Eye & Contact LensPub Date : 2022-07-01Epub Date: 2022-06-03DOI: 10.1097/ICL.0000000000000912
Duangratn Niruthisard, Simon S M Fung
{"title":"Recombinant Human Nerve Growth Factor for Pediatric Neurotrophic Keratopathy.","authors":"Duangratn Niruthisard, Simon S M Fung","doi":"10.1097/ICL.0000000000000912","DOIUrl":"https://doi.org/10.1097/ICL.0000000000000912","url":null,"abstract":"<p><strong>Abstract: </strong>A 4-year-old boy presented with right neurotrophic corneal ulcer, lagophthalmos, and facial palsy 8 months after neurosurgery for synchronous brain tumors. Initial treatment with topical antibiotics, topical corticosteroids, lubrication, and lateral tarsorrhaphy successfully treated the corneal epithelial defect; however, the cornea continued to demonstrate diffuse epitheliopathy and a dense stromal opacity and remained insensate on Cochet-Bonnet esthesiometry. After a course of topical cenegermin, central corneal sensation normalized, and the corneal epitheliopathy was markedly improved. Two years after the completion of cenegermin, corneal sensation was maintained; there were no recurrences of epithelial defects, and the stromal opacity had markedly improved. In vivo confocal microscopy (IVCM) demonstrated the presence of subbasal corneal innervation. This report highlights the safety and prolonged effects of cenegermin for the treatment of pediatric iatrogenic neurotrophic keratopathy, as evidenced by the clinical course and IVCM.</p>","PeriodicalId":502139,"journal":{"name":"Eye & Contact Lens","volume":" ","pages":"303-305"},"PeriodicalIF":2.3,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40121658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eye & Contact LensPub Date : 2022-03-01DOI: 10.1097/ICL.0000000000000879
Xueyang Wang, Deborah S Jacobs
{"title":"Contact Lenses for Ocular Surface Disease.","authors":"Xueyang Wang, Deborah S Jacobs","doi":"10.1097/ICL.0000000000000879","DOIUrl":"https://doi.org/10.1097/ICL.0000000000000879","url":null,"abstract":"<p><strong>Abstract: </strong>Ocular surface disease can be difficult to manage, causing patients discomfort and vision loss. Therapeutic contact lenses are an important treatment option that is often neglected because it is conventional wisdom that eyes that are dry or irritated are not good candidates for contact lens. In this focused review, we consider the substantial literature on the use of bandage soft contact lenses (BSCL), scleral lenses, and customized prosthetic devices in the management of ocular graft-vs-host disease. Reports on BSCLs for recurrent corneal erosion are reviewed, as is literature on scleral lenses and prosthetic replacement of the ocular surface ecosystem treatment for Stevens-Johnson syndrome. Clinical pearls for fitting BSCLs are presented, and the issue of antibiotic prophylaxis is considered.</p>","PeriodicalId":502139,"journal":{"name":"Eye & Contact Lens","volume":" ","pages":"115-118"},"PeriodicalIF":2.3,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39654021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eye & Contact LensPub Date : 2022-03-01DOI: 10.1097/ICL.0000000000000874
Aravind Roy, Venkata V Krishna Venuganti, Shreya S Chauhan, Prashant Garg
{"title":"Polymeric Drug Delivery Devices: Role in Cornea and External Disease.","authors":"Aravind Roy, Venkata V Krishna Venuganti, Shreya S Chauhan, Prashant Garg","doi":"10.1097/ICL.0000000000000874","DOIUrl":"https://doi.org/10.1097/ICL.0000000000000874","url":null,"abstract":"<p><strong>Abstract: </strong>The field of ophthalmic drug delivery is undergoing rapid changes not only in the evolution of pharmacologic agents but also in the novel drug delivery vehicles. The ocular surface has limitations to drug penetration because of the presence of tight junctions between basal epithelial cells, which limits the amount of drug that can be absorbed after topical instillation. In addition, nasolacrimal drainage reduces the precorneal residence time significantly. Contact lenses (CLs) have been considered as possible carriers for topical medications because they reside on the ocular surface for a sufficient length of time, and pharmacologic agents may be copolymerized with hydrogels allowing controlled drug diffusion. This strategy reduces the frequency of dosage while improving compliance. Modification of drug delivery vehicles is essential to allow sustained release of the drug from a polymeric complex, facilitate stability and residence time of the drug on the precorneal tear film, and improve penetration into biologic membranes. This review focuses on updates in CL-based and non-CL-based strategies in ophthalmic drug delivery.</p>","PeriodicalId":502139,"journal":{"name":"Eye & Contact Lens","volume":" ","pages":"119-126"},"PeriodicalIF":2.3,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39654022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eye & Contact LensPub Date : 2022-03-01DOI: 10.1097/ICL.0000000000000872
Michelle K Rhee
{"title":"Update on Myopia Control: The US Perspective.","authors":"Michelle K Rhee","doi":"10.1097/ICL.0000000000000872","DOIUrl":"https://doi.org/10.1097/ICL.0000000000000872","url":null,"abstract":"<p><strong>Abstract: </strong>Myopia is a global epidemic on the rise, garnering increased attention, particularly in therapeutics and prevention, and the field of myopia control. This study reviews the current management options including contact lenses, spectacles, atropine, and environmental and behavioral modifications. Particular attention is given to the US perspective.</p>","PeriodicalId":502139,"journal":{"name":"Eye & Contact Lens","volume":" ","pages":"105-109"},"PeriodicalIF":2.3,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39819504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eye & Contact LensPub Date : 2022-03-01DOI: 10.1097/ICL.0000000000000876
Motozumi Itoi, Motohiro Itoi
{"title":"Management of Keratoconus With Corneal Rigid Gas-Permeable Contact Lenses.","authors":"Motozumi Itoi, Motohiro Itoi","doi":"10.1097/ICL.0000000000000876","DOIUrl":"https://doi.org/10.1097/ICL.0000000000000876","url":null,"abstract":"<p><strong>Abstract: </strong>Vision correction using a corneal rigid gas-permeable contact lens, which is relatively safe, easy to replace, and economical, is still the basis of the management for keratoconus. For eyes with keratoconus, two fitting strategies have traditionally been used in Japan: apical touch fitting with spherical lenses and parallel fitting with multicurve lenses. These two techniques have different success rates depending on the type and severity of keratoconus. Therefore, it is important to classify eyes with keratoconus into four types according to the shape of the cornea and select the prescription techniques according to this classification. If the corneal GPs prescribed by these fitting methods cannot be used because of mechanical irritation to the corneal epithelium, the \"piggyback lens system\" is an effective option. Furthermore, proper lens care must be instructed to patients to prevent contact lens-related complications and maintain visual function. If these fittings and introductions can be performed properly, corneal GPs can safely provide effective and comfortable vision for many patients with keratoconus, even for those with severe keratoconus.</p>","PeriodicalId":502139,"journal":{"name":"Eye & Contact Lens","volume":" ","pages":"110-114"},"PeriodicalIF":2.3,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39654020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eye & Contact LensPub Date : 2022-02-01DOI: 10.1097/ICL.0000000000000861
Zhen Yi, Shen Jing, Wang Wenhua, Li Qian, Wang Ningli
{"title":"Evaluation of Orthokeratology Lens Fitting Assisted by Sagittal Height Simulation Software.","authors":"Zhen Yi, Shen Jing, Wang Wenhua, Li Qian, Wang Ningli","doi":"10.1097/ICL.0000000000000861","DOIUrl":"https://doi.org/10.1097/ICL.0000000000000861","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate a novel sagittal height fitting algorithm for estimation of alignment curve (AC) radius during Euclid orthokeratology lens trial.</p><p><strong>Methods: </strong>Chinese myopic children were recruited in this study and were randomly divided into two groups. The AC radius of one group was calculated by the novel fitting algorithm. The AC radius of the other group was decided by the optometrist using flat K readings and eccentricity values. The number of lens trials was recorded for each patient, and the consistencies of AC radius between the first trial lenses and the final ordered lenses were tested by Pearson correlations and Bland-Altman plots.</p><p><strong>Results: </strong>One hundred three adolescent patients (103 eyes) were enrolled, including 57 boys and 46 girls. The numbers of trials for the novel algorithm and traditional method were 1.2±0.4 times versus 1.4±0.5 times, respectively, and the difference between the two methods was significant (t=2.404, P=0.018). The difference of AC value between the first trial lens and the lens to be produced for the novel algorithm and traditional method 0.000±0.020 mm and 0.003±0.028 mm separately. There was no statistical difference between the two methods (t=0.748, P=0.456).</p><p><strong>Conclusions: </strong>The new sagittal height simulation software can accurately calculate the AC value of the orthokeratology lens suitable for the Chinese patients.</p>","PeriodicalId":502139,"journal":{"name":"Eye & Contact Lens","volume":" ","pages":"78-82"},"PeriodicalIF":2.3,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39844485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eye & Contact LensPub Date : 2022-02-01DOI: 10.1097/ICL.0000000000000871
Loretta Szczotka-Flynn
{"title":"Intrapatient and Interpatient Contact Lens Disinfection in the Age of COVID-19.","authors":"Loretta Szczotka-Flynn","doi":"10.1097/ICL.0000000000000871","DOIUrl":"https://doi.org/10.1097/ICL.0000000000000871","url":null,"abstract":"","PeriodicalId":502139,"journal":{"name":"Eye & Contact Lens","volume":" ","pages":"57"},"PeriodicalIF":2.3,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39844031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eye & Contact LensPub Date : 2022-02-01DOI: 10.1097/ICL.0000000000000866
John D Gelles, Kyla E Hillier, Sydney Krisa, Steven A Greenstein, Peter S Hersh
{"title":"Lipid Keratopathy Management With Therapeutic Scleral Lens Wear.","authors":"John D Gelles, Kyla E Hillier, Sydney Krisa, Steven A Greenstein, Peter S Hersh","doi":"10.1097/ICL.0000000000000866","DOIUrl":"https://doi.org/10.1097/ICL.0000000000000866","url":null,"abstract":"<p><strong>Purpose: </strong>To report on the use of scleral lens therapy for a patient with lipid keratopathy secondary to rigid gas permeable contact lens wear and ocular surface disease.</p><p><strong>Methods: </strong>Case report and literature review.</p><p><strong>Results: </strong>A 40-year-old man with a history of keratoconus and rigid gas permeable contact lens wear, resulting in corneal neovascularization and lipid keratopathy. The patient reported to our clinic with central lipid keratopathy secondary to rigid gas permeable lens wear and ocular surface disease. Given the density, central location, and subsequent visual limitations induced by lipid deposition and topographical irregularity, penetrating keratoplasty and scleral contact lens wear were discussed as possible treatment options. In this case, scleral lens wear provided both visual improvement and resolution of lipid keratopathy. After 3 years, the patient has remained stable, with significant visual improvement and near-complete resolution of lipid keratopathy.</p><p><strong>Conclusions: </strong>This case illustrates the use of scleral lens wear in the therapeutic management of lipid keratopathy secondary to rigid gas permeable lens wear and ocular surface disease. For patients limited by lipid keratopathy and topographical irregularity, scleral lens wear may be used to achieve both visual and therapeutic outcomes.</p>","PeriodicalId":502139,"journal":{"name":"Eye & Contact Lens","volume":" ","pages":"91-94"},"PeriodicalIF":2.3,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39933557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eye & Contact LensPub Date : 2022-01-01DOI: 10.1097/ICL.0000000000000856
Prithvi Chandrakanth, Hirika Gosalia, Shishir Verghese, C K Sunitha Menon, Ram Rammohan, Kalpana Narendran, Venkatapathy Narendran
{"title":"Office-Based Rapid Diagnosis and Management of External Ophthalmomyiasis Via Smartphone-Aided Innovative Tools in an Under-Resourced Setting.","authors":"Prithvi Chandrakanth, Hirika Gosalia, Shishir Verghese, C K Sunitha Menon, Ram Rammohan, Kalpana Narendran, Venkatapathy Narendran","doi":"10.1097/ICL.0000000000000856","DOIUrl":"https://doi.org/10.1097/ICL.0000000000000856","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the use of smartphone-based innovative tools named Anterior segment photography with intraocular lens (ASPI) and smartphone based intraocular lens microscope (IOLSCOPE) to demonstrate, treat, and diagnose the patients of ophthalmomyiasis caused by Oestrus ovis.</p><p><strong>Methods: </strong>A retrospective interventional case series of six patients infested with O. ovis presenting in a rural health center with symptoms of burning, itching, watering, and foreign body sensation diagnosed with ophthalmomyiasis. Diagnosis and treatment were performed using an innovative imaging technique that is, an optical system formed by intraocular lens (IOL) and smartphone.</p><p><strong>Results: </strong>The smartphone-based ASPI clearly detected and removed the moving larvae from the ocular surface, followed by microbiological diagnosis of O.ovis larvae with the help of an IOLSCOPE.</p><p><strong>Conclusion: </strong>The importance of ASPI and IOLSCOPE for the management of ophthalmomyiasis in peripheral health centers devoid of slitlamp and microscopes has been emphasized here.</p>","PeriodicalId":502139,"journal":{"name":"Eye & Contact Lens","volume":" ","pages":"54-56"},"PeriodicalIF":2.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39826548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}