Indian journal of pathology & microbiology最新文献

{"title":"Is Rspo1 a friend or foe in ESCC? Rethinking wnt signaling in tumor prognostics.","authors":"Haewon Byeon","doi":"10.4103/ijpm.ijpm_488_25","DOIUrl":"https://doi.org/10.4103/ijpm.ijpm_488_25","url":null,"abstract":"","PeriodicalId":502106,"journal":{"name":"Indian journal of pathology & microbiology","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149083653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of the histology of nonneoplastic kidney diseases in nephrectomies and nephroureterectomies performed for tumors.","authors":"Noora Mohd Ahmed, S V N Anuradha, Swarnalata Gowrishankar","doi":"10.4103/ijpm.ijpm_16_23","DOIUrl":"https://doi.org/10.4103/ijpm.ijpm_16_23","url":null,"abstract":"<p><strong>Background: </strong>Nephrectomies performed for tumors may harbor nonneoplastic kidney diseases and influence patient outcomes; hence, studying the uninvolved portion of the renal parenchyma at the time of histological tumor diagnosis is prudent. Careful histological assessment of the uninvolved renal parenchyma using light microscopy, special stains and immunofluorescence study gives valuable information regarding pre-existing renal damage.</p><p><strong>Materials and methods: </strong>This cross-sectional observational study evaluated 151 partial and radical nephrectomies and nephroureterectomies performed for tumors. Global glomerulosclerosis, tubular atrophy, interstitial fibrosis, interstitial inflammation, and arteriosclerosis were evaluated in the nontumor portion of the kidney, and their severity was scored. Nonneoplastic renal diseases, if present in the uninvolved renal parenchyma, were identified. Preoperative serum creatinine was correlated separately with global glomerulosclerosis, tubular atrophy, interstitial fibrosis, interstitial inflammation, and arteriosclerosis using Spearman's rank correlation.</p><p><strong>Results: </strong>Positive correlations were observed between global glomerulosclerosis, tubular atrophy, interstitial fibrosis, interstitial inflammation, and arteriosclerosis and preoperative serum creatinine, with a P value of < 0.001. Forty three of 151 cases (28.5%) showed nonneoplastic renal diseases. Diabetic nephropathy (24), hypertensive nephropathy (5), immunoglobulin A nephropathy (5), acute tubulointerstitial nephritis (2), chronic pyelonephritis (2), acute pyelonephritis (1), complement component 1q nephropathy (1), cortical necrosis (1), cholesterol emboli (1), and amyloidosis (1) were the nonneoplastic diagnoses made.</p><p><strong>Conclusions: </strong>Tumor nephrectomies can show a spectrum of nonneoplastic diseases in the uninvolved portion of the kidney, and histological changes in the renal parenchyma correlate well with serum creatinine. Thus, a detailed evaluation of the nontumor portion of the kidney is important.</p>","PeriodicalId":502106,"journal":{"name":"Indian journal of pathology & microbiology","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149083627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ruptured hepatic abscess due to mixed infection with Actinomyces israelii and Acinetobacter lwoffii.","authors":"Nidhi Bhatnagar, Ashish Ranjan, Nishtha Singh, Chinmoy Sahu","doi":"10.4103/ijpm.ijpm_979_25","DOIUrl":"https://doi.org/10.4103/ijpm.ijpm_979_25","url":null,"abstract":"","PeriodicalId":502106,"journal":{"name":"Indian journal of pathology & microbiology","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149077330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osseous metaplasia in neoplastic and non-neoplastic lesions: A comprehensive case series of 30 patients from a tertiary care center.","authors":"Neeti Goyal, Kritika Dewan, Navdeep Singh, Umesh Kapoor, Vandana Rana, Pragya Sharma, Prabha S Mishra, Shamresh Singh, Paresh Singhal, Arun Gupta","doi":"10.4103/ijpm.ijpm_1092_25","DOIUrl":"https://doi.org/10.4103/ijpm.ijpm_1092_25","url":null,"abstract":"<p><strong>Background: </strong>Osseous metaplasia (OM), distinct from calcification, is a rare histological event reported across various organs in both neoplastic and non-neoplastic contexts, typically as isolated case reports.</p><p><strong>Objective: </strong>This study presents a series of 30 cases of OM from diverse anatomical sites, aiming to broaden the understanding of its pathogenesis and clinical significance.</p><p><strong>Material and methods: </strong>A retrospective and prospective histopathological study was conducted over 12 months (August 24 to August 25) in a tertiary care center. Inclusion criteria encompassed all cases of OM confirmed on histology; cases lacking sufficient clinical or tissue data were excluded.</p><p><strong>Results: </strong>Eighteen cases (19 males, 11 females; age range: 31-74 years) were included. The most frequent sites were the thyroid, kidney, followed by lung, bladder, endometrium, and breast.</p><p><strong>Conclusion: </strong>This is one of the largest single-center series documenting OM across a spectrum of lesions. Recognizing OM can aid in accurate histological interpretation and may have prognostic value in certain tumors.</p>","PeriodicalId":502106,"journal":{"name":"Indian journal of pathology & microbiology","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149083644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FOXE1, IMP-3, and TERT expressions in papillary thyroid carcinomas.","authors":"Nurtac Sarikas, Nuray Can, Necdet Sut, Yavuz A Sezer, Buket Y Bulbul, Ebru Tastekin, Ufuk Usta, Fulya Oz Puyan, Tulin D Yalta, Funda Ustun","doi":"10.4103/ijpm.ijpm_909_24","DOIUrl":"https://doi.org/10.4103/ijpm.ijpm_909_24","url":null,"abstract":"<p><strong>Background: </strong>Papillary thyroid carcinoma (PTC) is the most common thyroid cancer. The present study aims to compare the forkhead box E1 (FOXE1), insulin-like growth factor II mRNA binding protein 3 (IMP-3), and telomerase reverse transcriptase (TERT) immunoexpressions with clinical and prognostic histopathological findings in patients with papillary thyroid carcinoma.</p><p><strong>Materials and methods: </strong>The study included 166 patients diagnosed with PTC. FOXE1, IMP-3, and TERT antibodies were applied to the sections, and the results were compared with patient characteristics.</p><p><strong>Results: </strong>The results revealed a significant relationship between FOXE1 positivity and the presence of lymphovascular invasion. There was also a significant relationship between TERT positivity and the absence of lymphocytic thyroiditis in the non-tumor thyroid tissue. No statistically significant relationship was observed between antibody staining patterns and the other studied parameters.</p><p><strong>Conclusions: </strong>In conclusion, FOXE1 immunoreactivity may be a sign of lymphovascular invasion in PTCs that are prone to local extension through lymphatic vessels or direct local invasion. The patients with FOXE1 positivity require close attention with regards to lymphovascular invasion and lymph node metastasis. The authors consider that prospective studies on larger series involving molecular analysis of fine-needle aspiration specimens would contribute to preoperative diagnosis and clinical management of the patients.</p>","PeriodicalId":502106,"journal":{"name":"Indian journal of pathology & microbiology","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149083573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pseudoendocrine differentiation in colorectal adenoarcinoma associated with EPCAM-mutated Lynch syndrome.","authors":"Arghya Bandyopadhyay, Asmita Chakrabarti, Ambalika Mondal, Ratnaprabha Maji, Gopinath Barui","doi":"10.4103/ijpm.ijpm_53_26","DOIUrl":"https://doi.org/10.4103/ijpm.ijpm_53_26","url":null,"abstract":"<p><strong>Abstract: </strong>Lynch syndrome (LS) is an autosomal dominant cancer predisposition syndrome caused by germline mutations in DNA mismatch repair genes or, less commonly, EPCAM deletions. LS-associated colorectal carcinomas often present at a young age and may show unusual histomorphological patterns, posing diagnostic challenges. We report a rare case of a 29-year-old female with EPCAM-mutated LS presenting as colonic adenocarcinoma with neuroendocrine-like rosette formation. The tumor initially mimicked mixed adenoneuroendocrine carcinoma (MANEC) due to biphasic histology and the presence of multiple rosettes. However, immunohistochemistry demonstrated negativity for synaptophysin and chromogranin, excluding true neuroendocrine differentiation with diffuse Pan CK and focal CDX2, CK20 positivity along with loss of MSH2 and MSH6. Further molecular analyses confirmed EPCAM exon 5-9 deletion. The tumor was ultimately classified as an MMR-deficient adenocarcinoma with pseudoendocrine morphology. This case broadens the histomorphological spectrum of LS-associated colorectal carcinomas and introduces the concept of a possible pseudoendocrine carcinoma arising in an epithelial malignancy. Recognition of this pattern is crucial to prevent misdiagnosis as MANEC, to guide appropriate management, facilitate familial screening, and highlight that not every rosette signifies neuroendocrine differentiation; some may represent LS in disguise.</p>","PeriodicalId":502106,"journal":{"name":"Indian journal of pathology & microbiology","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149083636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meissnerian neurofibroma: A rare histological variant of neurofibroma.","authors":"Zoya Hasan, Shramana Mandal, Prabhat Shrivastava, Archi Agrawal, Anshu Tiwari","doi":"10.4103/ijpm.ijpm_825_25","DOIUrl":"https://doi.org/10.4103/ijpm.ijpm_825_25","url":null,"abstract":"<p><strong>Abstract: </strong>Meissnerian neurofibroma is an extremely rare histological variant of neurofibroma, with less than ten reported cases of prominent differentiation toward pseudo-meissnerian bodies in the literature. The presence of focal or sparsely scattered pseudo-meissnerian bodies in neurofibromas is well documented in diffuse and plexiform types. It is also seen in various peripheral nerve sheath tumors, including schwannomas, as well as in congenital melanocytic nevi and neural crest hamartomas. The complete excision of the lesion is considered to be curative. We hereby present a rare case of prominent meissnerian differentiation in neurofibroma in a 26-year-old female.</p>","PeriodicalId":502106,"journal":{"name":"Indian journal of pathology & microbiology","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148893212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paraquat poisoning in pregnancy.","authors":"Pradeep Vaideeswar, Rahul Rajbhar","doi":"10.4103/ijpm.ijpm_957_24","DOIUrl":"https://doi.org/10.4103/ijpm.ijpm_957_24","url":null,"abstract":"<p><strong>Abstract: </strong>Paraquat, a toxic herbicide, continues to be widely used in developing nations despite restrictions and severe health risks. Several cases of poisoning have been reported due to intentional ingestion, producing dose-dependent clinical manifestations, chiefly targeting the lungs and kidneys. However, only a few cases have been reported in pregnancy. We report mortality due to paraquat-induced lung injury in a young pregnant woman, in whom the poisoning occurred following the ingestion of paraquat-contaminated soil as part of pregnancy-induced pica. The case underscores the critical need for early recognition and intervention.</p>","PeriodicalId":502106,"journal":{"name":"Indian journal of pathology & microbiology","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148893299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary renal neuroendocrine tumor in a 33-year-old female.","authors":"Sandeep Kaur, Vandana Rana, Neeti Goyal, Divya Shelly, Amit Agrawal","doi":"10.4103/ijpm.ijpm_157_26","DOIUrl":"https://doi.org/10.4103/ijpm.ijpm_157_26","url":null,"abstract":"<p><strong>Abstract: </strong>Primary neuroendocrine tumors (NETs) of the kidney are exceedingly rare, with an estimated incidence of only 0.13 per 1 million individuals. Their rarity is attributed to the absence of native neuroendocrine cells within the renal parenchyma. These tumors span the WHO grading spectrum, with well-differentiated lesions reported most frequently. They may also occur in association with congenital anomalies such as horseshoe kidney. In this study, we present a new case of a 33-year-old female diagnosed with a primary renal NET at our hospital. She underwent imaging studies, surgical excision, and histopathological and immunohistochemical analysis. The findings suggest that these tumors are rare and have nonspecific clinical and imaging features. The diagnosis heavily relies on immunohistochemical analysis. Primary renal well-differentiated NETs are associated with low malignant potential and a favorable prognosis. Surgical resection is the preferred treatment, and long-term follow-up is necessary to monitor the patient's condition.</p>","PeriodicalId":502106,"journal":{"name":"Indian journal of pathology & microbiology","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148893303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary hepatic interdigitating dendritic cell sarcoma: A rarity unveiled.","authors":"Lalit Khawse, Aatish Saraswat, Bhupesh Guleria, Ameet Kumar, Prerna Guleria, Rohit Agarwal","doi":"10.4103/ijpm.ijpm_871_25","DOIUrl":"https://doi.org/10.4103/ijpm.ijpm_871_25","url":null,"abstract":"<p><strong>Abstract: </strong>Interdigitating dendritic cell sarcoma (IDCS) is a rare malignancy originating from dendritic cells, which participate in immune response activity as antigen-presenting cells by stimulating T lymphocytes. We report the case of a 24-year-old man who experienced an involuntary 20 kg weight loss over 2 months, combined with a steadily growing, painless lump in his right upper abdomen. Upon examination, a hard, nontender, immobile mass measuring 16 × 16 cm was found in the right hypochondrium. A massive, well-defined hypodense lesion covering all segments of the liver's right lobe was excised and was diagnosed as IDCS due to its characteristic histomorphological and immunohistochemical features.</p>","PeriodicalId":502106,"journal":{"name":"Indian journal of pathology & microbiology","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148893285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}