{"title":"Ovarian-dedifferentiated endometrioid adenocarcinoma: A rare case report.","authors":"Cao Beibei, Zhen Junhai, Ru Guoqing, Peng Fang","doi":"10.4103/ijpm.ijpm_58_24","DOIUrl":null,"url":null,"abstract":"<p><strong>Abstract: </strong>We reported a case of dedifferentiated ovarian carcinoma in a 51-year-old woman. The microscopic tumor consisted of well-differentiated endometrioid carcinoma and undifferentiated carcinoma. Undifferentiated carcinoma was characterized by high-grade nuclear features, mainly solid growth, vacuolar nuclei, frequent nuclear division, and necrosis. Undifferentiated carcinoma did not express epithelial immune markers; p53 was completely deficient in both components; the expression of MMR proteins was only deficient in low-grade endometrioid carcinoma, while it was preserved in undifferentiated carcinoma; SMARCB1/INI1 was diffused expression in both components; SOX2 was diffusely expressed in undifferentiated carcinoma, but not in well-differentiated components; SMARCA4/BRG1 was inactivated in undifferentiated components. These resulted in a poor prognosis.</p>","PeriodicalId":502106,"journal":{"name":"Indian journal of pathology & microbiology","volume":" ","pages":""},"PeriodicalIF":0.5000,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian journal of pathology & microbiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/ijpm.ijpm_58_24","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
Abstract: We reported a case of dedifferentiated ovarian carcinoma in a 51-year-old woman. The microscopic tumor consisted of well-differentiated endometrioid carcinoma and undifferentiated carcinoma. Undifferentiated carcinoma was characterized by high-grade nuclear features, mainly solid growth, vacuolar nuclei, frequent nuclear division, and necrosis. Undifferentiated carcinoma did not express epithelial immune markers; p53 was completely deficient in both components; the expression of MMR proteins was only deficient in low-grade endometrioid carcinoma, while it was preserved in undifferentiated carcinoma; SMARCB1/INI1 was diffused expression in both components; SOX2 was diffusely expressed in undifferentiated carcinoma, but not in well-differentiated components; SMARCA4/BRG1 was inactivated in undifferentiated components. These resulted in a poor prognosis.
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