Acta dermatovenerologica Alpina, Pannonica, et Adriatica最新文献

Analysis of coagulation factors in angioedema/urticaria: increased values of D-dimer and fibrinogen in isolated angioedema. 血管性水肿/荨麻疹的凝血因子分析：孤立性血管性水肿中 D-二聚体和纤维蛋白原的数值升高。

Acta dermatovenerologica Alpina, Pannonica, et Adriatica Pub Date : 2024-05-15 DOI: 10.15570/actaapa.2024.13

Maja Štrajtenberger, L. Lugović-Mihić, A. Stipić-Marković, M. Artuković, Roman Mihić, Lorena Dolački, Nika-Barbara Pravica, Ivica Lokner

{"title":"Analysis of coagulation factors in angioedema/urticaria: increased values of D-dimer and fibrinogen in isolated angioedema.","authors":"Maja Štrajtenberger, L. Lugović-Mihić, A. Stipić-Marković, M. Artuković, Roman Mihić, Lorena Dolački, Nika-Barbara Pravica, Ivica Lokner","doi":"10.15570/actaapa.2024.13","DOIUrl":"https://doi.org/10.15570/actaapa.2024.13","url":null,"abstract":"INTRODUCTION\u0000Recent research has shown that blood coagulation and the extrinsic coagulation cascade are involved in the pathogenesis of chronic spontaneous urticaria (CSU), but little is known about the coagulation factors in angioedema.\u0000\u0000\u0000METHODS\u0000This study included 58 participants: 29 patients with chronic angioedema (14 with isolated angioedema and 15 with angioedema with wheals) and 29 healthy controls (HCs). We compared the values of coagulation factors in patients with isolated angioedema to those with wheals. Plasma levels of D-dimer, fibrinogen, and factor VII were measured by enzyme-linked immunosorbent assay (ELISA) for all participants.\u0000\u0000\u0000RESULTS\u0000Significantly higher D-dimer (p = 0.016; ε² = 0.381) and fibrinogen (p = 0.044; ε² = 0.331) levels were recorded in patients with angioedema (both groups) than in the HCs, with higher levels for angioedema with wheals. Factor VII and fibrinogen levels did not differ significantly between the groups with angioedema, but coagulation factors were more often elevated in both angioedema groups than in HCs.\u0000\u0000\u0000CONCLUSIONS\u0000One characteristic of angioedema is an elevated blood coagulation potential, which may help produce fibrin and may be important in controlling angioedema attacks.","PeriodicalId":502234,"journal":{"name":"Acta dermatovenerologica Alpina, Pannonica, et Adriatica","volume":"17 5","pages":"actaapa.2024.13"},"PeriodicalIF":0.0,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140976545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Remission of chronic urticaria in patients treated with omalizumab. 使用奥马珠单抗治疗的慢性荨麻疹患者病情缓解。

Acta dermatovenerologica Alpina, Pannonica, et Adriatica Pub Date : 2024-05-14 DOI: 10.15570/actaapa.2024.12

Klara Cvenkel, M. Bizjak, J. Šelb, M. Košnik

{"title":"Remission of chronic urticaria in patients treated with omalizumab.","authors":"Klara Cvenkel, M. Bizjak, J. Šelb, M. Košnik","doi":"10.15570/actaapa.2024.12","DOIUrl":"https://doi.org/10.15570/actaapa.2024.12","url":null,"abstract":"INTRODUCTION\u0000This study examined the remission probability and duration in chronic spontaneous urticaria (CSU) patients resistant to second-generation H1-antihistamines (sgAHs) undergoing omalizumab treatment.\u0000\u0000\u0000METHODS\u0000This is a retrospective observational study of 176 adult CSU patients exhibiting a significant pruritus component (≥ 8) of the weekly urticaria activity score (UAS7) despite four daily sgAH tablets and starting omalizumab treatment with 300 mg every 4 weeks. After excluding 13 nonresponders, we analyzed 163 omalizumab responders (mean age 51.8 years, 74.4% female). The intervals between applications were increased. Discontinuation was considered for patients that remained asymptomatic on a gradually reduced dosage (to 150 mg every 12 weeks) without sgAHs.\u0000\u0000\u0000RESULTS\u0000Omalizumab discontinuation was possible in 25.8% (42/163). The duration of omalizumab treatment before remission ranged from 7 to 63 months. Twenty-one patients (50.0%) maintained complete remission until the end of the observation period (September 2021) for 8 to 68 months. Of the relapsed patients, 71.4% (15/21) effectively controlled CSU with sgAHs. Six patients (28.6%; 6/21) required omalizumab reintroduction after 6 to 40 months of remission, responding favorably.\u0000\u0000\u0000CONCLUSIONS\u0000The study shows that a quarter of severe CSU patients achieve long-term remission. In addition, sgAHs effectively manage symptoms in a majority of relapsed cases, and those requiring omalizumab reintroduction respond favorably.","PeriodicalId":502234,"journal":{"name":"Acta dermatovenerologica Alpina, Pannonica, et Adriatica","volume":"47 20","pages":"actaapa.2024.12"},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140980947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral methotrexate in the treatment of Hailey‒Hailey disease: a case report. 口服甲氨蝶呤治疗海利-海利病：病例报告。

Acta dermatovenerologica Alpina, Pannonica, et Adriatica Pub Date : 2024-05-06 DOI: 10.15570/actaapa.2024.11

Iva Maširević Mudrić, Jovana Pelemiš, B. Lekić, S. Popadić

引用次数: 0

A case of multiple autoimmune syndrome comprising autoimmune thyroid disease, vitiligo, morphea, and lichen sclerosus. 一例由自身免疫性甲状腺疾病、白癜风、斑秃和硬皮病组成的多重自身免疫综合征。

Acta dermatovenerologica Alpina, Pannonica, et Adriatica Pub Date : 2024-04-12 DOI: 10.15570/actaapa.2024.10

Hana Gašper, V. Breznik

引用次数: 0

Treatment of plaque-psoriasis in HIV-positive patients. 治疗艾滋病毒阳性患者的斑块状银屑病。

Acta dermatovenerologica Alpina, Pannonica, et Adriatica Pub Date : 2024-03-01 DOI: 10.15570/actaapa.2024.8

Vita Jugovac, Marija Gulin, Dora Barić, D. Ledić Drvar, R. Ceovic

{"title":"Treatment of plaque-psoriasis in HIV-positive patients.","authors":"Vita Jugovac, Marija Gulin, Dora Barić, D. Ledić Drvar, R. Ceovic","doi":"10.15570/actaapa.2024.8","DOIUrl":"https://doi.org/10.15570/actaapa.2024.8","url":null,"abstract":"Psoriasis is a chronic inflammatory disease that can often accompany human immunodeficiency virus (HIV) epidemics. Development of psoriasis in HIV patients is correlated with a decrease in CD4+ count. Significant variability in the clinical presentation of psoriasis makes it a challenging disease to diagnose. Furthermore, associated immunodeficiency complicates standard treatment with immunosuppressive and biological therapy. Articles that match the terms psoriasis and HIV were searched in MEDLINE and Embase and selected based on their relevance. Highly active antiretroviral therapy (HAART) is a medication regimen used to manage and treat HIV infection. In treating mild psoriasis in HIV-positive patients, topical agents combined with HAART are considered first-line therapy, followed by phototherapy. Second-line therapy includes oral retinoids, alone or combined. In treating challenging cases, apremilast has been used due to its lack of immunosuppressive effect. In case of progressive and refractory disease, limited data from studies suggest that immunosuppressive or biological therapy may be effective. Treatment of psoriasis in HIV patients remains a challenge, which is largely attributable to its complicated etiopathology and lack of an approved therapy option. In treating severe psoriasis, close collaboration with an infectious disease specialist is highly recommended. Further research is needed, preferably with an aim toward developing individualized therapy.","PeriodicalId":502234,"journal":{"name":"Acta dermatovenerologica Alpina, Pannonica, et Adriatica","volume":"63 4","pages":"37-40"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140403881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COVID-19 and oral lesions: 2020-2024 outpatient case series and literature review. COVID-19 与口腔病变：2020-2024 年门诊病例系列和文献综述。

Acta dermatovenerologica Alpina, Pannonica, et Adriatica Pub Date : 2024-03-01 DOI: 10.15570/actaapa.2024.9

A. Glavina, Jozo Badrov, Marino Lukenda, Karmela Džaja, Dolores Biočina-Lukenda, L. Lugović-Mihić

{"title":"COVID-19 and oral lesions: 2020-2024 outpatient case series and literature review.","authors":"A. Glavina, Jozo Badrov, Marino Lukenda, Karmela Džaja, Dolores Biočina-Lukenda, L. Lugović-Mihić","doi":"10.15570/actaapa.2024.9","DOIUrl":"https://doi.org/10.15570/actaapa.2024.9","url":null,"abstract":"Data on oral lesions of coronavirus disease (COVID-19) are conflicting, and there are few evidence-based data on oral lesions directly caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The aim of this case series and literature review is to determine the prevalence of oral lesions associated with COVID-19 in outpatients and identify oral manifestations that are likely associated with COVID-19. We present 15 patients that came for their first specialist examination to the Oral Medicine Outpatient Clinic, Dental Clinic, Split, Croatia between November 2020 and January 2024. Their medical and dental history was taken following CARE guidelines. The prevalence of oral lesions associated with SARS-CoV-2 was 1.42% during the 4-year follow-up period. The most common oral lesions were nonspecific erosions, stomatitis, salivary flow disorders (xerostomia, oligosialia), salivary gland diseases (sialadenitis, chronic sialadenitis), candidiasis, pigmentation, aphthae, burning mouth syndrome, and geographic and fissured tongue. The mean latency period was 25.1 days. The site most commonly affected was the tongue (61.5%). Oral lesions associated with COVID-19 occurred in middle-aged patients, with an equal distribution by sex. They presented in a mild form and did not correlate with the severity of the clinical picture of COVID-19.","PeriodicalId":502234,"journal":{"name":"Acta dermatovenerologica Alpina, Pannonica, et Adriatica","volume":"3 12","pages":"41-48"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140404244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The relationship between sleep quality and chronotype differences and urticaria severity in patients with chronic spontaneous urticaria. 慢性自发性荨麻疹患者的睡眠质量和时间型差异与荨麻疹严重程度之间的关系。

Acta dermatovenerologica Alpina, Pannonica, et Adriatica Pub Date : 2024-03-01 DOI: 10.15570/actaapa.2024.6

Gulhan Gurel, Dilara Guler, H. A. Guler, İrem Nur Durusu Türkoğlu, Isın Nur Sultan Oncu, S. Soylu

{"title":"The relationship between sleep quality and chronotype differences and urticaria severity in patients with chronic spontaneous urticaria.","authors":"Gulhan Gurel, Dilara Guler, H. A. Guler, İrem Nur Durusu Türkoğlu, Isın Nur Sultan Oncu, S. Soylu","doi":"10.15570/actaapa.2024.6","DOIUrl":"https://doi.org/10.15570/actaapa.2024.6","url":null,"abstract":"INTRODUCTION\u0000Chronic spontaneous urticaria (CSU) is characterized by persistent or recurrent pruritic lesions that last more than 6 weeks. Patients with CSU may experience sleep disturbances, particularly due to itching. Biological rhythms (chronotypes) are categorized as morningness, intermediate, and eveningness types. This study evaluates the relationship between sleep quality, chronotype, and disease severity in CSU patients.\u0000\u0000\u0000METHODS\u0000The study included 53 CSU patients and 50 healthy controls. A sociodemographic data form was completed, and the disease severity was determined utilizing the Urticaria Activity Score over 7 days (UAS7). The Hospital Anxiety and Depression Scale (HADS), Insomnia Severity Index (ISI), and Pittsburgh Sleep Quality Index (PSQI) scales as well as the Morningness-Eveningness Scale (MEQ) were applied to the participants.\u0000\u0000\u0000RESULTS\u0000The CSU group had a significantly higher body mass index (BMI) than that of the healthy control group. In terms of sleep and chronotype scales, compared to the control group, the CSU group had higher ISI scores as well as subscale scores on the PSQI subscales, with the exception of habitual sleep efficiency and total PSQI scores. There was no difference between MEQ scores. In the correlation analysis, the UAS7 and PSQI total scores were found to be correlated, whereas in the logistic regression analysis the estimated relative risk of BMI and PSQI total score for CSU was found to be 1.13 and 1.45, respectively.\u0000\u0000\u0000CONCLUSIONS\u0000When dealing with CSU patients, it is necessary to conduct a sleep quality assessment as part of a holistic evaluation.","PeriodicalId":502234,"journal":{"name":"Acta dermatovenerologica Alpina, Pannonica, et Adriatica","volume":"220 6","pages":"7-11"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140402799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photoaging assessment by Glogau classification: correlation of dermoscopy findings in the coastal population of Indonesia. 用 Glogau 分类法评估光老化：印度尼西亚沿海居民皮肤镜检查结果的相关性。

Acta dermatovenerologica Alpina, Pannonica, et Adriatica Pub Date : 2024-03-01 DOI: 10.15570/actaapa.2024.5

Putu Martha Gerynda Sukma, Sri Linuwih Sw Menaldi, Larisa Paramitha Wibawa, S. Yusharyahya, Marsen Isbayuputra

{"title":"Photoaging assessment by Glogau classification: correlation of dermoscopy findings in the coastal population of Indonesia.","authors":"Putu Martha Gerynda Sukma, Sri Linuwih Sw Menaldi, Larisa Paramitha Wibawa, S. Yusharyahya, Marsen Isbayuputra","doi":"10.15570/actaapa.2024.5","DOIUrl":"https://doi.org/10.15570/actaapa.2024.5","url":null,"abstract":"INTRODUCTION\u0000To date, there is no gold standard for identifying photoaging. This study investigates the correlation of photoaging profiles based on the Glogau scale and the dermoscopy photoaging scale (DPAS) in a coastal population.\u0000\u0000\u0000METHODS\u0000An analytical cross-sectional study was conducted at Cilincing Municipal Health Center in Jakarta in October 2022. Individuals living in the coastal area, 20 years and older, with Fitzpatrick skin types III-V, and with a mean daily sun exposure of ≥ 3 hours were included. The Glogau scale and DPAS were assessed through history taking, physical examination, and dermoscopic examination. A Spearman correlation test was used to assess the correlation between the Glogau scale and DPAS.\u0000\u0000\u0000RESULTS\u0000Thirty individuals with a mean age of 41.5 ± 11.5 years participated in the study. The median Glogau score was 3 (range: 2-4). The mean DPAS score was 28.5 ± 5.6. Lentigo, hypo-hyperpigmented macules, telangiectasia, deep wrinkles, and superficial wrinkles were observed in all subjects. There was a moderate positive correlation between the Glogau scale and DPAS (r = 0.536, p = 0.002).\u0000\u0000\u0000CONCLUSIONS\u0000The Glogau scale has a significant correlation with DPAS. DPAS can serve as a reliable, easy, practical, and fast diagnostic tool to assess the severity of aging.","PeriodicalId":502234,"journal":{"name":"Acta dermatovenerologica Alpina, Pannonica, et Adriatica","volume":"8 4","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140404610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic accuracy of a short-form version of the diagnostic criteria for primary hyperhidrosis. 原发性多汗症诊断标准简表的诊断准确性。

Acta dermatovenerologica Alpina, Pannonica, et Adriatica Pub Date : 2024-03-01 DOI: 10.15570/actaapa.2024.7

M. Henning, Hajer I Al-Rahimi, G. B. Jemec, Ole B Pedersen

{"title":"Diagnostic accuracy of a short-form version of the diagnostic criteria for primary hyperhidrosis.","authors":"M. Henning, Hajer I Al-Rahimi, G. B. Jemec, Ole B Pedersen","doi":"10.15570/actaapa.2024.7","DOIUrl":"https://doi.org/10.15570/actaapa.2024.7","url":null,"abstract":"INTRODUCTION\u0000The gold standard method for diagnosing primary hyperhidrosis (PHH) is based on seven patient-reported criteria. By determining an individual criterion's diagnostic accuracy, one can identify short-version classification models.\u0000\u0000\u0000METHODS\u0000In this cross-sectional study, data were collected from Danish blood donors in 2021. Cohen's kappa and diagnostic accuracy were determined by comparing each criterion with the gold standard method.\u0000\u0000\u0000RESULTS\u0000The study included 1,039 participants. Of them, 59 (5.7%) had PHH and 980 (94.3%) were classified as control individuals. The PHH major criterion \"focal visible excessive sweating for at least 6 months without an apparent cause\" had the highest prevalence in the participants with PHH compared to the control individuals (100% vs. 0.6%; p < 0.0001). The agreement between this criterion and PHH was Cohen's kappa = 0.95 (95% confidence interval [CI] 0.91-0.99), and its sensitivity was 1.00 (95% CI 0.94-1.00) and specificity 0.99 (95% CI 0.99-1.00). The other criteria showed lower agreement and diagnostic accuracy.\u0000\u0000\u0000CONCLUSIONS\u0000The PHH major criterion showed near-perfect agreement and near-equal diagnostic accuracy compared with the gold standard method. This single criterion can be used as a short-form version to screen for PHH. Determination of reproducibility in independent populations is warranted.","PeriodicalId":502234,"journal":{"name":"Acta dermatovenerologica Alpina, Pannonica, et Adriatica","volume":"60 5","pages":"17-22"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140406472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Widespread dermatophytosis in a healthy adolescent: the first report of multidrug-resistant Trichophyton indotineae infection in the UAE. 一名健康青少年的大面积皮肤癣菌病：阿联酋首例耐多药毛癣菌感染病例。

Acta dermatovenerologica Alpina, Pannonica, et Adriatica Pub Date : 2024-02-13 DOI: 10.15570/actaapa.2024.4

Miloš D Pavlović, Shireen Marzouk, Leis Bećiri

引用次数: 0