Indian journal of pathology & microbiology最新文献

Protein expression of cancer stem cell markers ABCG2, podoplanin, and CD44 predicts early recurrence of oral squamous cell carcinoma: A study from Western India.

Indian journal of pathology & microbiology Pub Date : 2025-02-10 DOI: 10.4103/ijpm.ijpm_479_24

Trupti I Trivedi, Toral H Mandaliya, Priti P Trivedi

{"title":"Protein expression of cancer stem cell markers ABCG2, podoplanin, and CD44 predicts early recurrence of oral squamous cell carcinoma: A study from Western India.","authors":"Trupti I Trivedi, Toral H Mandaliya, Priti P Trivedi","doi":"10.4103/ijpm.ijpm_479_24","DOIUrl":"https://doi.org/10.4103/ijpm.ijpm_479_24","url":null,"abstract":"Objectives: For oral squamous cell carcinoma (OSCC), we are likely at a juncture in clinical management, where the benefits of therapies are beginning to plateau. Therefore, this study investigated the usefulness of adenosine triphosphate (ATP)-binding cassette subfamily G member 2 (ABCG2), podoplanin (PDPN), and cluster of differentiation (CD) 44 (CD44) that may help to identify patients with an aggressive phenotype and predict prognosis precisely.Materials and methods: The protein expression of ABCG2, PDPN, and CD44 was investigated in 125 OSCC patients using immunohistochemistry and correlated with clinicopathological parameters and disease outcomes. The data were evaluated using the Statistical Package for the Social Sciences (SPSS) software, and P value ≤0.05 was considered significant.Results: The protein expression of ABCG2, PDPN, and CD44 was noted in 56%, 43%, and 51%, respectively. ABCG2, PDPN, and CD44 show linear correlation with T3/T4 tumors, presence of metastatic lymph nodes (LNs), and advanced-stage disease. Cox multivariate regression analysis for progression-free survival (PFS) demonstrated that in early-stage patients, CD44 at step 1 (P = 0.007) followed by ABCG2 (P = 0.037) at step 2 was associated with reduced PFS. For overall survival (OS), only ABCG2 (P = 0.019) emerged as a potential parameter. Kaplan-Meier curves showed that the combined signature of ABCG2 with PDPN for total patients, and ABCG2 with CD44 for early-stage patients, emerged as more powerful risk predictors for identifying high-risk patients.Conclusion: Thus, the combined signature of ABCG2 with PDPN and CD44 could be useful in identifying high-risk patients for more aggressive therapy and effective personalized treatment in the future.","PeriodicalId":502106,"journal":{"name":"Indian journal of pathology & microbiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143401145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Massive edema of ovary masquerading as neoplasm in a preteen girl.

Indian journal of pathology & microbiology Pub Date : 2025-02-07 DOI: 10.4103/ijpm.ijpm_83_24

Ruchi Rathore, Surabhi Jain, Rajesh Kumari, Sandeep Mathur

引用次数: 0

Epidermal Growth Factor Receptor (EGFR) membranous and cytoplasmic overexpression on immunohistochemistry: An additional prognostic marker in oral squamous cell carcinoma.

Indian journal of pathology & microbiology Pub Date : 2025-02-07 DOI: 10.4103/ijpm.ijpm_272_24

Guddi Rani Singh, Shabana Azad, Tulika Singh, Manish Kumar, Kumari Sunny, Divya Sanehi, Debaditya Haldar

{"title":"Epidermal Growth Factor Receptor (EGFR) membranous and cytoplasmic overexpression on immunohistochemistry: An additional prognostic marker in oral squamous cell carcinoma.","authors":"Guddi Rani Singh, Shabana Azad, Tulika Singh, Manish Kumar, Kumari Sunny, Divya Sanehi, Debaditya Haldar","doi":"10.4103/ijpm.ijpm_272_24","DOIUrl":"https://doi.org/10.4103/ijpm.ijpm_272_24","url":null,"abstract":"Background: Oral carcinoma is one of the most frequently occurring cancers among Indian men. We conducted this study to find out any association between epidermal growth factor receptor (EGFR) overexpression by immunohistochemical methods with histopathological prognostic parameters like pathological tumor (pT) staging, tumor grade, lymph nodal involvement, extranodal extension (ENE), perineural invasion (PNI), lymphovascular invasion (LVI), and worst pattern of invasion (WPOI).Materials and methods: This prospective cross-sectional study was conducted in Pathology Department of our institute between December 2021 and November 2022, and a total of 113 confirmed cases of oral squamous cell carcinoma (OSCC) were included in our study. Clinicopathological parameters were recorded, and EGFR expression by immunohistochemistry was evaluated in these patients. The association of EGFR overexpression and the different histopathological parameters according to the College of American Pathologists (CAP) protocol was determined.Results: Out of 113 cases, 52 cases (46%) were positive for EGFR overexpression on immunohistochemistry. Significant association of EGFR overexpression was noted with pT stage, nodal status N0 versus N1-N2, ENE, PNI, LVI, and WPOI, with P value <0.05. No significant association was noted with tumor grade and nodal status N0-N1 versus N2-N3.Conclusion: EGFR overexpression can be used as a prognostic marker in addition to histopathological parameters. One can opt for wedge resection in place of extensive surgery if small punch biopsies show EGFR negativity and radiology shows uninvolved lymph nodes. In addition, in EGFR-positive OSCC cases, targeted therapy could be opted to avoid chemotherapy-related toxicity and increase patient survival.","PeriodicalId":502106,"journal":{"name":"Indian journal of pathology & microbiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143367205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Myeloid sarcoma of the gastrointestinal tract: Wolf in sheep's clothing!

Indian journal of pathology & microbiology Pub Date : 2025-02-07 DOI: 10.4103/ijpm.ijpm_477_24

Nisha Meena, Surbhi Goyal, Prerna Arora, Sanjeev Sachdeva, Puja Sakhuja

引用次数: 0

Navigating through the complexities of bullous presentation of cutaneous lichen planus: A comparative study.

Indian journal of pathology & microbiology Pub Date : 2025-02-07 DOI: 10.4103/ijpm.ijpm_320_24

Pragya Jain, Priya Yadav, Sonali Dixit, Chander Grover, Sonal Sharma

{"title":"Navigating through the complexities of bullous presentation of cutaneous lichen planus: A comparative study.","authors":"Pragya Jain, Priya Yadav, Sonali Dixit, Chander Grover, Sonal Sharma","doi":"10.4103/ijpm.ijpm_320_24","DOIUrl":"https://doi.org/10.4103/ijpm.ijpm_320_24","url":null,"abstract":"Introduction: Bullous spectrum of cutaneous lichen planus has two distinct forms lichen planus pemphigoids (LPPs) and bullous lichen planus (BLP). There is paucity of literature on the clinical, histopathological, and immunological profile of this rare presentation. We aim to describe the clinical, histological, and immunological features of this distinct form further proposing an algorithmic approach for diagnosis.Methodology: We conducted a retrospective observational study and reviewed cases of LPP and BLP which were diagnosed in the last 10 years (2011-21). Relevant information (clinical presentation, histology, immunofluorescence finding) was noted on pre-structured proforma and was analyzed.Results: Out of 1960 biopsies of cutaneous lichen planus, only 21 cases had clinical suspected bullous presentation while immunofluorescence was received for only 16 cases. BLP was seen in the younger age group in comparison with LPPs (25.7 years vs 36.8 years). Bulla was seen in all cases. Dermo-epidermal junctional split was seen in all cases of BLP and LPP. On direct immunofluorescence (DIF) all the cases of LPP either had 1-2+ IgG and/or C3 while cases of BLP were not immunoreactive or had only colloid bodies.Conclusion: This study describes in detail the clinicopathological profile of BLP and LPP and reiterates the importance of DIF during workup to arrive at a definitive diagnosis.","PeriodicalId":502106,"journal":{"name":"Indian journal of pathology & microbiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143367209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aberrant CD3 positive plasmablastic lymphoma of small bowel in a HIV negative, EBV negative patient: A case report.

Indian journal of pathology & microbiology Pub Date : 2025-02-07 DOI: 10.4103/ijpm.ijpm_228_24

Umama Idrees, Mayurakshi Das, Anuradha Sekaran, Duvvur N Reddy

引用次数: 0

Clear-cell meningioma: An uncommon aggressive variant of meningioma.

Indian journal of pathology & microbiology Pub Date : 2025-02-07 DOI: 10.4103/ijpm.ijpm_349_24

Shilpa P Tathe, Kirti N Jaiswal

{"title":"Clear-cell meningioma: An uncommon aggressive variant of meningioma.","authors":"Shilpa P Tathe, Kirti N Jaiswal","doi":"10.4103/ijpm.ijpm_349_24","DOIUrl":"https://doi.org/10.4103/ijpm.ijpm_349_24","url":null,"abstract":"Background: Clear-cell meningioma is a rare subtype, representing 0.2-0.8% of all meningiomas. It is classified as grade 2 according to World Health Organization (WHO) classification due to its aggressive clinical course. Morphologically, it can mimic other clear-cell tumors arising in the central nervous system, each having different clinical behavior, therapeutic protocol, and prognostic outcome.Aim: This study aims to describe clinicopathological characteristics of clear-cell meningioma and to discuss the histomorphological features and differential diagnosis.Materials and methods: The demographic, clinical, radiological, histopathological features, and follow-up of the patients were recorded and analyzed.Results: Clear-cell meningioma constituted 1.3% of all meningiomas. The age of the patients ranged from 16-46 years (mean age - 27 years), with a slight female predominance. Follow-up varied from six months to six years. Recurrence was noted in four patients while three patients died. Histopathology revealed sheets of clear cells with prominent blocky interstitial and perivascular collagen deposition. Focal vague whorl formation and occasional intranuclear inclusions could be identified on careful search. Conventional meningothelial areas or typical psammoma bodies were not seen.Conclusion: Clear-cell meningioma is a rare subtype of meningioma with aggressive behavior. The presence of blocky collagen, a careful search for whorl formation, and intranuclear inclusions are helpful in approaching the correct diagnosis. An interdisciplinary approach by correlating the clinical, radiological, and histological features can enhance the accuracy of diagnosis.","PeriodicalId":502106,"journal":{"name":"Indian journal of pathology & microbiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143367203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pleural small cell carcinoma: A case report.

Indian journal of pathology & microbiology Pub Date : 2025-02-07 DOI: 10.4103/ijpm.ijpm_610_24

Paheli Maru, Jahnavi Gandhi, Majal Shah, Ashini Shah, Priti Trivedi

引用次数: 0

A curious case of a solitary lower lip papule: A case report.

Indian journal of pathology & microbiology Pub Date : 2025-02-07 DOI: 10.4103/ijpm.ijpm_659_24

Rajarshi Debnath, Tripti Roy, Mou Das

引用次数: 0

Scapula metastasis as unusual site of extrahepatic spread of hepatocellular carcinoma: A case report.

Indian journal of pathology & microbiology Pub Date : 2025-02-07 DOI: 10.4103/ijpm.ijpm_581_24

Mayank Soni, Shrutikant Bhatia, Sweety Gupta, Ashok Singh, Manoj Gupta

引用次数: 0