Journal of Lower Genital Tract Disease最新文献

Clinical Characteristics and Diagnostic Markers of Genital Varicella-zoster in Women: A 12-year Retrospective Cohort. 女性生殖器水痘带状疱疹的临床特征和诊断指标：一项12年回顾性队列研究。

IF 2.1 4区医学

Journal of Lower Genital Tract Disease Pub Date : 2026-05-08 DOI: 10.1097/LGT.0000000000000957

Meller Nir, Rothman Noam, Gilboa Sarit, Baum Micha

{"title":"Clinical Characteristics and Diagnostic Markers of Genital Varicella-zoster in Women: A 12-year Retrospective Cohort.","authors":"Meller Nir, Rothman Noam, Gilboa Sarit, Baum Micha","doi":"10.1097/LGT.0000000000000957","DOIUrl":"https://doi.org/10.1097/LGT.0000000000000957","url":null,"abstract":"Background: Genital involvement in varicella-zoster virus (VZV) reactivation is uncommon and frequently misdiagnosed. Data on the clinical features of genital zoster are limited, particularly among female patients.Methods: We conducted a retrospective case series of female patients with genital involvement by VZV at a tertiary referral center between 2013 and 2025. Inclusion required polymerase chain reaction (PCR)-confirmed VZV from genital swabs. Demographic characteristics, immune status, pregnancy status, clinical presentation, diagnostic pathways, and treatment patterns were extracted from electronic medical records and summarized descriptively.Results: A total of 21 patients were included (median age, 32.5 y). Most patients were immunocompetent (71.4%), and six (28.6%) were pregnant. VZV was correctly identified at initial presentation in 61.9% of cases; the remainder were misdiagnosed as HSV (23.8%) or as bacterial or fungal conditions (14.3%). Documentation of sexual history and partner HSV status occurred in 28.6% of patients. Unilateral distribution was documented in 90.5% of cases, extragenital extension in 85.7%, and pain in 76.1%, representing the most consistent clinical features in the cohort. Notably, these findings were also present in cases that were initially misdiagnosed. Intravenous acyclovir was required in 23.8% of patients, predominantly among immunocompromised individuals. More than half of the cohort received systemic antibiotics before definitive diagnosis.Conclusions: Genital zoster is an under-recognized clinical entity with a relatively high rate of initial misdiagnosis. Recognition of three key clinical features-unilateral sacral distribution, pain, and extragenital extension-may substantially improve diagnostic accuracy, reduce misclassification as HSV, and mitigate sexual-health-related psychosocial burden.","PeriodicalId":50160,"journal":{"name":"Journal of Lower Genital Tract Disease","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147845495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association Between Salivary and Cervical Human Papillomavirus in Women With a History of Oral Sex. 有口交史的妇女唾液和宫颈人乳头瘤病毒的关系

IF 2.1 4区医学

Journal of Lower Genital Tract Disease Pub Date : 2026-05-01 DOI: 10.1097/LGT.0000000000000944

Mahdieh Akbari, Zoha Mohammadi Pour Yazdi, Yasaman Yazdandoost, Negar Yavari, Maryam Amir Chakhmaghi, Zahra Abbasi Shaye, Masoumeh Ghorbanzadeh, Fatemeh Yazadani, Azadeh Vaseei, Malihe Hasanzadeh Mofrad, Amir Avan

{"title":"Association Between Salivary and Cervical Human Papillomavirus in Women With a History of Oral Sex.","authors":"Mahdieh Akbari, Zoha Mohammadi Pour Yazdi, Yasaman Yazdandoost, Negar Yavari, Maryam Amir Chakhmaghi, Zahra Abbasi Shaye, Masoumeh Ghorbanzadeh, Fatemeh Yazadani, Azadeh Vaseei, Malihe Hasanzadeh Mofrad, Amir Avan","doi":"10.1097/LGT.0000000000000944","DOIUrl":"https://doi.org/10.1097/LGT.0000000000000944","url":null,"abstract":"Objective: Human papillomavirus (HPV) is a sexually transmitted DNA virus implicated in both cervical and oral squamous cell carcinomas (SCC). While HPV's role in cervical cancer is well established, the prevalence of oral HPV in women with genital infection-particularly in relation to sexual practices-remains underexplored in Iran. This study aimed to investigate the presence of HPV DNA in the saliva of Iranian women with confirmed genital HPV infection and a history of oral-genital contact.Methods: In this cross-sectional study, 111 women aged 15-65 with diagnosed genital HPV were recruited between 2021 and 2024. Saliva samples were collected and analyzed using polymerase chain reaction (PCR) to detect HPV DNA. Demographic and behavioral data were obtained using a questionnaire. The association between salivary HPV presence and sexual practices, HPV genotype, and clinical variables was statistically assessed.Results: HPV DNA was detected in the saliva of 25 participants (22.1%). High-risk genotypes, particularly HPV-16, were significantly more prevalent among those with concurrent oral and genital infections (p=.03). No statistically significant association was found between salivary HPV and smoking, alcohol use, or contraceptive method. Oral examinations in HPV-positive patients revealed no premalignant lesions.Conclusions: These findings indicate a notable prevalence of oral HPV in women with genital HPV, particularly those with high-risk genotypes; however, the clinical significance of salivary HPV detection remains uncertain, and routine oral HPV screening cannot currently be recommended. Further multicenter studies are warranted.","PeriodicalId":50160,"journal":{"name":"Journal of Lower Genital Tract Disease","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147822412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HPV Detection in Clinician-Collected, Self-Collected Vagina, Urine, and Menstrual Blood Samples. 临床采集、自行采集阴道、尿液和经血样本中的HPV检测。

IF 2.1 4区医学

Journal of Lower Genital Tract Disease Pub Date : 2026-04-28 DOI: 10.1097/LGT.0000000000000954

Stanton King Dat Ho, Stephanie Liu, Lesley Suk Kwan Lau, Annie Nga Yin Cheung, Man Yee Chu, Ka Yu Tse, Siu Fei Ngu, Karen Kar Leon Chan

{"title":"HPV Detection in Clinician-Collected, Self-Collected Vagina, Urine, and Menstrual Blood Samples.","authors":"Stanton King Dat Ho, Stephanie Liu, Lesley Suk Kwan Lau, Annie Nga Yin Cheung, Man Yee Chu, Ka Yu Tse, Siu Fei Ngu, Karen Kar Leon Chan","doi":"10.1097/LGT.0000000000000954","DOIUrl":"https://doi.org/10.1097/LGT.0000000000000954","url":null,"abstract":"Objective: This study evaluates the concordance, sensitivity, and specificity of self-collected samples-vaginal, urine, and menstrual blood-for detecting high-risk human papillomavirus (HrHPV) and high-grade squamous intraepithelial lesion (HSIL) compared with clinician-collected specimens for cervical cancer screening.Methods: This prospective study was carried out in the colposcopy clinic of a tertiary hospital in Hong Kong. A consecutive series of premenopausal women referred to our colposcopy clinic due to abnormal Pap smears were screened and recruited. All participants provided self-collected vaginal, urine, and menstrual blood samples. Clinicians collected cervical samples for cytology and HPV testing. A colposcopy examination was performed if indicated. Testing for HrHPV in specimens was analyzed using a 14-type HPV-DNA test (Cobas 4800). Colposcopy with biopsy was used as the reference standard for histologic confirmation of cervical pathology.Results: Of the 167 subjects included in the analysis, 85 (50.9%) had HrHPV infection. The overall concordance between clinician-collected HrHPV results and self-collected samples was 83.2% (vaginal), 79% (urine), and 82.1% (menstrual blood). Among the 167 cases, 139 underwent colposcopy and 42 cases (30.9%) of HSIL+ were identified. The relative sensitivity for HSIL was 0.89 (95% CI, 0.79-1.02) for vaginal, 0.76 (95% CI, 0.63-0.91) for urine, and 0.83 (95% CI, 0.70-0.98) for menstrual blood samples in comparison to clinician-collected cervical samples.Discussion: Self-collected vaginal, urine, and menstrual blood samples show moderate to good concordance with clinician-collected samples for HrHPV detection. However, only self-collected vaginal samples demonstrate comparable sensitivity and specificity for detecting HSIL.","PeriodicalId":50160,"journal":{"name":"Journal of Lower Genital Tract Disease","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147787706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vulvar Low-Grade Squamous Intraepithelial Lesion (LSIL) and Small Condyloma are Overlapping Clinicopathologic Entities. 外阴低级别鳞状上皮内病变（LSIL）和小尖锐湿疣是重叠的临床病理实体。

IF 2.1 4区医学

Journal of Lower Genital Tract Disease Pub Date : 2026-04-28 DOI: 10.1097/LGT.0000000000000956

Aaron Scolyer, James Scurry, Ross Pagano, Carlos Parra-Herran, Mario Preti, Niccolò Gallio, Eleonora Petra Preti, Tania Day

{"title":"Vulvar Low-Grade Squamous Intraepithelial Lesion (LSIL) and Small Condyloma are Overlapping Clinicopathologic Entities.","authors":"Aaron Scolyer, James Scurry, Ross Pagano, Carlos Parra-Herran, Mario Preti, Niccolò Gallio, Eleonora Petra Preti, Tania Day","doi":"10.1097/LGT.0000000000000956","DOIUrl":"https://doi.org/10.1097/LGT.0000000000000956","url":null,"abstract":"Objectives: Describe clinicopathologic features of vulvar low-grade squamous intraepithelial lesion (LSIL) and small condyloma to elaborate diagnostic criteria.Methods: Pathology database search identified vulvar biopsies reported as LSIL, wart, or condyloma. Exclusions included cancer specimens, concern for vulvar intraepithelial neoplasia (VIN), large condyloma, and inadequate slides or tissue blocks. After review of histopathology and p16, cases were designated as LSIL or condyloma, and clinical information was collected. Descriptive statistics and group comparisons were performed.Results: There were 42 women with 59 specimens; 24 patients (57%) had condyloma, 13 (31%) had LSIL, and 5 (12%) had both lesion types. Detection of LSIL/condyloma occurred as an incidental finding or secondary issue in 34 (81%). Previous or concurrent human papillomavirus (HPV)-associated VIN occurred in 23 (55%), 10 (24%) had lichen sclerosus, and 2 (5%) had graft-versus-host disease. Patients with condyloma were more likely to have negative cervicovaginal oncogenic HPV and undergo treatment than those with LSIL or both. Compared with condyloma cases, LSIL was more likely to appear flat and white or acetowhite, with smooth surface morphology on microscopy. Condyloma had a larger mean epithelial thickness and more often had elongated or irregular rete ridges. Block positive p16 was more frequent in LSIL than in condyloma.Conclusions: Vulvar LSIL and small condyloma have a subtle clinical appearance, usually identified during evaluation of another condition. While most clinicopathologic features overlap, LSIL is characterized by a smooth surface contour, normal or near-normal epithelial thickness, and a higher rate of p16 positivity than condyloma.","PeriodicalId":50160,"journal":{"name":"Journal of Lower Genital Tract Disease","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147787677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vulvar and Vaginal Melanoma: Real-world Clinical Outcomes and Prognostic Differences From a Single-center Experience. 外阴和阴道黑色素瘤：来自单中心经验的真实临床结果和预后差异。

IF 2.1 4区医学

Journal of Lower Genital Tract Disease Pub Date : 2026-04-27 DOI: 10.1097/LGT.0000000000000959

Nethanel Asher, Shirly Grynberg, Jacob Schachter, Ronnie Shapira-Frommer

{"title":"Vulvar and Vaginal Melanoma: Real-world Clinical Outcomes and Prognostic Differences From a Single-center Experience.","authors":"Nethanel Asher, Shirly Grynberg, Jacob Schachter, Ronnie Shapira-Frommer","doi":"10.1097/LGT.0000000000000959","DOIUrl":"https://doi.org/10.1097/LGT.0000000000000959","url":null,"abstract":"Objective: Vulvar and vaginal melanoma are rare gynecologic malignancies with aggressive clinical behavior and poor prognosis. Due to their low incidence and exclusion from most clinical trials, treatment decisions are often extrapolated from cutaneous melanoma data. This study aims to provide real-world insights into the clinical course and outcomes of vulvar and vaginal melanoma in the context of modern systemic therapy.Methods: We retrospectively analyzed 39 patients with vulvar or vaginal melanoma treated at a single tertiary cancer center between 2011 and 2023. Clinical and pathologic data, including tumor site, stage, treatment modalities, and outcomes, were collected. Systemic therapy regimens included anti-PD-1 antibody monotherapy (either pembrolizumab or nivolumab), anti-PD-1 + anti-CTLA4 combination therapy (ipilimumab and nivolumab), and chemotherapy combined with interleukin-2. Progression-free survival and overall survival were evaluated.Results: Patients frequently presented with locally advanced disease. High rates of multifocality, positive margins, and repeated local recurrence were observed, particularly in vulvar primaries. Among those treated for advanced disease (n = 28), combination immunotherapy yielded the most durable responses. Vulvar melanoma was associated with longer progression-free survival and overall survival compared with vaginal melanoma (median progression-free survival: 33 vs. 5 mo, HR = 3.8; median overall survival: 42 vs. 10 mo, HR = 7.8).Conclusions: Vulvar and vaginal melanoma present unique diagnostic and therapeutic challenges in gynecologic oncology. Site-specific prognosis and distinct response patterns to immunotherapy underscore the importance of individualized management strategies and multidisciplinary coordination in this rare population.","PeriodicalId":50160,"journal":{"name":"Journal of Lower Genital Tract Disease","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147787689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cervical Cancer Screening Patterns and Outcomes in Women Over 65 Years Old: A Retrospective Study of Medicare Patients. 65岁以上妇女宫颈癌筛查模式和结果：对医保患者的回顾性研究。

IF 2.1 4区医学

Journal of Lower Genital Tract Disease Pub Date : 2026-04-23 DOI: 10.1097/LGT.0000000000000958

Daniel Rodriguez, Tamela Fonseca, Tonya S King, Maria Moreno, Megan Swiger, Rebecca Lazensky, Toni Kilts, Beverly Long

{"title":"Cervical Cancer Screening Patterns and Outcomes in Women Over 65 Years Old: A Retrospective Study of Medicare Patients.","authors":"Daniel Rodriguez, Tamela Fonseca, Tonya S King, Maria Moreno, Megan Swiger, Rebecca Lazensky, Toni Kilts, Beverly Long","doi":"10.1097/LGT.0000000000000958","DOIUrl":"https://doi.org/10.1097/LGT.0000000000000958","url":null,"abstract":"Objective: This study aimed to examine cervical cancer screening rates and adherence to national guidelines for cervical cancer screening in women over 65, identify demographic and clinical characteristics associated with appropriate screening, and describe screening outcomes in a single-site cohort.Methods: This retrospective study includes women over 65 who had a Medicare wellness visit and/or annual gynecologic visit from January 1, 2022 to December 31, 2022. Bivariate analysis was used to evaluate patient and provider characteristics associated with inappropriate and appropriate screening practices. Significant factors were combined into multivariable models to identify the most important predictors of screening practices.Results: Of 1,787 patients, 1,537 met the criteria for screening cessation, while 250 did not. Among high-risk women, only 5.2% were screened appropriately. Screening was less likely to be performed as age increased (p<.001). Odds of appropriate screening in high-risk women were 6.7 times greater for those with a history of high-grade cervical dysplasia and 0.5 times lower with every 5-year increase in age over 65 years. Among the 82 women who underwent screening, 97.5% had normal cytology, and only 2.5% had abnormal cytology (ASC-US and ASC-H).Conclusion: Most women did not continue screening after the age of 65, including those defined as high-risk and/or not meeting the exit criteria for screening cessation. Providers should ensure that the criteria for screening cessation are met before ending screening. Additional studies are needed to develop strategies for identifying high-risk women during Medicare wellness visits.","PeriodicalId":50160,"journal":{"name":"Journal of Lower Genital Tract Disease","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147787658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HPV Prevalence Among Inuit Women in Northern Quebec, Canada: A Pre- and Post-Vaccination Analysis. 加拿大魁北克省北部因纽特妇女的HPV患病率：疫苗接种前后分析。

IF 2.1 4区医学

Journal of Lower Genital Tract Disease Pub Date : 2026-04-17 DOI: 10.1097/LGT.0000000000000953

Ghoufran Talib, Patricia Blais, Noemie Smith, Francois Coutlée, Eduardo L Franco, Paul Brassard

{"title":"HPV Prevalence Among Inuit Women in Northern Quebec, Canada: A Pre- and Post-Vaccination Analysis.","authors":"Ghoufran Talib, Patricia Blais, Noemie Smith, Francois Coutlée, Eduardo L Franco, Paul Brassard","doi":"10.1097/LGT.0000000000000953","DOIUrl":"https://doi.org/10.1097/LGT.0000000000000953","url":null,"abstract":"Objective: To assess changes in high-risk HPV prevalence among Inuit women in Nunavik following the introduction in 2008 among 12-year-old girls of the quadrivalent HPV vaccine program in Quebec.Methods: A total of 169 Inuit women aged 25-65 were recruited in Kuujjuaq, Nunavik, between July 2022 and December 2024. Participants self-collected cervico-vaginal samples under nurse supervision. HPV DNA testing was performed using real-time PCR (Cobas 4800), detecting HPV 16, 18, and 12 other high-risk types. Results were compared with historical data from 473 Inuit women (2002-2007), using the same genotypic categories. Age-stratified prevalence ratios (PR) were calculated to assess differences over time and odds ratios (OR) for HPV 16/18 detection by vaccination status.Results: Among 148 participants with results, overall high-risk HPV prevalence increased from 15.9% pre-vaccination to 22.3% post-vaccination, driven by a significant rise in other high-risk types among women aged 40+ (from 5.8% to 16.4%; PR=2.80, 95% CI: 1.16-6.75). HPV 16/18 prevalence showed a non-statistically significant decline among the 25-29 age group (6.8%-3.3%). Only one vaccinated participant tested positive for HPV 16/18 (OR=0.29, 95% CI: 0.0062-2.54).Conclusions: The quadrivalent HPV vaccine has reduced HPV 16/18 prevalence in the targeted younger population. Continued surveillance is warranted, particularly for nonvaccine high-risk types.","PeriodicalId":50160,"journal":{"name":"Journal of Lower Genital Tract Disease","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147693244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Clitoral Artery Doppler Parameters After Brachytherapy and Its Effects On Sexual Functions. 近距离治疗后阴蒂动脉多普勒参数的评价及其对性功能的影响。

IF 2.1 4区医学

Journal of Lower Genital Tract Disease Pub Date : 2026-04-14 DOI: 10.1097/LGT.0000000000000955

Belma Gözde Özdemir, Leyla Agakishiyeva, Ahmet Bilgi, Çetin Çelik

{"title":"Evaluation of Clitoral Artery Doppler Parameters After Brachytherapy and Its Effects On Sexual Functions.","authors":"Belma Gözde Özdemir, Leyla Agakishiyeva, Ahmet Bilgi, Çetin Çelik","doi":"10.1097/LGT.0000000000000955","DOIUrl":"https://doi.org/10.1097/LGT.0000000000000955","url":null,"abstract":"Objectives: Assessment of clitoral artery flow parameters (eg, pulsation and resistance indices) is important for individual patient evaluation of sexual function quality. Selected hormonal treatments may also influence these vascular features. The rationale stems from the functional improvements observed after the use of vasodilator agents in systemic diseases affecting vessels and nerves. In this study, we investigated the relationship between Doppler parameters and functional evaluations in patients who underwent brachytherapy.Materials and methods: This study was conducted at the Department of Obstetrics and Gynecology, Faculty of Medicine, University of Selçuk. Patients with endometrial or cervical cancer who underwent surgery between 2010 and 2024 were included. Some patients received brachytherapy, while others were followed with surgery alone. All patients underwent ultrasonographic evaluation and completed the Female Sexual Function Index (FSFI) questionnaire. The resistance index (RI) and pulsatility index (PI) were also evaluated.Results: A total of 42 patients were included in the study; 21 of them underwent surgery alone, and 21 received postoperative brachytherapy. Significant differences were found in the clitoral artery pulsatility and resistance indices between the hysterectomy-only group (group 1) and the hysterectomy-plus-brachytherapy group (group 2). Lower FSFI scores were associated with decreased PI and increased RI. No significant differences were found in other Doppler parameters. Mean FSFI scores were 17±8.6 in group 1 and 13.2±7.7 in group 2.Conclusions: Cancer surgery and adjuvant treatment methods can lead to sexual dysfunction through many mechanisms; therefore, the importance of quality of life assessment and examinations is clear.","PeriodicalId":50160,"journal":{"name":"Journal of Lower Genital Tract Disease","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147693262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mood Disorder Symptoms and Quality of Life in Women Attending a Specialized Vulvar Clinic in Southern Sweden. 在瑞典南部一家专门的外阴诊所就诊的妇女的情绪障碍症状和生活质量

IF 2.1 4区医学

Journal of Lower Genital Tract Disease Pub Date : 2026-04-09 DOI: 10.1097/LGT.0000000000000949

Helga Magnúsdóttir Halfin, Anna Löfroth, Ingrid Siemund, Florence Dalgard

{"title":"Mood Disorder Symptoms and Quality of Life in Women Attending a Specialized Vulvar Clinic in Southern Sweden.","authors":"Helga Magnúsdóttir Halfin, Anna Löfroth, Ingrid Siemund, Florence Dalgard","doi":"10.1097/LGT.0000000000000949","DOIUrl":"https://doi.org/10.1097/LGT.0000000000000949","url":null,"abstract":"Objectives: To evaluate the prevalence of mood disorder symptoms and measure the quality of life in women with vulvar dermatoses attending a specialized vulvar clinic in southern Sweden.Materials and methods: A questionnaire-based study among consecutive women attending the vulvar unit at the Department of Dermatology and Venereology at Skåne University Hospital. Sociodemographic factors were collected; depression and anxiety were assessed with the Hospital Anxiety and Depression Scale (HADS) and health-related quality of life with the EQ-5D VAS.Results: In all, 217 of 242 women participated (response rate 90%). Data was collected from March 2020 to January 2023. The largest diagnostic group was lichen sclerosus (62%), followed by lichen planus (9.2%) and pain disorders (5.5%). Symptoms of depression and anxiety were highest among women with pain disorders (n=12, anxiety symptoms 58.3%, depression symptoms 20%), followed by Candida vulvovaginitis (n=7, anxiety symptoms 57.2%, depression symptoms 0.0%) and pruritus vulvae (n=7, anxiety symptoms 42.9% and depression symptoms14.3%). Differences between these groups were not significant. The mean EQ-5D VAS score was 69.7±19.7.Conclusions: Women with pain disorders, Candida vulvovaginitis, and pruritus vulvae showed the highest levels of mood symptoms. These findings support the importance of assessing mood symptoms and quality of life in the management of women with vulvar disease.","PeriodicalId":50160,"journal":{"name":"Journal of Lower Genital Tract Disease","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147640453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pain Control for Outpatient Colposcopy, Loop Electrode Excision Procedure, Vulvar Biopsy, and Endometrial Biopsy. 门诊阴道镜检查、环电极切除、外阴活检和子宫内膜活检的疼痛控制。

IF 2.1 4区医学

Journal of Lower Genital Tract Disease Pub Date : 2026-04-03 DOI: 10.1097/LGT.0000000000000945

Mary M Hillard, Allison K Etcheverry, Gabrielle E Smotrich, Joey Bahng, Kathryn Dumas, Anita Mikkilineni, Sarah T Cigna

{"title":"Pain Control for Outpatient Colposcopy, Loop Electrode Excision Procedure, Vulvar Biopsy, and Endometrial Biopsy.","authors":"Mary M Hillard, Allison K Etcheverry, Gabrielle E Smotrich, Joey Bahng, Kathryn Dumas, Anita Mikkilineni, Sarah T Cigna","doi":"10.1097/LGT.0000000000000945","DOIUrl":"https://doi.org/10.1097/LGT.0000000000000945","url":null,"abstract":"Objectives/purposes of the study: Outpatient gynecologic biopsies elicit discomfort that negatively impacts patient satisfaction and limits the ability to obtain adequate sampling. We examined relevant studies focusing on colposcopy, loop electrode excision procedure, endometrial biopsies, or vulvar biopsies.Materials and methods: This systematic review conducted a search in PubMed, ClinicalTrials.gov, Embase, and Scopus databases following PRISMA Guidelines. Two reviewers independently extracted data from each study with Covidence software. Exclusion criteria included articles published before 2015, procedures done in inpatient hospital settings, and obstetric procedures. Studies were categorized by procedure type and compared by the primary data point of reduction in pain score during biopsy.Results: Of 8388 publications screened, 20 colposcopy and LEEP studies, 14 EMB studies, and 3 vulvar biopsy studies were included in the final review. The primary outcome measured across studies was pain score at the time of biopsy.Conclusions: Lidocaine spray, IUL, PCB, and oral NSAIDs were found to be effective pain control options during EMB. Vulvar biopsy is largely unstudied, but the procedure induces significant changes in VAS scores as compared with patient baselines. For colposcopy and LEEP, local anesthetic with injection of lidocaine is superior to nonpharmacologic interventions such as music. Lidocaine spray remains a better alternative than no pain intervention. Patient preference, while variable, is an important factor to consider when choosing an anesthetic intervention.","PeriodicalId":50160,"journal":{"name":"Journal of Lower Genital Tract Disease","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147610279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0