CCorGsDB: a database for clock correlated genes in the mouse and human central nervous systems.

José Luiz Araújo Santos, Vinícius Tenório Braga Cavalcante Pinto, Thales Eduardo da Silva Santos, Daniel Gomes Coimbra, Tiago Gomes de Andrade
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Abstract

We developed CCorGsDB, a web-based resource integrating mouse and human CNS co-expression networks filtered by circadian biomarkers. We validated the networks using time-series data from sixteen mouse regions and identified a conserved set of 251 orthologs enriched for RNA processing, chromatin regulation, and autism-related phenotypes. The database links CCorGs to disease terms and short-half-life CNS-active drugs with spatially resolved profiles. CCorGsDB is available at https://famed.ufal.br/ccorgs .

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CCorGsDB:小鼠和人类中枢神经系统时钟相关基因数据库。
我们开发了CCorGsDB,这是一个基于网络的资源,整合了通过昼夜节律生物标志物过滤的小鼠和人类中枢神经系统共表达网络。我们使用来自16个小鼠区域的时间序列数据验证了这些网络,并确定了一组保守的251个同源基因,这些同源基因丰富于RNA加工、染色质调控和自闭症相关表型。该数据库将CCorGs与疾病术语和短半衰期cns活性药物联系起来,具有空间解析的特征。CCorGsDB可在https://famed.ufal.br/ccorgs上获得。
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