Indian journal of pathology & microbiology最新文献

Prognostic significance of Lin28A protein expression in papillary thyroid carcinoma. 甲状腺乳头状癌中Lin28A蛋白表达的预后意义。

Indian journal of pathology & microbiology Pub Date : 2025-07-04 DOI: 10.4103/ijpm.ijpm_358_24

Emel Tekin, Damla Oflas, Bartu Badak, Nur Kebapçi, Aysen Akalin, Emine Dündar

{"title":"Prognostic significance of Lin28A protein expression in papillary thyroid carcinoma.","authors":"Emel Tekin, Damla Oflas, Bartu Badak, Nur Kebapçi, Aysen Akalin, Emine Dündar","doi":"10.4103/ijpm.ijpm_358_24","DOIUrl":"https://doi.org/10.4103/ijpm.ijpm_358_24","url":null,"abstract":"Objective: Papillary thyroid carcinoma (PTC) is the most commonly diagnosed endocrine malignancy. While the prognosis is favorable for most patients, the presence of lymph node metastasis is considered a high-risk factor for distant metastasis, the most important predictive factor for mortality. In this study, we aimed to investigate the association between Lin28A immunohistochemical expression and lymph node metastasis in PTC cases, accompanied by clinicopathological data.Materials and methods: A total of 143 cases diagnosed with PTC who underwent bilateral total thyroidectomy and regional lymph node dissection were included in the study. The slides were re-evaluated according to the latest classification. The demonstrative tumor sections were stained with the Lin28A. Any degree of widespread cytoplasmic staining was considered positive.Results: 72% of the cases were female, with an average age of 45.06 years. The most common tumor subtype were classic (70.6%), followed by the tall cell (11.9%). Lymph node metastasis was present in 51.7% of cases, while extrathyroidal spread was seen in 9.1%. The Lin28A staining was positive in 17.5% of cases. Statistically significant differences were found between Lin28A positivity and lymph node metastasis, perineural invasion, and extrathyroidal spread (respectively; P = 0.014, P = 0.004, P = 0.037).Conclusions: Lin28A, a proto-oncogene regulated by microRNA, has been shown to be overexpressed in many cancers with poor prognosis. This study's findings demonstrated Lin28A's positive relationship with lymph node metastasis in PTC cases. The Lin28 molecular pathway may be a potential therapeutic target in cases where standard treatment is inadequate, especially in relapsed and resistant cases.","PeriodicalId":502106,"journal":{"name":"Indian journal of pathology & microbiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bronchial squamous cell papilloma incidental finding in bronchoscopy following prolonged ventilator weaning: A case report. 支气管鳞状细胞乳头状瘤偶然发现支气管镜后延长呼吸机脱机：1例报告。

Indian journal of pathology & microbiology Pub Date : 2025-07-02 DOI: 10.4103/ijpm.ijpm_582_24

Hendris U C Wahyudin, Didik S Heriyanto, Brigitta N Halim, Andrew N Gunawan, Vincent Lau, Satria M E Hamdani, Yusrizal D Saleh

{"title":"Bronchial squamous cell papilloma incidental finding in bronchoscopy following prolonged ventilator weaning: A case report.","authors":"Hendris U C Wahyudin, Didik S Heriyanto, Brigitta N Halim, Andrew N Gunawan, Vincent Lau, Satria M E Hamdani, Yusrizal D Saleh","doi":"10.4103/ijpm.ijpm_582_24","DOIUrl":"https://doi.org/10.4103/ijpm.ijpm_582_24","url":null,"abstract":"Abstract: Bronchial squamous cell papilloma (BSCP) is an uncommon tumor seen in the bronchi, while squamous cell papillomas are frequently observed in different organs. The fortuitous detection of BSCP underscores the significance of comprehensive diagnostic assessments for respiratory conditions. This case details the situation of a 37-year-old, non-smoking female who was referred to our center due to seizures. After a three-week hospital stay, attempts were made to wean her off ventilator support. However, the patient experienced difficulties during spontaneous breathing trials. A bronchoscopy was performed to ascertain the etiology of these challenges, uncovering whitish polypoidal tumors with uneven surfaces. A forceps biopsy was conducted on the tumor, and histological examination revealed squamous epithelial cells without any atypia cells. Subsequent HPV DNA testing definitively identified the presence of HPV type 11, leading to the diagnosis of BSCP in the patient. This example highlights the crucial significance of bronchoscopy and histological testing in the detection and verification of uncommon benign lesions, enabling prompt and efficient treatment. While HPV infection associated with BSCP may be correlated with immunocompromised conditions, it was not directly connected to the extended process of weaning the patient off the ventilator. Performing regular bronchoscopy in individuals with impaired immune systems is crucial for the timely identification of non-cancerous abnormalities and the prevention of their advancement. The results of this case emphasize the importance of conducting routine diagnostic procedures to effectively manage respiratory diseases and provide appropriate care for patients.","PeriodicalId":502106,"journal":{"name":"Indian journal of pathology & microbiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144556413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diffuse peritoneal keratinization in endometrioid adenocarcinoma of ovary masquerading as metastatic deposit. 卵巢子宫内膜样腺癌的弥漫性腹膜角化伪装成转移沉积。

Indian journal of pathology & microbiology Pub Date : 2025-06-07 DOI: 10.4103/ijpm.ijpm_1005_23

Pratibha Gautam, Pragya Jain, Tripti Nakra, Bindiya Gupta

{"title":"Diffuse peritoneal keratinization in endometrioid adenocarcinoma of ovary masquerading as metastatic deposit.","authors":"Pratibha Gautam, Pragya Jain, Tripti Nakra, Bindiya Gupta","doi":"10.4103/ijpm.ijpm_1005_23","DOIUrl":"https://doi.org/10.4103/ijpm.ijpm_1005_23","url":null,"abstract":"Abstract: Diffuse keratinization of peritoneum can be seen in various neoplastic and non-neoplastic diseases. This exuberant keratinization exhorts a granulomatous response with multinucleated giant cell reaction. In malignancy of ovary or endometrium they mimic tumor deposits, sometimes leading to erroneous upstaging. We report one such case of ovarian endometroid adenocarcinoma in 42-year multigravida with multiple nodules over peritoneum and pelvic tissue. The case was intraoperatively staged as FIGO stage III due to nodularity over momentum and pelvic areas. Hematoxylin and eosin-stained section from the ovary revealed endometroid adenocarcinoma (FIGO grade 1) with extensive squamous morales. Sections from the omentum showed diffuse keratinization with granulomatous response against keratin. There were no viable tumor cells in the multiple sections examined. The peritoneal fluid for cytology was negative for malignancy. Final stage was given as FIGO stage IB. This case highlights this rare presentation in Ovarian endometroid adenocarcinoma posing diagnostic dilemma to clinician and pathologist and emphasizes upon the importance of clinicopathological discussion, fluid cytology and extensive sampling for accurate staging.","PeriodicalId":502106,"journal":{"name":"Indian journal of pathology & microbiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tumor hypoxia and cancer stem cell markers expression in oral squamous cell carcinoma- An Immunohistochemical analysis. 口腔鳞状细胞癌中肿瘤缺氧和肿瘤干细胞标志物的表达-免疫组织化学分析。

Indian journal of pathology & microbiology Pub Date : 2025-06-07 DOI: 10.4103/ijpm.ijpm_174_24

Ambika Murugesan, Saranyan Ravi, Manivannan Ekambaram, Sekar Balakrishnan, Kumaresan Indrapriyadharshini

{"title":"Tumor hypoxia and cancer stem cell markers expression in oral squamous cell carcinoma- An Immunohistochemical analysis.","authors":"Ambika Murugesan, Saranyan Ravi, Manivannan Ekambaram, Sekar Balakrishnan, Kumaresan Indrapriyadharshini","doi":"10.4103/ijpm.ijpm_174_24","DOIUrl":"https://doi.org/10.4103/ijpm.ijpm_174_24","url":null,"abstract":"Background: Oral cancer is the common reason for the poor prognosis in head and neck carcinomas and the increase in morbidity and mortality rates. The biological behavior of cancer is a complex process. About 50-60% of solid tumors exhibit hypoxic areas within the tumor stroma, which was influenced by the transcriptional activity of hypoxia inducible factor (HIF). HIF promotes stemness and the proliferation of vessel-like structures in tumors, which leads to invasion and metastasis.Aim: To evaluate and correlate the expression of HIF- 1α, MCT1, NESTIN, and SALL2 in the tumor proper and tumor periphery of non- metastatic, metastatic, and recurrent OSCC.Materials and methods: A Total of 60 proven OSCC cases with proper tumor center and periphery were collected. Among them, 25 were nonmetastatic, 25 were metastatic, and 10 were recurrent cases of OSCC. Immunohistochemical analysis of HIF- 1α, MCT1 NESTIN, SALL2, and CD31/PAS double staining was done.Results: Depending on the extent of stained tumor cells, the intensity of staining, and the index score, the expressions of both MCT1, SALL2, and NESTIN were highly significant in the periphery of OSCC with a P value of 0.001. The total number of vessels expressed in non-metastatic, metastatic, and recurrent OSCC were not significant, but overall expression of CD31/PAS was statistically significant in the periphery of the tumor with P value -0.024.Conclusion: Based on the above results, it is observed that the role of hypoxia helped in cancer stem cell (CSC) maintenance with the formation of vessel-like structures by tumor cells at an early stage of cancer promotes its development and recurrence.","PeriodicalId":502106,"journal":{"name":"Indian journal of pathology & microbiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anaplastic large T-cell Lymphoma presenting as obstructive jaundice: Revisiting the pathologist's role. 表现为梗阻性黄疸的间变性大t细胞淋巴瘤：重新审视病理学家的角色。

Indian journal of pathology & microbiology Pub Date : 2025-06-07 DOI: 10.4103/ijpm.ijpm_592_24

Shrey Bhatt, Ujjwal Sonika, Surbhi Goyal, Alok Kumar Singh, Puja Sakhuja

引用次数: 0

Clinicopathological association of programmed death-ligand 1 (PD-L1) expression in uterine cervical carcinomas: A cross-sectional observational study. 子宫癌中程序性死亡配体1 （PD-L1）表达的临床病理关联：一项横断面观察研究

Indian journal of pathology & microbiology Pub Date : 2025-06-07 DOI: 10.4103/ijpm.ijpm_572_24

Md Ashab Anwer, Ruchi Sinha, Shreekant Bharti, Surabhi, Tarun Kumar, Avinash Singh

{"title":"Clinicopathological association of programmed death-ligand 1 (PD-L1) expression in uterine cervical carcinomas: A cross-sectional observational study.","authors":"Md Ashab Anwer, Ruchi Sinha, Shreekant Bharti, Surabhi, Tarun Kumar, Avinash Singh","doi":"10.4103/ijpm.ijpm_572_24","DOIUrl":"https://doi.org/10.4103/ijpm.ijpm_572_24","url":null,"abstract":"Background: Programmed death ligand (PD-L1) binds to its receptor PD-1 on T-cells and inhibits the immune response of T-lymphocytes. Cancer cells evade immune surveillance by upregulating PD-L1 expression, leading to tumor progression. Anti-PD-L1 immunotherapy has emerged as a new treatment modality in various solid carcinomas. Food and Drug Administration (FDA) has approved PD-1/PD-L1 axis immunotherapy for immunohistochemically PD-L1 positive cervical cancer. In India, cervical cancer accounts for approximately 17% of all cancer deaths among women between 30 and 70 years. More than three-fourths of patients are diagnosed at an advanced stage.Materials and methods: A hospital-based, cross-sectional prospective study was conducted over five years. 119 histologically proven cases of cervical carcinoma meeting the inclusion criteria were included in the study. Sections were stained with PD-L1 antibody clone SP263 as recommended on Ventana Benchmark XT.Results: Of 119 cases, PD-L1 expression was found in 42 cases (35%). Patients over 45 years (75.6%) had higher PD-L1 positivity compared to those under 45 years (24.4%). 31% of squamous cell carcinoma was PD-L1 positive compared to adenocarcinoma (29%). PD-L1 expression was more frequent in poorly differentiated carcinoma (37.5%).Conclusion: A significant proportion of cervical cancers expressed PD-L1. Increased PD-L1 expression was seen with increasing age and poorly differentiated histological grade. Anti-PD-L1 immunotherapy can be an option in PD-L1-positive cervical cancer. The findings of our study support the requirement for further investigation of anti-PD-L1 immunotherapy for the treatment of PD-L1-positive cervical carcinomas.","PeriodicalId":502106,"journal":{"name":"Indian journal of pathology & microbiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synchronous occurrence of littoral cell angioma and multiple primary malignancies - A rare case report. 沿岸细胞血管瘤与多发性原发恶性肿瘤同时发生一例罕见报告。

Indian journal of pathology & microbiology Pub Date : 2025-06-07 DOI: 10.4103/ijpm.ijpm_603_24

Jaseela Teeka, Shahin Hameed, Shalini Kuruvilla, Karthika Kundil Veetil

引用次数: 0

TFE3-rearranged renal cell carcinoma - Expanding the histomorphological spectrum. tfe3重排肾细胞癌-扩大组织形态学谱。

Indian journal of pathology & microbiology Pub Date : 2025-06-07 DOI: 10.4103/ijpm.ijpm_859_24

Mohammed Shahin, Sushmita Vangapandu, Suvendu Purkait, Swarnendu Mandal, Prasant Nayak, Pavithra Ayyanar

{"title":"TFE3-rearranged renal cell carcinoma - Expanding the histomorphological spectrum.","authors":"Mohammed Shahin, Sushmita Vangapandu, Suvendu Purkait, Swarnendu Mandal, Prasant Nayak, Pavithra Ayyanar","doi":"10.4103/ijpm.ijpm_859_24","DOIUrl":"https://doi.org/10.4103/ijpm.ijpm_859_24","url":null,"abstract":"Background: Transcription factor E3 (TFE3)-rearranged renal cell carcinoma (RCC) shows heterogeneity involving clinical, morphological, and molecular features, and it has many histopathological differential diagnoses.Aim: We aimed to study the histomorphology of the TFE3-rearranged RCC to know the morphological pattern, cytomorphology, and morphological clues to diagnose and to know the tumor behavior and prognosis.Materials and methods: It was a retrospective study; a total of 104 renal cell tumors were diagnosed on nephrectomy from January 2022 to January 2024, out of which a histopathological diagnosis of TFE3-rearranged RCC was rendered in five cases.Results: The mean age was 40 years (range 30-62 years). The male-to-female ratio was 4:1. The growth patterns were isolated papillary (three cases), a dominant papillary (one case), and a mixed (one case). Abundant and both eosinophilic and clear cytoplasm (all cases), focal oncocyte-like morphology, and eosinophilic cytoplasmic inclusion or hyaline globules-like material were noted. Pseudostratification (three cases), the mid and apical position of the nuclei, and hobnail morphology (four cases) were noted. The papillary core showed psammoma bodies (four cases), foamy macrophages (all cases), hyalinization (four cases), and lymphoid aggregates (two cases). A moderate degree of peritumoral lymphocytic infiltration (three cases) and xanthogranulomatous inflammation (one case) were noted. On immunohistochemistry, all cases showed diffuse and strong positivity for TFE3, variable positivity for alpha methylacyl CoA racemase, and variable and apical accentuation of staining for CD10. CK7 was negative to occasional positive.Conclusion: Identifying this new molecularly defined tumor's morphology will help exclude the differential diagnosis and understand this tumor's clinical and biological features.","PeriodicalId":502106,"journal":{"name":"Indian journal of pathology & microbiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A rare case of co-occurrence of lupus nephritis and lymphoma. 狼疮性肾炎与淋巴瘤同时发生的罕见病例。

Indian journal of pathology & microbiology Pub Date : 2025-06-07 DOI: 10.4103/ijpm.ijpm_683_24

Chilaka Rajesh, Sanjeet Roy, S Elanthenral, Anu Korula, Utkarash Mishra, Ankit Jain, Suceena Alexander

{"title":"A rare case of co-occurrence of lupus nephritis and lymphoma.","authors":"Chilaka Rajesh, Sanjeet Roy, S Elanthenral, Anu Korula, Utkarash Mishra, Ankit Jain, Suceena Alexander","doi":"10.4103/ijpm.ijpm_683_24","DOIUrl":"https://doi.org/10.4103/ijpm.ijpm_683_24","url":null,"abstract":"Abstract: Systemic Lupus Erythematosus (SLE) is an autoimmune disorder known to increase the risk of lymphomas, typically after prolonged immunosuppressive therapy. We report a rare case of a 45-year-old woman who presented with fever, polyarthritis, and anasarca, and was concurrently diagnosed with lupus nephritis and marginal zone lymphoma without prior immunosuppression. Initial evaluation revealed hematologic abnormalities, renal involvement, and axillary lymphadenopathy. Kidney biopsy confirmed class III and V lupus nephritis, while lymph node biopsy unexpectedly revealed low-grade B-cell non-Hodgkin lymphoma. The patient was treated successfully with chemotherapy and supportive lupus therapy, showing marked clinical and laboratory improvement. This case underscores the importance of thorough evaluation of lymphadenopathy in SLE patients, even at initial presentation, and raises awareness of rare concurrent diagnoses. It highlights the complex relationship between autoimmune disease and malignancy, suggesting shared pathogenic mechanisms and the necessity for vigilant, long-term multidisciplinary management.","PeriodicalId":502106,"journal":{"name":"Indian journal of pathology & microbiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ovarian-dedifferentiated endometrioid adenocarcinoma: A rare case report. 卵巢去分化子宫内膜样腺癌1例报告。

Indian journal of pathology & microbiology Pub Date : 2025-06-07 DOI: 10.4103/ijpm.ijpm_58_24

Cao Beibei, Zhen Junhai, Ru Guoqing, Peng Fang

引用次数: 0