{"title":"Diagnostic accuracy of ultrasound-derived fat fraction for the detection and quantification of hepatic steatosis in patients with liver biopsy.","authors":"Yoshiko Nakamura, Masashi Hirooka, Yohei Koizumi, Ryo Yano, Yusuke Imai, Takao Watanabe, Osamu Yoshida, Yoshio Tokumoto, Masanori Abe, Yoichi Hiasa","doi":"10.1007/s10396-024-01472-6","DOIUrl":"https://doi.org/10.1007/s10396-024-01472-6","url":null,"abstract":"<p><strong>Purpose: </strong>This retrospective study was conducted to investigate the diagnostic accuracy of ultrasound-derived fat fraction (UDFF) for grading hepatic steatosis using liver histology as the reference standard.</p><p><strong>Methods: </strong>Seventy-three patients with liver disease were assessed using UDFF and liver biopsy. Pearson's test and the Bland-Altman plot were used to assess the correlation between UDFF and histological fat content in liver sections. The UDFF cutoff values for histologically proven steatosis grades were determined using the area under the receiver operating characteristic curve (AUROC).</p><p><strong>Results: </strong>The median age of the patients was 66 (interquartile range 54-74) years, and 33 (45%) were females. The UDFF values showed a stepwise increase with increasing steatosis grade (p < .001) and were strongly correlated with the histological fat content (r = .7736, p < .001). The Bland-Altman plot revealed a mean bias of 2.384% (95% limit of agreement, - 6.582 to 11.351%) between them. Univariate regression analysis revealed no significant predictors of divergence. The AUROCs for distinguishing steatosis grades of ≥ 1, ≥2, and 3 were 0.956 (95% confidence interval [CI], 0.910-1.00), 0.926 (95% CI, 0.860-0.993), and 0.971 (95% CI, 0.929-1.000), respectively. The UDFF cutoff value of > 6% had a sensitivity and specificity of 94.8% and 82.3%, respectively, for diagnosing steatosis grade ≥ 1. There was no association between UDFF and the fibrosis stage.</p><p><strong>Conclusion: </strong>UDFF shows strong agreement with the histological fat content and excellent diagnostic accuracy for grading steatosis. UDFF is a promising tool for detecting and quantifying hepatic steatosis in clinical practice.</p>","PeriodicalId":50130,"journal":{"name":"Journal of Medical Ultrasonics","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141452060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Disappearance of coronary artery to left ventricular fistula with diastolic mitral regurgitation","authors":"Ikuo Misumi, Kei Miyanaka, Iwaho Hazekawa, Koji Sato, Akihisa Tabira, Hiroki Usuku, Kenichi Tsujita","doi":"10.1007/s10396-024-01459-3","DOIUrl":"https://doi.org/10.1007/s10396-024-01459-3","url":null,"abstract":"","PeriodicalId":50130,"journal":{"name":"Journal of Medical Ultrasonics","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140810414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Suzuki, M. Hirokawa, Izumi Otsuka, Akira Miyauchi, Takashi Akamizu
{"title":"Calcium oxalate crystals as a cause of multiple punctate echogenic foci in benign thyroid lesions.","authors":"A. Suzuki, M. Hirokawa, Izumi Otsuka, Akira Miyauchi, Takashi Akamizu","doi":"10.1007/s10396-024-01448-6","DOIUrl":"https://doi.org/10.1007/s10396-024-01448-6","url":null,"abstract":"","PeriodicalId":50130,"journal":{"name":"Journal of Medical Ultrasonics","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140656129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Correction: Relationship between the change in infrapatellar fat pad thickness assessed using ultrasonography and anterior knee pain on squatting after anterior cruciate ligament reconstruction.","authors":"Ryo Shiraishi, Shinichiro Ueda","doi":"10.1007/s10396-024-01457-5","DOIUrl":"https://doi.org/10.1007/s10396-024-01457-5","url":null,"abstract":"","PeriodicalId":50130,"journal":{"name":"Journal of Medical Ultrasonics","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140663076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Takahiro Nishihara, Yoichi Takaya, N. Toh, Shinsuke Yuasa
{"title":"Severe traumatic tricuspid regurgitation detected 8 years after chest trauma.","authors":"Takahiro Nishihara, Yoichi Takaya, N. Toh, Shinsuke Yuasa","doi":"10.1007/s10396-024-01452-w","DOIUrl":"https://doi.org/10.1007/s10396-024-01452-w","url":null,"abstract":"","PeriodicalId":50130,"journal":{"name":"Journal of Medical Ultrasonics","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140674711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Naoko Mori, Li Li, Masazumi Matsuda, Yu Mori, Shunji Mugikura
{"title":"Prospects of perfusion contrast-enhanced ultrasound (CE-US) in diagnosing axillary lymph node metastases in breast cancer: a comparison with lymphatic CE-US","authors":"Naoko Mori, Li Li, Masazumi Matsuda, Yu Mori, Shunji Mugikura","doi":"10.1007/s10396-024-01444-w","DOIUrl":"https://doi.org/10.1007/s10396-024-01444-w","url":null,"abstract":"<p>Accurate diagnosis of lymph node (LN) metastasis is vital for prognosis and treatment in patients with breast cancer. Imaging 1modalities such as ultrasound (US), MRI, CT, and 18F-FDG PET/CT are used for preoperative assessment. While conventional US is commonly recommended due to its resolution and sensitivity, it has limitations such as operator subjectivity and difficulty detecting small metastases. This review shows the microanatomy of axillary LNs to enhance accurate diagnosis and the characteristics of contrast-enhanced US (CE-US), which utilizes intravascular microbubble contrast agents, making it ideal for vascular imaging. A significant focus of this review is on distinguishing between two types of CE-US techniques for axillary LN evaluation: perfusion CE-US and lymphatic CE-US. Perfusion CE-US is used to assess LN metastasis via transvenous contrast agent administration, while lymphatic CE-US is used to identify sentinel LNs and diagnose LN metastasis through percutaneous contrast agent administration. This review also highlights the need for future research to clarify the distinction between studies involving “apparently enlarged LNs” and “clinical node-negative” cases in perfusion CE-US research. Such research standardization is essential to ensure accurate diagnostic performance in various clinical studies. Future studies should aim to standardize CE-US methods for improved LN metastasis diagnosis, not only in breast cancer but also across various malignancies.</p>","PeriodicalId":50130,"journal":{"name":"Journal of Medical Ultrasonics","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140623955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of proteinuria at relapse on shear wave velocity assessed using ultrasound elastography in children with idiopathic nephrotic syndrome","authors":"Tomohiko Nishino, Shinya Tomori, Sayaka Ono, Kazuhiro Takahashi, Masakazu Mimaki","doi":"10.1007/s10396-024-01455-7","DOIUrl":"https://doi.org/10.1007/s10396-024-01455-7","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>Shear wave velocity (SWV) is an ultrasound elastography technique that provides much information for kidney disease assessment. However, the factors that alter SWV are not fully understood; it is unclear whether the variation in SWV seen in proteinuria associated with disease progression is due to tissue or proteinuria. This study investigated the effect of proteinuria on SWV.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>This prospective observational study compared SWV at remission with SWV at relapse in children treated for idiopathic nephrotic syndrome (INS) between April 2020 and December 2023. All relapses without oral steroids during the observation period were measured. SWV at remission was defined as the date closest to relapse during which repeated measurements were taken approximately every 3 months after steroid discontinuation.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>Eight patients were treated for INS with a median observation period of 21.9 months (11.8–27.1). Of the 15 relapses, five that met the definition were considered for the study. The median interval between the measurement at relapse and remission was 40 days (11–55). SWV was significantly lower at relapse than remission (2.40 ± 0.20 m/s vs. 2.14 ± 0.15 m/s, <i>P</i> < 0.01).</p><h3 data-test=\"abstract-sub-heading\">Conclusions</h3><p>SWV decreased in the presence of severe proteinuria at relapse compared to the remission measurements. Although more cases need to be studied, the decrease in SWV may reflect the mechanism by which protein leaks into the urine, not just a direct change caused by the presence of proteinuria.</p>","PeriodicalId":50130,"journal":{"name":"Journal of Medical Ultrasonics","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140569271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marie Tabaru, Ren Koda, Hitoshi Shitara, Hirotaka Chikuda, Yoshiki Yamakoshi
{"title":"Examination of rapid adjustment system based on screen score obtained using continuous shear wave elastography","authors":"Marie Tabaru, Ren Koda, Hitoshi Shitara, Hirotaka Chikuda, Yoshiki Yamakoshi","doi":"10.1007/s10396-024-01439-7","DOIUrl":"https://doi.org/10.1007/s10396-024-01439-7","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>Continuous shear wave elastography (C-SWE) can be expected to be applied to portable muscle elasticity diagnosis. To establish diagnostic technology, it will be necessary to improve measurement techniques and quantitative measurement accuracy.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>In this study, we investigated two screen scores: the quality index (<i>Q</i>-index), which determines whether the intensity of a power Doppler image is appropriate, and the shear wave propagation direction index (SWDI), which determines the uniformity of shear wave propagation.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>First, we performed numerical simulations with white noise and found that the coefficient of variation of shear wave velocity estimation was less than 5% when the normalized <i>Q</i>-index was greater than 0.27. Furthermore, regarding the SWDI, we clarified the relationship between the standard deviation in shear wave propagation direction and the SWDI. Next, the relationship between the <i>Q</i>-index and coefficient of variation of estimated shear wave velocity was evaluated through experiments using a tissue-mimicking phantom. The results showed that there was a negative correlation between the <i>Q</i>-index and the coefficient of variation, and the fluctuation of the propagation velocity could be inferred from the <i>Q</i>-index. Finally, we showed the results of applying the screen scores to muscle relaxation monitoring and confirmed its usefulness in clinical applications.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>By applying the screen scores, we showed improved stability in speed estimation in C-SWE, and demonstrated the possibility of clinical applicability.</p>","PeriodicalId":50130,"journal":{"name":"Journal of Medical Ultrasonics","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140569269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Assessment of drainage vein of focal nodular hyperplasia using contrast-enhanced ultrasound","authors":"Yukinobu Watanabe, Masahiro Ogawa, Aya Konishi, Seiichiro Suda, Yu Tamura, Masahiro Kaneko, Midori Hirayama, Naoki Matsumoto, Hirofumi Kogure","doi":"10.1007/s10396-024-01451-x","DOIUrl":"https://doi.org/10.1007/s10396-024-01451-x","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>Identification of drainage vessels is useful for differential diagnosis of hepatic tumors. Direct drainage to the hepatic vein has been reported to occur in focal nodular hyperplasia (FNH), but studies evaluating the drainage veins of FNH are limited. We aimed to investigate the detection rate of the FNH drainage vein and the factors related to visualization of the drainage vein on contrast-enhanced ultrasound (CEUS).</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>Fifty consecutive patients with 50 FNH lesions were retrospectively evaluated in this study. We calculated and compared the detection rate of the FNH drainage vein on CEUS, contrast-enhanced magnetic resonance imaging (CEMRI), and contrast-enhanced computed tomography (CECT), and identified the factors correlated with visualization of the FNH drainage vein on CEUS by using multivariate logistic regression analyses.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>Visualization of the drainage vein was confirmed in 31 of 50 lesions (62%) using CEUS, three of 44 lesions (6.8%) using CEMRI, and one of 18 lesions (5.6%) using CECT. The detection rate of the FNH drainage vein on CEUS was significantly higher than that on CEMRI and CECT (<i>p</i> < 0.001). Multivariate analysis identified lesion size (≥ 25 mm) and detection of the spoke-wheel pattern on Doppler US as independent factors for drainage vein detection in FNH.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>Our study showed that rapid FNH drainage to the hepatic vein was observed at a relatively high rate on CEUS, suggesting that CEUS focusing on detection of drainage veins is important for diagnosing FNH.</p>","PeriodicalId":50130,"journal":{"name":"Journal of Medical Ultrasonics","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140569065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Scientizing the stage between health and disease.","authors":"Yoshiki Hirooka","doi":"10.1007/s10396-024-01453-9","DOIUrl":"https://doi.org/10.1007/s10396-024-01453-9","url":null,"abstract":"","PeriodicalId":50130,"journal":{"name":"Journal of Medical Ultrasonics","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140735550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}