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Chronic peripheral edema in a patient with rheumatoid arthritis. 类风湿性关节炎患者的慢性外周水肿。
IF 1.2
Acta dermatovenerologica Alpina, Pannonica, et Adriatica Pub Date : 2018-03-01
Vesna Breznik, Klara Dai, Maruška Marovt
{"title":"Chronic peripheral edema in a patient with rheumatoid arthritis.","authors":"Vesna Breznik,&nbsp;Klara Dai,&nbsp;Maruška Marovt","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Chronic peripheral edema is a very common yet underestimated problem. It is of utmost importance to investigate various possible causes and understand the pathophysiological mechanisms of chronic peripheral edema in order to determine the optimal treatment. This case report presents the case of a polymorbid patient with a deformity-causing type of rheumatoid arthritis and a 1-year history of progressive symmetrical peripheral edema. Based on an extensive diagnostic investigation, the patient was diagnosed with a combined form of chronic peripheral edema comprised of true lymphedema, which was confirmed by lymphoscintigraphy, and filtration edema due to muscular inactivity. Edema as a side effect of tocilizumab was also suspected.</p>","PeriodicalId":502234,"journal":{"name":"Acta dermatovenerologica Alpina, Pannonica, et Adriatica","volume":" ","pages":"37-39"},"PeriodicalIF":1.2,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35955105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Primary systemic amyloidosis with skin and cardiac involvement: a case report 原发性系统性淀粉样变性伴皮肤及心脏受累1例
IF 1.2
Acta dermatovenerologica Alpina, Pannonica, et Adriatica Pub Date : 2018-03-01
Anja Trajber Horvat, Katarina Trčko, Vesna Jurčić, Pij Bogomir Marko
{"title":"Primary systemic amyloidosis with skin and cardiac involvement: a case report","authors":"Anja Trajber Horvat,&nbsp;Katarina Trčko,&nbsp;Vesna Jurčić,&nbsp;Pij Bogomir Marko","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Primary systemic amyloidosis is characterized by the deposition of insoluble monoclonal immunoglobulin light chains in various tissues and is usually associated with an underlying plasma cell dyscrasia. In the early stage of the disease, dermatological findings can be the only manifestation, as opposed to organ involvement in the later stages. A dermatologist can diagnose amyloidosis early with a skin biopsy stained with Congo red dye and other appropriate investigations. This case report describes a female patient with primary systemic amyloidosis confirmed histologically from a skin biopsy. When the diagnosis was established, cardiac involvement and monoclonal gammopathy were already present. Treatment with bortezomib and dexamethasone was initiated; due to side effects, the treatment was later switched to lenalidomide, which was better tolerated.</p>","PeriodicalId":502234,"journal":{"name":"Acta dermatovenerologica Alpina, Pannonica, et Adriatica","volume":" ","pages":"45-47"},"PeriodicalIF":1.2,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35955107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of regulatory T cells and anti-inflammatory cytokines in psoriasis. 调节性T细胞和抗炎细胞因子在银屑病中的作用。
IF 1.2
Acta dermatovenerologica Alpina, Pannonica, et Adriatica Pub Date : 2018-03-01
Agnieszka Owczarczyk-Saczonek, Joanna Czerwińska, Waldemar Placek
{"title":"The role of regulatory T cells and anti-inflammatory cytokines in psoriasis.","authors":"Agnieszka Owczarczyk-Saczonek,&nbsp;Joanna Czerwińska,&nbsp;Waldemar Placek","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Psoriasis is a chronic inflammatory disease with a genetic predisposition that can be triggered by environmental factors. Pathogenesis is characterized by activation of the Th1/Th2 axis and abnormalities of the Th17/Treg balance as well as deficiency of anti-inflammatory cytokines (IL-10, TGF-β). Regulatory lymphocytes (Treg), which are involved in homeostasis mechanisms, maintain tolerance and prevent autoimmune disorders. Only a few studies have investigated the presence of Treg marker expression and levels of anti-inflammatory cytokines in psoriatic skin and sera of patients with psoriasis. The results of studies are controversial. This article reviews and analyzes what is known about the role of Treg cells and anti-inflammatory cytokines in psoriasis.</p>","PeriodicalId":502234,"journal":{"name":"Acta dermatovenerologica Alpina, Pannonica, et Adriatica","volume":" ","pages":"17-23"},"PeriodicalIF":1.2,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35954622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Psoriasis and comorbidities: general practitioners' awareness. 银屑病及其合并症:全科医生的认识。
IF 1.2
Acta dermatovenerologica Alpina, Pannonica, et Adriatica Pub Date : 2018-03-01
Miguel Costa-Silva, Julia Vide, Sofia Lopes, Filomena Azevedo, Sofia Magina
{"title":"Psoriasis and comorbidities: general practitioners' awareness.","authors":"Miguel Costa-Silva,&nbsp;Julia Vide,&nbsp;Sofia Lopes,&nbsp;Filomena Azevedo,&nbsp;Sofia Magina","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Systemic inflammatory diseases such as psoriasis, systemic lupus erythematosus (SLE), and rheumatoid arthritis (RA) are associated with an increased prevalence of cardiovascular diseases (CVD) and other comorbidities. The primary aim of this study was to assess the screening practices of general practitioners (GPs) with regard to the most frequent comorbidities in patients with psoriasis.</p><p><strong>Methods: </strong>We adapted, with permission, a questionnaire that was used by Parsi et al. in 2012, which was then distributed to GP residents and consultants.</p><p><strong>Results: </strong>Overall, 372 questionnaires were collected. Significantly more physicians screen for CV risk factors in patients with RA and SLE than in patients with psoriasis. There was no statistically significant difference between GP residents in the initial and final phase of residency, or between GP residents and consultants regarding awareness of increased prevalence of CVD in psoriasis or comorbidity screening practices in psoriasis patients.</p><p><strong>Conclusions: </strong>Most GP residents and consultants that participated in this study are not aware of an increased CV risk in patients with psoriasis and assign greater importance regarding this risk to other inflammatory diseases such as RA and SLE.</p>","PeriodicalId":502234,"journal":{"name":"Acta dermatovenerologica Alpina, Pannonica, et Adriatica","volume":" ","pages":"5-7"},"PeriodicalIF":1.2,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35954619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A rare and isolated presentation of primary cutaneous anaplastic large cell lymphoma. 一例罕见且孤立的原发性皮肤间变性大细胞淋巴瘤。
IF 1.2
Acta dermatovenerologica Alpina, Pannonica, et Adriatica Pub Date : 2018-03-01
Maitri Shah, Manoj Pawar, Vijay Zawar
{"title":"A rare and isolated presentation of primary cutaneous anaplastic large cell lymphoma.","authors":"Maitri Shah,&nbsp;Manoj Pawar,&nbsp;Vijay Zawar","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Primary cutaneous anaplastic large cell lymphoma is a CD30+ lymphoproliferative disorder of the skin characterized by the absence of nodal and visceral involvement, low recurrence rate, spontaneous remission, and tendency to occur in patients older than 20 years. The case presented here is of a 15-year-old boy with grouped papular lesions arranged in an annular fashion with a central clearing on his right arm for 4 months that was diagnosed with a case of anaplastic lymphoma kinase-negative primary cutaneous CD30+ anaplastic large cell lymphoma. The CT scan, bone marrow biopsy, and laboratory data ruled out systemic involvement. He was treated with oral methotrexate 10 mg once a week, but was lost to follow-up.</p>","PeriodicalId":502234,"journal":{"name":"Acta dermatovenerologica Alpina, Pannonica, et Adriatica","volume":" ","pages":"33-34"},"PeriodicalIF":1.2,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35954624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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