medRxiv - Endocrinology最新文献_第7页

Reliability and Structure of Diabetes Diet Adherence Scale (D-DAS): A Follow-up Study among Type 2 Diabetes Patients of India 糖尿病饮食依从性量表 (D-DAS) 的可靠性和结构：印度 2 型糖尿病患者的随访研究

medRxiv - Endocrinology Pub Date : 2024-05-27 DOI: 10.1101/2024.05.25.24307586

Savitesh Kushwaha, Rachana Srivastava, Sanjay Kumar Bhadada, Vivek Sagar, Poonam Khanna

引用次数: 0

EFFICACY OF SIBUTRAMINE AND TOPIRAMATE COMBINATION IN WEIGHT LOSS: RETROSPECTIVE COHORT STUDY ON BRAZILIAN ADULTS 西布曲明和托吡酯复方制剂对减肥的疗效：对巴西成年人的回顾性队列研究

medRxiv - Endocrinology Pub Date : 2024-05-27 DOI: 10.1101/2024.05.25.24307923

Heloisa Harumi Yamamoto, Thiago Fraga Napoli, João Eduardo Nunes Salles

引用次数: 0

11β-HSD1 inhibitor efficacy in type 2 diabetes is cortisol-dependent 11β-HSD1 抑制剂对 2 型糖尿病的疗效与皮质醇有关

medRxiv - Endocrinology Pub Date : 2024-05-10 DOI: 10.1101/2024.05.10.24307180

Atinuke Wilton-Waddell, Layal Abi Farraj, Elton JR Vasconcelos, Emily Byrne, Angela E Taylor, Adrian Freeman, Damla Etal, Paul M Stewart, Wiebke Arlt, Ramzi Ajjan, Ana Tiganescu

{"title":"11β-HSD1 inhibitor efficacy in type 2 diabetes is cortisol-dependent","authors":"Atinuke Wilton-Waddell, Layal Abi Farraj, Elton JR Vasconcelos, Emily Byrne, Angela E Taylor, Adrian Freeman, Damla Etal, Paul M Stewart, Wiebke Arlt, Ramzi Ajjan, Ana Tiganescu","doi":"10.1101/2024.05.10.24307180","DOIUrl":"https://doi.org/10.1101/2024.05.10.24307180","url":null,"abstract":"Cortisol excess drives multiple adverse effects including hypertension, dyslipidemia, and delayed wound healing. Activation of cortisol by the enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) has shown promise as a therapeutic target for these comorbidities but clinical progress has been hampered by variable 11β-HSD1 inhibitor efficacy. Here, transcriptomic profiling of 11β-HSD1 target genes in primary skin fibroblasts as well as skin biopsies from type 2 diabetes individuals treated with the selective 11β-HSD1 inhibitor AZD4017 provide detailed mechanistic insights highlighting new areas of therapeutic potential. We report correlations between changes in 11β-HSD1 target gene expression, blood pressure, lipids, and wound healing with 1) cortisol levels (serum cortisol / dehydroepiandrosterone sulfate) and 2) peripheral 11β-HSD1 activity (serum cortisol / cortisone). Finally, we demonstrate that baseline cortisol levels and changes in placebo group cortisol levels are key determinants of 11β-HSD1 inhibitor efficacy. In conclusion, our findings pave the way for more effective targeting of 11β-HSD1 inhibitor treatment, improving the accuracy of future clinical studies. Larger trials of longer duration are now warranted to fully explore the therapeutic potential of 11β-HSD1 inhibitors across a range of cardiometabolic and age-associated indications.","PeriodicalId":501419,"journal":{"name":"medRxiv - Endocrinology","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140928283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wearable neuroprosthesis improves mobility and reduces pain in neuropathic participants 可穿戴神经假体改善神经病患者的活动能力并减轻疼痛

medRxiv - Endocrinology Pub Date : 2024-05-09 DOI: 10.1101/2024.05.08.24306164

Noemi Gozzi, Lauren Chee, Ingrid Odermatt, Sanne Kikkert, Greta Preatoni, Giacomo Valle, Nikolai Pfender, Felix Beuschlein, Nicole Wenderoth, Carl Zipser, Stanisa Raspopovic

{"title":"Wearable neuroprosthesis improves mobility and reduces pain in neuropathic participants","authors":"Noemi Gozzi, Lauren Chee, Ingrid Odermatt, Sanne Kikkert, Greta Preatoni, Giacomo Valle, Nikolai Pfender, Felix Beuschlein, Nicole Wenderoth, Carl Zipser, Stanisa Raspopovic","doi":"10.1101/2024.05.08.24306164","DOIUrl":"https://doi.org/10.1101/2024.05.08.24306164","url":null,"abstract":"Peripheral neuropathy (PN) is the most common complication of diabetes. It is characterized by sensory loss which often causes major health consequences including foot ulceration, chronic pain, poor mobility and increased risk of falls. However, present treatments do not counteract the cause of the disease, namely lack of sensory feedback, but rather aim at partial and temporal symptoms relief (e.g. analgesics for pain or creams for ulcers healing). Electrical stimulation is a promising solution for sensory restoration, but it is yet unknown if it can elicit perceivable sensations in PN damaged nerves and whether it could lead to any health or functional benefits. To this aim, we designed a wearable sensory neuroprosthesis providing targeted neurostimulation at the ankle level (NeuroStep) restoring feet lost sensations. We tested it in 14 participants with PN, evaluating its effects on functional outcomes and pain, and the cortical activation related to the restored sensations. Our system was able to restore lost sensations in all participants. The nerves of PN participants resulted significantly less excitable and sensitive than healthy individuals (N=22). Thanks to the neurostimulation, participants improved cadence and functional gait, with even stronger improvements in individuals with higher risk of falls. A full day of NeuroStep use led to a clinically significant reduction of 30.4% ± 9.2% in neuropathic pain. Restored sensations activated cortical patterns, as measured via fMRI, similar to the naturally located foot sensations, thus not requiring training by the user. NeuroStep restores intuitive sensations in PN participants, improving mobility and decreasing pain, possibly replacing multiple inefficient treatments. It holds potential to drastically improve patients’ quality of life thanks to functional and health benefits, while paving the way to new effective neuromodulation treatments.","PeriodicalId":501419,"journal":{"name":"medRxiv - Endocrinology","volume":"155 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140928518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Feasibility of time-restricted eating during pregnancy and effect on glycemic control in people with increased risk of gestational diabetes – a randomized controlled trial 孕期限时进食的可行性及对妊娠糖尿病高危人群血糖控制的影响--随机对照试验

medRxiv - Endocrinology Pub Date : 2024-05-07 DOI: 10.1101/2024.05.06.24306931

HS Skarstad, KL Haganes, MAJ Sujan, TM Gellein, MK Johansen, KÅ Salvesen, JA Hawley, T. Moholdt

{"title":"Feasibility of time-restricted eating during pregnancy and effect on glycemic control in people with increased risk of gestational diabetes – a randomized controlled trial","authors":"HS Skarstad, KL Haganes, MAJ Sujan, TM Gellein, MK Johansen, KÅ Salvesen, JA Hawley, T. Moholdt","doi":"10.1101/2024.05.06.24306931","DOIUrl":"https://doi.org/10.1101/2024.05.06.24306931","url":null,"abstract":"Time-restricted eating (TRE) is a nutritional intervention that confines the daily time-window for energy intake. TRE reduces fasting glucose concentrations in non-pregnant individuals, but whether this eating protocol is feasible and effective for glycemic control in pregnancy is unknown. The aim of this randomized controlled trial was to investigate the feasibility and effect of a 5-week TRE intervention among pregnant individuals at risk of gestational diabetes mellitus (GDM), compared with a usual-care control group. Participants underwent 2-h oral glucose tolerance tests and estimation of body composition, before and after the intervention. Interstitial glucose levels were continuously measured, and adherence rates and ratings of hunger were recorded daily. Thirty of 32 participants completed the trial. Participants allocated to TRE reduced their daily eating window from 12.3 (SD 1.3) to 9.9 (SD 1.0) h, but TRE did not affect glycemic measures, blood pressure, or body composition, compared with the control group. TRE increased hunger levels in the evening, but not in the morning, and induced only small changes in dietary intake. A 5-week TRE intervention was feasible for pregnant individuals with increased risk of GDM but had no effect on cardiometabolic outcomes.","PeriodicalId":501419,"journal":{"name":"medRxiv - Endocrinology","volume":"203 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140928282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary preference and susceptibility to type 2 diabetes mellitus: a wide-angle Mendelian randomization study 饮食偏好与 2 型糖尿病易感性：广角孟德尔随机研究

medRxiv - Endocrinology Pub Date : 2024-05-06 DOI: 10.1101/2024.05.05.24306877

Mia D. Lee, Benjamin F. Voight

引用次数: 0

Sex-differences in reporting of statin-associated diabetes mellitus to the US Food and Drug Administration 向美国食品药品管理局报告他汀类药物相关糖尿病的性别差异

medRxiv - Endocrinology Pub Date : 2024-05-03 DOI: 10.1101/2024.05.01.24306727

David P Kao, James Martin, Christina Aquilante, Elise L Shalowitz, Katarina Leyba, Elizabeth Kudron, Jane EB Reusch, Judith G. Regensteiner

引用次数: 0

Neonatal Obesity-Adiposity is Largely Driven by Maternal Hyperglycemia in-utero: Analysis of Real-Life Data from a Diabetes Clinic in India 新生儿肥胖在很大程度上是由母亲在胎儿期的高血糖引起的：来自印度糖尿病诊所的真实数据分析

medRxiv - Endocrinology Pub Date : 2024-04-30 DOI: 10.1101/2024.04.27.24306016

Sayali S. Deshpande-Joshi, Sonali S. Wagle, Madhura K. Deshmukh, Himangi Lubree, Hemant S. Damle, Suhas R. Otiv, Sanat B. Phatak, Rucha H. Wagh, K. Meenakumari, Smita N. Dhadge, Rajashree P. Kamat, Sayali G. Wadke, Deepa A. Raut, Dattatray S. Bhat, Souvik Bandyopadhyay, Chittaranjan S. Yajnik

引用次数: 0

Predictors of glycemic worsening in the next year in adults with screen-detected type 2 diabetes 筛查出的 2 型糖尿病成人患者下一年血糖恶化的预测因素

medRxiv - Endocrinology Pub Date : 2024-04-27 DOI: 10.1101/2024.04.25.24306391

Rebecca Schneider Aguirre, Tamara S Hannon, Robert V Considine, Yash Patel, M Sue Kirkman, Kieren J Mather

引用次数: 0

Prediabetes as a risk factor for all-cause and cause-specific mortality: a prospective analysis of 115,919 adults without diabetes in Mexico City 糖尿病前期是全因和特定原因死亡的风险因素：对墨西哥城 115 919 名未患糖尿病的成年人进行的前瞻性分析

medRxiv - Endocrinology Pub Date : 2024-04-16 DOI: 10.1101/2024.04.15.24305840

Carlos A. Fermín-Martínez, Omar Yaxmehen Bello-Chavolla, César Daniel Paz-Cabrera, Daniel Ramírez-García, Jerónimo Perezalonso-Espinosa, Luisa Fernández-Chirino, Arsenio Vargas-Vázquez, Juan Pablo Díaz-Sánchez, Padme Nailea Méndez-Labra, Alejandra Núñez-Luna, Martín Roberto Basile-Alvarez, Paulina Sánchez-Castro, Fiona Bragg, Louisa Gnatiuc Friedrichs, Diego Aguilar-Ramírez, Jonathan R. Emberson, Jaime Berumen-Campos, Pablo Kuri-Morales, Roberto Tapia-Conyer, Jesus Alegre-Díaz, Jacqueline A. Seiglie, Neftali Eduardo Antonio-Villa

引用次数: 0