[Clinical manifestation and pathophyisological bases of sarcopenia.]

Abstract

Age-related loss of skeletal muscle mass, strength and function is known as sarcopenia, and its diagnostic criteria is based on usual gait speed, grip strength, and skeletal muscle mass. Whereas underlying mechanisms of sarcopenia remains to be fully clarified, recent studies have suggested age-related changes in inflammatory status and humoral factors might contribute to the pathophysiology of sarcopenia and linkage between bone and muscle metabolism.