npj Biological Timing and Sleep最新文献_第7页

npj Biological Timing and Sleep Pub Date : 2025-04-02 DOI: 10.1038/s44323-025-00028-2

Charlotte Helfrich-Förster

引用次数: 0

Brain circadian clocks timing the 24h rhythms of behavior. 大脑的生理时钟为24小时的行为节律计时。

npj Biological Timing and Sleep Pub Date : 2025-03-22 DOI: 10.1038/s44323-025-00030-8

Jorge Mendoza

{"title":"Brain circadian clocks timing the 24h rhythms of behavior.","authors":"Jorge Mendoza","doi":"10.1038/s44323-025-00030-8","DOIUrl":"10.1038/s44323-025-00030-8","url":null,"abstract":"The mammalian circadian system is composed of multiple cellular biological clocks synchronized among each other, maintaining thus robust rhythms of behavior. The hypothalamic suprachiasmatic nucleus, or SCN, harbors the principal clock that coordinates circadian rhythms in peripheral tissues and brain structures. Besides the SCN, other central regions contain 24 h activity in electrical properties, metabolic processes and gene expression. Few of them show robust and self-sustained oscillatory activity, but others need the SCN to keep a prolonged rhythmic profile. Thereby, if the SCN is the main circadian organ in mammals, what is the biobehavioral relevance of a circadian brain with multiple clocks? The present review is an overview of the currently known brain circadian system in mammals; highlighting those structures characterized as circadian clocks and their potential role for the control of rhythmic behaviors, and the functional relationship with the SCN. Even if the SCN remains the principal central clock for the control of behavioral rhythms, a multiple brain circadian clock network might be much more advantageous for the organism, facilitating the behavioral and physiological adaption to the rhythmic environment, keeping thus a healthy status.","PeriodicalId":501704,"journal":{"name":"npj Biological Timing and Sleep","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12912386/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147349717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endocrine regulation of circadian rhythms. 昼夜节律的内分泌调节。

npj Biological Timing and Sleep Pub Date : 2025-03-08 DOI: 10.1038/s44323-025-00024-6

Kimberly Begemann, Oliver Rawashdeh, Iwona Olejniczak, Violetta Pilorz, Leonardo Vinícius Monteiro de Assis, Jazmin Osorio-Mendoza, Henrik Oster

{"title":"Endocrine regulation of circadian rhythms.","authors":"Kimberly Begemann, Oliver Rawashdeh, Iwona Olejniczak, Violetta Pilorz, Leonardo Vinícius Monteiro de Assis, Jazmin Osorio-Mendoza, Henrik Oster","doi":"10.1038/s44323-025-00024-6","DOIUrl":"10.1038/s44323-025-00024-6","url":null,"abstract":"Circadian clocks are internal timekeepers enabling organisms to adapt to recurrent events in their environment - such as the succession of day and night-by controlling essential behaviors such as food intake or the sleep-wake cycle. A ubiquitous cellular clock network regulates numerous physiological processes including the endocrine system. Levels of several hormones such as melatonin, cortisol, sex hormones, thyroid stimulating hormone as well as a number of metabolic factors vary across the day, and some of them, in turn, can feedback on circadian clock rhythms. In this review, we dissect the principal ways by which hormones can regulate circadian rhythms in target tissues - as phasic drivers of physiological rhythms, as zeitgebers resetting tissue clock phase, or as tuners, affecting downstream rhythms in a more tonic fashion without affecting the core clock. These data emphasize the intricate interaction of the endocrine system and circadian rhythms and offer inroads into tissue-specific manipulation of circadian organization.","PeriodicalId":501704,"journal":{"name":"npj Biological Timing and Sleep","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12912344/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147350011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Introduction of novel objects to the home cage of mice repeatedly disturbs sleep for seven days with minimal stress induction. 在7天的时间里，在最小的应激诱导下，将新物体引入老鼠的家笼，反复干扰它们的睡眠。

npj Biological Timing and Sleep Pub Date : 2025-02-21 DOI: 10.1038/s44323-025-00027-3

Christine Egebjerg, Mie Gunni Kolmos, René Lemcke, Klas Abelson, Birgitte Rahbek Kornum

{"title":"Introduction of novel objects to the home cage of mice repeatedly disturbs sleep for seven days with minimal stress induction.","authors":"Christine Egebjerg, Mie Gunni Kolmos, René Lemcke, Klas Abelson, Birgitte Rahbek Kornum","doi":"10.1038/s44323-025-00027-3","DOIUrl":"10.1038/s44323-025-00027-3","url":null,"abstract":"The increasing prevalence of low sleep quality is a significant issue, particularly among adolescents, necessitating a deeper understanding of its biological consequences. In sleep research, various protocols are used for sleep deprivation or disturbance, each presenting its own set of confounding factors crucial to consider. We developed a standardized seven-day sleep disturbance protocol using daily four-hour exposures to novel objects to minimize mouse stress. Objects were selected and characterized for their wake-promoting properties, and exposure timing was structured to reduce variability and enhance experimental reliability and reproducibility. During the four hours of sleep disturbance, the mice were efficiently sleep-deprived during each exposure. Thus, the selected objects efficiently kept the mice awake also after seven days exposure. On the first day of sleep disturbance, the protocol induced a sleep deprivation effect when measured over 24 h (hours), but by the seventh day, the mice recovered the sleep loss over the 24 h. Thus, this method induces an acute sleep loss, but over days it induces a sleep disturbance and not a full sleep deprivation. Fecal corticosterone concentrations remained unchanged during the seven days of sleep disturbances, suggesting that voluntary wakefulness is not stressful. Importantly, we show that the mice compensate for their sleep loss during the week of sleep disturbance, highlighting the need for better validation of long-term sleep deprivation protocols in the sleep field to accurately separate sleep deprivation from sleep disturbance.","PeriodicalId":501704,"journal":{"name":"npj Biological Timing and Sleep","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12912346/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147350038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ecology of timekeeping: feeding times effect clock-controlled behavior, metabolism and reproduction in diurnal vertebrates. 计时生态学：摄食时间影响昼行性脊椎动物的生物钟控制行为、代谢和繁殖。

npj Biological Timing and Sleep Pub Date : 2025-02-21 DOI: 10.1038/s44323-025-00022-8

Vatsala Tripathi, Sanjay Kumar Bhardwaj, Vinod Kumar

{"title":"Ecology of timekeeping: feeding times effect clock-controlled behavior, metabolism and reproduction in diurnal vertebrates.","authors":"Vatsala Tripathi, Sanjay Kumar Bhardwaj, Vinod Kumar","doi":"10.1038/s44323-025-00022-8","DOIUrl":"10.1038/s44323-025-00022-8","url":null,"abstract":"To most, if not all, species, the food availability shows both daily and seasonal fluctuations in its timing, quality, and abundance. Hence, coupled with the appetite (urge to eat), it results in species-specific foraging (eating or feeding) patterns, an ecological determinant of almost all the aspects of behavior and physiology in animals. The feeding times control mutually inclusive physiological events by affecting metabolic homeostasis (a direct effect) and/ or by their synchronization effects on the underlying circadian rhythms (an indirect effect). Experiments have shown that food intake at an inappropriate time of the day (i.e., at a wrong time relative to the internal circadian clock) negatively affects the circadian homeostasis and consequently the behavior, metabolism and reproduction in animals. The food availability times as a conditioning environment influence epigenetics, evidenced by chromatin activation/ silencing at genome levels in several species. Here, we review briefly the experimental evidence largely from birds and mammals to provide insights into when and how daily feeding times affect the clock-controlled behavior, metabolism and reproductive fitness in diurnal species.","PeriodicalId":501704,"journal":{"name":"npj Biological Timing and Sleep","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12912345/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147350019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of exercise on sleep and sleep disorders. 运动对睡眠和睡眠障碍的影响。

npj Biological Timing and Sleep Pub Date : 2025-02-03 DOI: 10.1038/s44323-024-00018-w

Abdulmenaf Korkutata, Mustafa Korkutata, Michael Lazarus

引用次数: 0

Deletion of Arntl, a component of the molecular clock, in adipocytes leads to cellular hypertrophy by increasing insulin sensitivity via FGF21. 脂肪细胞中Arntl（分子钟的一个组成部分）的缺失通过FGF21增加胰岛素敏感性，导致细胞肥大。

npj Biological Timing and Sleep Pub Date : 2025-02-03 DOI: 10.1038/s44323-025-00023-7

Hirotake Ishii, Satoshi Kitaura, Taira Wada, Shigeki Shimba

{"title":"Deletion of Arntl, a component of the molecular clock, in adipocytes leads to cellular hypertrophy by increasing insulin sensitivity via FGF21.","authors":"Hirotake Ishii, Satoshi Kitaura, Taira Wada, Shigeki Shimba","doi":"10.1038/s44323-025-00023-7","DOIUrl":"10.1038/s44323-025-00023-7","url":null,"abstract":"Brain and muscle Arnt-like protein 1 (BMAL1), encoded by Aryl hydrocarbon receptor nuclear translocator like 1 (Arntl) gene, is a transcription factor that regulates the circadian rhythm of the expressions of several genes. The link between the loss of BMAL1 function in adipose tissue and obesity has been reported. Although these previous studies have suggested that dysregulation of lipolysis is a contributing factor, but the detailed mechanism has not been fully understood. This study aimed to elucidate the role of BMAL1 in adipocytes using adipocyte-specific Arntl deficient (AAKO) mice. Deletion of Arntl in adipocytes leads to increased cellular insulin sensitivity, which in turn, inhibited lipolysis in adipocytes and caused cellular hypertrophy. The expression levels of Fgf21 in adipose tissue were significantly elevated in AAKO mice compared to Arntl flox/flox mice. Double knockout of Arntl and Fgf21 in adipocytes abolished metabolic phenotypes such as decreased circulating non-esterified fatty acid levels, adipocyte hypertrophy, and increased insulin sensitivity in AAKO mice. These results indicated that BMAL1 regulates fat mobilization and insulin signaling in adipocytes via FGF21 during the stationary phase. This is the possible mechanism by which disruption of circadian rhythm induces obesity.","PeriodicalId":501704,"journal":{"name":"npj Biological Timing and Sleep","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12912397/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147349981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reflections of a conceptualist. 概念主义者的思考。

npj Biological Timing and Sleep Pub Date : 2025-01-08 DOI: 10.1038/s44323-024-00021-1

Till Roenneberg

引用次数: 0

Sleep-stage dependent patterning of slowly propagating brain activity. 缓慢传播的大脑活动的睡眠阶段依赖模式。

npj Biological Timing and Sleep Pub Date : 2025-01-07 DOI: 10.1038/s44323-024-00017-x

Xufu Liu, Dante Picchioni, Yifan Yang, Hendrik Mandelkow, Jacco A de Zwart, Jeff H Duyn, Xiao Liu

{"title":"Sleep-stage dependent patterning of slowly propagating brain activity.","authors":"Xufu Liu, Dante Picchioni, Yifan Yang, Hendrik Mandelkow, Jacco A de Zwart, Jeff H Duyn, Xiao Liu","doi":"10.1038/s44323-024-00017-x","DOIUrl":"10.1038/s44323-024-00017-x","url":null,"abstract":"Endogenous brain activity plays a key role during sleep, facilitating important functions like learning and memory consolidation. Its precise mechanisms are not yet understood. Recent functional MRI (fMRI) research has revealed structured multi-second waves that travel across the cortex along a hierarchical functional gradient during wakefulness. However, how these waves are modulated across different sleep stages remains unclear. Here, we present compelling evidence of significant changes in both the frequency and spatiotemporal patterns of these waves across sleep stages. Notably, during rapid eye movement (REM) sleep, we observed a predominance of propagations from sensory/motor areas to higher-order networks. These patterns were distinct from other sleep stages, with key regions like the thalamus, pons, and visual cortex-linked to PGO waves-activating at the earliest phase of waves. Similar to PGO waves, these fMRI waves were coupled with REM activity, suggesting their potential role in supporting memory consolidation and learning processes.","PeriodicalId":501704,"journal":{"name":"npj Biological Timing and Sleep","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12912439/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147350067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adaptive introgression in modern human circadian rhythm genes. 现代人类昼夜节律基因的适应性渗进。

npj Biological Timing and Sleep Pub Date : 2025-01-01 Epub Date: 2025-12-04 DOI: 10.1038/s44323-025-00060-2

Christopher Kendall, Amin Nooranikhojasteh, Guilherme Debortoli, Vinicius Cauê Furlan Roberto, Marla Mendes, David Samson, Esteban Parra, Bence Viola, Michael A Schillaci

{"title":"Adaptive introgression in modern human circadian rhythm genes.","authors":"Christopher Kendall, Amin Nooranikhojasteh, Guilherme Debortoli, Vinicius Cauê Furlan Roberto, Marla Mendes, David Samson, Esteban Parra, Bence Viola, Michael A Schillaci","doi":"10.1038/s44323-025-00060-2","DOIUrl":"10.1038/s44323-025-00060-2","url":null,"abstract":"Interbreeding between modern humans and archaic hominins, including Neanderthals and Denisovans, occurred as modern humans migrated outside of Africa. Here, we report on evidence of adaptive introgression from archaic hominins within genomic regions associated with circadian rhythm cycling, chronotype, and sleep using 76 worldwide modern human populations from the Human Genome Diversity Project and 1000 Genomes Project. We identified 265 independent segments suggestive of adaptive introgression, where 22 of these segments show evidence of positive selection. We tested for evidence of a latitudinal cline within 35 core haplotypes, finding no clear latitude gradient, and identified the likely archaic donor for each of these haplotypes. We found that several genes with evidence of adaptive introgression are associated with affective disorders, chronotype, and respiratory diseases. Lastly, many of the variants are eQTLs for several genes that are significantly enriched in immunity pathways.","PeriodicalId":501704,"journal":{"name":"npj Biological Timing and Sleep","volume":"2 1","pages":"41"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12678189/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145703613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0