Heloisa Harumi Yamamoto, Thiago Fraga Napoli, João Eduardo Nunes Salles
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EFFICACY OF SIBUTRAMINE AND TOPIRAMATE COMBINATION IN WEIGHT LOSS: RETROSPECTIVE COHORT STUDY ON BRAZILIAN ADULTS
Introduction Obesity is a chronic, prevalent, multifactorial disease, stigmatized and linked to multiple long-term complications, which makes the treatment currently available below of the expectations from what is necessary to combat it. Because of this limitation, off-label medications for the treatment of obesity, such as topiramate, have been widely used, in association with on-label medications, such as sibutramine, in order to achieve more effective weight loss.
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