Indian journal of pathology & microbiology最新文献_第2页

Cutaneous blastic plasmacytoid dendritic cell neoplasm masquerading as T cell lymphoma in a young adolescent female. 皮肤母细胞浆细胞样树突状细胞肿瘤伪装成T细胞淋巴瘤。

IF 0.5

Indian journal of pathology & microbiology Pub Date : 2026-09-03 DOI: 10.4103/ijpm.ijpm_170_26

S Saudamini, Sunil Pasricha, Meenakshi Kamboj, S Ethel Shange, Anurag Mehta

引用次数: 0

STK11 adnexal tumor mimicking a female adnexal tumor of probable Wolffian origin (FATWO) associated with Peutz-Jeghers syndrome: A brief review. STK11附件肿瘤模拟可能起源于Wolffian （FATWO）的女性附件肿瘤，与Peutz-Jeghers综合征相关：简要回顾。

IF 0.5

Indian journal of pathology & microbiology Pub Date : 2026-09-03 DOI: 10.4103/ijpm.ijpm_239_26

Musheera Aziz, Bharat Rekhi, Swarnalata Gowrishankar, Trupti Pai, Prachi Bapat

{"title":"STK11 adnexal tumor mimicking a female adnexal tumor of probable Wolffian origin (FATWO) associated with Peutz-Jeghers syndrome: A brief review.","authors":"Musheera Aziz, Bharat Rekhi, Swarnalata Gowrishankar, Trupti Pai, Prachi Bapat","doi":"10.4103/ijpm.ijpm_239_26","DOIUrl":"https://doi.org/10.4103/ijpm.ijpm_239_26","url":null,"abstract":"Abstract: Lately, STK11 adnexal tumors have been described in patients with Peutz-Jeghers syndrome (PJS), showing overlap with other adnexal tumors, especially female adnexal tumor of probable Wolffian origin (FATWO). To date, there is no documentation of this tumor from the Indian subcontinent. A 25-year-old female with mucocutaneous pigmented macules presented with acute abdominal pain along with a family history of surgical resection for gastrointestinal polyps in her mother and sister. Imaging revealed a well-defined, cystic right adnexal mass, distinct from the ovary, measuring 4.1 cm. Her colonoscopic examination was unremarkable. She underwent paraovarian cystectomy. Histopathological examination revealed a tumor composed of epithelioid cells arranged in various growth patterns with mild nuclear atypia. Immunohistochemically, the tumor cells were positive for pan-keratin, calretinin, CD10, FOXL2, and androgen receptor, the latter in 50% of the tumor cell nuclei. Initially, a diagnosis of FATWO was considered. Targeted next-generation sequencing revealed a pathogenic STK11 exon 4 frameshift mutation (c. 574dup), which was subsequently confirmed as a germline alteration on peripheral blood testing by Sanger sequencing, thereby establishing the diagnosis of an STK11 tumor with PJS. The differential diagnoses of this tumor and the judicious application of immunohistochemical stains, along with genetic testing (including high-throughput molecular testing in a clinical context) for an exact diagnosis, are discussed herein. A literature review including the molecular results of this rare tumor is also presented.","PeriodicalId":502106,"journal":{"name":"Indian journal of pathology & microbiology","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148893311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retinal pigment epithelial carcinoma masquerading as choroidal melanoma-A rare case report. 视网膜色素上皮癌伪装成脉络膜黑色素瘤1例报道。

IF 0.5

Indian journal of pathology & microbiology Pub Date : 2026-09-03 DOI: 10.4103/ijpm.ijpm_27_26

Bidhan C Das, Dipankar Das, Ganesh C Kuri, Apurba Deka

引用次数: 0

Mast cell density in different histological grades of oral squamous cell carcinoma: A cross-sectional study in a tertiary care center in Northeast India. 不同组织学级别的口腔鳞状细胞癌的肥大细胞密度：印度东北部三级保健中心的横断面研究。

IF 0.5

Indian journal of pathology & microbiology Pub Date : 2026-09-03 DOI: 10.4103/ijpm.ijpm_75_26

Deexa Sinha, Kamal Kali Das, Abhijit Datta, Nishtha Das, Pinki Chakma

{"title":"Mast cell density in different histological grades of oral squamous cell carcinoma: A cross-sectional study in a tertiary care center in Northeast India.","authors":"Deexa Sinha, Kamal Kali Das, Abhijit Datta, Nishtha Das, Pinki Chakma","doi":"10.4103/ijpm.ijpm_75_26","DOIUrl":"https://doi.org/10.4103/ijpm.ijpm_75_26","url":null,"abstract":"Background: Mast cells accumulate in peritumoral tissue in cutaneous malignancies and various other malignancies and contribute to a permissive microenvironment for carcinogenesis. They promote tumor angiogenesis by inducing neovascularization. Most cases of oral squamous cell carcinoma (OSCC) are moderately to well differentiated, whereas poorly differentiated cases are rare. The objective of the study is to evaluate tumor mast cell density across different histological grades of OSCC in patients of a tertiary care center of Northeast India.Materials and methods: The study included 139 patients diagnosed histopathologically, and mast cell density was analyzed by toluidine blue stain; density was counted in hotspots (nhpf). Poorly differentiated OSCC ( n = 2) was analyzed descriptively. Well-differentiated versus moderately differentiated OSCC was compared using t -test or Mann-Whitney U test (Statistical Package for the Social Sciences v25).Results: Well-differentiated OSCC: 70 (50.4%), moderately differentiated OSCC: 67 (48.2%), and poorly differentiated OSCC: 2 (1.4%). There was no statistically significant difference in mast cell density between well-differentiated versus moderately differentiated grades ( P = 0.068), although variations in mean values were noted. Density was lower in poorly differentiated OSCC cases.Conclusions: Our study results showed no statistically significant difference in mast cell density among OSCC grades. Larger poorly differentiated OSCC samples are needed for future studies.","PeriodicalId":502106,"journal":{"name":"Indian journal of pathology & microbiology","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148893275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary central nervous system extranodal NK/T-cell lymphoma predominantly composed of anaplastic cells: A case report. 原发性中枢神经系统结外NK/ t细胞淋巴瘤主要由间变性细胞组成：1例报告。

IF 0.5

Indian journal of pathology & microbiology Pub Date : 2026-09-03 DOI: 10.4103/ijpm.ijpm_170_25

Huan Chen, Liu Shi, JiaSi Li, Feng Zhang

{"title":"Primary central nervous system extranodal NK/T-cell lymphoma predominantly composed of anaplastic cells: A case report.","authors":"Huan Chen, Liu Shi, JiaSi Li, Feng Zhang","doi":"10.4103/ijpm.ijpm_170_25","DOIUrl":"https://doi.org/10.4103/ijpm.ijpm_170_25","url":null,"abstract":"Abstract: Extranodal NK/T-cell lymphoma (ENKTL) of the central nervous system (CNS) is very rare. We herein report a case of ENKTL originating from the CNS in a 79-year-old woman. The patient presented with episodic seizures, left-sided limb weakness, altered mental status, and dysarthria for more than 1 month. Radiological examination revealed a solitary mass in the (laterality) frontal lobe of the brain, which was surgically removed. Histopathology revealed a tumor showing diffuse growth of large anaplastic cells with multiple reniform nuclei, horseshoe nuclei, and doughnut-like nuclei. Immunohistochemically, the tumor cells were diffusely positive for CD3, CD30, Gramazyme B, and TIA1 and negative for ALK and CD56. It was almost misdiagnosed as ALK-negative anaplastic large cell lymphoma, but positivity for cytotoxic markers and EBER-ISH helped establish the diagnosis of ENKTL. To the best of our knowledge, this anaplastic variant of ENKTL has not been reported in the CNS. We present this case to describe an uncommon aggressive variant of ENKTL at CNS as a rare location with diagnostic pitfalls.","PeriodicalId":502106,"journal":{"name":"Indian journal of pathology & microbiology","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148893277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic characteristics of anti-endomysial antibody in the diagnosis of celiac disease-A multicenter prospective observational study. 抗肌内膜抗体在乳糜泻诊断中的诊断特点——一项多中心前瞻性观察研究

IF 0.5

Indian journal of pathology & microbiology Pub Date : 2026-07-25 DOI: 10.4103/ijpm.ijpm_1027_25

Alka Kumari, Aditya V Pachisia, Sanjay Kumar, Divya Sharma, Anam Ahmed, Sonu Sharma, Ashish Chauhan, Rimlee Dutta, Prasenjit Das, Sushil Falodia, Saroj K Sinha, Vineet Ahuja, Govind K Makharia

{"title":"Diagnostic characteristics of anti-endomysial antibody in the diagnosis of celiac disease-A multicenter prospective observational study.","authors":"Alka Kumari, Aditya V Pachisia, Sanjay Kumar, Divya Sharma, Anam Ahmed, Sonu Sharma, Ashish Chauhan, Rimlee Dutta, Prasenjit Das, Sushil Falodia, Saroj K Sinha, Vineet Ahuja, Govind K Makharia","doi":"10.4103/ijpm.ijpm_1027_25","DOIUrl":"https://doi.org/10.4103/ijpm.ijpm_1027_25","url":null,"abstract":"Background: Anti-endomysial antibody (EMA) has demonstrated high specificity and reasonable sensitivity for the diagnosis of celiac disease (CeD). We aimed to evaluate the diagnostic accuracy of EMA in our patients with CeD.Materials and methods: In this prospective study, we included patients of treatment-naïve CeD as cases who were recruited under an Indian National CeD Biorepository and had already tested positive for IgA anti-tTG, hence diagnosed as CeD based on standard criteria. Patients with other enteropathies, functional dyspepsia and gastroesophageal reflux disease, in whom IgA anti-tTG was negative, were taken as controls. Both cases and controls underwent testing for EMA using an immunofluorescence-based assay (Inova Diagnostic, USA). Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were calculated.Results: The mean age of patients with CeD and controls was 28.3 ± 12.2 and 35.5 ± 10.72, respectively ( P < 0.001). EMA was positive in only 50.9% (141 of 277) patients with CeD, while in the control group, 1 out of 90 (1.1%) had positive EMA. The sensitivity, specificity, PPV, and NPV were 50.9, 98.9, 99.3, and 39.6%, respectively. Diagnostic odds ratio, positive LR, and negative LR were 92.3, 45.8, and 0.49, respectively.Conclusion: EMA test has high specificity and low sensitivity. Only half of adult CeD patients had positive EMA.","PeriodicalId":502106,"journal":{"name":"Indian journal of pathology & microbiology","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148709090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cost-effective digital morphology training for resource-limited laboratories: A 12-year experience from China. 为资源有限的实验室提供具有成本效益的数字形态学培训：中国12年的经验。

IF 0.5

Indian journal of pathology & microbiology Pub Date : 2026-06-02 DOI: 10.4103/ijpm.ijpm_309_25

Haidi Tang, Menghan Yang, Wei Yang

{"title":"Cost-effective digital morphology training for resource-limited laboratories: A 12-year experience from China.","authors":"Haidi Tang, Menghan Yang, Wei Yang","doi":"10.4103/ijpm.ijpm_309_25","DOIUrl":"https://doi.org/10.4103/ijpm.ijpm_309_25","url":null,"abstract":"Background: Mastery of cellular morphology interpretation is fundamental to the professional growth of clinical laboratory physicians. Conventional morphology training has limitations, while digital platforms have their own challenges. There is an urgent need to balance the benefits of traditional and online learning to optimize morphology training.Methods: This 12-year longitudinal predictive modeling study used a mixed-methods design. It involved 301 medical professionals from the First Affiliated Hospital of Harbin Medical University, with 244 remaining after applying exclusion criteria. Participants received traditional classroom training and online learning. A pre-training survey was used to stratify participants in 2024. Competency was assessed via a 100-item digital image bank, and multivariate logistic regression and nomogram construction were performed for analysis.Results: The results showed that online learning, professional experience, professional title, and age significantly predicted morphological test scores. Early-career practitioners preferred online modules and performed better digitally, while senior staff showed a strong preference for traditional workshops. After implementing a personalized training program in 2024 based on career-stage preferences, there was a significant improvement in morphology examination scores, with a 6.90-point mean elevation. The program also reduced the incidence of subthreshold performance by 63.19% and optimized resource utilization, reducing training hours by 52.2% and teaching space by 50%.Conclusion: This study validates the importance of aligning training methods with career stage-specific cognitive variations and technological adaptability. It provides a practical prediction tool for cultivating morphological expertise, advancing medical morphology pedagogy in the digital age.","PeriodicalId":502106,"journal":{"name":"Indian journal of pathology & microbiology","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148207521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Secondary B-acute lymphoblastic leukemia following lenalidomide maintenance in multiple myeloma. 来那度胺维持治疗多发性骨髓瘤后继发性b急性淋巴细胞白血病。

IF 0.5

Indian journal of pathology & microbiology Pub Date : 2026-04-01 Epub Date: 2026-06-02 DOI: 10.4103/ijpm.ijpm_1266_25

Raghuveer S Prabhu, R Pranav, Jay Mehta

{"title":"Secondary B-acute lymphoblastic leukemia following lenalidomide maintenance in multiple myeloma.","authors":"Raghuveer S Prabhu, R Pranav, Jay Mehta","doi":"10.4103/ijpm.ijpm_1266_25","DOIUrl":"https://doi.org/10.4103/ijpm.ijpm_1266_25","url":null,"abstract":"Abstract: Following the advent of immunomodulatory agents (IMiDs) in the treatment of multiple myeloma (MM), the progression-free survival has improved significantly. This has also led to increased recognition of second primary malignancy (SPM), like myelodysplastic syndrome (MDS)/acute myeloid leukemia (AML) among MM patients treated with IMiDs, especially lenalidomide. The occurrence of acute lymphoblastic leukemia (ALL) post lenalidomide therapy is rare. A 61 years old male with kappa light chain MM was treated with lenalidomide-dexamethasone induction for 6 cycles, followed by lenalidomide maintenance for 2 years, and achieved very good partial response. 7 months after stopping therapy, he developed severe thrombocytopenia. Bone marrow examination at this point revealed B-ALL with 4% clonal plasma cells. A diagnosis of secondary B-ALL, related to lenalidomide, was considered. Increased incidence of SPM is recognized in MM among lenalidomide-treated patients. This is especially the case if they have been given sequential or concomitant oral melphalan. An increased incidence of SPM is also seen post autotransplant using high-dose melphalan. Usually, hematological SPMs seen in this scenario are myeloid malignancies like MDS/AML. There are emerging data, in the form of case reports and case series, of ALL occurrence as a second primary. Our case report adds credence to this observation. Our case also highlights the potential of lenalidomide monotherapy to cause SPM, in the absence of alkylating agents. Clinicians should recognize the rare possibility of ALL among patients with MM treated with lenalidomide for a prolonged duration.","PeriodicalId":502106,"journal":{"name":"Indian journal of pathology & microbiology","volume":"69 2","pages":"351-353"},"PeriodicalIF":0.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148364771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The shape-shifter: A case of pleomorphic giant cell carcinoma of prostate. 变形者：前列腺多形性巨细胞癌1例。

IF 0.5

Indian journal of pathology & microbiology Pub Date : 2026-04-01 Epub Date: 2026-06-30 DOI: 10.4103/ijpm.ijpm_658_25

Seema Rao, Md Ali Osama, Sunayana Misra, Satnam S Chhabra, K L Kalra

引用次数: 0

Epithelioid trophoblastic tumor presenting as a lung mass without uterine involvement: Pitfalls in morphology and immunohistochemistry. 上皮样滋养细胞肿瘤表现为肺肿块，未累及子宫：形态学和免疫组织化学缺陷。

IF 0.5

Indian journal of pathology & microbiology Pub Date : 2026-04-01 Epub Date: 2026-04-27 DOI: 10.4103/ijpm.ijpm_460_25

Wenjia Sun, Na Fang

引用次数: 0