npj Biological Timing and Sleep最新文献_第5页

Psychometric properties of the two-item Pittsburgh Sleep Quality Index (PSQI-2) in a cohort of community-dwelling older men: the MrOS sleep study. 两项匹兹堡睡眠质量指数（PSQI-2）在社区老年男性队列中的心理测量特性：磁共振睡眠研究。

npj Biological Timing and Sleep Pub Date : 2026-03-09 DOI: 10.1038/s44323-025-00069-7

Luiz Menezes-Júnior

{"title":"Psychometric properties of the two-item Pittsburgh Sleep Quality Index (PSQI-2) in a cohort of community-dwelling older men: the MrOS sleep study.","authors":"Luiz Menezes-Júnior","doi":"10.1038/s44323-025-00069-7","DOIUrl":"10.1038/s44323-025-00069-7","url":null,"abstract":"The Pittsburgh Sleep Quality Index (PSQI) is widely used, but can be impractical in large studies due to its length. The two-item version (PSQI-2) is a promising alternative, with underexplored longitudinal properties in older adults. We evaluated its validity against the full PSQI in the MrOS Sleep Study cohort of older men. Cross-sectional validity (Bland-Altman, ROC curves for PSQI > 5) and longitudinal properties (ICC, change score correlation, accuracy for ΔPSQI > 3) were assessed. The PSQI-2 showed a strong cross-sectional association with the full PSQI (b = 2.167, p < 0.001), explaining 72% of its variance. For identifying poor sleep quality, the PSQI-2 demonstrated excellent accuracy (AUC = 0.89) with an optimal cutoff of ≥2 (sensitivity=77.5%, specificity=84.5%). Longitudinally, both instruments showed moderate test-retest reliability (PSQI-2 ICC = 0.579; PSQI ICC = 0.639). The correlation between their change scores was strong (r = 0.682, p < 0.001), and the PSQI-2 showed reasonable accuracy (AUC = 0.754) in detecting clinically meaningful change (Δ PSQI > 3). The PSQI-2 is a valid and reliable tool for cross-sectional screening of poor sleep quality in older men at the cutoff of ≥2. It is also responsive to directional change over time and can identify individuals with clinically significant changes in sleep.","PeriodicalId":501704,"journal":{"name":"npj Biological Timing and Sleep","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12972079/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147392179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tracing infant sleep neurophysiology longitudinally from 3 to 6 months: EEG insights into brain development. 从3到6个月纵向追踪婴儿睡眠神经生理学：脑电图对大脑发育的洞察。

npj Biological Timing and Sleep Pub Date : 2026-03-03 DOI: 10.1038/s44323-026-00071-7

Matthieu Beaugrand, Valeria Jaramillo, Christophe Mühlematter, Sarah F Schoch, Vivien Reicher, Andjela Markovic, Salome Kurth

{"title":"Tracing infant sleep neurophysiology longitudinally from 3 to 6 months: EEG insights into brain development.","authors":"Matthieu Beaugrand, Valeria Jaramillo, Christophe Mühlematter, Sarah F Schoch, Vivien Reicher, Andjela Markovic, Salome Kurth","doi":"10.1038/s44323-026-00071-7","DOIUrl":"10.1038/s44323-026-00071-7","url":null,"abstract":"Sleep is critical for brain plasticity during early development, yet individual maturation of sleep neurophysiology in infancy remains poorly characterized. Slow wave activity (SWA) is a key marker of cortical maturation and experience-dependent plasticity, making early regional sleep dynamics highly relevant for neurodevelopmental health. We conducted a longitudinal high-density EEG study in 11 healthy infants, of whom 9 contributed analyzable EEG data at both 3 and 6 months. We assessed non-rapid eye movement (NREM) sleep and analyzed the maturation of SWA (0.75-4.25 Hz), theta power (4.5-7.5 Hz), and sigma power (9.75-14.75 Hz) across scalp regions and their associations with behavioral development. From 3 to 6 months, SWA increased maximally in occipital regions, while theta power exhibited a global increase. Sigma power, initially concentrated centrally, dispersed towards frontal regions. Greater frontal power increases correlated with higher motor (theta) and personal-social skill scores (sigma) at 6 months. These findings establish a framework for typical infant sleep EEG maturation, highlighting frequency-specific and regionally distinct developmental patterns. This study provides the first longitudinal evidence that early changes in sleep EEG topography reflect individual developmental trajectories, supporting its utility as a non-invasive and yet precise biomarker for early identification of atypical neurodevelopment at preverbal ages.","PeriodicalId":501704,"journal":{"name":"npj Biological Timing and Sleep","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12957383/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147350083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Control vs. salience: a new axis of circadian brain-body organization. 控制与突出：昼夜节律脑-体组织的新轴。

npj Biological Timing and Sleep Pub Date : 2026-02-16 DOI: 10.1038/s44323-025-00065-x

Olivier Demers, Sanaz Ghaffari, Chen Li, Russell Butler

{"title":"Control vs. salience: a new axis of circadian brain-body organization.","authors":"Olivier Demers, Sanaz Ghaffari, Chen Li, Russell Butler","doi":"10.1038/s44323-025-00065-x","DOIUrl":"10.1038/s44323-025-00065-x","url":null,"abstract":"Circadian robustness is usually cast on a single weak-strong continuum, but multi-system data suggest a different picture. We followed 52 healthy young adults for ~30 days with wearable locomotor (accelerometry; ACC) and autonomic (heart rate; BPM) signals and paired these with structural and resting-state fMRI. From person-level circadian feature vectors (stability, amplitude, acrophase, and ACC-BPM alignment/lag), we uncovered a Control-Salience axis of brain-body organization. A control-anchored archetype showed ACC-dominant rhythms-higher activity stability and amplitude, later BPM acrophase, and a longer ACC → BPM phase lead-together with stronger connectivity in cognitive control networks. A complementary salience-anchored archetype exhibited BPM-dominant rhythms-earlier BPM acrophase, higher BPM relative amplitude, tighter ACC-BPM coupling-and stronger connectivity in salience and attention networks. Across individuals, cross-system alignment (ACC-BPM lag) tracked control-network coherence, whereas rhythm timing and amplitude related selectively to cortical geometry and network strength. These findings recast circadian health as axis-based and system-specific: individuals organize along a spectrum from stability-anchored, locomotor-led profiles to coupling-anchored, autonomic-dominated profiles with distinct neural correlates. The Control-Salience axis refines mechanistic models of circadian risk and points to alignment-aware, network-targeted strategies for monitoring and intervention.","PeriodicalId":501704,"journal":{"name":"npj Biological Timing and Sleep","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12912377/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147350026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Naturalistic light exposure patterns in relation to medication status, mood symptoms, and chronotype. 自然光照模式与药物状态、情绪症状和睡眠类型的关系。

npj Biological Timing and Sleep Pub Date : 2026-02-02 DOI: 10.1038/s44323-025-00062-0

Rebecca J Fitton, Julia E Stone, Alicia C Lander, Melisa Hrnjic, Malisa T Burge, Elizabeth J Buller, Amber P White, Andrew J K Phillips, Sean W Cain, Elise M McGlashan

{"title":"Naturalistic light exposure patterns in relation to medication status, mood symptoms, and chronotype.","authors":"Rebecca J Fitton, Julia E Stone, Alicia C Lander, Melisa Hrnjic, Malisa T Burge, Elizabeth J Buller, Amber P White, Andrew J K Phillips, Sean W Cain, Elise M McGlashan","doi":"10.1038/s44323-025-00062-0","DOIUrl":"10.1038/s44323-025-00062-0","url":null,"abstract":"Light assists in regulating mood, and selective serotonin reuptake inhibitors (SSRIs) increase non-visual light sensitivity. It remains unclear whether light exposure patterns differ between individuals taking SSRIs compared to unmedicated individuals with no psychiatric history, or how everyday light exposure relates to mood and chronotype. This study examined objective light exposure (melanopic EDI) in relation to medication status (SSRI vs. control), mood symptoms, and chronotype. Participants (n = 76; 38 SSRIs, 38 controls) completed at least one week of field light monitoring using a wearable sensor and questionnaires assessing mood (DASS-21) and chronotype (MEQ). Overall light exposure did not differ between groups. However, when accounting for group, greater morning light exposure was associated with lower depressive and stress symptoms, and more time spent above 50 melanopic EDI was associated with fewer depressive symptoms. Greater morningness was linked to higher morning and daytime melanopic EDI, more time in bright light (>50 and >250 melanopic EDI), and differences in light regularity. These findings show that light exposure, particularly its timing and amount, relates to mood and chronotype, regardless of SSRI use. Future research targeting light behaviour may offer an accessible, cost-effective strategy for improving mood in both clinical and non-clinical populations.","PeriodicalId":501704,"journal":{"name":"npj Biological Timing and Sleep","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12912433/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147350031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glucocorticoid-dependence and independence of the circadian liver transcriptome. 昼夜肝转录组的糖皮质激素依赖性和独立性。

npj Biological Timing and Sleep Pub Date : 2026-02-02 eCollection Date: 2026-01-01 DOI: 10.1038/s44323-025-00068-8

Robert J Maidstone, A Louise Hunter, Mudassar Iqbal, Nicola Begley, Matthew Baxter, Andrew S I Loudon, Magnus Rattray, David W Ray

{"title":"Glucocorticoid-dependence and independence of the circadian liver transcriptome.","authors":"Robert J Maidstone, A Louise Hunter, Mudassar Iqbal, Nicola Begley, Matthew Baxter, Andrew S I Loudon, Magnus Rattray, David W Ray","doi":"10.1038/s44323-025-00068-8","DOIUrl":"10.1038/s44323-025-00068-8","url":null,"abstract":"The liver, a key metabolic organ, shows clear day-night variation in gene and protein expression, and in metabolic pathway activity. Liver cells possess molecular circadian clocks, but systemic factors are critical contributors to the circadian rhythmicity of liver gene expression. Glucocorticoid action is reported to be one such factor. Glucocorticoids are essential hormones, with strong circadian oscillations, which control multiple cellular processes via the glucocorticoid receptor (GR). We compare clock factor and GR binding at promoters and enhancers linked to rhythmic genes and find increased clock factor binding at those promoter elements where GR is also present. Genes with GR binding at the promoter are more highly expressed and more likely to be detected as rhythmic. We then test the role of GR directly, by profiling rhythmic gene expression in mice with/without hepatocyte-targeted GR deletion. Notably, we observe only a small effect of GR deletion, with most rhythmic genes showing unchanged rhythmicity, despite evidence for local GR binding. We find a small number of genes showing lost or gained rhythmicity with GR deletion; genes which lose rhythmicity associate with GR binding sites. Contrary to expectations, GR appears redundant for conveying timing information to most of the rhythmic liver transcriptome.","PeriodicalId":501704,"journal":{"name":"npj Biological Timing and Sleep","volume":"3 ","pages":"6"},"PeriodicalIF":0.0,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12864027/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146121778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chronic sleep restriction activates complement and coagulation cascades: a molecular link to accelerated brain aging. 长期睡眠不足会激活补体和凝血级联反应：一种加速大脑衰老的分子联系。

npj Biological Timing and Sleep Pub Date : 2026-01-27 DOI: 10.1038/s44323-025-00066-w

Pawan K Jha, Utham K Valekunja, Akhilesh B Reddy

引用次数: 0

CCorGsDB: a database for clock correlated genes in the mouse and human central nervous systems. CCorGsDB：小鼠和人类中枢神经系统时钟相关基因数据库。

npj Biological Timing and Sleep Pub Date : 2026-01-09 DOI: 10.1038/s44323-025-00064-y

José Luiz Araújo Santos, Vinícius Tenório Braga Cavalcante Pinto, Thales Eduardo da Silva Santos, Daniel Gomes Coimbra, Tiago Gomes de Andrade

引用次数: 0

Conserved eukaryotic factors XCT and COP1 work together to control circadian clock function and reproductive timing in plants. 保守的真核因子XCT和COP1共同控制植物的生物钟功能和生殖时间。

npj Biological Timing and Sleep Pub Date : 2026-01-01 Epub Date: 2026-01-09 DOI: 10.1038/s44323-025-00057-x

Roderick W Kumimoto, Carine M Marshall, Hongtao Zhang, Stacey L Harmer

{"title":"Conserved eukaryotic factors XCT and COP1 work together to control circadian clock function and reproductive timing in plants.","authors":"Roderick W Kumimoto, Carine M Marshall, Hongtao Zhang, Stacey L Harmer","doi":"10.1038/s44323-025-00057-x","DOIUrl":"10.1038/s44323-025-00057-x","url":null,"abstract":"Circadian rhythms align biological processes with environmental cycles to enhance fitness. Eukaryotic circadian oscillators rely on transcriptional-translational feedback loops, although specific oscillator components vary among lineages. The plant oscillator consists of a uniquely complex network of transcriptional regulators. These clock genes regulate each other's expression and influence key developmental processes such as the transition from vegetative to reproductive growth. Here, we investigate the function of XAP5 CIRCADIAN TIMEKEEPER (XCT), a protein conserved across eukaryotes and previously implicated in RNA processing and circadian regulation in Arabidopsis thaliana. We show that XCT genetically and physically interacts with CONSTITUTIVE PHOTOMORPHOGENIC 1 (COP1), an E3 ubiquitin ligase also conserved across eukaryotes. Both XCT and COP1 regulate the abundance and activity of the oscillator component EARLY FLOWERING3 (ELF3) to modulate circadian function and flowering time. These findings demonstrate how broadly conserved factors collaborate with plant-specific regulators to maintain circadian integrity and coordinate developmental timing.","PeriodicalId":501704,"journal":{"name":"npj Biological Timing and Sleep","volume":"3 1","pages":"2"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12789028/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145954829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual roles of circadian clock proteins in development and adult homeostasis. 生理时钟蛋白在发育和成人体内平衡中的双重作用。

npj Biological Timing and Sleep Pub Date : 2026-01-01 Epub Date: 2026-01-09 DOI: 10.1038/s44323-025-00061-1

Matthew Choi, Stacy Liang, Juan R Alvarez-Dominguez

引用次数: 0

Motivation meets sleep: tuning arousal via nucleus accumbens and Basal Ganglia circuits. 动机与睡眠相遇：通过伏隔核和基底神经节回路调节唤醒。

npj Biological Timing and Sleep Pub Date : 2025-12-08 DOI: 10.1038/s44323-025-00059-9

Fares J P Sayegh, Patricia Bonnavion

引用次数: 0