Journal of Lower Genital Tract Disease最新文献_第7页

Development and Effectiveness of a Mobile Application for Vulvar Self-examination: A Quasi-Experimental Study. 外阴自我检查移动应用程序的开发和有效性：一项准实验研究。

IF 2.4 4区医学

Journal of Lower Genital Tract Disease Pub Date : 2024-10-01 DOI: 10.1097/LGT.0000000000000835

Tuğba Dündar, Hilmiye Aksu, Emine Gerçek Öter, Belma Toptaş Acar, Sevgi Özsoy

{"title":"Development and Effectiveness of a Mobile Application for Vulvar Self-examination: A Quasi-Experimental Study.","authors":"Tuğba Dündar, Hilmiye Aksu, Emine Gerçek Öter, Belma Toptaş Acar, Sevgi Özsoy","doi":"10.1097/LGT.0000000000000835","DOIUrl":"https://doi.org/10.1097/LGT.0000000000000835","url":null,"abstract":"Objective: The aim of this study was to develop a mobile application for vulvar self-examination and to examine its effect on performing vulvar self-examination.Materials and methods: This is a quasi-experimental study. Forty-seven women accepted to participate. The mobile application was uploaded to the women's phones and the women's vulvar self-examination practices were followed through the application for 6 months. Obtained data were analyzed with descriptive statistics and the McNemar's test.Results: The mean age of the participants was 35.34 ± 9.85 years. Initially, out of all the participants, none performed vulvar self-examination, 95.7% did not regularly have their yearly gynecological examination, 29% did not have pap smear, and 91.5% had no information about vulvar self-examination. In the third month after the mobile application was downloaded, 68.1% were performing vulvar self-examination and this percentage decreased to 57.4% in the sixth month without a significant difference (p < .05). The women reported that they had difficulty in performing the examination in the first follow-up and did not have time to do it in the second follow-up.Conclusions: The mobile application increased the rate of examination, and there was no significant difference in the number of the women performing the examination between the follow-ups.","PeriodicalId":50160,"journal":{"name":"Journal of Lower Genital Tract Disease","volume":"28 4","pages":"365-370"},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mycoplasma genitalium 's Antibiotic Resistance in Sexually Transmitted Infections Clinics in Israel. 以色列性传播感染诊所中生殖器支原体的抗生素耐药性。

IF 2.4 4区医学

Journal of Lower Genital Tract Disease Pub Date : 2024-10-01 Epub Date: 2024-07-09 DOI: 10.1097/LGT.0000000000000828

Maya Azrad, Nora Saleh, Inbar Yorish Zur, Daniella Becker, Noga Shiloah, Sonia Habib, Avi Peretz

{"title":"Mycoplasma genitalium 's Antibiotic Resistance in Sexually Transmitted Infections Clinics in Israel.","authors":"Maya Azrad, Nora Saleh, Inbar Yorish Zur, Daniella Becker, Noga Shiloah, Sonia Habib, Avi Peretz","doi":"10.1097/LGT.0000000000000828","DOIUrl":"10.1097/LGT.0000000000000828","url":null,"abstract":"Objectives: To determine the prevalence of antibiotic resistance rate in Mycoplasma genitalium, and distribution of mutations associated with this resistance, among patients that attended sexually transmitted infections (STI) investigation clinics.Materials and methods: This cross-sectional study included M. genitalium -positive samples (urine, vaginal, rectal, and pharyngeal swabs) collected from 170 patients attending two STI investigation clinics, which were subjected to macrolide and quinolone resistance mutations analyses. Data regarding patient age, sex, and material/anatomical site of testing were collected.Results: Macrolide-resistance mutations were identified in 48.8% of samples and were more common among males ( p < .0001) and in rectal samples ( p < .05). A2059C was the most prevalent macrolide-resistance mutation (18.2%). Quinolone resistance was detected in 23% of the samples, with S83I being the most common (17.1%) mutation. Rate of co-resistance to macrolides and quinolones was 21.2%.Conclusions: The high rate of antibiotic resistance found in the current study, especially to macrolides, underscores the importance of antibiotic resistance monitoring in M. genitalium isolates in cases of persistent or recurrent urethritis/cervicitis, in cases of treatment failure and among specific populations. Such surveillance will improve treatment regimens and cure rates.","PeriodicalId":50160,"journal":{"name":"Journal of Lower Genital Tract Disease","volume":" ","pages":"356-359"},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141560177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Severe Vulvovaginal Candidiasis Associated With Sodium-Glucose Cotransporter 2 Inhibitor Use in Postmenopausal Women. 绝经后妇女使用钠-葡萄糖共转运体 2 抑制剂引发的严重外阴阴道念珠菌病

IF 2.4 4区医学

Journal of Lower Genital Tract Disease Pub Date : 2024-10-01 Epub Date: 2024-09-02 DOI: 10.1097/LGT.0000000000000839

Vera Y Miao, Marlene Wijaya, Gayle Fischer, Rebecca B Saunderson

{"title":"Severe Vulvovaginal Candidiasis Associated With Sodium-Glucose Cotransporter 2 Inhibitor Use in Postmenopausal Women.","authors":"Vera Y Miao, Marlene Wijaya, Gayle Fischer, Rebecca B Saunderson","doi":"10.1097/LGT.0000000000000839","DOIUrl":"10.1097/LGT.0000000000000839","url":null,"abstract":"Objective: The authors present a case series of severe vulvovaginal candidiasis in postmenopausal women using sodium-glucose cotransporter-2 inhibitor (SGLT2i) medications for the management of their diabetes mellitus.Materials and methods: Twenty-four cases from a private vulvovaginal specialist clinic are described.Results: All 24 patients were referred with severe and persistent vulvar pruritus, pain, and erythema. Examination findings varied between patients and included erythema, edema, erosions, adherent white discharge, and fissuring, which were extensive and often involved the mons pubis, labia majora, and extended to the perineum and perianal region, mimicking psoriasis and/or irritant dermatitis. The clinical presentation in this postmenopausal group hindered a timely diagnosis, resulting in a delay in appropriate management. Fortunately, all patients improved on oral antifungal treatment, and in those that ceased their SGLT2i medication, there was resolution of the condition.Conclusions: While candidiasis is reported to occur with SGLT2i, severe genital mycotic infections are not yet a well-recognized adverse effect and may be missed. The presentation in these cases was persistent and severe. Clinicians should have a high index of suspicion in postmenopausal women presenting with vulvar pain, pruritus, and extensive erythema that mimics psoriasis or irritant dermatitis, if they are on SGLT2i therapy.","PeriodicalId":50160,"journal":{"name":"Journal of Lower Genital Tract Disease","volume":" ","pages":"371-376"},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142114276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reduction in Unindicated Cervical Cancer Screening in Adolescents in a Large Health Care System. 减少大型医疗保健系统中青少年未指定的宫颈癌筛查。

IF 2.4 4区医学

Journal of Lower Genital Tract Disease Pub Date : 2024-10-01 Epub Date: 2024-07-23 DOI: 10.1097/LGT.0000000000000831

Bertie Geng, Carlos R Oliveira, Hillary Hosier, Sangini S Sheth, Alla Vash-Margita

{"title":"Reduction in Unindicated Cervical Cancer Screening in Adolescents in a Large Health Care System.","authors":"Bertie Geng, Carlos R Oliveira, Hillary Hosier, Sangini S Sheth, Alla Vash-Margita","doi":"10.1097/LGT.0000000000000831","DOIUrl":"10.1097/LGT.0000000000000831","url":null,"abstract":"Objectives: Evidence-based guidelines recommend against screening for cervical cancer (Pap testing) in average-risk adolescents <21 years old. Despite this, many still undergo unindicated screenings with subsequent detrimental reproductive health and economic consequences. The authors' aim was to reduce unindicated cervical cancer screening in individuals <21 years old in a large health care system by utilizing an electronic provider notification.Methods: Starting in July 2020, a Best Practice Advisory (BPA) appeared in the electronic medical record (EMR) if providers ordered Pap testing on individuals <21 years old. This BPA reiterated that screening was not indicated for average-risk adolescents and prompted users to choose an indication if they wanted to proceed. A retrospective chart review, pre/post intervention study was performed comparing individuals <21 years old with Pap testing performed before and after intervention (January 2019-June 2020 and July 2020-June 2021, respectively). Patient characteristics were extracted from the EMR and analyzed using Fisher exact tests, Kruskal-Wallis tests, and logistic regression.Results: There were 140 subjects included: 106 preintervention and 34 postintervention. There were no differences in baseline characteristics. Neither Pap nor human papillomavirus testing results differed between the groups. Preintervention, 6.6% of cytology tests were indicated compared to 20.6% postintervention ( p = .042). The proportion of indicated human papillomavirus testing did not differ preintervention and postintervention at 65% and 45%, respectively ( p = .295). The overall reduction in unindicated cervical cancer screening postintervention was 13.9% (95% CI = 4.0-23.7).Conclusions: The authors demonstrated that incorporating a BPA to the EMR reduces unindicated cervical cancer screening.","PeriodicalId":50160,"journal":{"name":"Journal of Lower Genital Tract Disease","volume":" ","pages":"345-350"},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141749473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Knowledge of the Human Papillomavirus Vaccine and Willingness to Accept Vaccination in the Postpartum Period. 对人类乳头状瘤病毒疫苗的了解以及产后接受疫苗接种的意愿。

IF 2.4 4区医学

Journal of Lower Genital Tract Disease Pub Date : 2024-10-01 Epub Date: 2024-07-26 DOI: 10.1097/LGT.0000000000000827

Nidhi Chawla, Jennifer Marshall, Alexandra Dubinskaya, Dorothy Wakefield, Jonathan Shepherd, Veronica Maria Pimentel

{"title":"Knowledge of the Human Papillomavirus Vaccine and Willingness to Accept Vaccination in the Postpartum Period.","authors":"Nidhi Chawla, Jennifer Marshall, Alexandra Dubinskaya, Dorothy Wakefield, Jonathan Shepherd, Veronica Maria Pimentel","doi":"10.1097/LGT.0000000000000827","DOIUrl":"10.1097/LGT.0000000000000827","url":null,"abstract":"Objectives: Human papillomavirus (HPV) vaccines prevent cervical cancer. The inpatient postpartum period presents a unique window for vaccination. The authors' study investigates HPV vaccine knowledge, barriers to vaccination, and willingness to get vaccinated during inpatient postpartum care.Materials and methods: The authors conducted a cross-sectional survey of 147 participants, age 18 to 26, who delivered at the authors' institution between November 1, 2019, and April 30, 2020. Participants completed a questionnaire that included demographics, vaccine knowledge, hesitancies, and willingness to vaccinate. The authors used descriptive statistics and compared groups with chi-square or Wilcoxon rank sum for categorical variables and t -test for continuous variables.Results: Of the 147 patients, 58 (39.46%) were fully vaccinated against HPV and 89 (60.54%) of participants were unvaccinated or partially vaccinated. There was a greater proportion of African American and Asian participants among unvaccinated women (28.1% vs 20.7% and 16.9% vs 1.7%, respectively). Most unvaccinated participants (52.9%) were willing to get vaccinated in the postpartum unit. Both vaccinated and unvaccinated groups were similarly aware that the HPV vaccine prevents cervical and oropharyngeal cancers and genital warts. The top barrier to future vaccination was forgetting to complete the vaccination series.Conclusions: Most women were not fully vaccinated but were willing to receive their first dose while in the postpartum unit. African American women were less likely to be vaccinated and expressed more unwillingness to accept vaccination. The authors identified barriers to HPV vaccination that can be tackled with the initiation of inpatient postpartum vaccination.","PeriodicalId":50160,"journal":{"name":"Journal of Lower Genital Tract Disease","volume":" ","pages":"340-344"},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141762197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surgical Treatment for Provoked Vulvodynia: A Systematic Review. 外阴炎的手术治疗：系统回顾

IF 2.4 4区医学

Journal of Lower Genital Tract Disease Pub Date : 2024-10-01 Epub Date: 2024-08-06 DOI: 10.1097/LGT.0000000000000834

Koray Görkem Saçıntı, Hosna Razeghian, Jacob Bornstein

{"title":"Surgical Treatment for Provoked Vulvodynia: A Systematic Review.","authors":"Koray Görkem Saçıntı, Hosna Razeghian, Jacob Bornstein","doi":"10.1097/LGT.0000000000000834","DOIUrl":"10.1097/LGT.0000000000000834","url":null,"abstract":"Objective: Provoked vulvodynia (PV), characterized by vulvar pain upon touch or pressure, is the leading cause of pain during sexual intercourse. It causes a significant decline in overall quality of life, including sexual dysfunction and mental distress. Surgical interventions, such as perineoplasty and vestibulectomy, are considered a last resort for PV cases unresponsive to less invasive therapies. This systematic review evaluates the efficacy of surgery for PV and suggests areas for future research.Materials and methods: The literature search encompassed PubMed, Scopus, Web of Science, and Cochrane Library, identifying relevant peer-reviewed studies up to August 21, 2023.Results: Out of 1102 records retrieved, 29 met the eligibility criteria. Surgery was typically considered after failed conservative treatments. In 15 of the 29 studies defining surgical success as a significant reduction in dyspareunia, success rates ranged from 52% to 93%. Six studies using validated scales for pain assessment noted a significant reduction in vulvar pain following surgery ( p < .001). Two studies reported enhancements in sexual function ranging from 57% to 87%, while 3 studies found 89%-97% of women regained the ability to engage in sexual intercourse after surgery. Patient satisfaction rates ranged from 79% to 93%. Bartholin cysts occurred in up to 9% of cases, the most common complication reported.Conclusion: Surgery seems to be an effective and safe PV treatment option with success rates ranging from 52% to 97%, depending on the variation of outcome measures. Randomized clinical trials with established outcome measures are needed to determine the best surgical approach with minimal operative risk and optimal long-term outcomes.","PeriodicalId":50160,"journal":{"name":"Journal of Lower Genital Tract Disease","volume":" ","pages":"379-390"},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141894788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence and Type of HPV Genital Infection in Girls: A Systematic Review and Meta-Analysis. 女孩 HPV 生殖器感染的流行率和类型：系统回顾与元分析》。

IF 2.4 4区医学

Journal of Lower Genital Tract Disease Pub Date : 2024-10-01 Epub Date: 2024-07-26 DOI: 10.1097/LGT.0000000000000826

Raianne Kívia de Azevedo Bispo, Marcelo Cunio Machado Fonseca, Neila Maria de Góis Speck

{"title":"Prevalence and Type of HPV Genital Infection in Girls: A Systematic Review and Meta-Analysis.","authors":"Raianne Kívia de Azevedo Bispo, Marcelo Cunio Machado Fonseca, Neila Maria de Góis Speck","doi":"10.1097/LGT.0000000000000826","DOIUrl":"10.1097/LGT.0000000000000826","url":null,"abstract":"Objectives: This investigation explored the prevalence of human papillomavirus (HPV) infection by subtypes in girls aged up to 12.Methods: Four indexed databases, PubMed, EMBASE, Cochrane, and LILACS, were evaluated. Twenty-nine observational studies published between 1992 and 2018 were included.Results: The prevalence of genital condyloma acuminatum or HPV-positive serology due to prior infection among girls with suspected/confirmed sexual abuse was 25%, and without a history or information about abuse, 8%. The analysis indicated that low-risk HPV types were the most prevalent among this group, corresponding to 86.6% of the identified types. Human papillomavirus 6 and 11 were the most prevalent types, followed by HPV 16 and 2. Moreover, the analysis identified limited epidemiological data on genital warts in children up to 12 years. Several studies focused on convenience sampling, sexually abused girls, or failed to separate data by gender.Conclusion: Findings of the systematic review and prevalence meta-analysis indicate that the occurrence of HPV infection in girls aged 12 or younger is relatively rare, underscoring the significance of understanding the prevalence of HPV in the pediatric population. However, it is essential to be cautious when applying these results to the pediatric population, given cases of girls who are suspected of or have suffered sexual abuse. There is a pressing need for further research to fill the information gap on HPV infection in this vulnerable group.","PeriodicalId":50160,"journal":{"name":"Journal of Lower Genital Tract Disease","volume":" ","pages":"332-339"},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141762198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ASCCP President's Message. ASCCP主席的话。

IF 2.4 4区医学

Journal of Lower Genital Tract Disease Pub Date : 2024-10-01 DOI: 10.1097/LGT.0000000000000844

Francisco A R Garcia

引用次数: 0

ASCCP Clinical Consensus: Screening Recommendations for Clear Cell Adenocarcinomas in People Exposed to DES In Utero. ASCCP临床共识：子宫内暴露于DES人群中透明细胞腺癌的筛查建议。

IF 2.4 4区医学

Journal of Lower Genital Tract Disease Pub Date : 2024-10-01 DOI: 10.1097/LGT.0000000000000842

Jenna Z Marcus, Erin Nelson, Mitchell Linder, David P Chelmow

{"title":"ASCCP Clinical Consensus: Screening Recommendations for Clear Cell Adenocarcinomas in People Exposed to DES In Utero.","authors":"Jenna Z Marcus, Erin Nelson, Mitchell Linder, David P Chelmow","doi":"10.1097/LGT.0000000000000842","DOIUrl":"10.1097/LGT.0000000000000842","url":null,"abstract":"Objectives: The cohort of diethylstilbestrol (DES)-exposed people is aging, and a substantial fraction have already passed the age of 65, when unexposed average-risk people may exit cervical cancer screening provided they have had adequate prior screening. Current guidelines exclude individuals with a history of in utero exposure to DES. This clinical consensus includes a systematic review of relevant studies and provides updated guidance for surveillance of the aging DES-exposed cohort.Methods: A literature search was performed to find all relevant DES and clear cell adenocarcinoma (CCA) papers that addressed key clinical questions. Study quality was assessed and recommendations were rated on strength (A-E) and quality of evidence (I-III) using the system described for previous American Society of Colposcopy and Cervical Pathology consensus guidelines.Results: DES-exposed patients were 40 times more likely (standardized incidence ratio = 40.9; 95% CI, 13.1-126.2) to develop cervical and vaginal CCAs compared with unexposed individuals, with most cases diagnosed in individuals between the ages of 15 and 31. DES exposure in utero significantly increases the risk of CCA compared with nonexposed people, but the absolute risk of CCA is low. While CCA does seem to occur in older exposed patients, cases were rare and calculated incidence rates were extremely low, with the largest in any of the cohorts at 2.86 per million women-years.Conclusions: The American Society of Colposcopy and Cervical Pathology recommends people with prenatal exposure to DES receive annual screening for CCA with cytology until the age of 65 and discontinue screening beyond the age of 65 provided they otherwise meet criteria for cessation of screening.","PeriodicalId":50160,"journal":{"name":"Journal of Lower Genital Tract Disease","volume":"28 4","pages":"351-355"},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Host Gene Methylation as a Triage Test for HPV-Positive Women-A Cohort Study. 将宿主基因甲基化作为人乳头瘤病毒（HPV）阳性女性的分流测试评估--一项队列研究。

IF 2.4 4区医学

Journal of Lower Genital Tract Disease Pub Date : 2024-10-01 Epub Date: 2024-07-26 DOI: 10.1097/LGT.0000000000000830

Pedro Vieira-Baptista, Mariana Costa, Juliane Hippe, Carlos Sousa, Martina Schmitz, Ana-Rita Silva, Alfred Hansel, Mario Preti

{"title":"Evaluation of Host Gene Methylation as a Triage Test for HPV-Positive Women-A Cohort Study.","authors":"Pedro Vieira-Baptista, Mariana Costa, Juliane Hippe, Carlos Sousa, Martina Schmitz, Ana-Rita Silva, Alfred Hansel, Mario Preti","doi":"10.1097/LGT.0000000000000830","DOIUrl":"10.1097/LGT.0000000000000830","url":null,"abstract":"Objectives: This study was designed to evaluate the performance of a host gene methylation marker panel (ASTN1, DLX1, ITGA4, RXFP3, SOX17, and ZNF671) in the triage of human papillomavirus (HPV)-positive women, its possible impact in a cervical cancer screening program, and the possible influence of the variation of the rate of HPV16/18 in its performance.Materials and methods: Cohort study in which consecutive women referred for colposcopy in an organized cervical cancer screening program had repeated HPV testing, colposcopy, and biopsies. The women that remained HPV positive at the time of colposcopy were tested with the panel of DNA methylation markers. The performance of the test was evaluated and compared to standard practice.Results: The study test had a sensitivity and specificity for cervical intraepithelial neoplasia (CIN) 2+ of 60.8% (49.1-71.6%) and 88.4% (83.2-92.5%), respectively. For CIN3+, it was of 78.0% (64.0-88.5%) and 86.0% (80.8-90.2%), respectively. The rate and level of methylation positively correlated with the severity of disease. The use of methylation reduces the referral for colposcopy to 25.5%, while detecting 78.0% of the CIN3+ cases. Referral of all HPV16/18-positive cases and triage of the other high-risk HPV-positive cases with methylation, detects 90.0% of the cases of CIN3+, while reducing the number of referrals to 43.2%. The variation in the rate of HPV16/18 does not relevantly affect the performance of the methylation panel.Conclusions: The studied methylation panel has a high sensitivity and specificity for CIN3+ and reduces the rate of referrals for colposcopy, without relevant variation according to the rate of HPV16/18.","PeriodicalId":50160,"journal":{"name":"Journal of Lower Genital Tract Disease","volume":" ","pages":"326-331"},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141762196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0