Journal of Lower Genital Tract Disease最新文献_第9页

Clinical Characteristics and Detection Sensitivity of Cervical Cancer Screening in Vaginal Intraepithelial Neoplasia. 阴道上皮内瘤变中宫颈癌筛查的临床特征和检测灵敏度。

IF 3.7 4区医学

Journal of Lower Genital Tract Disease Pub Date : 2023-12-18 DOI: 10.1097/lgt.0000000000000793

Yusha Chen, Qiaoyun Chen, Huifeng Xue, Jinwen Zheng, Jiancui Chen, Xiangqin Zheng

引用次数: 0

Dequalinium Chloride for the Treatment of Vulvovaginal Infections: A Systematic Review and Meta-Analysis. 用于治疗外阴阴道感染的 Dequalinium Chloride：系统回顾与元分析》。

IF 3.7 4区医学

Journal of Lower Genital Tract Disease Pub Date : 2023-12-07 DOI: 10.1097/lgt.0000000000000790

Fanny Eckel, Alex Farr, Julia Deinsberger, Karin Kernmayer-Farr, Philipp Foessleitner

引用次数: 0

An Alternative to Cytology in Triaging Cisgender Men and Transgender Women With HIV for High-Resolution Anoscopy. 在对感染 HIV 的顺性别男性和变性女性进行高分辨率肛门镜检查时，细胞学检查的替代方法。

IF 3.7 4区医学

Journal of Lower Genital Tract Disease Pub Date : 2023-11-03 DOI: 10.1097/lgt.0000000000000773

Shane M Mudrinich, Minh Ly T Nguyen, Danielle M Blemur, Xinzhu Wang, Yun F Wang, Uma Krishnamurti, Marina Mosunjac, Lisa C Flowers

引用次数: 0

Incidence of Vulvar Lichen Sclerosus and of Cancer Among Vulvar Lichen Sclerosus Patients: Does Socioeconomic Status Have a Role? Vulvar Lichen sclerous和癌症在Vulvar sclerous患者中的发病率：社会经济状况有作用吗？

IF 3.7 4区医学

Journal of Lower Genital Tract Disease Pub Date : 2023-10-01 DOI: 10.1097/LGT.0000000000000767

Alessandro Borghi, Stefano Ferretti, Lucrezia Pacetti, Fabio Falcini, Monica Corazza

{"title":"Incidence of Vulvar Lichen Sclerosus and of Cancer Among Vulvar Lichen Sclerosus Patients: Does Socioeconomic Status Have a Role?","authors":"Alessandro Borghi, Stefano Ferretti, Lucrezia Pacetti, Fabio Falcini, Monica Corazza","doi":"10.1097/LGT.0000000000000767","DOIUrl":"https://doi.org/10.1097/LGT.0000000000000767","url":null,"abstract":"Objective: Socioeconomic status (SES) impacts on the incidence of many inflammatory diseases and cancers, but there is no evidence on its implication in vulvar lichen sclerosus (VLS). The authors aimed to assess possible associations between SES and both occurrence of VLS and cancer occurrence among VLS patients.Materials and methods: A retrospective cohort of women resident in the province of Ferrara, Italy, affected with VLS diagnosed between 2001 and 2020, was investigated for assessing any association of SES with VLS and cancer incidence. The SES was expressed through an ecological-based deprivation index identifying 5 subgroups.Result: Four-hundred women were diagnosed with VLS during the study period, with double the number of cases in the second decade (2011-2020) compared with the first (2001-2010). More VLS patients belonged to the high rather than the low SES groups (p = .032). From VLS diagnosis to 2018 (1,958.4 total person*years at risk), 22 patients received their first diagnosis of cancer, mainly the skin, breast, and vulva. No significant differences in cancer incidence were found between high/medium-high and low/medium-low SES subjects.Conclusions: The fact that more VLS patients belonged to the highest socioeconomic classes may be due to a more frequent diagnosis in those with greater health seeking behavior and resources. An involvement of SES-related factors in VLS pathophysiological background can also be taken into consideration. Both the lack of marked social and economic differences in the study area and the availability of free visits and screening may account for the lack of association between SES and cancer development.","PeriodicalId":50160,"journal":{"name":"Journal of Lower Genital Tract Disease","volume":"27 4","pages":"373-377"},"PeriodicalIF":3.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41180394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Commentary on New Guidance for Human Papillomavirus-Related Cancer Screening Among Sexual and Gender Minority Populations. 对性和性别少数群体中人类乳头瘤病毒相关癌症筛查新指南的评论。

IF 3.7 4区医学

Journal of Lower Genital Tract Disease Pub Date : 2023-10-01 DOI: 10.1097/LGT.0000000000000764

Sarah S Jackson, Karen L Parker

引用次数: 0

Optical Coherence Tomography Can Reduce Colposcopic Referral Rates in Patients With High-Risk Human Papillomavirus. 光学相干断层扫描可以降低高危人类乳头瘤病毒患者的阴道镜转诊率。

IF 3.7 4区医学

Journal of Lower Genital Tract Disease Pub Date : 2023-10-01 Epub Date: 2023-05-03 DOI: 10.1097/LGT.0000000000000746

Xiao Xiao, Lei Yan, Xue Yang, Zhixian Zhou, Liye Shi, Chun Fu

{"title":"Optical Coherence Tomography Can Reduce Colposcopic Referral Rates in Patients With High-Risk Human Papillomavirus.","authors":"Xiao Xiao, Lei Yan, Xue Yang, Zhixian Zhou, Liye Shi, Chun Fu","doi":"10.1097/LGT.0000000000000746","DOIUrl":"10.1097/LGT.0000000000000746","url":null,"abstract":"Objective: This study aimed to evaluate the feasibility of combined human papillomavirus (HPV) and optical coherence tomography (OCT) cervical cancer screening strategies.Materials and methods: The OCT and cytology results were compared with the pathological results to calculate the sensitivity, specificity, positive predictive value, negative predictive value, and immediate cervical intraepithelial neoplasia grade 3 or worse (CIN3+) risk. The authors compared the efficiency of colposcopy by using different triage strategies. They discussed differentiation in OCT screening in different age groups.Results: Eight hundred thirteen participants with high-risk HPV-positive and cervical cytology results underwent OCT before colposcopy between March 1 and October 1, 2021. The HPV16/18 genotyping with OCT triage has a specificity of CIN3+ lesions (61.1%; 95% CI = 57.6%-64.6%), intraepithelial neoplasia grade 2 or worse (CIN2+) (66.0%; 95% CI = 62.4%-69.6%). The HPV16/18 genotyping with cytology triage has a specificity of CIN3+ (44.0%; 95% CI = 40.4%-47.6%), CIN2+ (47.0%; 95% CI = 43.2%-50.8%). The OCT triage has a higher positive predictive value compared with the cytology, with a significant difference in CIN2+ lesions (45.0%; 95% CI = 38.8%-51.3% vs 29.2%; 95% CI = 24.7%-33.7%).Conclusions: The combination of OCT and high-risk HPV triage (both genotyping and nongenotyping) had a similar immediate CIN3+ risk stratification and reduced the number of colposcopies compared with the cytological triage strategy.","PeriodicalId":50160,"journal":{"name":"Journal of Lower Genital Tract Disease","volume":" ","pages":"324-330"},"PeriodicalIF":3.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9498268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comorbidities in Male Patients With Lichen Sclerosus: A Case-Control Study. 男性硬化性苔藓患者合并症的病例对照研究。

IF 3.7 4区医学

Journal of Lower Genital Tract Disease Pub Date : 2023-10-01 DOI: 10.1097/LGT.0000000000000769

Niina K Hieta, Marjut A M Haataja, Lotta Tapana

{"title":"Comorbidities in Male Patients With Lichen Sclerosus: A Case-Control Study.","authors":"Niina K Hieta, Marjut A M Haataja, Lotta Tapana","doi":"10.1097/LGT.0000000000000769","DOIUrl":"https://doi.org/10.1097/LGT.0000000000000769","url":null,"abstract":"Objective: Lichen sclerosus (LS) is a chronic inflammatory skin disease. In male patients, it usually involves the glans penis and foreskin and can cause phimosis or meatal stenosis. The aim of this cross-sectional case-control study was to identify clinically important comorbidities in male patients with LS.Materials and methods: By searching Turku University Hospital electronic health records, the authors identified 630 male patients diagnosed with LS between 2004 and 2020. To investigate possible comorbidities, the authors compared this patient group to a 10-fold larger control group.Results: The incidence of LS increased during the study period, from 5 to 27.5 per 100,000 men. Patients were most often diagnosed at 21 to 25 years of age. Patients with LS exhibited markedly increased risks of penile carcinoma (odds ratio [OR], 81.0; 95% CI = 10.82-3516.7; p < .001) and carcinoma in situ of the penis (OR = 60.5; 95% CI = 7.32-2738.9; p < .001). Patients also more commonly exhibited lichen planus (OR = 16.8; 95% CI = 8.97-32.39; p < .001), psoriasis (OR = 3.3; 95% CI = 1.80-5.70; p = .004), angina pectoris (OR = 1.8; 95% CI = 1.10-2.81; p = .013), obesity (OR = 2.6; 95% CI = 1.72-3.77; p < .001), type 2 diabetes (OR = 2.3; 95% CI = 1.74-3.09; p < .001), and hypertension (OR = 1.9; 95% CI = 1.53-2.37; p < .001). The most commonly performed urological procedures were operation for phimosis, uroflowmetry, and ultrasound measurement of residual urine.Conclusions: Genital malignancies, other dermatological conditions, and diseases related to metabolic syndrome should be considered when treating patients with LS.","PeriodicalId":50160,"journal":{"name":"Journal of Lower Genital Tract Disease","volume":"27 4","pages":"378-383"},"PeriodicalIF":3.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10545057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41156599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plasma Cell Vulvitis: A Classification Into Two Clinical Phenotypes. 浆细胞性外阴炎：分为两种临床表型。

IF 3.7 4区医学

Journal of Lower Genital Tract Disease Pub Date : 2023-10-01 DOI: 10.1097/LGT.0000000000000771

Jeanne Wendling, Françoise Plantier, Micheline Moyal-Barracco

{"title":"Plasma Cell Vulvitis: A Classification Into Two Clinical Phenotypes.","authors":"Jeanne Wendling, Françoise Plantier, Micheline Moyal-Barracco","doi":"10.1097/LGT.0000000000000771","DOIUrl":"https://doi.org/10.1097/LGT.0000000000000771","url":null,"abstract":"Objective: The etiology of plasma cell vulvitis (PCV) is debated. The authors aimed to test the hypothesis that PCV could be divided into 2 clinical phenotypes.Methods: Patients with a clinico-pathological diagnosis of PCV and with available vulvar photos seen in a vulvar clinic were retrospectively studied. The cases of PCV were divided into 2 groups: non-lichen-associated (primary PCV) and lichen-associated (secondary PCV). The 2 groups were compared in terms of age, menopausal status, location of the PCV, and 12 histologic parameters (Fisher exact test, p < .05).Results: Thirty-five patients (20 primary and 15 secondary PCV) were included. The 2 groups did not differ in terms of age (mean, 65; range, 50-85) or menopausal status. Primary PCV was located exclusively on the vestibule for 19/20 patients, whereas secondary PCV was extravestibular for 14 of 15 patients, either exclusively (2) or both extravestibular and vestibular (12). One patient with secondary PCV had solely vestibular involvement. Five histological features were observed significantly more often in case of secondary PCV: epidermal atrophy, parakeratosis, dermal and epidermal neutrophils, and dermal eosinophils.Conclusions: Plasma cell vulvitis can be divided clinically into 2 phenotypes. Primary non-lichen-associated PCV is restricted to the vestibule and could be the vulvar counterpart of atrophic vaginitis. Secondary lichen-associated PCV is both extravestibular and vestibular, and its clinical and histological features should be looked for outside the PCV areas. This division of PCV into 2 clinical phenotypes could have therapeutic implications.","PeriodicalId":50160,"journal":{"name":"Journal of Lower Genital Tract Disease","volume":"27 4","pages":"384-389"},"PeriodicalIF":3.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41153556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fat Grafting in Vulvar Lichen Sclerosus: Long Term Follow-Up. 秃发性硬化性地衣的脂肪移植：长期随访。

IF 2.4 4区医学

Journal of Lower Genital Tract Disease Pub Date : 2023-10-01 Epub Date: 2023-08-07 DOI: 10.1097/LGT.0000000000000766

Veronica Boero, Massimiliano Brambilla, Eugenia Di Loreto, Giulia Emily Cetera, Sonia Cipriani, Francesca Boggio, Ermelinda Monti, Giada Libutti, Carlotta Caia, Fabio Parazzini

{"title":"Fat Grafting in Vulvar Lichen Sclerosus: Long Term Follow-Up.","authors":"Veronica Boero, Massimiliano Brambilla, Eugenia Di Loreto, Giulia Emily Cetera, Sonia Cipriani, Francesca Boggio, Ermelinda Monti, Giada Libutti, Carlotta Caia, Fabio Parazzini","doi":"10.1097/LGT.0000000000000766","DOIUrl":"10.1097/LGT.0000000000000766","url":null,"abstract":"Objective: The rationale for the use of autologous fat grafting in the treatment of vulvar lichen sclerosus (VLS) consists in reduction of inflammation, regeneration of tissues, volume increase, and pain fiber control. The main outcome of this study was the evaluation of patients' satisfaction after treatment. Secondary outcomes included modifications in symptoms, psychosexual wellbeing, vulvar hydration, and histology after surgery.Methods: Eligible for this study were women aged 18-85 years with a histological diagnosis of VLS who underwent at least one autologous vulvar fat grafting at the authors' center, between 2010 and 2019. In 2021, all women underwent a clinical reevaluation, comprehensive of vulvoscopy, vulvar biopsy, and handing out of validated questionnaires.Results: Overall, 88.7% of patients declared themselves very satisfied/satisfied with the procedure. All symptoms were improved postsurgery; in particular, the difference was statistically significant for pruritus, burning, and dyspareunia ( p < .05). Sexual function was also improved at time of reevaluation, as were depressive and anxiety symptoms ( p < .05). No cases of vulvar intraepithelial neoplasia or cancer occurred during follow-up and vulvar architecture remained stable, although patients reported a significantly reduced need for topical steroids ( p < .0001). Lastly, in postoperative biopsies, inflammatory infiltrate was stable or reduced, and the distribution of elastic fibers was comparable or restored in most patients.Conclusions: Patient satisfaction with fat grafting is detectable up to 11 years after surgery, and as such, it may represent a valid therapeutic option in selected cases of VLS.","PeriodicalId":50160,"journal":{"name":"Journal of Lower Genital Tract Disease","volume":" ","pages":"365-372"},"PeriodicalIF":2.4,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10310709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nonsclerotic Lichen Sclerosus: Definition of a Concept and Pathologic Description. 非硬化性硬化性地衣：一个概念的定义和病理学描述。

IF 3.7 4区医学

Journal of Lower Genital Tract Disease Pub Date : 2023-10-01 Epub Date: 2023-07-19 DOI: 10.1097/LGT.0000000000000760

Tania Day, M Angelica Selim, Jill I Allbritton, James Scurry

{"title":"Nonsclerotic Lichen Sclerosus: Definition of a Concept and Pathologic Description.","authors":"Tania Day, M Angelica Selim, Jill I Allbritton, James Scurry","doi":"10.1097/LGT.0000000000000760","DOIUrl":"10.1097/LGT.0000000000000760","url":null,"abstract":"Objective: Nonsclerotic lichen sclerosus (NSLS) refers to the clinicopathologic situation of examination findings consistent with lichen sclerosus (LS) but without dermal sclerosis on microscopy. This review aims to describe the features of NSLS and provide a classification framework.Methods: The International Society of the Study of Vulvovaginal Diseases tasked the Difficult Pathologic Diagnoses Committee with development of consensus documents for conditions with problematic histopathology. The Difficult Pathologic Diagnoses Committee reviewed the literature on NSLS and formulated descriptions and diagnostic criteria, then approved by the International Society of the Study of Vulvovaginal Diseases membership.Results: Nonsclerotic LS may be categorized into 4 histopathologic subtypes: lichenoid dermatitis, hypertrophic lichenoid dermatitis, dermal fibrosis without acanthosis, and dermal fibrosis with acanthosis. Each has a pathologic differential diagnosis of 1 or more entities, so clinical correlation is required for final diagnosis of LS. There is no evidence to support a reliable association between absent sclerosis and clinical appearance, duration, or oncogenic potential of LS.Conclusions: Pathologists and clinicians should be familiar with the concept of NSLS and its implications for patient management. Use of the term \"early LS\" to indicate a lack of sclerosis in presumed LS should be abandoned. Clinical correlation is required to confirm LS from among the differential diagnoses.","PeriodicalId":50160,"journal":{"name":"Journal of Lower Genital Tract Disease","volume":" ","pages":"358-364"},"PeriodicalIF":3.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8e/85/jlgtd-27-358.PMC10545066.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9837693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0