Journal of Lower Genital Tract Disease最新文献_第2页

Workplace Human Papillomavirus Prevention Practices by Obstetrics and Gynecology Residents. 妇产科住院医师在工作场所预防人乳头瘤病毒的做法。

IF 2.1 4区医学

Journal of Lower Genital Tract Disease Pub Date : 2026-04-02 DOI: 10.1097/LGT.0000000000000948

Jasmine Eliwa, Patricia J Goedecke, Jim Wan, Alexa Swailes

引用次数: 0

Multicenter Evaluation of 2 Vaginal Self-Collection Devices for HPV Testing. 2种阴道自采集装置用于HPV检测的多中心评价。

IF 2.1 4区医学

Journal of Lower Genital Tract Disease Pub Date : 2026-04-01 DOI: 10.1097/LGT.0000000000000947

Shihai Huang, Kevin Nelson, Luciana Gentil, Yan Zhang, John Birdsall, Erika Herrero-Garcia, Danijela Lucic, Neelam Dhiman, Jacqueline X Emmons, Shiaolan Ho, Ekaterina Pestova, Klara Abravaya

{"title":"Multicenter Evaluation of 2 Vaginal Self-Collection Devices for HPV Testing.","authors":"Shihai Huang, Kevin Nelson, Luciana Gentil, Yan Zhang, John Birdsall, Erika Herrero-Garcia, Danijela Lucic, Neelam Dhiman, Jacqueline X Emmons, Shiaolan Ho, Ekaterina Pestova, Klara Abravaya","doi":"10.1097/LGT.0000000000000947","DOIUrl":"https://doi.org/10.1097/LGT.0000000000000947","url":null,"abstract":"Objective: This study evaluated the clinical performance of vaginal specimens collected using a new self-collection device and a well-established self-collection device, compared with cervical specimens collected by clinicians for HPV detection.Methods: A total of 1,763 women undergoing routine cervical screening or referred to colposcopy provided self-collected vaginal specimens, using simpli-COLLECT HPV swab (SCS) and Evalyn Brush (EB), and one clinician-collected (CC) cervical specimen. Specimens were tested with the Alinity m HR HPV assay, and the results were used to determine positive and negative percent agreement (PPA and NPA), relative clinical sensitivity and specificity.Results: For the combined populations (screening and referred to colposcopy), PPA and NPA between SCS and CC specimens were 94.0% and 86.0%, respectively, and between EB and CC specimens were 94.2% and 88.4%, respectively. The PPA and NPA between SCS and EB vaginal specimens were 95.5% and 93.7%. The relative clinical sensitivity for ≥ CIN2 between vaginal specimens and CC specimens was 1.00 and 1.02 for SCS and EB, respectively. The relative clinical specificity between vaginal specimens and CC specimens was 0.90 and 0.92 for SCS and EB specimens, respectively.Conclusion: This study is among the first US multicenter evaluations comparing 2 self-collection devices on the same molecular platform. It demonstrated that the clinical sensitivity of the Alinity m HR HPV assay for cervical disease detection (≥ CIN2) using both SCS and EB self-collected vaginal specimens is comparable to that in CC specimens. Overall, HPV agreement rates were consistent with those reported for other validated self-collected devices.","PeriodicalId":50160,"journal":{"name":"Journal of Lower Genital Tract Disease","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147595939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physician Perspectives on the Transition to Primary Human Papillomavirus Testing for Cervical Cancer Screening. 医生对宫颈癌筛查过渡到原发性人乳头瘤病毒检测的看法。

IF 2.1 4区医学

Journal of Lower Genital Tract Disease Pub Date : 2026-03-16 DOI: 10.1097/LGT.0000000000000942

Peter W Ketch, Teresa K L Boitano, Norma A Longinos, Sellers A Swann, Christopher M Mayer, Warner K Huh, Isabel C Scarinci

{"title":"Physician Perspectives on the Transition to Primary Human Papillomavirus Testing for Cervical Cancer Screening.","authors":"Peter W Ketch, Teresa K L Boitano, Norma A Longinos, Sellers A Swann, Christopher M Mayer, Warner K Huh, Isabel C Scarinci","doi":"10.1097/LGT.0000000000000942","DOIUrl":"https://doi.org/10.1097/LGT.0000000000000942","url":null,"abstract":"Objective: To identify barriers and facilitators to transitioning to primary human papillomavirus (HPV) testing from current cervical cancer screening practices among community OB/GYN physicians.Methods: We conducted an exploratory qualitative study with in-depth interviews of 10 community-based OB/GYNs. Interviews were semistructured, utilizing an interview guide informed by the Consolidated Framework for Implementation Research, designed to explore current screening practices, perceptions of cytology versus primary HPV testing, recommended screening intervals, patient and physician acceptance of HPV-based testing, and anticipated changes in practice. Interviews were coded for recurring themes and organized into provider-, patient-, and system-level domains.Results: Identified barriers included interprovider variability in cervical cancer screening practices, fear of missing a cancer, concerns about loss of follow-up, patient preferences for more frequent screening, and talking about HPV with patients as a stressful/difficult process. Identified facilitators included awareness of possible upcoming changes in cervical cancer screening recommendations and previous adjustments in approach to cervical cancer screening.Conclusions: Transitioning to this evidence-based cervical cancer screening modality will require targeted, multilevel strategies to address physician concerns and to promote the acceptability and adoption of primary HPV testing.","PeriodicalId":50160,"journal":{"name":"Journal of Lower Genital Tract Disease","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147470055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Barriers to Cervical Cancer Screening Follow-up: A Study of an Inpatient Screening Program. 宫颈癌筛查随访的障碍：住院患者筛查项目的研究。

IF 2.1 4区医学

Journal of Lower Genital Tract Disease Pub Date : 2026-03-16 DOI: 10.1097/LGT.0000000000000943

Connie Cai, Lynn Richards-McDonald, Cornelia L Trimble

引用次数: 0

Integrating Cervical Cancer Screening Into Pre-existing, Low-resource Mexican-US Border Clinics. 将宫颈癌筛查整合到现有的、资源匮乏的美墨边境诊所。

IF 2.1 4区医学

Journal of Lower Genital Tract Disease Pub Date : 2026-03-16 DOI: 10.1097/LGT.0000000000000940

Kay Daniels, Michelle J Khan, Lynne Gaffikin, Rodolfo Alejandro Gonzalez Montoya, Paul D Blumenthal

引用次数: 0

Effectiveness of Qingdu Suppository on Persistent HR-HPV and Associated Factors: A Retrospective Study. 青毒栓治疗持续性HR-HPV的疗效及相关因素的回顾性研究。

IF 2.1 4区医学

Journal of Lower Genital Tract Disease Pub Date : 2026-03-04 DOI: 10.1097/LGT.0000000000000937

Xiaoye Qiao, Hanxue Fu, Weihua Geng, Jiaoying Lou

{"title":"Effectiveness of Qingdu Suppository on Persistent HR-HPV and Associated Factors: A Retrospective Study.","authors":"Xiaoye Qiao, Hanxue Fu, Weihua Geng, Jiaoying Lou","doi":"10.1097/LGT.0000000000000937","DOIUrl":"https://doi.org/10.1097/LGT.0000000000000937","url":null,"abstract":"Objectives: Persistent infection with high-risk human papillomavirus (HR-HPV) is a major cause of cervical precancerous lesions and cervical cancer. This study aimed to evaluate the effectiveness of Qingdu Suppository (QDS) in promoting HPV clearance and to identify predictors of treatment response.Methods: This was a prospective observational cohort with retrospective analysis. A total of 60 patients with persistent HR-HPV infection were included (30 QDS and 30 non-QDS). The primary endpoint was HPV clearance, defined as 2 consecutive negative PCR results ≥6 months apart. Intention-to-treat (ITT, n=66, with lost-to-follow-up treated as persistent infection) and per-protocol (PP, n=60) analyses were performed. Inverse probability of treatment weighting (IPTW) was applied, and robust (sandwich) variance estimators were used to obtain valid confidence intervals.Results: In the IPTW-weighted analysis, QDS was associated with higher HPV clearance than non-QDS (55.2% vs. 3.4%, p<.001). HPV clearance was significantly higher in the QDS group than in the non-QDS group (55.2% vs. 3.4%, p<.001). QDS remained an independent predictor of clearance (adjusted OR=33.1, 95% CI: 4.5-243.6, p=.001), with consistent benefits across subgroups.Conclusions: Using a strict endpoint of 2 consecutive negatives, QDS was associated with higher HPV clearance. Results were consistent across analytic approaches but should be interpreted with caution, given the limited sample size and nonrandomized design. QDS may represent a promising adjunctive therapy, but its efficacy and long-term benefits require confirmation in larger multicenter randomized controlled trials.","PeriodicalId":50160,"journal":{"name":"Journal of Lower Genital Tract Disease","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147357255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Association Between Vulvodynia and Subsequent Morbidity Across the Life Course. 外阴痛与生命过程中后续发病率的关系。

IF 2.1 4区医学

Journal of Lower Genital Tract Disease Pub Date : 2026-03-02 DOI: 10.1097/LGT.0000000000000939

Bernard L Harlow, Jane Yan, Hanna Mühlrad, Donghao Lu, Nina Bohm-Starke

{"title":"The Association Between Vulvodynia and Subsequent Morbidity Across the Life Course.","authors":"Bernard L Harlow, Jane Yan, Hanna Mühlrad, Donghao Lu, Nina Bohm-Starke","doi":"10.1097/LGT.0000000000000939","DOIUrl":"https://doi.org/10.1097/LGT.0000000000000939","url":null,"abstract":"Objective: Vulvodynia is chronic vulvar pain frequently associated with other comorbid chronic pain conditions. However, it is unclear whether women with vulvodynia experience higher rates of non-pain-related disorders after first onset of vulvar pain relative to unexposed women.Methods: Women born in Sweden between 1981 and 1996 were identified from Sweden's Medical Birth Register (N=832,276) and assigned \"exposed\" if diagnosed with localized provoked vulvodynia (n=4,787), vaginismus (n=2,063), or both (n=867) between 2001 and 2018. Two women with no vulvar pain were matched to women with vulvar pain by birth year and assigned a reference year aligned with women's vulvar pain diagnosis. We assessed the cumulative incidence of new-onset conditions 1 year or later after vulvodynia diagnosis and comparable time periods among unexposed women. We further assessed the risk difference among all new-onset global ICD-10-recorded diagnostic codes, and risk difference, relative risks, and attributable fraction among highly observed new-onset ICD-10 codes.Results: Among all ICD-10-coded global categories, we observed 4 to 5 more new-onset infectious disease codes (95% CI: 3.7-5.3) per 100 women, and 3 to 4 more new-onset global mental health (95% CI: 3.0-4.5), genital tract (2.6-4.5), and skin condition (95% CI: 2.7-4.2) codes per 100 women exposed to vulvar pain relative to those unexposed. New-onset conditions with the largest relative risks and attributable fractions included candidiasis, STDS, mood/anxiety disorders, dermatitis, and irregular menstruation.Conclusions: Women with vulvodynia may have a compromised immune system that increases the risk of a wide spectrum of other health-related conditions after a vulvodynia diagnosis.","PeriodicalId":50160,"journal":{"name":"Journal of Lower Genital Tract Disease","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147327962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Upadacitinib for the Treatment of Recalcitrant Vulvar Lichen Sclerosus. Upadacitinib治疗顽固性外阴硬化性地衣。

IF 2.1 4区医学

Journal of Lower Genital Tract Disease Pub Date : 2026-03-02 DOI: 10.1097/LGT.0000000000000941

Courtney M Kenyon, Jamie W Rhoads, Margaret M Cocks

引用次数: 0

Adherence to 2019 ASCCP Cervical Cancer Screening Guidelines at a Community Health Network. 在社区卫生网络中遵守2019年ASCCP宫颈癌筛查指南。

IF 2.1 4区医学

Journal of Lower Genital Tract Disease Pub Date : 2026-02-27 DOI: 10.1097/LGT.0000000000000938

Lindsey C Peck, Madeline C Petty, Allison R Walker, Sarah P Huepenbecker, Ashley B Graul

{"title":"Adherence to 2019 ASCCP Cervical Cancer Screening Guidelines at a Community Health Network.","authors":"Lindsey C Peck, Madeline C Petty, Allison R Walker, Sarah P Huepenbecker, Ashley B Graul","doi":"10.1097/LGT.0000000000000938","DOIUrl":"https://doi.org/10.1097/LGT.0000000000000938","url":null,"abstract":"Objective: We evaluated the adherence of cervical cancer screening (CCS) to ASCCP guidelines in the United States within a single hybrid community-academic institution.Methods: In this retrospective cohort study, pap smears from October 2022 through December 2023 were abstracted from the electronic medical record. Adherence with CCS was determined by collecting tests ordered, the interval between tests, and subsequent result management. The findings were classified as adherent (appropriate order, interval, and management) or nonadherent. Descriptive statistics were employed.Results: Three hundred and forty-eight pap smears were included; 225 (65%) were normal and 123 (35%) were abnormal. Two hundred thirty-two (67%) were nonadherent with ASCCP guidelines, while 116 (33%) were adherent. Of the nonadherent pap smears, 71 (31%) were ordered incorrectly, most commonly due to lack of HPV cotesting (87%); 190 (55%) were performed at an incorrect interval, most commonly due to an inappropriately short interval (89%); and 63 (18%) were managed inappropriately, most commonly due to lack of indicated colposcopy (57%) or unnecessary colposcopy (33%). Based on specific cytology results, overall adherence, appropriateness of interval, and order type did not vary between results (p=.18, p=.71, p=.23, respectively); however, the subsequent management was significantly different based on the cytology (p<.001). There were significant differences among provider type (p=.01) and practice (p<.001), but no difference by age, BMI, or medical comorbidity.Conclusions: In this cohort, the majority of pap smears were nonadherent, largely due to underutilization of HPV cotesting, overscreening, and lack of indicated colposcopy. With clear guidelines available, there is significant room for improvement.","PeriodicalId":50160,"journal":{"name":"Journal of Lower Genital Tract Disease","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147312040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinicopathologic Overlap of Vulvar Vitiligo With Lichen Sclerosus and Dermatitis. 外阴白癜风伴硬化地衣和皮炎的临床病理重叠。

IF 2.1 4区医学

Journal of Lower Genital Tract Disease Pub Date : 2026-01-01 Epub Date: 2025-11-12 DOI: 10.1097/LGT.0000000000000922

Jacqueline du Plessis, James Scurry, Christopher W Toon, Gayle Fischer, Hong Tran, Tania Day

{"title":"Clinicopathologic Overlap of Vulvar Vitiligo With Lichen Sclerosus and Dermatitis.","authors":"Jacqueline du Plessis, James Scurry, Christopher W Toon, Gayle Fischer, Hong Tran, Tania Day","doi":"10.1097/LGT.0000000000000922","DOIUrl":"10.1097/LGT.0000000000000922","url":null,"abstract":"Objectives: The aims of the study were to describe clinicopathologic features of vulvar biopsies diagnostic for vitiligo and assess the link between vitiligo and genital symptoms.Methods: The pathology database identified vulvar biopsies showing vitiligo, defined as absent or rare melanocytes on HMB-45, Sox-10, or Melan-A stains. Inclusion criteria were age 18 or over and availability of slides and medical records. Clinical data included demographics, comorbid conditions, symptoms, examination, treatment, and response. Histopathologic review documented site, epidermal characteristics, dermal collagen change, and lymphocytic infiltrate. Cases were stratified by histologic evidence of lichenoid dermatosis.Results: Vulvar biopsies demonstrated vitiligo in 36 women with a median age of 56 years. Simultaneous histologic diagnosis of lichen sclerosus (LS) or lichenoid dermatitis was present in 23 (64%). Seven (19%) showed otherwise normal skin, while 5 (14%) had lichen simplex chronicus and 1 (3%) had spongiotic dermatitis. Itch was more frequent in the lichenoid group [21/23 (91%) vs 6/13 (46%); p = .005], while asymptomatic status was more likely in the normal/dermatitis group [5/13 (38%) vs 2/23 (9%); p = .001]. Three of 7 (43%) women with isolated histologic vitiligo reported pain and/or itch; 2 of their clinicians provided topical steroid maintenance and follow-up for presumed LS. Of 19 women with histologic LS, 11 (58%) lacked basal layer degeneration, of whom 6 (54%) reported concurrent topical steroid or calcineurin inhibitor use.Conclusions: Symptomatic women with biopsy-proven vulvar vitiligo usually have an additional dermatologic condition, but histopathologic diagnosis of overlapping conditions is complicated by basal layer assessment and nonsclerotic LS.","PeriodicalId":50160,"journal":{"name":"Journal of Lower Genital Tract Disease","volume":"30 1","pages":"53-59"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145795288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0