{"title":"Embryonic reference values for nuchal translucency thickness and ductus venosus blood flow at 8-10 + 6 gestational weeks.","authors":"Toshiyuki Hata, Miyu Konishi, Aya Koyanagi, Yasunari Miyagi, Takahito Miyake, Nobuhiko Hayashi","doi":"10.1007/s10396-026-01645-5","DOIUrl":"https://doi.org/10.1007/s10396-026-01645-5","url":null,"abstract":"<p><strong>Purpose: </strong>To measure embryonic nuchal translucency (NT) thickness and ductus venosus (DV) blood flow indices using transvaginal two-dimensional sonography and Doppler ultrasound at 8-10 + 6 weeks.</p><p><strong>Methods: </strong>Transvaginal scans were performed for 149 normal and three abnormal embryos (trisomy 18 with ventricular septal defect (VSD), tricuspid insufficiency (TR), and intrauterine fetal death with trisomy 21) at 8-10 + 6 weeks. NT thickness, S wave (cm/s), D wave (cm/s), \"a\" wave (cm/s), S/a, pulsatility index (PI), and resistance index (RI) of DV were measured, and reference values for each parameter were determined.</p><p><strong>Results: </strong>NT, S, D, S/a, PI, and RI increased linearly with advancing gestation (p < 0.01). The 'a' (mean, 5.55 cm/s; SD, 1.8 cm/s) value was constant at 8-10 + 6 weeks of gestation. There were significant linear correlations between NT, S, D, S/a, PI, and RI, and crown-rump length (CRL) (p < 0.01). The \"a\" value remained unchanged with increasing CRL during this period. NT thickness (2.8 mm) in the trisomy 18 patient with VSD was high at 10 + 6 weeks, and reversed \"a\" wave was evident in the patient with TR at 10 + 1 weeks. In a fetus with intrauterine fetal death with trisomy 21 at 11 weeks and 6 days, NT thickness was 2.1 mm, and reversed DV flow was noted at 9 weeks and 6 days.</p><p><strong>Conclusion: </strong>Our results provide reference values for NT thickness and DV flow parameters, which may advance our understanding of embryonic growth and promote earlier prenatal diagnosis of chromosome abnormalities and/or cardiac anomalies before 11 weeks.</p>","PeriodicalId":50130,"journal":{"name":"Journal of Medical Ultrasonics","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147845385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Correction: Relationship between ultrasonographic findings and subscales of the Knee Injury and Osteoarthritis Outcome Score in patients with early knee osteoarthritis: a multicenter study.","authors":"Yushin Mizuno, Yasushi Takata, Yosuke Shima, Kenichi Goshima, Kazunari Kuroda, Tomoyuki Kanayama, Yoshihiro Ishida, Naoki Takemoto, Manase Nishimura, Takuya Sengoku, Satoru Demura, Junsuke Nakase","doi":"10.1007/s10396-026-01641-9","DOIUrl":"https://doi.org/10.1007/s10396-026-01641-9","url":null,"abstract":"","PeriodicalId":50130,"journal":{"name":"Journal of Medical Ultrasonics","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147787102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Enhancing thrombolytic therapy in Japan-dwelling Japanese using clinical ultrasound with microbubble contrast agent.","authors":"Takako Shirakawa, Tsutomu Matsuura, Norio Sekine, Hiroyuki Takahashi, Hirotaka James Okano, Takao Ohki, Kentaro Kasa, Yoshitaka Mine, Tomoyuki Ohta","doi":"10.1007/s10396-026-01620-0","DOIUrl":"https://doi.org/10.1007/s10396-026-01620-0","url":null,"abstract":"<p><strong>Purpose: </strong>To determine in vitro the efficacy and safety of thrombolysis in blood from Japanese subjects using standard diagnostic ultrasound (US) with or without microbubbles.</p><p><strong>Methods: </strong>Blood from six healthy Japan-dwelling Japanese (mean age 22.3 years), who have relatively low susceptibility to thrombosis because of heredity and dietary habits, was left at room temperature for 24 or 72 h. Each clot-containing well was submerged in a 150-mL heparin-physiologic saline bath (5 units heparin/mL) and rotated at 180 rpm. The 30-min US treatment conditions were: (1) no US or microbubbles; (2) grayscale US (4.5 MHz); (3) color Doppler; (4) grayscale US with addition of 4-μL perflubutane microbubbles (Sonazoid; GE Healthcare Pharma Corporation, Tokyo Japan) to the bath every 5 min; and (5) color Doppler with microbubble addition as above. The Aplio i800 (Canon Medical Systems, Tochigi Japan) US system was used with the i8CX1 transducer.</p><p><strong>Results: </strong>Among six subjects with clots, the number of 24-h clots that changed to hypoechoic under each condition was as follows: (1) 0, (2) 3, (3) 5, (4) 6, and (5) 5. For 72-h clots, the number of changes was: (1) 0, (2) 1, (3) 3, (4) 6, and (5) 3. In Masson's trichrome-stained specimens, US treatment generated less fibrin within the light-blue amorphous element than in the control. No rupture of red blood cells was observed.</p><p><strong>Conclusion: </strong>We confirmed that standard clinical diagnostic US, used for grayscale or color Doppler imaging, enhanced thrombolysis. Thrombolytic efficacy was greater with combination of Sonazoid and US than with US alone.</p>","PeriodicalId":50130,"journal":{"name":"Journal of Medical Ultrasonics","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147640375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ultrasound synthetic aperture imaging with SpecularNet for enhanced needle visualization.","authors":"Che-Chou Shen, Liang-Chun Tung","doi":"10.1007/s10396-026-01623-x","DOIUrl":"https://doi.org/10.1007/s10396-026-01623-x","url":null,"abstract":"<p><strong>Purpose: </strong>Ultrasound imaging has been routinely used for needle guidance due to its real-time capability and cost-efficiency. However, conventional ultrasound with fixed-angle transmission often suffers from reduced visualization of oblique needles when the specular echoes are reflected away from the receiving transducer.</p><p><strong>Methods: </strong>Synthetic transmit aperture (STA) beamforming with delay and standard deviation (DASD) relies on the variation of echo magnitude among various incident angles to construct the image. It can be further integrated with the specular information of the needle shaft predicted by convolutional neural networks (CNN) models to improve the image contrast in needle detection. The proposed SpecularNet estimates the orientation and the specular probability of the needle from pixel-wise STA channel data.</p><p><strong>Results: </strong>The proposed specular STA-DASD was validated using experiments. Results indicated that, for needle orientations between 10° and 40°, the specular STA-DASD improved the needle-to-speckle ratio (NSR) by 11.0 dB and the needle-to-artifact ratio (NAR) by 18.9 dB compared to the conventional STA-DASD. Compared to standard specular beamforming, the inference to specular information can be efficiently performed in SpecularNet, while both the NSR and NAR of the corresponding specular STA-DASD also improve by another 25-30 dB.</p><p><strong>Conclusion: </strong>The efficacy of the proposed specular STA-DASD beamforming was demonstrated for enhancement of needle visualization. The specular information could be predicted using SpecularNet with high computational efficiency to guide the transmit/receive apodization and to suppress background noise and artifacts using image weighting.</p>","PeriodicalId":50130,"journal":{"name":"Journal of Medical Ultrasonics","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147619198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reply to comment on RE: Restricted morphological changes in infrapatellar fat pad during walking is revealed as a dynamics feature in symptomatic knee osteoarthritis.","authors":"Yosuke Ishii, Miharu Sugimoto, Akinori Nekomoto, Atsuo Nakamae, Kexin Zhu, Takato Hashizume, Kohei Matsumura, Yuko Nakashima, Makoto Takahashi, Nobuo Adachi","doi":"10.1007/s10396-025-01605-5","DOIUrl":"10.1007/s10396-025-01605-5","url":null,"abstract":"","PeriodicalId":50130,"journal":{"name":"Journal of Medical Ultrasonics","volume":" ","pages":"253-254"},"PeriodicalIF":2.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145758187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The past and future of high-intensity focused ultrasound (HIFU) treatment.","authors":"Shin Yoshizawa","doi":"10.1007/s10396-026-01639-3","DOIUrl":"10.1007/s10396-026-01639-3","url":null,"abstract":"","PeriodicalId":50130,"journal":{"name":"Journal of Medical Ultrasonics","volume":" ","pages":"127-128"},"PeriodicalIF":2.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147640361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reliability of liver stiffness measurements using shear wave elastography: impact of skin-to-capsule distance and subcutaneous tissue structure.","authors":"Keisuke Osakabe, Keiko Sugimoto, Hiroji Takai, Yusuke Sano, Keisuke Maeda, Koji Suzuki, Naohiro Ichino","doi":"10.1007/s10396-025-01582-9","DOIUrl":"10.1007/s10396-025-01582-9","url":null,"abstract":"<p><strong>Purpose: </strong>Shear wave velocity (Vs) measurements can be unstable in individuals with obesity or with a skin-capsule distance (SCD) of ≥ 20 mm. However, instability of Vs has also been observed in cases where SCD is not markedly increased; therefore, the present study aimed to investigate the factors contributing to reduced VsN (net amount of effective shear wave velocity), an index that reflects the reliability of individual Vs measurements.</p><p><strong>Methods: </strong>In total, 317 individuals who underwent community-based health screening were included in this study. We investigated the relationship between VsN and physical findings, laboratory data, SCD, and structure of the SCD (single vs. multilayered) to identify factors associated with decreased VsN.</p><p><strong>Results: </strong>Multiple regression analysis revealed that body fat percentage (β = - 0.135, p = 0.011), SCD (β = - 0.347, p < 0.0001), and the structure of the SC region (β = - 0.295, p < 0.0001) were independently associated with decreased VsN. In cases where the SCD exceeded 20 mm, the VsN within the SCD was significantly lower in the multilayer structural type [52 (28-75)] than in the single-layer structural type [95 (77-99)] (p = 0.004). Furthermore, even when the SCD was 20 mm or less, the VsN within the SCD was significantly lower in the multilayer structure type [80 (68-89)] than in the single-layer structure type [99 (92-100)] (p < 0.0001).</p><p><strong>Conclusion: </strong>The results show that, in addition to SCD thickness, its internal structure reduces the VsN and contributes to Vs measurement instability.</p>","PeriodicalId":50130,"journal":{"name":"Journal of Medical Ultrasonics","volume":" ","pages":"147-156"},"PeriodicalIF":2.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145226339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A novel technique of ultrasound-guided nerve root block: anterior compression lateral approach.","authors":"Naofumi Hashiguchi, Yasushi Fujiwara, Nanoha Sato, Akiko Matsumoto, Yasushi Murakami, Shinji Kotaka, Ryo Ota, Nobuo Adachi","doi":"10.1007/s10396-025-01588-3","DOIUrl":"10.1007/s10396-025-01588-3","url":null,"abstract":"<p><strong>Purpose: </strong>Conventional posterior ultrasound-guided selective cervical nerve root block (SNRB) often fails to deliver injectate reliably into the neural foramen, while fluoroscopic guidance involves radiation exposure and specialized equipment. We developed a novel anterior compression lateral (ACL) ultrasound-guided approach to provide radiation-free, real-time visualization with improved intraforaminal delivery. This study compared ACL with conventional ultrasound (US) and fluoroscopy (FL) in terms of needle placement accuracy and injectate distribution.</p><p><strong>Methods: </strong>This retrospective single-center cohort study measured needle tip distance from the lateral mass on anteroposterior radiographs. Contrast distribution was classified as foraminal, junctional, or extraforaminal on radiographs and confirmed with axial CT in the US and ACL subgroups. Craniocaudal spread distance was also quantified.</p><p><strong>Results: </strong>A total of 114 patients with cervical radiculopathy underwent SNRB using FL (n = 56), US (n = 25), or ACL (n = 33). Radiographic intraforaminal distribution occurred in 76.8% of FL, 72.7% of ACL, and 16.0% of US injections (P < 0.0001). Needle tips in US and ACL were positioned more lateral than FL (mean offsets 4.3 ± 6.8 mm and 2.5 ± 3.9 mm vs - 3.5 ± 2.6 mm, respectively). Injectate spread was greater with US (30.8 ± 9.6 mm) and ACL (25.9 ± 15.1 mm) than FL (15.9 ± 10.7 mm) (P < 0.0001). On CT, ACL achieved higher intraforaminal contrast than US (72.7% vs 16.0%, P < 0.0001). No major complications occurred.</p><p><strong>Conclusion: </strong>The ACL ultrasound-guided approach delivers intraforaminal injectate with accuracy comparable to fluoroscopy while eliminating radiation exposure. It outperforms conventional posterior ultrasound in targeting consistency and offers a precise, accessible option for outpatient cervical SNRB.</p>","PeriodicalId":50130,"journal":{"name":"Journal of Medical Ultrasonics","volume":" ","pages":"217-225"},"PeriodicalIF":2.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13092517/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145314163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparing reference points in strain elastography for predicting autoimmune thyroiditis.","authors":"Yi-Chen Ho, Chi-Yu Kuo, Ming-Nan Chien, Shih-Ping Cheng","doi":"10.1007/s10396-025-01593-6","DOIUrl":"10.1007/s10396-025-01593-6","url":null,"abstract":"<p><strong>Purpose: </strong>Chronic autoimmune thyroiditis shows increased stiffness on elastography. The sternocleidomastoid (SCM) or strap muscles have been used as references in strain elastography in prior studies. We aimed to compare the effects of different reference points in strain elastography on its diagnostic performance.</p><p><strong>Methods: </strong>Patients referred for thyroidectomy underwent strain elastography assessment of the non-tumor-bearing thyroid parenchyma. The strain ratio was determined using either the adjacent SCM muscle or the trachea at the same depth as reference points. Final pathological results served as the standard.</p><p><strong>Results: </strong>A total of 174 patients were analyzed, with 39 (22%) diagnosed with autoimmune thyroiditis. Multivariate logistic regression identified thyroid peroxidase antibodies, thyroglobulin antibodies, and the strain ratio using the trachea as a reference as independent predictors of thyroiditis. The area under the receiver operating characteristic curve was significantly higher with the trachea as the reference compared to the SCM (0.854 vs. 0.611). Sensitivity analyses indicated that diagnostic performance was not affected by patient age or body habitus.</p><p><strong>Conclusions: </strong>Different reference points in strain elastography significantly influence the predictability of autoimmune thyroiditis, and using the trachea as a reference improves diagnostic performance.</p>","PeriodicalId":50130,"journal":{"name":"Journal of Medical Ultrasonics","volume":" ","pages":"139-146"},"PeriodicalIF":2.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145497398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Optimizing forceps delivery safety: predicting anal sphincter injury with intrapartum ultrasound.","authors":"Shin Hashiramoto, Hiroko Takita, Tatsuya Arakaki, Yuka Yamashita, Mayumi Kaneko, Ryu Matsuoka, Akihiko Sekizawa","doi":"10.1007/s10396-025-01587-4","DOIUrl":"10.1007/s10396-025-01587-4","url":null,"abstract":"<p><strong>Purpose: </strong>To assess whether intrapartum ultrasound parameters can predict obstetric anal sphincter injury (OASI) in forceps deliveries.</p><p><strong>Methods: </strong>This retrospective cohort study included women undergoing forceps delivery for live, singleton, term cephalic pregnancies at Showa Medical University Hospital, between April 2021 and September 2024. Ultrasound was performed immediately before forceps application to evaluate angle of progression (AoP), head direction (HD), transperineal ultrasound (TUS) station, and midline angle (MLA) at rest and during pushing. Delta (Δ) values were calculated as differences between pushing and resting. OASI was diagnosed clinically and via transanal ultrasound. Parameters were compared between women with and without OASI. The Benjamini-Hochberg procedure corrected for multiple testing, with significance below < 0.05.</p><p><strong>Results: </strong>Among 256 women, 23 (8.9%) developed OASI. Maternal, labor, and neonatal characteristics were similar between groups. Several intrapartum ultrasound parameters were significantly associated with OASI: TUS station during pushing (median 3.2 and 4.2, p = 0.002, q = 0.012), ΔTUS station (1.1 and 1.6, p = 0.006, q = 0.042), HD at rest (28° and 38°, p < 0.0001 q < 0.001), HD during pushing (32° and 50°, p < 0.0001, q < 0.001), and ΔHD (3.2° and 10°, p = 0.0005, q = 0.004). HD during pushing showed the best predictive performance (AUC = 0.871), with an optimal cutoff of 36° (sensitivity 0.69, specificity 0.90).</p><p><strong>Conclusion: </strong>Intrapartum ultrasound, particularly HD during pushing, is a valuable predictor of OASI in forceps deliveries. A cut-off value of 36° may identify women at higher risk and improve forceps delivery safety.</p>","PeriodicalId":50130,"journal":{"name":"Journal of Medical Ultrasonics","volume":" ","pages":"189-197"},"PeriodicalIF":2.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145394803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}