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[FITT principle of exercise in the management of lifestyle-related diseases]. [FITT运动在生活方式相关疾病管理中的原则]。
Clinical calcium Pub Date : 2016-03-01
Fuminori Katsukawa
{"title":"[FITT principle of exercise in the management of lifestyle-related diseases].","authors":"Fuminori Katsukawa","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>FITT principle (frequency, intensity, time, and type) of exercise is a framework for exercise prescription. A general recommendation is to accumulate at least 30 minutes of moderate-intensity exercise on most days of the week (total of 150 minutes per week). In this article, evidence was reviewed to clarify optimum exercise conditions for managing lifestyle-related diseases such as hypertension, diabetes, dyslipidemia, obesity and metabolic syndrome. The effect of resistance exercise was also reviewed.</p>","PeriodicalId":502100,"journal":{"name":"Clinical calcium","volume":"26 3","pages":"447-51"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145351281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Vitamin D, obesity, and diabetes:new technology toward drug development against metabolic diseases]. [维生素D、肥胖和糖尿病：针对代谢性疾病的药物开发新技术]。
Clinical calcium Pub Date : 2016-03-01
Yugo Miyata, Iichiro Shimomura
{"title":"[Vitamin D, obesity, and diabetes:new technology toward drug development against metabolic diseases].","authors":"Yugo Miyata, Iichiro Shimomura","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Obesity and diabetes are rapidly reaching epidemic proportions in many parts of world and are becoming one of the major public health problems. Many studies have been performed to develop treatments for obesity and diabetes. In clinical aspect, for example, vitamin D was assumed to be a causal factor of obesity and diabetes, and the effect of vitamin D supplementation on the patients was assessed. In addition to clinical study, basic researchers have tried to elucidate the mechanisms of obesity and diabetes. Recent studies show novel techniques for finding etiologic factors in obesity and diabetes. These effort will accelerate progress toward total eradication of obesity and diabetes.</p>","PeriodicalId":502100,"journal":{"name":"Clinical calcium","volume":"26 3","pages":"385-91"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145351284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Genome-Wide Association Studies for life-style related diseases]. [与生活方式相关疾病的全基因组关联研究]。
Clinical calcium Pub Date : 2016-03-01
Shiro Maeda
{"title":"[Genome-Wide Association Studies for life-style related diseases].","authors":"Shiro Maeda","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>After the completion of human genome project, development of single nucleotide polymorphism (SNP) typing technology and collation of information regarding linkage disequilibrium in the human genome have facilitated genome-wide association studies (GWAS) for investigating genes associated with disease susceptibility across the entire human genome. In case of type 2 diabetes, approximately 100 genetic loci have been identified and confirmed as susceptibility to the disease through GWAS in different ethnic groups, including Japanese, European, East Asian and South Asian populations. However, integration of these information accounts for less than 20% of the disease heritability, and thus most of the heritability of type 2 diabetes remain to be identified. Since the rationale of GWAS is based on the hypothesis that common variants contribute to the susceptibility to common diseases, common disease-common variant hypothesis, GWAS have selectively identified common susceptibility variants (allele frequency>=0.05) with lower effect size (odds ratio<1.5), that is a limitation of the GWAS approach. Although GWAS have brought a significant breakthrough in the field of genetic study for life-style related diseases, new approaches other than GWAS, such as whole genome sequencing to identify rare variants with greater effect size or integration of genetic and environmental information, will be required to elucidate a heritability of life-style related diseases completely.</p>","PeriodicalId":502100,"journal":{"name":"Clinical calcium","volume":"26 3","pages":"419-25"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145351314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Chronic kidney disease and nutrition]. 【慢性肾病与营养】。
Clinical calcium Pub Date : 2016-03-01
Takuya Yoshida, Hiromichi Kumagai
{"title":"[Chronic kidney disease and nutrition].","authors":"Takuya Yoshida, Hiromichi Kumagai","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Abnormalities of mineral metabolism develop with decline of renal function in chronic kidney disease (CKD), and it is called as a CKD-mineral and bone disorder (CKD-MBD). The standard approach for management of CKD-MBD is to keep serum phosphorus, calcium, and parathyroid hormone in the reference range by dietary intervention and medications. It has been recently pointed out that starting the treatment from early CKD is important for suppressing CKD-MBD.</p>","PeriodicalId":502100,"journal":{"name":"Clinical calcium","volume":"26 3","pages":"369-74"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145351242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Bone disorder and nutrition]. [骨骼紊乱和营养]。
Clinical calcium Pub Date : 2016-03-01
Mikiko Ito, Sarasa Tanaka
{"title":"[Bone disorder and nutrition].","authors":"Mikiko Ito, Sarasa Tanaka","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The nutrition is important for prevention and improvement in bone disorder. Especially osteoporosis associated with nutrition. It has entered the super-aged society in 2007, a further increase in osteoporosis patients are concerned in Japan. Many studies have shown that associated with calcium, vitamin D, vitamin K intake and bone density and fracture. Relationship of osteoporosis and nutrition, despite the general awareness is high, calcium intake is not at all reached the achievement to recommend dietary allowance. In addition, vitamin D deficiency rickets in children, which has been considered in the past of the disorder, there is an increasing trend from such exposure shortage to the infancy of sunlight, vitamin D deficiency in pregnant women, the recommended breastfeeding. Improvement of lifestyle and diet from young age is important for bone disorder prevention.</p>","PeriodicalId":502100,"journal":{"name":"Clinical calcium","volume":"26 3","pages":"375-83"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145351250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The nutrition of acute phase in patients with metabolic syndrome]. [代谢综合征患者急性期的营养]。
Clinical calcium Pub Date : 2016-03-01
Rie Tsutsumi, Mayu Sebe
{"title":"[The nutrition of acute phase in patients with metabolic syndrome].","authors":"Rie Tsutsumi, Mayu Sebe","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In this session, we describe the acute phase in patients with metabolic syndrome from two sides; acute disease that occurs higher in patients with metabolic syndrome such as colonary heart disease and stroke, and acute aggravation of diabetes such as diabetic ketoacidosis and hyperosmolar hyperglycemic syndrome. The electrolyte imbalance is frequently detected in critical ill patients. It is reported that the extreme abnormalities of ionized calcium concentrations are independent predictors of mortality. In addition, from clinical database MIMIC-Ⅱ,calcium supplementation improves clinical outcome in intensive care unit patients. Although metabolic syndrome; lifestyle-related disease, is a chronic disease, the possibility of falling into acute disease by having it becomes very high and improvement of electrolyte imbalance, especially hypocalcaemia is expected to effective on clinical outcome.</p>","PeriodicalId":502100,"journal":{"name":"Clinical calcium","volume":"26 3","pages":"459-62"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145351295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Application for Lifestyle disease by iPS cells technologies]. [iPS细胞技术在生活方式疾病中的应用]。
Clinical calcium Pub Date : 2016-03-01
Yasuhiro Takashima
{"title":"[Application for Lifestyle disease by iPS cells technologies].","authors":"Yasuhiro Takashima","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Currently it is less advanced to understand the pathology of lifestyle disease by using iPS cells because there is partly less direct connection between life style disease and iPS cells. So much more scientists focus on regenerative medicine such as beta cells therapy using iPS cells technologies. It will be indeed a powerful tool to generate beta cells from iPS cells as even in type2 diabetes patients, hyposecretion of insulin from beta cells in pancreas is one of causes. Another reason is complexity of the pathology of life style disease. There are a lot of reasons to cause lifestyle disease. Lifestyle diseases include cancer, chronic liver disease, Type 2 diabetes, heart disease, metabolic syndrome, chronic renal failure, stroke, and obesity. Since obesity is one of major causes of lifestyle diseases, we want to focus on adipogenesis from iPS cells in this review. We analysed and established the differentiation protocol into adipocytes from mouse ES cells and human iPS cells. The other point in this review is the starting pluripotent cells for differentiation. Quality of pluripotent stem cells are one of most critical factors to succeed in getting well-differentiated cells. Recently, we have developed new naive human pluripotent stem cells (PSC),\"Reset cells\". Naive PSC have more similar to human epibast cells than conventional human PSC. They will be more ideal cells for differentiation because of their hypomethylated status and earlier stage of development.</p>","PeriodicalId":502100,"journal":{"name":"Clinical calcium","volume":"26 3","pages":"433-9"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145351233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Adiponectin receptor-targeted therapy for lifestyle-related diseases]. [脂联素受体靶向治疗生活方式相关疾病]。
Clinical calcium Pub Date : 2016-03-01
Masato Iwabu, Toshimasa Yamauchi, Miki Okada-Iwabu, Takashi Kadowaki
{"title":"[Adiponectin receptor-targeted therapy for lifestyle-related diseases].","authors":"Masato Iwabu, Toshimasa Yamauchi, Miki Okada-Iwabu, Takashi Kadowaki","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Given that appropriate control of responses of the body to nutritional status is assumed to modulate the pace of aging, thus prolonging lifespan and maintaining youth in humans, expectations are mounting worldwide for modalities targeting the pathways in metabolic regulation for healthy longevity. Of these, this review focuses attention on adiponectin-targeted therapy and discusses milestones in this approach, which include the discovery of the ability of adiponectin to protect against lifestyle-related diseases, identification of its receptors (AdipoRs), elucidation of AdipoR-mediated signaling pathways that promote healthy longevity and acquisition of small-molecule AdipoR agonist, and explores future prospects on adiponectin-targeted therapy.</p>","PeriodicalId":502100,"journal":{"name":"Clinical calcium","volume":"26 3","pages":"413-8"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145351248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Nutrition and atherosclerotic cardiovascular disease]. 营养与动脉粥样硬化性心血管疾病。
Clinical calcium Pub Date : 2016-03-01
Wao Tsutsui, Yoshio Fujioka
{"title":"[Nutrition and atherosclerotic cardiovascular disease].","authors":"Wao Tsutsui, Yoshio Fujioka","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Atherosclerotic lesion called atheroma includes large amounts of cholesterol. Intake of cholesterol and quality of free fatty acids contributes to the increase of serum cholesterol level and the development of atherosclerosis. A high level of low-density lipoprotein cholesterol is established as a the most dangerous risk factor to promote atherosclerosis. However, recent dietary instruction is focusing on the diet pattern instead of the dietary individual nutrients including cholesterol. We discuss the problem concerning dietary lipids and others for the prevention of atherosclerosis.</p>","PeriodicalId":502100,"journal":{"name":"Clinical calcium","volume":"26 3","pages":"355-61"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145351258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Key treatment of lifestyle-related diseases:nutritional education and practice]. 【生活方式相关疾病的重点治疗：营养教育与实践】。
Clinical calcium Pub Date : 2016-03-01
Hisami Yamanaka-Okumura, Hiroshi Tatano, Daisuke Kajiura, Chise Yamaguchi, Masashi Masuda, Yutaka Taketani
{"title":"[Key treatment of lifestyle-related diseases:nutritional education and practice].","authors":"Hisami Yamanaka-Okumura, Hiroshi Tatano, Daisuke Kajiura, Chise Yamaguchi, Masashi Masuda, Yutaka Taketani","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In modern times, calcium and vegetable intake is known to be generally insufficient in the population. In addition, many patients increasingly have lifestyle-related diseases, such as obesity, and they require lifestyle modification to increase their energy consumption compared to their energy intake. Therefore, it is important for these patients to continue weight loss and to improve their dietary habits. The overall energy density (ED) of one's diet decreases by eating more vegetables and fruits. Moreover, higher vegetable intake contributes to an improvement in lifestyle as well as improves the calcium intake. In this article, we show that sufficient vegetable intake provides satiety and satisfaction.</p>","PeriodicalId":502100,"journal":{"name":"Clinical calcium","volume":"26 3","pages":"441-6"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145351226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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