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Indian journal of pathology & microbiology最新文献

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The unraveling of a rare case of prostate adenocarcinoma presenting as orbital mass. 一例罕见的以眼眶肿块表现的前列腺癌病例的分析。
Indian journal of pathology & microbiology Pub Date : 2025-04-01 Epub Date: 2024-06-04 DOI: 10.4103/ijpm.ijpm_879_23
Girish A Kadkol, Jaydeep N Pol, Ashwini V Ratnakar, Kunal U Patil
{"title":"The unraveling of a rare case of prostate adenocarcinoma presenting as orbital mass.","authors":"Girish A Kadkol, Jaydeep N Pol, Ashwini V Ratnakar, Kunal U Patil","doi":"10.4103/ijpm.ijpm_879_23","DOIUrl":"10.4103/ijpm.ijpm_879_23","url":null,"abstract":"<p><strong>Abstract: </strong>Prostate adenocarcinoma (PC) is commonly known to have bone metastasis but its orbital metastasis is rare accounting for only 8.5% of cases. Most of the reported cases of orbital metastasis are in previously diagnosed PC cases. However, orbital metastasis as a sole manifestation of presentation is extremely rare, and to our knowledge, only three cases have been published similar to our present case. A 72-year-old male presented with diplopia and pain in the right eye for six months. On examination, right eye proptosis was noted. A computed tomography (CT) scan showed an enhancing, destructive soft tissue lesion involving the right orbit. The histopathological evaluation revealed a metastatic adenocarcinoma possibly of prostatic origin. Immunohistochemistry (IHC) confirmed the above diagnosis. We report this unique case of metastatic PC presenting with only ocular manifestation, emphasizing the crucial role played by diagnostic modalities like histopathology and IHC in unraveling such occult dilemmatic scenarios.</p>","PeriodicalId":502106,"journal":{"name":"Indian journal of pathology & microbiology","volume":"68 2","pages":"424-427"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unique presentation of oral glial choristoma in a middle aged lady post teeth extraction with osteomyelitis; A case report. 一位中年妇女拔牙后并发骨髓炎的口腔胶质组织瘤的独特表现一份病例报告。
Indian journal of pathology & microbiology Pub Date : 2025-03-13 DOI: 10.4103/ijpm.ijpm_660_24
Rakesh K Gupta, Santhosh Rao, Manish Kumar
{"title":"Unique presentation of oral glial choristoma in a middle aged lady post teeth extraction with osteomyelitis; A case report.","authors":"Rakesh K Gupta, Santhosh Rao, Manish Kumar","doi":"10.4103/ijpm.ijpm_660_24","DOIUrl":"https://doi.org/10.4103/ijpm.ijpm_660_24","url":null,"abstract":"<p><strong>Abstract: </strong>Glial choristoma (GC) is a rare developmental malformation commonly occur in nasal cavity and infrequently present at other sites like palate, tongue, pharynx, lips, and submandibular region. It usually occurs in the children either as an incidental finding or mass lesion or in association with cleft palate. GC is diagnosed by the demonstration of glial tissue on histopathology. A conservative excision is usually curative, however, misdiagnosis can leads to unnecessary surgical procedure. Herein, we report a unique case of GC in a middle aged lady, with recent history of multiple teeth extraction with associated osteomyelitis.</p>","PeriodicalId":502106,"journal":{"name":"Indian journal of pathology & microbiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143627328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rare case of IgG4-related retroperitoneal fibrosis mimicking renal cell carcinoma: A diagnostic challenge. 罕见病例igg4相关的腹膜后纤维化模拟肾细胞癌：一个诊断挑战。
Indian journal of pathology & microbiology Pub Date : 2025-03-13 DOI: 10.4103/ijpm.ijpm_568_24
Blessy Mathew, Devika Gupta, Gaurav Pratap Singh Gahlot, Puneet Takkar
{"title":"Rare case of IgG4-related retroperitoneal fibrosis mimicking renal cell carcinoma: A diagnostic challenge.","authors":"Blessy Mathew, Devika Gupta, Gaurav Pratap Singh Gahlot, Puneet Takkar","doi":"10.4103/ijpm.ijpm_568_24","DOIUrl":"https://doi.org/10.4103/ijpm.ijpm_568_24","url":null,"abstract":"<p><strong>Abstract: </strong>IgG4-RD is an immune-mediated systemic fibroinflammatory condition with characteristic clinicopathological findings. The exact etiology is uncertain. A combination of environmental and genetic factors is considered to be involved. It can affect multiple organs often mimicking malignancy or infectious disorder. Because of myriad of clinical presentations, the clinical diagnosis is cumbersome and requires a detailed histopathological, radiological, and serological workup. IgG4-retroperitoneal fibrosis is usually seen as a component of systemic manifestation of the disease that presents as mass lesion causing pressure and pain symptoms. These clinical symptoms are usually of insidious onset with gradually progressive course. The early diagnosis and treatment is essential to prevent its long-term irreversible complications. Isolated retroperitoneal fibrosis due to IgG4-RD is rare, as is being reported in our elderly male patient. Our case report highlights the rare presentation of IgG4-related RPF mimicking renal cell carcinoma.</p>","PeriodicalId":502106,"journal":{"name":"Indian journal of pathology & microbiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143627325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Silent intruders: Hematolymphoid neoplasms revealed in the jaws: a series of three cases. 沉默的入侵者：在颌骨发现的血淋巴肿瘤：一系列的三个病例。
Indian journal of pathology & microbiology Pub Date : 2025-03-13 DOI: 10.4103/ijpm.ijpm_512_24
Trupti Jain, Sudeep Kumar, Shivangni Rajoria, R Keerthika, Akhilesh Chandra, Rahul Agarwal
{"title":"Silent intruders: Hematolymphoid neoplasms revealed in the jaws: a series of three cases.","authors":"Trupti Jain, Sudeep Kumar, Shivangni Rajoria, R Keerthika, Akhilesh Chandra, Rahul Agarwal","doi":"10.4103/ijpm.ijpm_512_24","DOIUrl":"https://doi.org/10.4103/ijpm.ijpm_512_24","url":null,"abstract":"<p><strong>Abstract: </strong>The head and neck regions, rich in lymph nodes, are common initial sites for nodal and extranodal hematolymphoid neoplasms, particularly B-cell neoplasms. Lymphomas, including Hodgkin's and non-Hodgkin's types, range from indolent to aggressive and often affect the oral and maxillofacial areas. Plasma cell neoplasms, such as solitary bone plasmacytoma (SBP) and solitary extramedullary plasmacytoma (SEP), must be distinguished from multiple myeloma (MM) due to varied treatment modalities. Diagnosing these neoplasms is challenging, requiring thorough examination. Timely recognition and management of plasma cell tumors in the head and neck, especially SBP, are essential to prevent disease progression. These tumors can mimic other malignancies and indicate early MM, necessitating detailed evaluation. Healthcare providers should be aware of the higher risk of oral NHL in HIV-positive patients and consider NHL in the differential diagnosis of intraoral lesions to improve outcomes. Herein, we present three cases with usual presentations in the oral cavity that resulted in unusual diagnoses.</p>","PeriodicalId":502106,"journal":{"name":"Indian journal of pathology & microbiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143627327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hydatid cyst arising in a mature cystic teratoma ovary. 成熟卵巢囊性畸胎瘤中产生的包虫囊肿。
Indian journal of pathology & microbiology Pub Date : 2025-03-13 DOI: 10.4103/ijpm.ijpm_526_24
Anchana Gulati, Nishi Sood, Sarita Agnihotri, Digvijay S Dattal, Gauri Nakra
{"title":"Hydatid cyst arising in a mature cystic teratoma ovary.","authors":"Anchana Gulati, Nishi Sood, Sarita Agnihotri, Digvijay S Dattal, Gauri Nakra","doi":"10.4103/ijpm.ijpm_526_24","DOIUrl":"https://doi.org/10.4103/ijpm.ijpm_526_24","url":null,"abstract":"","PeriodicalId":502106,"journal":{"name":"Indian journal of pathology & microbiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143627322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Arterio-veno-lymphatic vascular malformation presenting as an anterior mediastinal mass. 动脉-静脉-淋巴血管畸形，表现为前纵隔肿块。
Indian journal of pathology & microbiology Pub Date : 2025-03-13 DOI: 10.4103/ijpm.ijpm_457_24
Busra Özdemir Çiflik, Mehmet Cetin, Gozde E Taşar Kapakli, Sebahattin S Ermancik, Mehmet Buyukevli, Koray Aydogdu
{"title":"Arterio-veno-lymphatic vascular malformation presenting as an anterior mediastinal mass.","authors":"Busra Özdemir Çiflik, Mehmet Cetin, Gozde E Taşar Kapakli, Sebahattin S Ermancik, Mehmet Buyukevli, Koray Aydogdu","doi":"10.4103/ijpm.ijpm_457_24","DOIUrl":"https://doi.org/10.4103/ijpm.ijpm_457_24","url":null,"abstract":"<p><strong>Abstract: </strong>Mediastinal lymphatic venous malformation (LVM) is considered tumor-like vascular dysplasias that are rarely found in the mediastinum. Clinical presentation of LVMs varies depending on the patient. Patients may be asymptomatic or may present with symptoms such as cough, chest pain, dyspnea, and hemoptysis. A 4-year-old girl was admitted to the hospital with complaints of coughing attacks, shortness of breath in the right lateral decubitus position, and restlessness. A contrast-enhanced thorax computed tomography scan was performed to evaluate the relationship between the major mediastinal vascular structures and the mass. A left anterolateral thoracotomy was performed. The pathology was reported as an arterio-veno-lymphatic vascular malformation. Mediastinal LVMs are extremely rare but may present with severe life-threatening symptoms due to compression of major mediastinal structures. This report highlights that mediastinal LVM has a differential diagnosis and its management can be challenging.</p>","PeriodicalId":502106,"journal":{"name":"Indian journal of pathology & microbiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143627318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Plasmacytoid subtype of urothelial carcinoma - Report of two rare cases and unusual features. 浆细胞样亚型尿路上皮癌——报告两例罕见和不寻常的特征。
Indian journal of pathology & microbiology Pub Date : 2025-03-13 DOI: 10.4103/ijpm.ijpm_354_24
Sagar Ranjan Tripathy, Pavithra Ayyanar, Deepak Kumar Das, Sandip Kumar Barik
{"title":"Plasmacytoid subtype of urothelial carcinoma - Report of two rare cases and unusual features.","authors":"Sagar Ranjan Tripathy, Pavithra Ayyanar, Deepak Kumar Das, Sandip Kumar Barik","doi":"10.4103/ijpm.ijpm_354_24","DOIUrl":"https://doi.org/10.4103/ijpm.ijpm_354_24","url":null,"abstract":"<p><strong>Abstract: </strong>Plasmacytoid urothelial carcinoma is a rare but aggressive subtype of urothelial carcinoma. The histopathologic mimics include plasmacytoma, metastasis from invasive lobular breast carcinoma, and gastric signet ring cell carcinoma. A 58-year-old male presented with painless hematuria. TURBT showed a urothelial tumor with plasmacytoid morphology. Lymphovenous emboli, necrosis, detrusor muscle invasion, and urothelial carcinoma in situ were noted. Tumor cells were positive for GATA-3, CK7, and CD138, focally positive for CK20, and negative for p63, CD38, and HER2. Expression of E-cadherin was lost. Follow-up PET-CT of a 63-year-old, treated case of carcinoma urinary bladder revealed a new onset lytic lesion in the sacrum and left ilium. Biopsy from the sacral mass showed a tumor with similar morphology infiltrating the bony trabeculae. Tumor cells were positive for CK, CK7, and CD138, focally positive for GATA-3, p63, and CK20, while negative for CD38. Expression of E-cadherin was retained. We report two cases of plasmacytoid urothelial carcinoma with differential diagnosis and unusual immunohistochemical features.</p>","PeriodicalId":502106,"journal":{"name":"Indian journal of pathology & microbiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143627323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vulvar dermatofibrosarcoma protuberans masquerading as angiomyxoma: A case report and review of 85 cases. 伪装成血管粘液瘤的外阴隆突性皮肤纤维肉瘤：附85例报告并复习。
Indian journal of pathology & microbiology Pub Date : 2025-03-13 DOI: 10.4103/ijpm.ijpm_695_21
Niraj N Mahajan, Vartika Srivastava, Kusum Jashnani, Abhiram M Kasbe, Nandita Kaushal, Akshaya Bansode, Anushka Papney
{"title":"Vulvar dermatofibrosarcoma protuberans masquerading as angiomyxoma: A case report and review of 85 cases.","authors":"Niraj N Mahajan, Vartika Srivastava, Kusum Jashnani, Abhiram M Kasbe, Nandita Kaushal, Akshaya Bansode, Anushka Papney","doi":"10.4103/ijpm.ijpm_695_21","DOIUrl":"https://doi.org/10.4103/ijpm.ijpm_695_21","url":null,"abstract":"<p><strong>Abstract: </strong>Dermatofibrosarcoma protuberans (DFSP) is a rare cutaneous mesenchymal locally aggressive sarcoma with high recurrence. We report a case of recurrent vulvar DFSP, and a literature review was performed with a PubMed search using the terms \"Dermatofibrosarcoma protuberans\" and \"vulva.\" Total 85 cases with vulvar DFSP were analyzed for their clinicopathological features among fibrosarcomatous DFSP (FS-DFSP) and non-FS-DFSP. Listless asymptomatic growth had resulted in delay in presentation of 2.3 years. Tumor size was significantly more in FS-DFSP (P 0.005). Higher mitotic rate is found to have strong association with FS-DFSP (P 0.0001). FS-DFSP has more recurrences compared with non-FS-DFSP (P 0.0001). DFSP with FS transformation was more aggressive as there was significant difference in metastasis (P 0.073, OR 0.18) and mortality (P 0.210, OR 0.19). To investigate the risk of outcome, 59 cases were included following the exclusion of <6 months follow-up. Age (>50 years) was found to be a risk for metastasis and death from the disease. Tumor size (>5 cm) and mitosis (≥5/10-HPF among non-FS-DFSP) were found to be the risk for the LR. Different histological diagnosis was made initially in 32%, and local excision was performed without margins in 65% of vulvar DFSP because of initial incorrect diagnosis. Therefore, pre-treatment biopsy or re-biopsy should be performed with immunohistochemistry for definitive diagnosis to exclude histologic mimics. The optimal treatment is wide local excision with 3-cm margin or with margin assessment for both primary and recurrent DFSP. As most recurrences occur within the first three years of wide excision in DFSP, regular follow-up visits are advocated.</p>","PeriodicalId":502106,"journal":{"name":"Indian journal of pathology & microbiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143627329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aberrant CD3 positive plasmablastic lymphoma of small bowel in a HIV negative, EBV negative patient: A case report. 1例HIV阴性、EBV阴性患者发生小肠异常CD3阳性浆母细胞淋巴瘤。
Indian journal of pathology & microbiology Pub Date : 2025-02-07 DOI: 10.4103/ijpm.ijpm_228_24
Umama Idrees, Mayurakshi Das, Anuradha Sekaran, Duvvur N Reddy
{"title":"Aberrant CD3 positive plasmablastic lymphoma of small bowel in a HIV negative, EBV negative patient: A case report.","authors":"Umama Idrees, Mayurakshi Das, Anuradha Sekaran, Duvvur N Reddy","doi":"10.4103/ijpm.ijpm_228_24","DOIUrl":"https://doi.org/10.4103/ijpm.ijpm_228_24","url":null,"abstract":"<p><strong>Abstract: </strong>Plasmablastic lymphoma (PBL) is an aggressive lymphoma with the proliferation of plasmablastic cells with a plasma cell immunophenotype and immunonegativity for B-cell markers. Here we present a case of jejunal PBL in an 82-year-old human immunodeficiency virus (HIV) negative and Epstein-Barr (EBV) negative male who presented with subacute intestinal obstruction and histopathological examination showed a large cell lymphoma with plasmablastic differentiation diffusely infiltrating full thickness of the jejunal wall. Neoplastic cells were immunopositive for CD138, MUM-1, EMA, and CD56, along with aberrant expression of pan T-cell marker CD3. No restrictions for kappa and lambda light chains were noted. Ki67 index was >90%. Tumor cells were immunonegative for CD20, CD5, CD7, CD30, and PAX 5. Suspicion of this rare and high-grade lymphoma in immunocompetent patients and at extra-nodal locations along with awareness of diagnostic pitfalls in its immunoprofile will aid in accurate diagnosis and prognostication.</p>","PeriodicalId":502106,"journal":{"name":"Indian journal of pathology & microbiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143367202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pleural small cell carcinoma: A case report. 胸膜小细胞癌1例。
Indian journal of pathology & microbiology Pub Date : 2025-02-07 DOI: 10.4103/ijpm.ijpm_610_24
Paheli Maru, Jahnavi Gandhi, Majal Shah, Ashini Shah, Priti Trivedi
{"title":"Pleural small cell carcinoma: A case report.","authors":"Paheli Maru, Jahnavi Gandhi, Majal Shah, Ashini Shah, Priti Trivedi","doi":"10.4103/ijpm.ijpm_610_24","DOIUrl":"https://doi.org/10.4103/ijpm.ijpm_610_24","url":null,"abstract":"<p><strong>Abstract: </strong>Small cell carcinoma (SCC) is most commonly found in the lung. Extrapulmonary SCC has been reported in various organs. Despite its rarity, primary pleural SCC should be considered along with mesothelioma in the case of a pleura-based mass because of the difference in prognosis and treatment. To highlight the role of morphology and IHC in arriving at a diagnosis of primary pleural SCC. Pleural biopsy with its hematoxylin and eosin-stained and immunohistochemistry slides. Tumor cells were immunoreactive for synaptophysin, chromogranin, CK7, TTF1, and BerEP4, along with focal reactivity for calretinin. The cells were negative for CK5/6, WT1, and mesothelin. A detailed morphological examination plays an important role in ruling out all the tumors displaying small cell features at this site, and a limited IHC panel can aid in arriving at a diagnosis of primary pleural SCC.</p>","PeriodicalId":502106,"journal":{"name":"Indian journal of pathology & microbiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143367211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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