{"title":"Lifetime Cervical Cancer Screening and Social Determinants of Health in the Canadian Longitudinal Study on Aging.","authors":"Melissa Lavecchia, Amanda Selk, Maura Marcucci, Andra Nica, Parminder Raina, Waldo Jimenez, Julie Mv Nguyen","doi":"10.1097/LGT.0000000000000895","DOIUrl":"10.1097/LGT.0000000000000895","url":null,"abstract":"<p><strong>Objectives: </strong>In Canada, cervical cancer rates remain well above the World Health Organization target, despite screening and vaccination programs. Modeling reveals that those who have never undergone screening represent one of the highest risk populations. The Canadian Longitudinal Study on Aging (CLSA) prospectively collected health outcomes on >50,000 individuals. The authors sought to identify the prevalence of Canadian female participants having never undergone cervical cancer screening and the association with social determinants of health.</p><p><strong>Methods: </strong>The authors performed a cross-sectional analysis from CLSA data. The main outcome was self-report of ever having undergone a Pap smear. Regression analyses evaluated the association between demographic or social determinants of health and self-reported lifetime cervical cancer screening.</p><p><strong>Results: </strong>The population-based sample comprised 22,910 participants aged 45-85, of whom 99.8% had available information on cervical cancer screening ( n = 22,720). The prevalence of never having undergone a Pap smear was 14.1%; weighted prevalence, 11.8% (95% CI = 11.0-12.6). The following factors were associated with never having undergone screening: older age (10-year) (OR = 1.5, 95% CI = 1.4-1.6), lower education (low vs. high) (OR = 1.5, 95% CI = 1.2-1.9), lower household income (low vs. high) (OR = 1.7, 95% CI = 1.3-2.3), having a religious affiliation (OR = 1.3, 95% CI = 1.1-1.5), and never being married/lived in common law (OR = 1.5, 95% CI = 1.2-1.9). Notably, not having a family physician was also associated (OR = 2.3, 95% CI = 1.6-3.3). However, among participants who never underwent a Pap smear, 97% reported having a family physician.</p><p><strong>Conclusions: </strong>This analysis highlights inequities in cervical cancer screening in the Canadian context. These insights are critical in informing a more equitable approach to implementing human papillomavirus (HPV)-based screening.</p>","PeriodicalId":50160,"journal":{"name":"Journal of Lower Genital Tract Disease","volume":" ","pages":"310-319"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Laura Alicia Fleider, Marcela Celis Amórtegui, Elsa Díaz López, Luis García Bernal, Rene Danilo Salazar Molina, Carlos Arturo Buitrago Duque, Carmen Irela Troya Moreno, Natalia Pérez Pérez, Edwar Alexander Herrera, Angie Mora Calderón, Elizabeth Duarte, Amalia Castro, Laura Rubano, José Humberto Belmino Chaves, Janeth Márquez Acosta, Ana María Soilán
{"title":"Consensus on Quality Standards for Colposcopy and Colposcopy Training From the Latin-American Federation of Lower Genital Tract Pathology and Colposcopy.","authors":"Laura Alicia Fleider, Marcela Celis Amórtegui, Elsa Díaz López, Luis García Bernal, Rene Danilo Salazar Molina, Carlos Arturo Buitrago Duque, Carmen Irela Troya Moreno, Natalia Pérez Pérez, Edwar Alexander Herrera, Angie Mora Calderón, Elizabeth Duarte, Amalia Castro, Laura Rubano, José Humberto Belmino Chaves, Janeth Márquez Acosta, Ana María Soilán","doi":"10.1097/LGT.0000000000000908","DOIUrl":"10.1097/LGT.0000000000000908","url":null,"abstract":"<p><strong>Objective: </strong>The aim of the study was to provide recommendations on quality standards for colposcopy and colposcopy training.</p><p><strong>Methods: </strong>A panel of experts from the Latin-American Federation of the Lower Genital Tract Pathology and Colposcopy agreed on quality standards for colposcopy and colposcopy training.</p><p><strong>Results: </strong>A total of 17 general recommendations and the rationale behind them were provided. Eight colposcopy quality standards and nine standards for colposcopy training were issued.</p><p><strong>Conclusions: </strong>Adherence to the proposed standards could help ensure quality care of women. Colposcopists must be trained and certified.</p>","PeriodicalId":50160,"journal":{"name":"Journal of Lower Genital Tract Disease","volume":"29 4","pages":"329-334"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12435255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145088016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Features of Vulvodynia Associated With Ehlers-Danlos Syndrome.","authors":"Lisa M Bird, Veronica R Olaker, Rachel J Pope","doi":"10.1097/LGT.0000000000000903","DOIUrl":"10.1097/LGT.0000000000000903","url":null,"abstract":"<p><strong>Objectives: </strong>The purpose of this study was to identify factors with uniquely high prevalence in vulvodynia-Ehlers-Danlos syndrome comorbid patients in order to identify patients who may need referral and to better understand management of this population.</p><p><strong>Methods: </strong>This cross-sectional study was conducted in January 2025 using the TriNetX Platform Global Collaborative Network Database with statistical comparison of vulvodynia-Ehlers-Danlos comorbid cohort and vulvodynia non-Ehlers-Danlos cohort. Bonferroni correction was performed due to analysis of 100 demographic, associated condition, and treatment factors with statistical significance at p = .0005.</p><p><strong>Results: </strong>Five hundred seventy vulvodynia-Ehlers-Danlos patients and 49,457 vulvodynia non-Ehlers-Danlos patients were identified with a mean age of 39 and 48 ( p < .0001), respectively. Vulvodynia-Ehlers-Danlos comorbid patients had more frequent chronic pain, musculoskeletal, neurologic, gynecologic, immune, and psychiatric conditions. Vulvodynia-Ehlers-Danlos patients had higher rates of most nonsurgical interventions but similar vaginal estrogen ( p = .0412) and vulvar surgery rates ( p = .4249). Vulvodynia-Ehlers-Danlos patients had signs of more frequent medical contact with more post-op visits, vaccines, and inpatient admissions ( p < .0001). Study limitations are those inherent to the TriNetX database, with ability to see associations but not causation.</p><p><strong>Conclusions: </strong>Clinicians treating genital pain have a role in the treatment of vulvodynia-Ehlers-Danlos patients given the array of prevalent pelvic conditions. Clinicians should keep the high rate of muscular, neurologic, and immune conditions in mind when evaluating the vulvodynia etiology in this population, as well as the higher rate of gynecologic comorbidities, which could result in hormone-mediated etiology from chronic estrogen use. With a higher rate of mood disorders, mental health inquiry is also important.</p>","PeriodicalId":50160,"journal":{"name":"Journal of Lower Genital Tract Disease","volume":" ","pages":"376-379"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144592819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Joyce Zhang, Kuang-Yi Wen, Jessica Liang, Victoria Diamond, Sandra Dayaratna
{"title":"Feasibility and Acceptability of Human Papillomavirus Based Self-sampling in Underserved Minorities in the United States: A Scoping Review.","authors":"Joyce Zhang, Kuang-Yi Wen, Jessica Liang, Victoria Diamond, Sandra Dayaratna","doi":"10.1097/LGT.0000000000000907","DOIUrl":"10.1097/LGT.0000000000000907","url":null,"abstract":"<p><strong>Objective: </strong>The aim of the review evaluates the feasibility and acceptability of human papillomavirus (HPV) self-sampling in underscreened communities to increase cervical cancer screening rates in the United States.</p><p><strong>Methods: </strong>Database searches were conducted on PubMed, CINAHL, MEDLINE, CENTRAL, and ClinicalTrials.gov using the following search terms: HPV or human papillomavirus viruses, self-sampling, self-swabbing, or self-collection, acceptability, feasibility, and United States. The study aims to identify factors related to the feasibility and acceptability of HPV self-sampling uptake.</p><p><strong>Results: </strong>Sixteen studies were included in this scoping review. Most studies reviewed associated factors, such as demographic data (age and ethnicity), and socioeconomic data (income, education level, and insurance status). There was a higher HPV self-sampling rate (75%-100%) in the 11 studies where there was an in-person component including completing self-sampling kits in-person after recruitment, scheduled appointments or education sessions compared with studies where kits were returned by mail (3%-93%). Eleven studies measured acceptability and/or feasibility, and subjects reported the self-sampling process and devices were acceptable and easy to use. Of the 11 that measured feasibility and acceptability, 3 studies noted that the majority preferred self-sampling over clinician-collected Pap tests. Six studies incorporated community health worker-led education prior to distributing self-sampling kits, and improved attitudes toward self-sampling. Two studies evaluated the incidence of abnormal results between self-sampling and clinician-collected Pap test and found no difference.</p><p><strong>Conclusions: </strong>HPV self-sampling is seen as an acceptable and feasible option for cervical cancer screening for underscreened individuals. Furthermore, patient-facing education components led by community health workers greatly influenced participants' decision to self-sample.</p>","PeriodicalId":50160,"journal":{"name":"Journal of Lower Genital Tract Disease","volume":" ","pages":"348-358"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144976097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anisha V Patel, Waveley Qiu, Rita Sartor, Maya Wilcox, Beth A Jones, Raul U Hernandez-Ramirez, Wanyi Tang, Sarah Megiel, Abigail Girgis, Jaime Foster, Guangyu Tong, Donna Spiegelman, Sangini S Sheth
{"title":"Factors Associated With Timely Receipt of Colposcopy After Abnormal Cervical Cancer Screening.","authors":"Anisha V Patel, Waveley Qiu, Rita Sartor, Maya Wilcox, Beth A Jones, Raul U Hernandez-Ramirez, Wanyi Tang, Sarah Megiel, Abigail Girgis, Jaime Foster, Guangyu Tong, Donna Spiegelman, Sangini S Sheth","doi":"10.1097/LGT.0000000000000905","DOIUrl":"10.1097/LGT.0000000000000905","url":null,"abstract":"<p><strong>Objective: </strong>The aim of the study was to examine factors associated with timely colposcopy following abnormal cervical cancer screening among patients receiving care at an urban safety-net obstetrics and gynecology clinic.</p><p><strong>Methods: </strong>In this cohort study, the authors reviewed the care cycle of index abnormal cervical cancer screening requiring colposcopy follow-up from 3 separate years: 2016, 2018, and 2021. Primary outcomes included colposcopy attendance and timely colposcopy evaluation based on established guidelines. Multivariable log binomial regression models were used to evaluate patient characteristics and outcomes.</p><p><strong>Results: </strong>Across the 3 years, the authors identified 820 abnormal cervical cancer screening results from 752 patients for which a colposcopy was indicated. Of these patients, 42.2% identified as non-Hispanic Black, 79.7% were English-speaking, and 80.0% were publicly insured. Pap tests requiring colposcopy resulted in completion 85.2% of the time, with 59.8% completed within guideline-concordant intervals. Human papillomavirus-vaccinated patients were less likely to attend colposcopy (relative risk [RR] = 0.84, 95% confidence interval [CI] = 0.76-0.93). Current smokers had lower colposcopy attendance compared to never-smokers (RR = 0.89, 95% CI = 0.81-0.98). Timely colposcopy took place 59.6% of the time in 2016, 56.9% of the time in 2018, and 63.3% of the time in 2021. Patients aged 40-49 and 50-64 were more likely to complete colposcopy within guideline recommended intervals than those younger than age 30 (RR = 1.23, 95% CI = 1.03-1.47; RR = 1.38, 95% CI = 1.15-1.66).</p><p><strong>Conclusions: </strong>Despite modest overall improvement in the rate of guideline-concordant colposcopy attendance, significant gaps in timely follow-up persist. Targeted interventions are needed to improve follow-up care, particularly for younger patients and smokers.</p>","PeriodicalId":50160,"journal":{"name":"Journal of Lower Genital Tract Disease","volume":" ","pages":"320-328"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144592818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rafaela Germano Toledo, Yasmin Dias, Rafael R H Martin, Michele R Hacker, Andrew Wiechert, Huma Farid
{"title":"General Versus Local Anesthesia in Loop Electrosurgical Excision Procedures: A Systematic Review and Meta-Analysis.","authors":"Rafaela Germano Toledo, Yasmin Dias, Rafael R H Martin, Michele R Hacker, Andrew Wiechert, Huma Farid","doi":"10.1097/LGT.0000000000000906","DOIUrl":"10.1097/LGT.0000000000000906","url":null,"abstract":"<p><strong>Objective: </strong>Loop electrosurgical excision (LEEP) is the standard of care for high-grade cervical intraepithelial neoplasia. The primary aim of this study was to compare patient-reported outcomes among patients who received local anesthesia (LA) during LEEP with those who received GA.</p><p><strong>Methods: </strong>PubMed, Embase, and Cochrane databases were searched for studies comparing GA with LA in LEEP. Primary outcomes were postprocedure pain and satisfaction, including the likelihood of choosing the same anesthesia method again. Statistical analysis used Review Manager 5.4, heterogeneity was assessed with I2 , and a random-effects model was applied.</p><p><strong>Results: </strong>Six studies (2,169 patients; 1,536 LA, 633 GA) met inclusion criteria. Postprocedure pain was slightly lower with GA than LA (standardized mean difference: -0.49, 95% CI = -1.88, 0.89), but this was not statistically significant. Satisfaction was higher for GA (odds ratio: 1.62; 95% CI = 0.94, 2.79), though not significantly. GA patients had larger cone volumes (mean difference: 0.46 cm 3 ; 95% CI = 0.29, 0.62), and deeper excisions, though depth was not statistically significant (mean difference: 0.75 mm; 95% CI = -0.23, 1.74).</p><p><strong>Conclusions: </strong>While GA was associated with minimally lower pain and greater satisfaction, these differences were not statistically or clinically meaningful. GA was also linked to larger cone volumes, potentially increasing risks for future pregnancies. Given the higher risks and costs of GA, LA may be preferable for LEEP.</p>","PeriodicalId":50160,"journal":{"name":"Journal of Lower Genital Tract Disease","volume":" ","pages":"359-364"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144651108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Havva Gökce Terzioglu, Alessa Aragao, Julieta E Barroeta
{"title":"Expertise in Gynecological Pathology Impacts Diagnosis of Atypical Glandular Cell Category in Cervical Cytology.","authors":"Havva Gökce Terzioglu, Alessa Aragao, Julieta E Barroeta","doi":"10.1097/LGT.0000000000000912","DOIUrl":"10.1097/LGT.0000000000000912","url":null,"abstract":"<p><strong>Objectives: </strong>The Pap test is effective for detecting squamous neoplasia, but the interpretation of atypical glandular cell (AGC) remains challenging because of its rarity, complex cytologic features, and interobserver variability. Although AGC represents a small proportion of Pap test diagnoses, it often leads to extensive follow-up. This study aimed to assess whether gynecologic pathology expertise improves diagnostic accuracy and reduces unnecessary interventions in AGC interpretation.</p><p><strong>Methods: </strong>A retrospective review of AGC cases diagnosed between 2014 and 2024 at the authors' institution was conducted. Among 107,615 Pap smears, 301 (0.28%) were initially classified as AGC. Of these, 221 had slides available for review, and 184 had adequate histologic follow-up. Cases were re-evaluated by a cytopathologist with additional gynecologic pathology training, blinded to clinical information, and reclassified according to the Bethesda System.</p><p><strong>Results: </strong>Reclassification identified 62 cases as AGC, 1 as adenocarcinoma in situ, and 4 as adenocarcinoma. The remaining 117 cases were reassigned to other diagnostic categories. The malignancy rate increased from 39.1% to 53.9%, and the positive predictive value for significant histologic findings was 59.7%. Cytology-histology concordance improved from 26.6% to 64.1% ( p = .002).</p><p><strong>Conclusions: </strong>Gynecologic pathology expertise enhanced the diagnostic accuracy of AGC, improved malignancy detection, and significantly increased cytohistologic correlation. While decreasing sensitivity, it increases positive predictive value of AGC interpretation. These findings highlight the value of specialized training and the need for a specific, criteria-based approach to minimize unnecessary follow-up and optimize patient care.</p>","PeriodicalId":50160,"journal":{"name":"Journal of Lower Genital Tract Disease","volume":" ","pages":"297-303"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144975936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ana Carolina Simões, Ayane Cristine Sarmento, Antonio Carlos Aquino, José Eleutério-Jr, Isabel Cristina do Val Guimarães, Megan L Falsetta, Ana Katherine Gonçalves
{"title":"Treatment Interventions for Usual-Type Vulvar Intraepithelial Neoplasia: A Systematic Review and Meta-analysis.","authors":"Ana Carolina Simões, Ayane Cristine Sarmento, Antonio Carlos Aquino, José Eleutério-Jr, Isabel Cristina do Val Guimarães, Megan L Falsetta, Ana Katherine Gonçalves","doi":"10.1097/LGT.0000000000000901","DOIUrl":"10.1097/LGT.0000000000000901","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to evaluate the efficacy of treatments for usual-type vulvar intraepithelial neoplasia (uVIN).</p><p><strong>Methods: </strong>This review followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, searching PubMed, Embase, Scopus, Web of Science, the Cochrane Central Register of Controlled Trials, PsycINFO, and Clinical Trial Databases in July 2024. Clinical trials comparing treatments for uVIN to a placebo or other treatments were included. The risk of bias was assessed using the Cochrane Risk of Bias (RoB 2.0) tool, and the strength of evidence was evaluated using the GRADE approach.</p><p><strong>Results: </strong>Out of 10,306 studies, 8 met the inclusion criteria. A meta-analysis of 2 studies comparing imiquimod 5% to placebo found that 55.3% of women in the imiquimod group experienced total lesion resolution, compared to 0% in the placebo group (risk ratio = 18.21, 95% CI = 2.60-127.69). Cidofovir 1% had a complete response rate of 41%, while imiquimod 5% showed a 42% response. Imiquimod 5% was well-tolerated and showed a trend toward noninferiority to surgical treatments. Ultrasonic surgical aspiration is less scary than CO 2 laser vaporization, with similar efficacy. Sinecatechins 10% showed lesion improvement in the best observed clinical response compared to those in the placebo group ( p = .002), while indole-3-carbinol and Omiganan were ineffective despite adherence to treatment protocols.</p><p><strong>Conclusions: </strong>Imiquimod 5% is an effective treatment for uVIN with comparable results to surgery. Cidofovir 1% is another effective option. Less invasive treatments are beneficial for multifocal or extensive lesions but combining medical and surgical approaches has not been studied.</p>","PeriodicalId":50160,"journal":{"name":"Journal of Lower Genital Tract Disease","volume":" ","pages":"365-372"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144235756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vibe Munk Bertelsen, Berit Bargum Booth, Mette Tranberg, Christina Blach Kristensen, Mary Holten Bennetsen, Lone Kjeld Petersen, Pinar Bor
{"title":"Dynamic Spectral Imaging and Regular Colposcopy in CIN2+ Detection for HPV-Positive and/or Low-Grade Cytology Referrals.","authors":"Vibe Munk Bertelsen, Berit Bargum Booth, Mette Tranberg, Christina Blach Kristensen, Mary Holten Bennetsen, Lone Kjeld Petersen, Pinar Bor","doi":"10.1097/LGT.0000000000000910","DOIUrl":"10.1097/LGT.0000000000000910","url":null,"abstract":"<p><strong>Objectives: </strong>Dynamic Spectral Imaging colposcopy (DSI), an AI-driven technology, may improve cervical cancer diagnostics. This study aimed to evaluate the cervical intraepithelial neoplasia grade 2 or worse (CIN2+) sensitivity of DSI compared to regular colposcopy in individuals referred due to human papillomavirus (HPV)-positive and/or low-grade cytology.</p><p><strong>Methods: </strong>This multicenter comparative cross-sectional study included individuals aged ≥18 years referred for colposcopy due to HPV positivity and/or low-grade cytology. Participants underwent either DSI or regular colposcopy. Colposcopists first identified the most suspicious area; in the DSI group, this was done before reviewing the DSI color map. The worst colored area was then selected, followed by additional biopsies. All participants had 4 cervical biopsies taken, with the most severe diagnosis as the gold standard. The primary outcome was CIN2+ detection sensitivity comparison between groups using a chi-square test.</p><p><strong>Results: </strong>A total of 411 individuals underwent examination with DSI and 308 had regular colposcopy. The sensitivity for detecting CIN2+ with DSI was 69.3% (95% CI = 61.2-76.7) with an average of 1.3 biopsies, comparable to the sensitivity of the regular group when 2 biopsies were taken (68.3%, 95% CI = 58.3-77.2). No significant sensitivity differences were observed between groups when 3 or 4 biopsies were combined.</p><p><strong>Conclusion: </strong>The DSI color map did not show a clinically significant improvement in CIN2+ detection sensitivity compared to regular colposcopy. However, multiple biopsies enhanced sensitivity and remained superior for CIN2+ detection in both colposcopy groups.</p>","PeriodicalId":50160,"journal":{"name":"Journal of Lower Genital Tract Disease","volume":" ","pages":"335-341"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12435238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144977122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jill T Shah, William Mark Richardson, Kaitlin Martins, Sophia Manduca, Dolly Taiwò, Rebecca Podolsky, Miriam Keltz Pomeranz, Alisa N Femia
{"title":"Potential Association Between Lichen Sclerosus and Breast Cancer: A Cross-sectional Study in All of Us Research Program.","authors":"Jill T Shah, William Mark Richardson, Kaitlin Martins, Sophia Manduca, Dolly Taiwò, Rebecca Podolsky, Miriam Keltz Pomeranz, Alisa N Femia","doi":"10.1097/LGT.0000000000000902","DOIUrl":"10.1097/LGT.0000000000000902","url":null,"abstract":"","PeriodicalId":50160,"journal":{"name":"Journal of Lower Genital Tract Disease","volume":" ","pages":"387-388"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144592820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}