Harvey W Kaufman, Damian P Alagia, Ky Van, Barbara Van Der Pol
{"title":"Chlamydia and Gonorrhea Testing in Pregnancy: Time to Improve Adherence and Update Recommendations.","authors":"Harvey W Kaufman, Damian P Alagia, Ky Van, Barbara Van Der Pol","doi":"10.1097/LGT.0000000000000829","DOIUrl":"10.1097/LGT.0000000000000829","url":null,"abstract":"<p><strong>Objective: </strong>The aim of the study is to evaluate adherence to national recommendations for Chlamydia trachomatis (chlamydia) and Neisseria gonorrhoeae (gonorrhea) testing during pregnancy including tests for cure/clearance and for persistence/potential reinfection at time of delivery.</p><p><strong>Methods: </strong>The authors evaluated results of chlamydia and gonorrhea nucleic acid amplification tests (NAAT) performed by major national reference laboratory from January 2010 through July 2022.</p><p><strong>Results: </strong>Of 3,519,781 uniquely identified pregnant individuals, the authors identified 4,077,212 pregnancies. Among pregnancies that had chlamydia or gonorrhea testing, 3.7% (149,422/4,055,016) and 0.4% (15,858/ 4,063,948) were initially positive, respectively. Initial tests occurred in the first trimester for approximately 88%. Of those initially chlamydia test positive, 71% were retested; 15.8% in <4 weeks and 37.3% >8 weeks (similarly for gonorrhea). Among patients initially test positive in early/mid pregnancy, more than one-third had no evidence of late pregnancy retesting. Individuals who were initially test negative and subsequently retested positive were approximately 50% likely to have the last available result be positive. Among all whom initially tested positive and were retested, 6.8% and 4.0%, were positive for chlamydia and gonorrhea, respectively on their last test before estimated delivery. There was no subsequent negative test before estimated delivery for 35.1% and 36.9% chlamydia or gonorrhea infected patients, respectively.</p><p><strong>Conclusions: </strong>Adherence to current recommendations is suboptimal and may not be adequate to reduce disease burden. Professional societies and practice plans should work to encourage better adherence to existing guidelines to protect the health of women and their newborns. The authors propose recommendations that may be helpful in reducing disease burden.</p>","PeriodicalId":50160,"journal":{"name":"Journal of Lower Genital Tract Disease","volume":" ","pages":"360-364"},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141749472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Megha Ramaswamy, Bianca Hall, Helen Cejtin, Carolyn Sufrin, Shawana Moore, Noah Nattell, Dominique Jodry, Lisa Flowers
{"title":"Cervical Cancer Prevention in Individuals With Criminal Legal System Involvement.","authors":"Megha Ramaswamy, Bianca Hall, Helen Cejtin, Carolyn Sufrin, Shawana Moore, Noah Nattell, Dominique Jodry, Lisa Flowers","doi":"10.1097/LGT.0000000000000833","DOIUrl":"10.1097/LGT.0000000000000833","url":null,"abstract":"<p><strong>Objectives: </strong>Women with a history of criminal legal system involvement have cervical cancer rates that are 4-5 times higher than the general population-a disparity that has persisted for nearly 50 years. The authors' objective is to describe the intersection of mass incarceration in the United States and risk factors for cervical cancer to offer equitable prevention and treatment strategies for the field.</p><p><strong>Methods: </strong>A group was convened by American Society for Colposcopy and Cervical Pathology members and experts in the field to address a topic of importance relevant to cervical cancer elimination in underserved groups. This topic has received consistent attention from the American Society for Colposcopy and Cervical Pathology. After convening multiple times to discuss salient issues on the topic, the group proposed 12 specific recommendations related to vaccination, screening, treatment, practice, research, and policy to address the burden of cervical cancer among individuals with criminal legal system involvement.</p><p><strong>Results: </strong>At least 10% of the incarcerated population is at risk for cervical cancer. Clinicians in all areas of practice will encounter patients with incarceration histories or current incarceration, regularly throughout their careers.</p><p><strong>Conclusions: </strong>Clinicians who provide preventive care for people at risk of cervical cancer can play a critical role in eliminating disparities for this vulnerable population, by drawing on these expert recommendations.</p>","PeriodicalId":50160,"journal":{"name":"Journal of Lower Genital Tract Disease","volume":" ","pages":"321-325"},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141898753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tuğba Dündar, Hilmiye Aksu, Emine Gerçek Öter, Belma Toptaş Acar, Sevgi Özsoy
{"title":"Development and Effectiveness of a Mobile Application for Vulvar Self-examination: A Quasi-Experimental Study.","authors":"Tuğba Dündar, Hilmiye Aksu, Emine Gerçek Öter, Belma Toptaş Acar, Sevgi Özsoy","doi":"10.1097/LGT.0000000000000835","DOIUrl":"https://doi.org/10.1097/LGT.0000000000000835","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to develop a mobile application for vulvar self-examination and to examine its effect on performing vulvar self-examination.</p><p><strong>Materials and methods: </strong>This is a quasi-experimental study. Forty-seven women accepted to participate. The mobile application was uploaded to the women's phones and the women's vulvar self-examination practices were followed through the application for 6 months. Obtained data were analyzed with descriptive statistics and the McNemar's test.</p><p><strong>Results: </strong>The mean age of the participants was 35.34 ± 9.85 years. Initially, out of all the participants, none performed vulvar self-examination, 95.7% did not regularly have their yearly gynecological examination, 29% did not have pap smear, and 91.5% had no information about vulvar self-examination. In the third month after the mobile application was downloaded, 68.1% were performing vulvar self-examination and this percentage decreased to 57.4% in the sixth month without a significant difference (p < .05). The women reported that they had difficulty in performing the examination in the first follow-up and did not have time to do it in the second follow-up.</p><p><strong>Conclusions: </strong>The mobile application increased the rate of examination, and there was no significant difference in the number of the women performing the examination between the follow-ups.</p>","PeriodicalId":50160,"journal":{"name":"Journal of Lower Genital Tract Disease","volume":"28 4","pages":"365-370"},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mycoplasma genitalium 's Antibiotic Resistance in Sexually Transmitted Infections Clinics in Israel.","authors":"Maya Azrad, Nora Saleh, Inbar Yorish Zur, Daniella Becker, Noga Shiloah, Sonia Habib, Avi Peretz","doi":"10.1097/LGT.0000000000000828","DOIUrl":"10.1097/LGT.0000000000000828","url":null,"abstract":"<p><strong>Objectives: </strong>To determine the prevalence of antibiotic resistance rate in Mycoplasma genitalium, and distribution of mutations associated with this resistance, among patients that attended sexually transmitted infections (STI) investigation clinics.</p><p><strong>Materials and methods: </strong>This cross-sectional study included M. genitalium -positive samples (urine, vaginal, rectal, and pharyngeal swabs) collected from 170 patients attending two STI investigation clinics, which were subjected to macrolide and quinolone resistance mutations analyses. Data regarding patient age, sex, and material/anatomical site of testing were collected.</p><p><strong>Results: </strong>Macrolide-resistance mutations were identified in 48.8% of samples and were more common among males ( p < .0001) and in rectal samples ( p < .05). A2059C was the most prevalent macrolide-resistance mutation (18.2%). Quinolone resistance was detected in 23% of the samples, with S83I being the most common (17.1%) mutation. Rate of co-resistance to macrolides and quinolones was 21.2%.</p><p><strong>Conclusions: </strong>The high rate of antibiotic resistance found in the current study, especially to macrolides, underscores the importance of antibiotic resistance monitoring in M. genitalium isolates in cases of persistent or recurrent urethritis/cervicitis, in cases of treatment failure and among specific populations. Such surveillance will improve treatment regimens and cure rates.</p>","PeriodicalId":50160,"journal":{"name":"Journal of Lower Genital Tract Disease","volume":" ","pages":"356-359"},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141560177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vera Y Miao, Marlene Wijaya, Gayle Fischer, Rebecca B Saunderson
{"title":"Severe Vulvovaginal Candidiasis Associated With Sodium-Glucose Cotransporter 2 Inhibitor Use in Postmenopausal Women.","authors":"Vera Y Miao, Marlene Wijaya, Gayle Fischer, Rebecca B Saunderson","doi":"10.1097/LGT.0000000000000839","DOIUrl":"10.1097/LGT.0000000000000839","url":null,"abstract":"<p><strong>Objective: </strong>The authors present a case series of severe vulvovaginal candidiasis in postmenopausal women using sodium-glucose cotransporter-2 inhibitor (SGLT2i) medications for the management of their diabetes mellitus.</p><p><strong>Materials and methods: </strong>Twenty-four cases from a private vulvovaginal specialist clinic are described.</p><p><strong>Results: </strong>All 24 patients were referred with severe and persistent vulvar pruritus, pain, and erythema. Examination findings varied between patients and included erythema, edema, erosions, adherent white discharge, and fissuring, which were extensive and often involved the mons pubis, labia majora, and extended to the perineum and perianal region, mimicking psoriasis and/or irritant dermatitis. The clinical presentation in this postmenopausal group hindered a timely diagnosis, resulting in a delay in appropriate management. Fortunately, all patients improved on oral antifungal treatment, and in those that ceased their SGLT2i medication, there was resolution of the condition.</p><p><strong>Conclusions: </strong>While candidiasis is reported to occur with SGLT2i, severe genital mycotic infections are not yet a well-recognized adverse effect and may be missed. The presentation in these cases was persistent and severe. Clinicians should have a high index of suspicion in postmenopausal women presenting with vulvar pain, pruritus, and extensive erythema that mimics psoriasis or irritant dermatitis, if they are on SGLT2i therapy.</p>","PeriodicalId":50160,"journal":{"name":"Journal of Lower Genital Tract Disease","volume":" ","pages":"371-376"},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142114276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nidhi Chawla, Jennifer Marshall, Alexandra Dubinskaya, Dorothy Wakefield, Jonathan Shepherd, Veronica Maria Pimentel
{"title":"Knowledge of the Human Papillomavirus Vaccine and Willingness to Accept Vaccination in the Postpartum Period.","authors":"Nidhi Chawla, Jennifer Marshall, Alexandra Dubinskaya, Dorothy Wakefield, Jonathan Shepherd, Veronica Maria Pimentel","doi":"10.1097/LGT.0000000000000827","DOIUrl":"10.1097/LGT.0000000000000827","url":null,"abstract":"<p><strong>Objectives: </strong>Human papillomavirus (HPV) vaccines prevent cervical cancer. The inpatient postpartum period presents a unique window for vaccination. The authors' study investigates HPV vaccine knowledge, barriers to vaccination, and willingness to get vaccinated during inpatient postpartum care.</p><p><strong>Materials and methods: </strong>The authors conducted a cross-sectional survey of 147 participants, age 18 to 26, who delivered at the authors' institution between November 1, 2019, and April 30, 2020. Participants completed a questionnaire that included demographics, vaccine knowledge, hesitancies, and willingness to vaccinate. The authors used descriptive statistics and compared groups with chi-square or Wilcoxon rank sum for categorical variables and t -test for continuous variables.</p><p><strong>Results: </strong>Of the 147 patients, 58 (39.46%) were fully vaccinated against HPV and 89 (60.54%) of participants were unvaccinated or partially vaccinated. There was a greater proportion of African American and Asian participants among unvaccinated women (28.1% vs 20.7% and 16.9% vs 1.7%, respectively). Most unvaccinated participants (52.9%) were willing to get vaccinated in the postpartum unit. Both vaccinated and unvaccinated groups were similarly aware that the HPV vaccine prevents cervical and oropharyngeal cancers and genital warts. The top barrier to future vaccination was forgetting to complete the vaccination series.</p><p><strong>Conclusions: </strong>Most women were not fully vaccinated but were willing to receive their first dose while in the postpartum unit. African American women were less likely to be vaccinated and expressed more unwillingness to accept vaccination. The authors identified barriers to HPV vaccination that can be tackled with the initiation of inpatient postpartum vaccination.</p>","PeriodicalId":50160,"journal":{"name":"Journal of Lower Genital Tract Disease","volume":" ","pages":"340-344"},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141762197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Raianne Kívia de Azevedo Bispo, Marcelo Cunio Machado Fonseca, Neila Maria de Góis Speck
{"title":"Prevalence and Type of HPV Genital Infection in Girls: A Systematic Review and Meta-Analysis.","authors":"Raianne Kívia de Azevedo Bispo, Marcelo Cunio Machado Fonseca, Neila Maria de Góis Speck","doi":"10.1097/LGT.0000000000000826","DOIUrl":"10.1097/LGT.0000000000000826","url":null,"abstract":"<p><strong>Objectives: </strong>This investigation explored the prevalence of human papillomavirus (HPV) infection by subtypes in girls aged up to 12.</p><p><strong>Methods: </strong>Four indexed databases, PubMed, EMBASE, Cochrane, and LILACS, were evaluated. Twenty-nine observational studies published between 1992 and 2018 were included.</p><p><strong>Results: </strong>The prevalence of genital condyloma acuminatum or HPV-positive serology due to prior infection among girls with suspected/confirmed sexual abuse was 25%, and without a history or information about abuse, 8%. The analysis indicated that low-risk HPV types were the most prevalent among this group, corresponding to 86.6% of the identified types. Human papillomavirus 6 and 11 were the most prevalent types, followed by HPV 16 and 2. Moreover, the analysis identified limited epidemiological data on genital warts in children up to 12 years. Several studies focused on convenience sampling, sexually abused girls, or failed to separate data by gender.</p><p><strong>Conclusion: </strong>Findings of the systematic review and prevalence meta-analysis indicate that the occurrence of HPV infection in girls aged 12 or younger is relatively rare, underscoring the significance of understanding the prevalence of HPV in the pediatric population. However, it is essential to be cautious when applying these results to the pediatric population, given cases of girls who are suspected of or have suffered sexual abuse. There is a pressing need for further research to fill the information gap on HPV infection in this vulnerable group.</p>","PeriodicalId":50160,"journal":{"name":"Journal of Lower Genital Tract Disease","volume":" ","pages":"332-339"},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141762198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bertie Geng, Carlos R Oliveira, Hillary Hosier, Sangini S Sheth, Alla Vash-Margita
{"title":"Reduction in Unindicated Cervical Cancer Screening in Adolescents in a Large Health Care System.","authors":"Bertie Geng, Carlos R Oliveira, Hillary Hosier, Sangini S Sheth, Alla Vash-Margita","doi":"10.1097/LGT.0000000000000831","DOIUrl":"10.1097/LGT.0000000000000831","url":null,"abstract":"<p><strong>Objectives: </strong>Evidence-based guidelines recommend against screening for cervical cancer (Pap testing) in average-risk adolescents <21 years old. Despite this, many still undergo unindicated screenings with subsequent detrimental reproductive health and economic consequences. The authors' aim was to reduce unindicated cervical cancer screening in individuals <21 years old in a large health care system by utilizing an electronic provider notification.</p><p><strong>Methods: </strong>Starting in July 2020, a Best Practice Advisory (BPA) appeared in the electronic medical record (EMR) if providers ordered Pap testing on individuals <21 years old. This BPA reiterated that screening was not indicated for average-risk adolescents and prompted users to choose an indication if they wanted to proceed. A retrospective chart review, pre/post intervention study was performed comparing individuals <21 years old with Pap testing performed before and after intervention (January 2019-June 2020 and July 2020-June 2021, respectively). Patient characteristics were extracted from the EMR and analyzed using Fisher exact tests, Kruskal-Wallis tests, and logistic regression.</p><p><strong>Results: </strong>There were 140 subjects included: 106 preintervention and 34 postintervention. There were no differences in baseline characteristics. Neither Pap nor human papillomavirus testing results differed between the groups. Preintervention, 6.6% of cytology tests were indicated compared to 20.6% postintervention ( p = .042). The proportion of indicated human papillomavirus testing did not differ preintervention and postintervention at 65% and 45%, respectively ( p = .295). The overall reduction in unindicated cervical cancer screening postintervention was 13.9% (95% CI = 4.0-23.7).</p><p><strong>Conclusions: </strong>The authors demonstrated that incorporating a BPA to the EMR reduces unindicated cervical cancer screening.</p>","PeriodicalId":50160,"journal":{"name":"Journal of Lower Genital Tract Disease","volume":" ","pages":"345-350"},"PeriodicalIF":2.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141749473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Koray Görkem Saçıntı, Hosna Razeghian, Jacob Bornstein
{"title":"Surgical Treatment for Provoked Vulvodynia: A Systematic Review.","authors":"Koray Görkem Saçıntı, Hosna Razeghian, Jacob Bornstein","doi":"10.1097/LGT.0000000000000834","DOIUrl":"10.1097/LGT.0000000000000834","url":null,"abstract":"<p><strong>Objective: </strong>Provoked vulvodynia (PV), characterized by vulvar pain upon touch or pressure, is the leading cause of pain during sexual intercourse. It causes a significant decline in overall quality of life, including sexual dysfunction and mental distress. Surgical interventions, such as perineoplasty and vestibulectomy, are considered a last resort for PV cases unresponsive to less invasive therapies. This systematic review evaluates the efficacy of surgery for PV and suggests areas for future research.</p><p><strong>Materials and methods: </strong>The literature search encompassed PubMed, Scopus, Web of Science, and Cochrane Library, identifying relevant peer-reviewed studies up to August 21, 2023.</p><p><strong>Results: </strong>Out of 1102 records retrieved, 29 met the eligibility criteria. Surgery was typically considered after failed conservative treatments. In 15 of the 29 studies defining surgical success as a significant reduction in dyspareunia, success rates ranged from 52% to 93%. Six studies using validated scales for pain assessment noted a significant reduction in vulvar pain following surgery ( p < .001). Two studies reported enhancements in sexual function ranging from 57% to 87%, while 3 studies found 89%-97% of women regained the ability to engage in sexual intercourse after surgery. Patient satisfaction rates ranged from 79% to 93%. Bartholin cysts occurred in up to 9% of cases, the most common complication reported.</p><p><strong>Conclusion: </strong>Surgery seems to be an effective and safe PV treatment option with success rates ranging from 52% to 97%, depending on the variation of outcome measures. Randomized clinical trials with established outcome measures are needed to determine the best surgical approach with minimal operative risk and optimal long-term outcomes.</p>","PeriodicalId":50160,"journal":{"name":"Journal of Lower Genital Tract Disease","volume":" ","pages":"379-390"},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141894788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"ASCCP President's Message.","authors":"Francisco A R Garcia","doi":"10.1097/LGT.0000000000000844","DOIUrl":"https://doi.org/10.1097/LGT.0000000000000844","url":null,"abstract":"","PeriodicalId":50160,"journal":{"name":"Journal of Lower Genital Tract Disease","volume":"28 4","pages":"319-320"},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}