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Journal of Experimental & Clinical Cancer Research最新文献

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The PPTC7/BNIP3/NIX axis induces cGAS/STING-mediated senescence and augments CAR-T efficacy by repressing tumor-intrinsic mitophagy. PPTC7/BNIP3/NIX轴诱导cGAS/ sting介导的衰老，并通过抑制肿瘤自噬来增强CAR-T的疗效。
IF 12.8 1区 医学
Journal of Experimental & Clinical Cancer Research Pub Date : 2026-04-18 DOI: 10.1186/s13046-026-03713-7
Kuai Yu, Xinxin Xiong, Bo Lu, Yaqun Wang, Tiantian Sun, Mei Xie, Xiaojun Xu, Yuanbin Song, Wei Xiao
{"title":"The PPTC7/BNIP3/NIX axis induces cGAS/STING-mediated senescence and augments CAR-T efficacy by repressing tumor-intrinsic mitophagy.","authors":"Kuai Yu, Xinxin Xiong, Bo Lu, Yaqun Wang, Tiantian Sun, Mei Xie, Xiaojun Xu, Yuanbin Song, Wei Xiao","doi":"10.1186/s13046-026-03713-7","DOIUrl":"https://doi.org/10.1186/s13046-026-03713-7","url":null,"abstract":"","PeriodicalId":50199,"journal":{"name":"Journal of Experimental & Clinical Cancer Research","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147718615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Liquid biopsy reveals the immune status and protein profiles linked to CTC burden and clinical outcomes in metastatic breast cancer. 液体活检揭示了转移性乳腺癌中与CTC负担和临床结果相关的免疫状态和蛋白质谱。
IF 12.8 1区 医学
Journal of Experimental & Clinical Cancer Research Pub Date : 2026-04-18 DOI: 10.1186/s13046-026-03709-3
Keerthi Kurma, Thomas Bardol, Caroline Mollevi, Zahra Eslami-S, Françoise Garima, Marie Alexandre, Angélique Bobrie, Gerald Lossaint, Blandine Massemin, Véronique D'Hondt, Séverine Guiu, Laure Cayrefourcq, William Jacot, Catherine Alix-Panabières
{"title":"Liquid biopsy reveals the immune status and protein profiles linked to CTC burden and clinical outcomes in metastatic breast cancer.","authors":"Keerthi Kurma, Thomas Bardol, Caroline Mollevi, Zahra Eslami-S, Françoise Garima, Marie Alexandre, Angélique Bobrie, Gerald Lossaint, Blandine Massemin, Véronique D'Hondt, Séverine Guiu, Laure Cayrefourcq, William Jacot, Catherine Alix-Panabières","doi":"10.1186/s13046-026-03709-3","DOIUrl":"10.1186/s13046-026-03709-3","url":null,"abstract":"","PeriodicalId":50199,"journal":{"name":"Journal of Experimental & Clinical Cancer Research","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147718588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DNA base lesion-containing G-quadruplex mediates transcriptome reprogramming in EGFR-TKI resistance of non-small cell lung cancer. 含DNA碱基病变的g -四重体介导非小细胞肺癌EGFR-TKI耐药的转录组重编程。
IF 12.8 1区 医学
Journal of Experimental & Clinical Cancer Research Pub Date : 2026-04-14 DOI: 10.1186/s13046-026-03702-w
Xinming Jing, Zheng Liu, Lujie Yang, Yanli Xiong, Shixun Li, Ruyi Hang, Xiao Yang, Xiaoyan Dai, Jiangyang Li, Jing Yang, Yi Cheng, Ziqi Jiang, Huifen Cao, Philipp Kapranov, Qian Chen, Dong Wang, Wei Guo, Zhou Huang, Mengxia Li
{"title":"DNA base lesion-containing G-quadruplex mediates transcriptome reprogramming in EGFR-TKI resistance of non-small cell lung cancer.","authors":"Xinming Jing, Zheng Liu, Lujie Yang, Yanli Xiong, Shixun Li, Ruyi Hang, Xiao Yang, Xiaoyan Dai, Jiangyang Li, Jing Yang, Yi Cheng, Ziqi Jiang, Huifen Cao, Philipp Kapranov, Qian Chen, Dong Wang, Wei Guo, Zhou Huang, Mengxia Li","doi":"10.1186/s13046-026-03702-w","DOIUrl":"https://doi.org/10.1186/s13046-026-03702-w","url":null,"abstract":"","PeriodicalId":50199,"journal":{"name":"Journal of Experimental & Clinical Cancer Research","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147678274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting PSMD14 enhances immunotherapy efficacy by promoting PD-L1 degradation and reshaping the tumor microenvironment in breast cancer. 靶向PSMD14通过促进PD-L1降解和重塑乳腺癌肿瘤微环境来提高免疫治疗效果。
IF 12.8 1区 医学
Journal of Experimental & Clinical Cancer Research Pub Date : 2026-04-14 DOI: 10.1186/s13046-026-03710-w
Shichao Wen, Yuhan Liu, Qi Liu, Liqian Su, Yuhua Wang, Yiqiu Ma, Jingxuan Wang
{"title":"Targeting PSMD14 enhances immunotherapy efficacy by promoting PD-L1 degradation and reshaping the tumor microenvironment in breast cancer.","authors":"Shichao Wen, Yuhan Liu, Qi Liu, Liqian Su, Yuhua Wang, Yiqiu Ma, Jingxuan Wang","doi":"10.1186/s13046-026-03710-w","DOIUrl":"https://doi.org/10.1186/s13046-026-03710-w","url":null,"abstract":"","PeriodicalId":50199,"journal":{"name":"Journal of Experimental & Clinical Cancer Research","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147693373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tumor microenvironment remodeling by STING agonism sensitizes endothelial cells to cytotoxic anti-PD-L1/L2 antibody. 通过STING激动作用重塑肿瘤微环境使内皮细胞对细胞毒性抗pd - l1 /L2抗体敏感。
IF 12.8 1区 医学
Journal of Experimental & Clinical Cancer Research Pub Date : 2026-04-14 DOI: 10.1186/s13046-026-03711-9
Ahmad Salameh, Elisabetta Bolli, Manuela Iezzi, Christine Gagliardi, Laura Conti, Chiara Cossu, Paul Blezinger, Alessia Lamolinara, Andrew Lewis, Michael A Curran, Federica Cavallo, Federica Pericle
{"title":"Tumor microenvironment remodeling by STING agonism sensitizes endothelial cells to cytotoxic anti-PD-L1/L2 antibody.","authors":"Ahmad Salameh, Elisabetta Bolli, Manuela Iezzi, Christine Gagliardi, Laura Conti, Chiara Cossu, Paul Blezinger, Alessia Lamolinara, Andrew Lewis, Michael A Curran, Federica Cavallo, Federica Pericle","doi":"10.1186/s13046-026-03711-9","DOIUrl":"https://doi.org/10.1186/s13046-026-03711-9","url":null,"abstract":"","PeriodicalId":50199,"journal":{"name":"Journal of Experimental & Clinical Cancer Research","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147693332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Autologous tumor-immune effusion cocultures enable ex vivo functional profiling of radiotherapy-immunotherapy combinations. 自体肿瘤-免疫积液共培养使放射治疗-免疫治疗联合的体外功能分析成为可能。
IF 12.8 1区 医学
Journal of Experimental & Clinical Cancer Research Pub Date : 2026-04-14 DOI: 10.1186/s13046-026-03707-5
Rebecca Zirnbauer, Daphni Ammon, Berta Mosleh, Nora Speiser, Anna Theophil, Markus Fabits, Mir Ali Reza Hoda, Michael Bergmann, Johannes Laengle
{"title":"Autologous tumor-immune effusion cocultures enable ex vivo functional profiling of radiotherapy-immunotherapy combinations.","authors":"Rebecca Zirnbauer, Daphni Ammon, Berta Mosleh, Nora Speiser, Anna Theophil, Markus Fabits, Mir Ali Reza Hoda, Michael Bergmann, Johannes Laengle","doi":"10.1186/s13046-026-03707-5","DOIUrl":"https://doi.org/10.1186/s13046-026-03707-5","url":null,"abstract":"","PeriodicalId":50199,"journal":{"name":"Journal of Experimental & Clinical Cancer Research","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147693393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unbiased profiling of translational landscape reveals TNFR2 as a translation-dependent vulnerability in colorectal cancer. 无偏倚的翻译分析显示TNFR2在结直肠癌中是一种翻译依赖性易感性。
IF 12.8 1区 医学
Journal of Experimental & Clinical Cancer Research Pub Date : 2026-04-11 DOI: 10.1186/s13046-026-03706-6
Yiying Chen, Yufeng Gao, Haixia Wang, Weiqian Li, Fanqi Zhou, Hao Sun, Jia Yu, Dongling Zou, Fang Wang
{"title":"Unbiased profiling of translational landscape reveals TNFR2 as a translation-dependent vulnerability in colorectal cancer.","authors":"Yiying Chen, Yufeng Gao, Haixia Wang, Weiqian Li, Fanqi Zhou, Hao Sun, Jia Yu, Dongling Zou, Fang Wang","doi":"10.1186/s13046-026-03706-6","DOIUrl":"10.1186/s13046-026-03706-6","url":null,"abstract":"","PeriodicalId":50199,"journal":{"name":"Journal of Experimental & Clinical Cancer Research","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147663570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The aryl hydrocarbon receptor, CIITA and HLA-II: who is watching the watchdog? 芳烃受体、CIITA和HLA-II：谁是看门狗？
IF 12.8 1区 医学
Journal of Experimental & Clinical Cancer Research Pub Date : 2026-04-10 DOI: 10.1186/s13046-026-03692-9
Doriana Fruci, Patrizio Giacomini
{"title":"The aryl hydrocarbon receptor, CIITA and HLA-II: who is watching the watchdog?","authors":"Doriana Fruci, Patrizio Giacomini","doi":"10.1186/s13046-026-03692-9","DOIUrl":"10.1186/s13046-026-03692-9","url":null,"abstract":"","PeriodicalId":50199,"journal":{"name":"Journal of Experimental & Clinical Cancer Research","volume":"45 1","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13067543/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147655144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Osteoglycin (OGN) reverses epithelial to mesenchymal transition and invasiveness in colorectal cancer via EGFR/Akt pathway. 更正：Osteoglycin （OGN）通过EGFR/Akt通路逆转结直肠癌上皮细胞向间质细胞的转变和侵袭性。
IF 12.8 1区 医学
Journal of Experimental & Clinical Cancer Research Pub Date : 2026-04-10 DOI: 10.1186/s13046-026-03704-8
Xiang Hu, Ya-Qi Li, Qing-Guo Li, Yan-Lei Ma, Jun-Jie Peng, San-Jun Cai
{"title":"Correction: Osteoglycin (OGN) reverses epithelial to mesenchymal transition and invasiveness in colorectal cancer via EGFR/Akt pathway.","authors":"Xiang Hu, Ya-Qi Li, Qing-Guo Li, Yan-Lei Ma, Jun-Jie Peng, San-Jun Cai","doi":"10.1186/s13046-026-03704-8","DOIUrl":"10.1186/s13046-026-03704-8","url":null,"abstract":"","PeriodicalId":50199,"journal":{"name":"Journal of Experimental & Clinical Cancer Research","volume":"45 1","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13067713/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147647355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cadherin 17 and digestive cancers: from diagnostic to therapeutic opportunities. 钙粘蛋白17与消化道癌症：从诊断到治疗的机会。
IF 12.8 1区 医学
Journal of Experimental & Clinical Cancer Research Pub Date : 2026-04-02 DOI: 10.1186/s13046-026-03693-8
Benjamin Fernandez, Léa Lopez, Thibaut Matis, Sandrine Dabernat, Samuel Amintas
{"title":"Cadherin 17 and digestive cancers: from diagnostic to therapeutic opportunities.","authors":"Benjamin Fernandez, Léa Lopez, Thibaut Matis, Sandrine Dabernat, Samuel Amintas","doi":"10.1186/s13046-026-03693-8","DOIUrl":"https://doi.org/10.1186/s13046-026-03693-8","url":null,"abstract":"","PeriodicalId":50199,"journal":{"name":"Journal of Experimental & Clinical Cancer Research","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147610236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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