{"title":"The grit personality trait, eating behavior, and obesity among Japanese adults","authors":"Noriaki Kurita, Takako Maeshibu, Tetsuro Aita, Takafumi Wakita, Hiroe Kikuchi","doi":"10.1101/2024.04.13.24305766","DOIUrl":"https://doi.org/10.1101/2024.04.13.24305766","url":null,"abstract":"Background: Despite the stigma attributing obesity to a lack of willpower, research on the interrelationships among an individual's willpower, eating behaviors, and obesity is lacking. Objective: This study aimed to quantify the extent to which multidimensional eating behaviors mediated the association between obesity and grit, which share commonalities with self-control. Methods: This cross-sectional study involved Japanese adults across a wide range of age groups. Grit was measured using an 8-item short grit scale. Multidimensional eating behaviors were measured using the Japanese version of the 21-item Three-Factor Eating Questionnaire-R21, comprising uncontrolled eating, emotional eating, and cognitive restraint. Obesity was defined as a body mass index ≥25.0 kg/m2, which is the World Health Organization's cutoff specific to Asian populations in the Asia-Pacific region. A series of logistic regression models were created to analyze the association between grit and obesity with and without eating behaviors. Mediation analyses using the Karlson Holm Breen method were performed to determine whether eating behavior mediated this association. Results: Of the 1641 adults, 26.8% were obese. A higher grit level was associated with a lower likelihood of obesity, less uncontrolled and emotional eating, and higher cognitive restraint. Uncontrolled and emotional eating fully mediated the association between grit and obesity, whereas cognitive restraint only partially mediated this association. Conclusions: The inverse association between grit and obesity was mediated by multidimensional eating behaviors. Identifying impairments in eating behaviors, rather than focusing on an individual's lack of willpower, may contribute to dispelling the aforementioned stigma and facilitating a dialogue for the prevention and management of obesity.","PeriodicalId":501419,"journal":{"name":"medRxiv - Endocrinology","volume":"302 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140613024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jason M Samuels, Mayur Patel, Christianne L. Roumie, Wesley Self, Luke Funk, Matthew Spann, Kevin Niswender
{"title":"Patients experience with preoperative use of anti-obesity medications and associations with bariatric surgery expectations","authors":"Jason M Samuels, Mayur Patel, Christianne L. Roumie, Wesley Self, Luke Funk, Matthew Spann, Kevin Niswender","doi":"10.1101/2024.04.14.24305798","DOIUrl":"https://doi.org/10.1101/2024.04.14.24305798","url":null,"abstract":"<strong>Objective</strong> This study investigated associations between patients’ experiences with anti-obesity medications and weight loss expectations prior to bariatric surgery.","PeriodicalId":501419,"journal":{"name":"medRxiv - Endocrinology","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140612811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luís Jesuíno de Oliveira Andrade, Gabriela Correia Matos de Oliveira, Luísa Correia Matos de Oliveira, Roseanne Montargil Rocha, Luís Matos de Oliveira
{"title":"Individualized Glycemic Index: A New Approach to Personalized Glycemic Control","authors":"Luís Jesuíno de Oliveira Andrade, Gabriela Correia Matos de Oliveira, Luísa Correia Matos de Oliveira, Roseanne Montargil Rocha, Luís Matos de Oliveira","doi":"10.1101/2024.04.12.24305746","DOIUrl":"https://doi.org/10.1101/2024.04.12.24305746","url":null,"abstract":"<strong>Introduction</strong> The assessment of glycemic control is fundamental for diabetes management. However, traditional measures have limitations, including susceptibility to non-glycemic factors. To address these limitations, there is a growing need for personalized metrics of glycemic control that take into account individual variability and provide a more comprehensive assessment of glycemic response.","PeriodicalId":501419,"journal":{"name":"medRxiv - Endocrinology","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140612603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Wearables and smartphones for modifiable risk factors in metabolic health: a scoping review protocol","authors":"Victoria Brügger, Tobias Kowatsch, Mia Jovanova","doi":"10.1101/2024.04.15.24305819","DOIUrl":"https://doi.org/10.1101/2024.04.15.24305819","url":null,"abstract":"<strong>Background</strong> Metabolic diseases, such as cardiovascular diseases and diabetes, contribute significantly to global mortality and disability. Wearable devices and smartphones increasingly track physiological and lifestyle risk factors and can improve the management of metabolic diseases. However, the absence of clear guidelines for deriving meaningful signals from these devices often hampers cross-study comparisons.","PeriodicalId":501419,"journal":{"name":"medRxiv - Endocrinology","volume":"74 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140612595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chang Cao, Jing Yuan, Elizabeth R. Gilbert, Mark A. Cline, Fan Lam, King C. Li, Ryan N. Dilger
{"title":"Increased circulating interleukin concentrations in type 2 diabetes mellitus: A systematic review and meta-analysis","authors":"Chang Cao, Jing Yuan, Elizabeth R. Gilbert, Mark A. Cline, Fan Lam, King C. Li, Ryan N. Dilger","doi":"10.1101/2024.04.13.24305775","DOIUrl":"https://doi.org/10.1101/2024.04.13.24305775","url":null,"abstract":"<strong>BACKGROUND</strong> Chronic systemic inflammation links to type 2 diabetes mellitus (T2DM) onset, and the potential role of interleukins in this pathogenic process is increasingly recognized.","PeriodicalId":501419,"journal":{"name":"medRxiv - Endocrinology","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140612605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Artificial Intelligence in Diabetes Care: Evaluating GPT-4’s Competency in Reviewing Diabetic Patient Management Plan in Comparison to Expert Review","authors":"Agnibho Mondal, Arindam Naskar","doi":"10.1101/2024.04.12.24305732","DOIUrl":"https://doi.org/10.1101/2024.04.12.24305732","url":null,"abstract":"<strong>Background</strong> The escalating global burden of diabetes necessitates innovative management strategies. Artificial intelligence, particularly large language models like GPT-4, presents a promising avenue for improving guideline adherence in diabetes care. Such technologies could revolutionize patient management by offering personalized, evidence-based treatment recommendations.","PeriodicalId":501419,"journal":{"name":"medRxiv - Endocrinology","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140612531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Deryck Yeung, Amlan Talukder, Min Shi, David M. Umbach, Yuanyuan Li, Alison Motsinger-Reif, Zheng Fan, Leping Li
{"title":"Differences in sleep spindle wave density between patients with diabetes mellitus and matched controls: implications for sensing and regulation of peripheral blood glucose","authors":"Deryck Yeung, Amlan Talukder, Min Shi, David M. Umbach, Yuanyuan Li, Alison Motsinger-Reif, Zheng Fan, Leping Li","doi":"10.1101/2024.04.11.24305676","DOIUrl":"https://doi.org/10.1101/2024.04.11.24305676","url":null,"abstract":"<strong>Background</strong> Brain waves during sleep are involved in sensing and regulating peripheral glucose level. Whether brain waves in patients with diabetes differ from those of healthy subjects is unknown. We examined the hypothesis that patients with diabetes have reduced sleep spindle waves, a form of brain wave implicated in periphery glucose regulation during sleep.","PeriodicalId":501419,"journal":{"name":"medRxiv - Endocrinology","volume":"86 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140577695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ebenezer Oduro Antiri, Thomas Hormenu, Edward Wilson Ansah, Stephen Ocansey, Rudolf Aaron Arthur, Eric Awlime-Ableh, Iddrisu Salifu, Benjamin Nyane, Augustine Mac-Hubert Gabla, Juliet Elikem Paku
{"title":"Efficacy of a physical activity regimen on visual outcomes among persons newly diagnosed with abnormal glucose tolerance: Study protocol for a pilot randomized controlled trial","authors":"Ebenezer Oduro Antiri, Thomas Hormenu, Edward Wilson Ansah, Stephen Ocansey, Rudolf Aaron Arthur, Eric Awlime-Ableh, Iddrisu Salifu, Benjamin Nyane, Augustine Mac-Hubert Gabla, Juliet Elikem Paku","doi":"10.1101/2024.04.10.24305644","DOIUrl":"https://doi.org/10.1101/2024.04.10.24305644","url":null,"abstract":"Background: Abnormal Glucose Tolerance (AGT), which encompasses diabetes and prediabetes, is a growing health problem globally. It is affecting millions and predisposing such patients to several complications, including ocular complications. Physical activity has been found to improve glycemic levels, but the specific effect on visual outcomes in a newly diagnosed African population with AGT is yet to be explored fully. This pilot randomized controlled trial seeks to evaluate the efficacy of a physical activity intervention among newly diagnosed persons with AGT in Cape Coast, Ghana.","PeriodicalId":501419,"journal":{"name":"medRxiv - Endocrinology","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140578150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thomas Uslar, Roberto Olmos, Alberth Burnier, Benjamín Sanfuentes, Pauline Böhm, Maria Paz Orellana, Francisco J. Guarda, Álvaro Huete, Nicolás Mertens, Cecilia Besa, Marcelo Andía, Alejandro Majerson, Jaime Cartes, Carlos Fardella, Fidel Allende, Sandra Solari, Anand Vaidya, Rene Baudrand
{"title":"The Spectrum from Overt Primary Aldosteronism to Mild Dysregulated Aldosterone Production in Incidentally Discovered Adrenocortical Adenomas","authors":"Thomas Uslar, Roberto Olmos, Alberth Burnier, Benjamín Sanfuentes, Pauline Böhm, Maria Paz Orellana, Francisco J. Guarda, Álvaro Huete, Nicolás Mertens, Cecilia Besa, Marcelo Andía, Alejandro Majerson, Jaime Cartes, Carlos Fardella, Fidel Allende, Sandra Solari, Anand Vaidya, Rene Baudrand","doi":"10.1101/2024.04.10.24305640","DOIUrl":"https://doi.org/10.1101/2024.04.10.24305640","url":null,"abstract":"<strong>Background</strong> Incidental adrenocortical adenomas (IA) are common. Current guidelines suggest screening for primary aldosteronism (PA) only in cases of hypertension or hypokalemia. This study aimed to evaluate the spectrum from overt PA to mild dysregulated aldosterone production with a sensitive protocol irrespective of blood pressure (BP) and potassium in patients with IA.","PeriodicalId":501419,"journal":{"name":"medRxiv - Endocrinology","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140577924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andrew S. Perry, Paolo Piaggi, Shi Huang, Matthew Nayor, Jane Freedman, Kari North, Jennifer Below, Clary Clish, Venkatesh L. Murthy, Jonathan Krakoff, Ravi V. Shah
{"title":"Human metabolic chambers reveal a coordinated metabolic-physiologic response to nutrition","authors":"Andrew S. Perry, Paolo Piaggi, Shi Huang, Matthew Nayor, Jane Freedman, Kari North, Jennifer Below, Clary Clish, Venkatesh L. Murthy, Jonathan Krakoff, Ravi V. Shah","doi":"10.1101/2024.04.08.24305087","DOIUrl":"https://doi.org/10.1101/2024.04.08.24305087","url":null,"abstract":"The emerging field of precision nutrition is based on the notion that inter-individual responses across diets of different calorie-macronutrient content may contribute to inter-individual differences in metabolism, adiposity, and weight gain. Free-living diet studies have been traditionally challenged by difficulties in controlling adherence to prescribed calories and macronutrient content and rarely allow a period of metabolic stability prior to metabolic measures (to minimize influences of weight changes). In this context, key physiologic measures central to precision nutrition responses may be most precisely quantified via whole room indirect calorimetry over 24-h, in which precise control of activity and nutrition can be achieved. In addition, these studies represent unique “N of 1” human crossover metabolic-physiologic experiments during which specific molecular pathways central to nutrient metabolism may be discerned. Here, we quantified 263 circulating metabolites during a ≈40-day inpatient admission in which up to 94 participants underwent seven monitored 24-h nutritional interventions of differing macronutrient composition in a whole-room indirect calorimeter to capture precision metabolic responses. Broadly, we observed heterogenous responses in metabolites across dietary chambers, with the exception of carnitines which tracked with 24-h respiratory quotient. We identified excursions in shared metabolic species (e.g., carnitines, glycerophospholipids, amino acids) that mapped onto gold-standard calorimetric measures of substrate oxidation preference and lipid availability. These findings support a coordinated metabolic-physiologic response to nutrition, highlighting the relevance of these controlled settings to uncover biological pathways of energy utilization during precision nutrition studies.","PeriodicalId":501419,"journal":{"name":"medRxiv - Endocrinology","volume":"58 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140577792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}