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Clinical calcium最新文献

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[Changes in bone quality and strength with bone-forming agents]. [骨形成剂对骨质量和强度的影响]。
Clinical calcium Pub Date : 2016-01-01
Naohisa Miyakoshi
{"title":"[Changes in bone quality and strength with bone-forming agents].","authors":"Naohisa Miyakoshi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Among the anti-osteoporotic agents clinically available in Japan, teriparatide is the only bone anabolic agent offering potent osteogenic effects. Regarding bone quality, studies have shown that teriparatide increases bone collagen content and enzymatic cross-links and decreases pentosidine, a surrogate marker of advanced glycation end-products. In addition to these improvements in bone collagen cross-links, increased bone mineral density and improvement of bone microarchitecture contribute to increases in bone strength with teriparatide administration. Teriparatide has been shown to markedly reduce the risk of new vertebral fractures in patients with osteoporosis. Recent clinical studies have suggested a role for teriparatide in accelerating healing for osteoporotic fractures. Teriparatide is promising for the prevention of vertebral collapse progression after vertebral fracture.</p>","PeriodicalId":502100,"journal":{"name":"Clinical calcium","volume":"26 1","pages":"117-24"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145351306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Osteoporosis in chronic obstructive pulmonary disease.] [慢性阻塞性肺病中的骨质疏松症。]
Clinical calcium Pub Date : 2016-01-01
Toyohiro Hirai
{"title":"[Osteoporosis in chronic obstructive pulmonary disease.]","authors":"Toyohiro Hirai","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Chronic Obstructive Pulmonary Disease(COPD)is characterized by persistent airflow limitation that is associated with chronic inflammatory process caused by inhaled noxious particles such as cigarette smoke. COPD involves not only the lungs but also extrapulmonary abnormalities as systemic effects. Osteoporosis is one of major comorbidities in COPD, and is often under-diagnosed. Osteoporosis in COPD is associated with various factors including smoking, decreased body mass index, and systemic inflammation. It should be recognized that COPD is a risk factor for osteoporosis and bone fracture, and early diagnosis and management for both COPD and osteoporosis are important.</p>","PeriodicalId":502100,"journal":{"name":"Clinical calcium","volume":"26 10","pages":"1393-1398"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145351174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Reduced ADL, QOL and musculoskeletal dysfunction associated with respiratory disease.] [与呼吸系统疾病相关的ADL、QOL和肌肉骨骼功能障碍降低。]
Clinical calcium Pub Date : 2016-01-01
Toshiaki Homma
{"title":"[Reduced ADL, QOL and musculoskeletal dysfunction associated with respiratory disease.]","authors":"Toshiaki Homma","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Chronic respiratory disease, such as chronic obstructive pulmonary disease(COPD)continues to cause a heavy health and economic burden in the world. Lower-limb muscle dysfunction is a prominent and major extrapulmonary features in individuals with moderate-to-very severe COPD and has important clinical implications, such as reduced exercise tolerance, activity of daily living(ADL), health related quality of life(HRQOL)and even survival. Osteoporosis is also an important systemic feature of COPD. Osteoprotic fracture cause many symptoms and complications, including the impairment of ventilation, and create a heavy economic burden. Comprehensive treatments(drug medication and non-drug treatment)for these impairments, such as pulmonary rehabilitation, are recommended. Pulmonary rehabilitation improves dyspnea, exercise capacity, ADL, and HRQOL, each of which is recognized predictors of mortality.</p>","PeriodicalId":502100,"journal":{"name":"Clinical calcium","volume":"26 10","pages":"1451-1458"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145351189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Topics for basic research(osteoclast and bone resorption)in ASBMR 2015]. 【ASBMR 2015基础研究主题（破骨细胞与骨吸收）】。
Clinical calcium Pub Date : 2016-01-01
Nobuyuki Udagawa
{"title":"[Topics for basic research(osteoclast and bone resorption)in ASBMR 2015].","authors":"Nobuyuki Udagawa","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This is a brief report summarizing topics in ASBMR 2015 held at Washington State Convention Center in Seattle on October 9-12th. In this paper, I report some topics from presentation of basic research(especially osteoclast and bone resorption)in ASBMR 2015.</p>","PeriodicalId":502100,"journal":{"name":"Clinical calcium","volume":"26 1","pages":"128-32"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145351246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Bone quantitative ultrasound]. [骨定量超声]。
Clinical calcium Pub Date : 2016-01-01
Mami Matsukawa
{"title":"[Bone quantitative ultrasound].","authors":"Mami Matsukawa","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The conventional ultrasonic bone densitometry system can give us information of bone as ultrasonic wave velocity and attenuation. However, the data reflect both structural and material properties of bone. In order to focus only on the bone matrix properties without the effect of bone structure, studies of microscopic Brillouin scattering technique are introduced. The wave velocity in a trabecula was anisotropic and depended on the position and structure of the cancellous bone. The glycation also affected on the wave velocities in bone. As a new bone quality, the piezoelectricity of bone is also discussed.</p>","PeriodicalId":502100,"journal":{"name":"Clinical calcium","volume":"26 1","pages":"57-64"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145351268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Pathogenesis of atypical femoral fracture]. [不典型股骨骨折的发病机制]。
Clinical calcium Pub Date : 2016-01-01
Ken Iwata, Tasuku Mashiba
{"title":"[Pathogenesis of atypical femoral fracture].","authors":"Ken Iwata, Tasuku Mashiba","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We demonstrated microdamage accumulation in the fracture sites in the patients of subtrochanteric atypical femoral fracture with long term bisphosphonate therapy and of incomplete shaft fracture of lateral femoral bowing without bisphosphonate therapy. Based on these findings, pathogenesis of atypical femoral fracture is revealed stress fracture caused by accumulation of microdamages between distal to the lesser trochanter and proximal to the supracondylar flare in the femur in association with severely suppressed bone turnover and/or abnormal lower limb alignment, that causes stress concentration on the lateral side cortex of the femur.</p>","PeriodicalId":502100,"journal":{"name":"Clinical calcium","volume":"26 1","pages":"73-9"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145351292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Pharmacokinetics of Zoledronic acid[once-yearly bisphosphonate(intravenous infusion)].] 唑来膦酸的药代动力学[一年一次的双膦酸盐（静脉输注）]。
Clinical calcium Pub Date : 2016-01-01
Satoshi Tanaka
{"title":"[Pharmacokinetics of Zoledronic acid[once-yearly bisphosphonate(intravenous infusion)].]","authors":"Satoshi Tanaka","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Zoledronic acid hydrate(zoledronic acid)is an osteoporosis therapeutic agent which shows the fracture suppression effect with once-yearly intravenous infusion. Although zoledronic acid is quickly disappeared from the blood after intravenous infusion, it is taken into the bone immediately and incorporated into the bone tissue. In addition, zoledronic acid shows the potent suppression effect on bone resorption by inhibiting farnesyl diphosphate synthase of the mevalonate pathway(FPPS)strongly. In vivo study, the single intravenous administration of zoledronic acid to the mature ovariectomized(OVX)rats demonstrated to suppress the decreasing bone strength dose-dependently in 32 weeks, corresponding to more than one year in human. Changes in bone resorption markers in the study of Japanese osteoporosis patients(ZONE Study)indicated that bone resorption inhibition action was maintained also over one year. The fracture suppression and increase of bone density with once-yealy administration was demonstrated in clinical trials in the osteoporosis patients in Japan and other countries, and zoledronic acid was currently approved for osteoporosis in September 2016 in Japan. Zoledronic acid is expected to contribute to the treatment of osteoporosis as a new bisphosphonate with once-yearly administration.</p>","PeriodicalId":502100,"journal":{"name":"Clinical calcium","volume":"26 11","pages":"1605-1613"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145351130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Mechano-bioscience in heart disease and regenerative medicine.] 心脏病和再生医学中的机械生物科学。
Clinical calcium Pub Date : 2016-01-01
Shota Kurotsu, Masaki Ieda
{"title":"[Mechano-bioscience in heart disease and regenerative medicine.]","authors":"Shota Kurotsu, Masaki Ieda","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>During cardiac development and maturation, the heart continuously receives hemodynamic stimuli, referred to mechanical stress. Mechanical stress governs both cardiac development and differentiation, and also plays an important role in the maintenance of cardiac homeostasis. Indeed, cardiac hypertrophic changes emerge as a result of adaptation to mechanical overload. However, it is difficult to measure the mechanical stress precisely. Therefore, the molecular mechanisms of hemodynamics-related diseases are minimally understood. The progress in mechanobioscience field has a potential to uncover the mechanisms of cardiac diseases, and is expected to result in drug discovery in the future.</p>","PeriodicalId":502100,"journal":{"name":"Clinical calcium","volume":"26 12","pages":"1697-1702"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145351164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Clinical manifestation and pathophyisological bases of sarcopenia.] [肌肉减少症的临床表现及病理生理基础]
Clinical calcium Pub Date : 2016-01-01
Sumito Ogawa
{"title":"[Clinical manifestation and pathophyisological bases of sarcopenia.]","authors":"Sumito Ogawa","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Age-related loss of skeletal muscle mass, strength and function is known as sarcopenia, and its diagnostic criteria is based on usual gait speed, grip strength, and skeletal muscle mass. Whereas underlying mechanisms of sarcopenia remains to be fully clarified, recent studies have suggested age-related changes in inflammatory status and humoral factors might contribute to the pathophysiology of sarcopenia and linkage between bone and muscle metabolism.</p>","PeriodicalId":502100,"journal":{"name":"Clinical calcium","volume":"26 12","pages":"1703-1708"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145351179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Hypoxemia and Osteoporosis-Possible roles of HIF1α on Respiratory disease-related Osteoporosis-.] [低氧血症和骨质疏松- HIF1α在呼吸系统疾病相关骨质疏松中的可能作用]
Clinical calcium Pub Date : 2016-01-01
Takeshi Miyamoto
{"title":"[Hypoxemia and Osteoporosis-Possible roles of HIF1α on Respiratory disease-related Osteoporosis-.]","authors":"Takeshi Miyamoto","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Osteoporosis is a disease characterized by increased risks for bone fragility fractures, and is caused by various factors such as aging and menopause. Increase in the number of osteoporosis patients becomes a big concern in the developed countries. Recently, the mechanisms underlying postmenopausal osteoporosis development were being clarified, and several diseases such as respiratory diseases and diabetes were reportedly caused secondary osteoporosis. HIF1α was demonstrated required for osteoclast activation and bone loss in postmenopausal osteoporosis women. However, the roles of HIF1α on respiratory disease-related osteoporosis development remained to be elucidated.</p>","PeriodicalId":502100,"journal":{"name":"Clinical calcium","volume":"26 10","pages":"1429-1435"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145351194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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