npj Biological Timing and Sleep最新文献_第6页

Publishing sleep and chronobiology research without barriers. 毫无障碍地发表睡眠和时间生物学研究。

npj Biological Timing and Sleep Pub Date : 2025-12-06 DOI: 10.1038/s44323-025-00063-z

John O'Neill

引用次数: 0

Temperature compensation of the Arabidopsis circadian clock. 拟南芥生物钟的温度补偿。

npj Biological Timing and Sleep Pub Date : 2025-12-04 DOI: 10.1038/s44323-025-00058-w

Akari E Maeda, Norihito Nakamichi

引用次数: 0

Circadian regulation of extracellular vesicle biogenesis, composition, and release. 细胞外囊泡生物发生、组成和释放的昼夜节律调节。

npj Biological Timing and Sleep Pub Date : 2025-11-03 DOI: 10.1038/s44323-025-00053-1

Jonathan D Church, Elizaveta Kadukhina, Ignacio Aiello, Carla V Finkielstein

{"title":"Circadian regulation of extracellular vesicle biogenesis, composition, and release.","authors":"Jonathan D Church, Elizaveta Kadukhina, Ignacio Aiello, Carla V Finkielstein","doi":"10.1038/s44323-025-00053-1","DOIUrl":"10.1038/s44323-025-00053-1","url":null,"abstract":"Circadian rhythms in mammals are governed by cell-autonomous oscillators that synchronize physiological functions through central and peripheral communication. Extracellular vesicles (EVs) mediate intercellular and systemic signaling, with time-of-day-dependent release and cargo composition regulated by the circadian clock. This regulation involves both transcriptional and post-transcriptional mechanisms affecting genes involved in EV biogenesis. Studies in diverse models show EVs impact physiological and pathological processes, including inflammation, cardiovascular disease, chronic kidney disease, and cancer. EVs also serve as important biomarkers, especially in cancer. The accompanying article explores how clock proteins regulate multiple aspects of EV biology and highlights the significance of circadian dysregulation in EV-associated pathologies. Understanding EV-mediated signaling within the framework of circadian rhythms is critical for improving disease diagnosis, informing treatment strategies, developing therapeutic applications, and enhancing the diagnostic utility of EVs. This insight may pave the way for novel chronotherapy approaches in clinical practice.","PeriodicalId":501704,"journal":{"name":"npj Biological Timing and Sleep","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12912312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147349950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The circadian clock of Populus affects physiological, transcriptional and metabolomic responses to osmotic and ionic components of salt stress. 杨树的生理时钟影响渗透和离子组分对盐胁迫的生理、转录和代谢反应。

npj Biological Timing and Sleep Pub Date : 2025-10-01 DOI: 10.1038/s44323-025-00052-2

Cristian Ibáñez, Alexander Vergara, David Castro, Luisa Bascunan-Godoy, Johan Sjölander, Manuela Jurca, Pierre A Pin, Ove Nilsson, Maria E Eriksson

{"title":"The circadian clock of Populus affects physiological, transcriptional and metabolomic responses to osmotic and ionic components of salt stress.","authors":"Cristian Ibáñez, Alexander Vergara, David Castro, Luisa Bascunan-Godoy, Johan Sjölander, Manuela Jurca, Pierre A Pin, Ove Nilsson, Maria E Eriksson","doi":"10.1038/s44323-025-00052-2","DOIUrl":"10.1038/s44323-025-00052-2","url":null,"abstract":"The circadian oscillator is an innate timing mechanism present in most organisms, including plants. In this study, Populus tremula × P. tremuloides (Populus) trees with reduced expression of circadian clock components were exposed to gradually increases in the osmotic and ionic components of salt stress. Reduced levels of the morning components PttLATE ELONGATED HYPOCOTYL 1 and 2 (PttLHY1,2) or of the evening components PttPSEUDO-RESPONSE REGULATOR 7a and b (PttPRR7a,b) and PttGIGANTEA1,2 (PttGI1,2) affected growth adaptation under stress conditions. PttLHY1,2 regulated growth under NaCl treatment via the control of PttCyclin D3 expression. PttPRR7a,b and PttGI1,2 were instrumental in maintaining growth in roots by enabling effective adaptation of the metabolome. Major changes in the root metabolome under prolonged stress included alterations in carbohydrate, amino acids, and fatty acids. This study places the circadian clock at the centre of adaptation to adverse conditions in trees and will help the development of stress-resistant trees.","PeriodicalId":501704,"journal":{"name":"npj Biological Timing and Sleep","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12912307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147350089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preventive circadian medicine: improving health with sleep checkups. 预防性昼夜医学：通过睡眠检查改善健康。

npj Biological Timing and Sleep Pub Date : 2025-09-04 DOI: 10.1038/s44323-025-00047-z

Yoichi Minami, Akifumi Kishi, Hiroki R Ueda

引用次数: 0

Afternoon to early evening bright light exposure reduces later melatonin production in adolescents. 下午到傍晚接触强光会减少青少年后期褪黑激素的产生。

npj Biological Timing and Sleep Pub Date : 2025-06-30 DOI: 10.1038/s44323-025-00040-6

Rafael Lazar, Fatemeh Fazlali, Marine Dourte, Christian Epple, Oliver Stefani, Manuel Spitschan, Christian Cajochen

{"title":"Afternoon to early evening bright light exposure reduces later melatonin production in adolescents.","authors":"Rafael Lazar, Fatemeh Fazlali, Marine Dourte, Christian Epple, Oliver Stefani, Manuel Spitschan, Christian Cajochen","doi":"10.1038/s44323-025-00040-6","DOIUrl":"10.1038/s44323-025-00040-6","url":null,"abstract":"Whether light exposure during the day reduces non-visual light effects later in the evening has not been studied in adolescents. We investigate whether afternoon-early evening (AEE) light interventions (130 lx, 2500 lx, 4.5 h, compared to 6.5 lx illuminance) would increase melatonin levels during later evening light exposure (130 lx) in a counterbalanced crossover study with 22 adolescents (14-17 years, 11 female). Contrary to our hypothesis, evening melatonin levels decreased after AEE bright light exposure, while sleepiness and vigilance were unaffected, and skin temperature showed no clear changes. The AEE light had acute alerting effects and bright light exposure in the 32 h before laboratory entry was associated with higher evening melatonin and sleepiness. These findings suggest that bright AEE light increases alertness but may delay melatonin production by interfering with circadian rhythms. The study highlights the complex effects of light timing and its implications for managing adolescents' light exposure.","PeriodicalId":501704,"journal":{"name":"npj Biological Timing and Sleep","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12912342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147349684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatise on an alternative perspective on the two-process model of sleep regulation. 关于睡眠调节双过程模型的另一种观点的论述。

npj Biological Timing and Sleep Pub Date : 2025-06-18 DOI: 10.1038/s44323-025-00038-0

Frederik Bes

引用次数: 0

CHRONO regulates the circadian clock via the REV-ERBα - BMAL1 loop. CHRONO通过rev - erba - BMAL1回路调节生物钟。

npj Biological Timing and Sleep Pub Date : 2025-06-03 DOI: 10.1038/s44323-025-00041-5

Qin Zhou, Lanxin Gao, Ruohan Wang, Shaoying Lan, Dan Li, Ximing Qin

{"title":"CHRONO regulates the circadian clock via the REV-ERBα - BMAL1 loop.","authors":"Qin Zhou, Lanxin Gao, Ruohan Wang, Shaoying Lan, Dan Li, Ximing Qin","doi":"10.1038/s44323-025-00041-5","DOIUrl":"10.1038/s44323-025-00041-5","url":null,"abstract":"The period length of the circadian clock is important for organisms to maintain homeostasis. CHRONO has been shown to play an important role in regulating the period of the mammalian clock and has recently been implicated to function in several important physiological aspects. However, the mechanisms underlying transcriptional regulation by CHRONO to determine the circadian period remain elusive. Here, we report that CHRONO acts as a transcriptional repressor on JUN/FOS complexes independent of the classical BMAL1/CLOCK complexes. CHRONO can regulate BMAL1 expression by differentially regulating REV-ERBα and REV-ERBβ. We further developed a mathematical model and the model simulations strongly agreed with our findings that CHRONO acts on both REV-ERBα and BMAL1 to regulate the circadian period. The model also sheds light on the physiological significance of the fact that CHRONO cycles in most of the mammalian tissues. Thus, our experimental and computational approaches reveal the molecular mechanisms of regulating the circadian period by an important circadian component, CHRONO.","PeriodicalId":501704,"journal":{"name":"npj Biological Timing and Sleep","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12912403/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147349989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regulatory links between the circadian clock and stress-induced biomolecular condensates. 生物钟与应激诱导的生物分子凝聚物之间的调节联系。

npj Biological Timing and Sleep Pub Date : 2025-05-27 DOI: 10.1038/s44323-025-00036-2

Gabriela Brown, Dawn H Nagel

{"title":"Regulatory links between the circadian clock and stress-induced biomolecular condensates.","authors":"Gabriela Brown, Dawn H Nagel","doi":"10.1038/s44323-025-00036-2","DOIUrl":"10.1038/s44323-025-00036-2","url":null,"abstract":"The circadian clock is a conserved timekeeping mechanism that is essential for integrating different environmental cues such as light and temperature to coordinate biological processes with the time of day. While much is known about transcriptional regulation by the clock, the role of post-transcriptional regulation, particularly through sequestration into biomolecular condensate such as stress granules, remains less understood. Stress granules are dynamic RNA-protein assemblies that play a critical role in the cellular response to stress by sequestering mRNAs to regulate translation during stressful conditions. In animals and fungi, the circadian clock regulates stress granule formation and mRNA translation by controlling key factors such as eIF2α, which orchestrates the rhythmic sequestration and translation of specific mRNAs. In plants, it has been shown that some transcripts, despite coming from arrhythmic expression, are rhythmically translated. In addition, some clock-controlled genes (CCGs) are induced in response to heat stress only at the transcriptional level and not at the translational level. Together this highlights a layer of clock regulation beyond transcription. This review discusses the intersection between the circadian clock and heat stress-related biomolecular condensates across eukaryotes, with a particular focus on plants. We discuss how the clock may regulate stress granule dynamics and preferential translation of mRNAs at specific times of the day or during stress responses, thereby enhancing cellular function and energy efficiency. By integrating evidence from animals, fungi, and plants, we highlight emerging questions regarding the role of biomolecular condensates as post-transcriptional mechanisms in controlling circadian rhythms and stress tolerance in plants.","PeriodicalId":501704,"journal":{"name":"npj Biological Timing and Sleep","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12912334/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147350052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comprehensive integrative analysis of circadian rhythms in human saliva. 人类唾液昼夜节律的综合综合分析。

npj Biological Timing and Sleep Pub Date : 2025-05-10 DOI: 10.1038/s44323-025-00035-3

Nina Nelson, Deeksha Malhan, Janina Hesse, Ouda Aboumanify, Müge Yalçin, Georg Lüers, Angela Relógio

{"title":"Comprehensive integrative analysis of circadian rhythms in human saliva.","authors":"Nina Nelson, Deeksha Malhan, Janina Hesse, Ouda Aboumanify, Müge Yalçin, Georg Lüers, Angela Relógio","doi":"10.1038/s44323-025-00035-3","DOIUrl":"10.1038/s44323-025-00035-3","url":null,"abstract":"The circadian clock orchestrates vital physiological functions, with its dysregulation implicated in various pathologies. Assessing human clock status via the measurement of circadian rhythms is crucial for health management and disease treatment. Saliva provides a non-invasive means for such analysis. In this study, we examined circadian rhythms and related parameters in 21 healthy individuals (n = 4 - 19 per experiment), assessing different data types, including saliva gene expression with our TimeTeller® methodology, hormone levels, cell composition, and self-assessment tests for chronotype evaluation. While substantial individual variability of the circadian profiles was observed, we found significant correlations between the acrophases of ARNTL1 gene expression and of cortisol, and both acrophases correlated with the bedtime of individuals on the sampling day. Our findings validate the robustness and reliability of our method for determining peripheral clock circadian rhythms in humans, offering potential for clinical applications in diverse cohorts.","PeriodicalId":501704,"journal":{"name":"npj Biological Timing and Sleep","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12912387/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147349952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0