methods: </strong>Retrospective review of 1,745 adolescents undergoing diagnostic polysomnography. Demographic characteristics, age, body mass index percentile, and polysomnography parameters were obtained. Descriptive statistics comparing race/ethnicity were analyzed. Linear regression of log-transformed obstructive apnea-hypopnea index, and logistic regression of moderate-severe OSA (obstructive apnea-hypopnea index ≥ 5 events/h) adjusting for covariates were analyzed.</p><p><strong>Results: </strong>A total of 58.2% adolescents were Hispanic, 24.1% NH-White, 4.3% NH-Asian/Pacific Islander, 4.2% NH-Black/African American, and 6.6% NH-other. Compared to the NH-White group, the Hispanic group had higher obstructive apnea-hypopnea index and any level of OSA severity, the Black/African American group had higher any level of OSA, and the NH-Asian group had higher moderate-severe OSA. Multiple linear regression of log-obstructive apnea-hypopnea index identified a positive association with Hispanic ethnicity (β: 0.25, <i>P</i> value < .05). Compared to the NH-White group, the Hispanic and the Asian/Pacific Islander groups were 1.45 (95% confidence interval: 1.10, 1.93) and 1.81 (95% confidence interval: 1.05, 3.10) times more likely to have moderate-severe OSA, respectively, after adjusting for relevant covariates. Stratified analysis by sex identified an association only among males between Hispanic ethnicity (odds ratio: 1.85, 95% confidence interval: 1.27, 2.70) and Asian/Pacific Islander ethnicity (odds ratio: 2.62, 95% confidence interval: 1.35, 5.11) and moderate-severe OSA, compared to the NH-White group.</p><p><strong>Conclusions: </strong>Among adolescents undergoing polysomnography evaluation, we identified OSA racial/ethnic and sex disparities in Hispanic and NH-Asian adolescents. Community level studies with adequate representation of these minority groups are needed to identify factors associated with the reported increased susceptibility.</p><p><strong>Citation: </strong>Landeo-Gutierrez J, Ryu J, Tantisira K, Bhattacharjee R. Ethnic/racial and sex disparities in obstructive sleep apnea among adolescents in southern California. <i>J Clin Sleep Med</i>. 2024;20(10):1637-1645.</p>","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":" ","pages":"1637-1645"},"PeriodicalIF":3.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11446114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141443651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A case of middle-aged central sleep apnea due to Joubert syndrome with different treatment effects of oxygen and acetazolamide.","authors":"Ryoko Murashima, Satomi Shiota, Ai Sugiyama, Koshin Katsu, Yumi Kuroda, Yoshihiko Sato, Yoichiro Mitsuishi, Nanako Shiroshita, Fusae Kawana, Takatoshi Kasai, Toshiaki Akashi, Kazuhisa Takahashi","doi":"10.5664/jcsm.11224","DOIUrl":"10.5664/jcsm.11224","url":null,"abstract":"<p><p>We report a case of severe central sleep apnea incidentally diagnosed during polysomnography for suspected obstructive sleep apnea. Characteristic clinical features included episodic hyperventilation followed by apnea from hypocapnia, which did not follow a Cheyne-Stokes pattern. Combined with the identification of cerebellar and brainstem malformations known as the \"molar tooth sign\" on a brain magnetic resonance imaging, developmental delay, and motor coordination problems, Joubert syndrome (a congenital disease) was first diagnosed at the age of 50 years. Central apneas were also observed during wakefulness, although not continuously. During sleep, continuous positive airway pressure and adaptive servo-ventilation were ineffective at the referring clinic and at our hospital. Supplemental oxygen decreased the frequency of central apneas and significantly shortened the duration of each central sleep apnea compared with room air. In contrast, the opposite response was observed with acetazolamide administration.</p><p><strong>Citation: </strong>Murashima R, Shiota S, Sugiyama A, et al. A case of middle-aged central sleep apnea due to Joubert syndrome with different treatment effects of oxygen and acetazolamide. <i>J Clin Sleep Med</i>. 2024;20(10):1705-1710.</p>","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":" ","pages":"1705-1710"},"PeriodicalIF":3.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11446119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141447467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Racial and ethnic disparities in pediatric obstructive sleep apnea: insights from a large study on adolescents in southern California.","authors":"Tue T Te, Thea T Phan","doi":"10.5664/jcsm.11306","DOIUrl":"10.5664/jcsm.11306","url":null,"abstract":"","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":" ","pages":"1567-1568"},"PeriodicalIF":3.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11446116/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141917973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Weighted blankets used in pediatric sleep treatment in attention-deficit/hyperactivity disorder and childhood maltreatment: where are we now and where are we going?","authors":"Danielle M Simmons, Narong Simakajornboon","doi":"10.5664/jcsm.11304","DOIUrl":"10.5664/jcsm.11304","url":null,"abstract":"","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":" ","pages":"1563-1566"},"PeriodicalIF":3.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11446128/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141917974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The importance of methodological vigilance in the peer-review process.","authors":"Nancy A Collop","doi":"10.5664/jcsm.11404","DOIUrl":"https://doi.org/10.5664/jcsm.11404","url":null,"abstract":"","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142331478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ning Zhang, Kun Peng, Jin-Xia Guo, Qing Liu, Ai-Lian Xiao, Hui Jing
{"title":"Microstructural brain abnormalities and associated neurocognitive dysfunction in obstructive sleep apnea: a pilot study with diffusion kurtosis imaging.","authors":"Ning Zhang, Kun Peng, Jin-Xia Guo, Qing Liu, Ai-Lian Xiao, Hui Jing","doi":"10.5664/jcsm.11184","DOIUrl":"10.5664/jcsm.11184","url":null,"abstract":"<p><strong>Study objectives: </strong>We assessed possible brain abnormalities in adult patients with moderate and severe obstructive sleep apnea using the mean kurtosis (MK) from diffusion kurtosis imaging and analyzed the correlation between MK and cognitive function.</p><p><strong>Methods: </strong>A total of 30 patients with moderate or severe obstructive sleep apnea and 30 healthy controls evaluated by the Montreal Cognitive Assessment scale were enrolled. All participants underwent diffusion kurtosis imaging and 3-dimensional T1-weighted imaging on a 3.0T magnetic resonance scanner. The MK values of gray and white matter brain regions were compared. Partial correlation analysis was used to analyze the correlation between respiratory sleep parameters/cognitive score and MK values in different brain regions.</p><p><strong>Results: </strong>Compared with the healthy controls, the MK of 20 brain regions (13 after false discovery rate correction) and cognitive scores in the obstructive sleep apnea group were significantly lower. In the obstructive sleep apnea group, apnea-hypopnea index was negatively correlated with the MK in the white matter of the right occipital lobe; lowest oxygen saturation was positively correlated with the MK in the bilateral parietal, precentral, and right postcentral cortex; total score on the Montreal Cognitive Assessment scale was positively correlated with MK in the left hippocampus; language function was positively correlated with MK in the white matter of the left parietal lobe; and delayed recall was positively correlated with the MK in right insula cortex and bilateral cingulate. After false discovery rate correction, only the correlations of lowest oxygen saturation with right precentral gyrus cortex and bilateral parietal cortex were significant.</p><p><strong>Conclusions: </strong>MK values of diffusion kurtosis imaging may provide valuable information in assessing the neurological impacts of obstructive sleep apnea.</p><p><strong>Citation: </strong>Zhang N, Peng K, Guo J-X, Liu Q, Xiao A-L, Jing H. Microstructural brain abnormalities and associated neurocognitive dysfunction in obstructive sleep apnea: a pilot study with diffusion kurtosis imaging. <i>J Clin Sleep Med.</i> 2024;20(10):1571-1578.</p>","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":" ","pages":"1571-1578"},"PeriodicalIF":3.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11446125/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140854291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Indu Ayappa, Robert Laumbach, Kathleen Black, Michael Weintraub, Priya Agarwala, Akosua Twumasi, Haley Sanders, Iris Udasin, Denise Harrison, Rafael E de la Hoz, Yingfeng Chen, Nishay Chitkara, Anna E Mullins, Horacio Romero Castillo, David M Rapoport, Shou-En Lu, Jag Sunderram
{"title":"Nasal resistance and inflammation: mechanisms for obstructive sleep apnea from chronic rhinosinusitis.","authors":"Indu Ayappa, Robert Laumbach, Kathleen Black, Michael Weintraub, Priya Agarwala, Akosua Twumasi, Haley Sanders, Iris Udasin, Denise Harrison, Rafael E de la Hoz, Yingfeng Chen, Nishay Chitkara, Anna E Mullins, Horacio Romero Castillo, David M Rapoport, Shou-En Lu, Jag Sunderram","doi":"10.5664/jcsm.11216","DOIUrl":"10.5664/jcsm.11216","url":null,"abstract":"<p><strong>Study objectives: </strong>We have previously estimated that the prevalence of obstructive sleep apnea (OSA) among World Trade Center rescue and recovery workers is 75% and identified that having symptoms of chronic rhinosinusitis (CRS) is an independent risk factor for OSA in this population. Nasal inflammation and/or elevated awake nasal resistance that carried over into sleep could explain this association. To understand the mechanism(s) for the elevated risk of OSA observed in World Trade Center responders with CRS symptoms we examined if elevated awake supine nasal resistance was associated with OSA, CRS and/or nasal inflammatory biomarkers.</p><p><strong>Methods: </strong>A total of 601 individuals (83% male, average age 53 years, body mass index = 29.9 ± 5.5 kg/m<sup>2</sup>) enrolled in the World Trade Center Health Program and without significant snoring prior to September 11, 2001 underwent 2 nights of home sleep apnea testing, measurements of anterior rhinomanometry in the supine position, and nasal lavage.</p><p><strong>Results: </strong>Awake supine nasal resistance was not associated with OSA; 74.8% and 74.4% of the participants with low and high nasal resistance respectively, had OSA. Patients with CRS had elevated nasal inflammatory markers (interleukin 6, interleukin 8, eosinophilic cationic protein, and neutrophil) but did not have high nasal resistance. Nasal inflammatory markers were not correlated with nasal resistance.</p><p><strong>Conclusions: </strong>As awake nasal resistance did not explain the relationship of CRS to OSA in this large and well characterized dataset, our findings suggest that either \"sleep\" nasal resistance or other factors such as increased supraglottic inflammation, perhaps through impairing upper airway reflex mechanisms, or systemic inflammation are involved in the pathophysiology of OSA in the World Trade Center population.</p><p><strong>Citation: </strong>Ayappa I, Laumbach R, Black K, et al. Nasal resistance and inflammation: mechanisms for obstructive sleep apnea from chronic rhinosinusitis. <i>J Clin Sleep Med</i>. 2024;20(10):1627-1636.</p>","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":" ","pages":"1627-1636"},"PeriodicalIF":3.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11446130/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141421612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}