Journal of Medical Ultrasonics最新文献

{"title":"Constructing a predictive model for anti-Müllerian hormone levels in reproductive-age women based on transvaginal three-dimensional ultrasound.","authors":"Xing Si, Xuewei He","doi":"10.1007/s10396-025-01581-w","DOIUrl":"10.1007/s10396-025-01581-w","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate the predictive value of transvaginal three-dimensional (3D) ultrasound imaging parameters for anti-Müllerian hormone (AMH) levels in women of reproductive age.</p><p><strong>Methods: </strong>A retrospective study was conducted on 492 patients who underwent ovarian reserve function assessments at Hangzhou Traditional Chinese Medicine Hospital. The patients were randomly divided into a training set (n = 420) and a validation set (n = 72). All participants underwent transvaginal 3D ultrasound to measure antral follicle count (AFC), ovarian volume (OV), peak systolic flow velocity (PSV), and resistance index (RI). Morning fasting venous blood samples were collected for AMH level measurement. Pearson correlation analysis was used to assess the relationships between age, AFC, OV, PSV, RI, and AMH. Multiple linear regression analysis was used to construct a unified regression model and a grouped regression model. The performance of the models was evaluated by comparing the root mean squared error (RMSE) and mean absolute error (MAE) between predicted and actual values.</p><p><strong>Results: </strong>AMH showed a strong negative correlation with age and a positive correlation with OV, AFC, and PSV. AMH was significantly correlated with AFC and OV (r = 0.844 and 0.759, respectively; both P < 0.05), but only weakly correlated with PSV (r = 0.176, P < 0.05). The RMSE and MAE of the grouped regression prediction model were lower than those of the unified regression model.</p><p><strong>Conclusion: </strong>The grouped regression AMH prediction model developed through multiple linear regression analysis demonstrated favorable performance, enabling accurate individualized prediction of AMH levels, thereby assisting clinicians in evaluating the fertility potential of women of reproductive age.</p>","PeriodicalId":50130,"journal":{"name":"Journal of Medical Ultrasonics","volume":" ","pages":"169-177"},"PeriodicalIF":2.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound-guided Achilles tendon rupture repair using knotless barbed suture: a cadaveric study.","authors":"Toru Omodani, Michael Khadavi, Yoshifumi Takatsume, Alexandre Lavigne","doi":"10.1007/s10396-025-01592-7","DOIUrl":"10.1007/s10396-025-01592-7","url":null,"abstract":"<p><strong>Purpose: </strong>To describe a novel, minimally invasive, ultrasound-guided Achilles tendon repair technique using a knotless barbed suture and to assess its feasibility in a cadaveric model.</p><p><strong>Methods: </strong>A midportion Achilles tendon rupture was simulated in a Thiel-embalmed cadaver. The tendon was repaired percutaneously under ultrasound guidance using a 0.6-mm USP 1 knotless barbed suture mounted on a 19-gauge, 3.5-inch curved needle. The needle was advanced intratendinously under continuous ultrasound guidance. Tendon reapproximation was assessed with ultrasound and confirmed by anatomical dissection. The resting plantar flexion angle was measured before and after the repair.</p><p><strong>Results: </strong>The Achilles tendon repair technique resulted in successful reapproximation of the tendon ends with anatomic alignment. Post-repair ultrasound and dissection confirmed accurate intratendinous suture placement and full tendon continuity. The resting plantar flexion angle increased from 23° to 50° after the repair.</p><p><strong>Conclusion: </strong>This is the first report of an ultrasound-guided Achilles tendon repair using a knotless barbed suture. The technique appears feasible in a cadaveric model and may represent a promising minimally invasive option for patients requiring improved tendon approximation. Its office-based approach may reduce surgical risks associated with conventional repair and tendon elongation seen with conservative treatment. Further biomechanical and clinical studies are warranted to evaluate its safety, durability, and functional outcomes.</p>","PeriodicalId":50130,"journal":{"name":"Journal of Medical Ultrasonics","volume":" ","pages":"227-234"},"PeriodicalIF":2.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13092523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145309793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneous dichorionic diamniotic twin pregnancy simultaneously implanted in a cesarean scar.","authors":"Keiko Aihoshi, Munekage Yamaguchi, Jun Sakata, Takeshi Motohara, Eiji Kondoh","doi":"10.1007/s10396-025-01570-z","DOIUrl":"10.1007/s10396-025-01570-z","url":null,"abstract":"","PeriodicalId":50130,"journal":{"name":"Journal of Medical Ultrasonics","volume":" ","pages":"243-244"},"PeriodicalIF":2.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145034572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic performance of ultrasound attenuation imaging in detecting hepatic steatosis.","authors":"Hamed Naghibi, Madjid Shakiba, Narges Azizi","doi":"10.1007/s10396-025-01585-6","DOIUrl":"10.1007/s10396-025-01585-6","url":null,"abstract":"<p><strong>Purpose: </strong>Hepatic steatosis is a hallmark of metabolic dysfunction-associated steatotic liver disease, and increased hepatic fat (or steatosis) is associated with liver inflammation, fibrosis, and adverse outcomes. While MRI-derived proton density fat fraction (MRI-PDFF) is an accurate noninvasive reference standard, ultrasound attenuation imaging (UAI) offers an accessible cost-effective alternative. We herein systematically review and meta-analyze the accuracy of UAI in grading hepatic steatosis.</p><p><strong>Methods: </strong>We searched Embase, PubMed/Medline, Scopus, and Web of Science through December 22, 2024, for studies comparing UAI with MRI-PDFF. Data on diagnostic performance were extracted from eligible studies. Pooled diagnostic odds ratios (DOR), sensitivity, specificity, likelihood ratios, and areas under the curve (AUCs) were calculated using random-effects models, with heterogeneity assessed through I².</p><p><strong>Results: </strong>Twelve studies with a total of 3344 patients were included. For differentiating grade 0 from grade ≥ 1 steatosis, the pooled AUC was 0.82 (95% CI 0.78-0.85) and DOR was 21.10 (I² = 67.2%), with sensitivity and specificity of 83%. For differentiating grades ≤ 1 from grade ≥ 2, the AUC was 0.80 (95% CI 0.73-0.86), DOR 19.87 (I² = 89%), sensitivity 84%, and specificity 80%. For differentiating grades ≤ 2 from grade 3, the AUC was 0.78 (95% CI 0.66-0.87), DOR 19.21 (I² = 85.3%), sensitivity 86%, and specificity 80%.</p><p><strong>Conclusion: </strong>UAI exhibits good diagnostic accuracy for grading hepatic steatosis and offers a practical, noninvasive alternative to MRI-PDFF, being particularly well-suited for screening and patient follow-up. Standardized protocols and further multicenter studies are needed to promote its clinical application.</p>","PeriodicalId":50130,"journal":{"name":"Journal of Medical Ultrasonics","volume":" ","pages":"157-168"},"PeriodicalIF":2.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145642117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Restricted morphological changes in infrapatellar fat pad during walking is revealed as a dynamics feature in symptomatic knee osteoarthritis.","authors":"Hinpetch Daungsupawong, Viroj Wiwanitkit","doi":"10.1007/s10396-025-01604-6","DOIUrl":"10.1007/s10396-025-01604-6","url":null,"abstract":"","PeriodicalId":50130,"journal":{"name":"Journal of Medical Ultrasonics","volume":" ","pages":"251"},"PeriodicalIF":2.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145745480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound-based prediction model for years to peak height velocity using multiple secondary ossification centers.","authors":"Kosuke Uemura, Mizue Saita, Koji Wagatsuma, Wataru Iwamoto, Daichi Morikawa, Yoshimasa Saigo, Toshio Naito","doi":"10.1007/s10396-025-01571-y","DOIUrl":"10.1007/s10396-025-01571-y","url":null,"abstract":"<p><strong>Purpose: </strong>Determining peak height velocity age (PHVA) is crucial for understanding child growth and development and preventing injuries. Previous studies have used anthropometric measurements or X-ray evaluation to predict the timing of PHV, whereas ultrasound provides a radiation-free and portable alternative. This study aimed to predict the years to PHV by assessing multiple secondary ossification centers using ultrasound.</p><p><strong>Methods: </strong>A total of 12 sites across eight bones were evaluated using ultrasound in 181 children aged 6-12 years between June and December 2019. Height data were tracked from school entry until December 2022, with PHVA calculated using AUXAL software. Multivariable regression analysis was performed using bone maturity as the explanatory variable and the difference between ultrasound measurement age and PHVA as the dependent variable.</p><p><strong>Results: </strong>A total of 159 participants were included in the final analysis. The hook of the hamate, calcaneus plantar thickness, plantar sesamoid, and tibial tuberosity were identified as significant variables for PHV prediction. The prediction equation was: Years to PHV = 1.206 + (0.562 × calcaneus plantar thickness) - (1.120 × plantar sesamoid) - (0.675 × tibial tuberosity) + (0.229 × hook of the hamate). This model achieved an adjusted R² of 0.782.</p><p><strong>Conclusion: </strong>Ultrasound evaluation of multiple secondary ossification centers may provide a valuable method for predicting years to PHV.</p>","PeriodicalId":50130,"journal":{"name":"Journal of Medical Ultrasonics","volume":" ","pages":"199-207"},"PeriodicalIF":2.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13092546/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145368837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between knee joint angles and infrapatellar fat pad stiffness in patients with knee osteoarthritis.","authors":"Shinya Ogaya, Satoshi Horiguchi, Riona Kaizu, Mai Tomita, Moko Kitahara, Kenta Horiuchi, Satoshi Kido, Takashi Matsuno","doi":"10.1007/s10396-025-01584-7","DOIUrl":"10.1007/s10396-025-01584-7","url":null,"abstract":"<p><strong>Purpose: </strong>The infrapatellar fat pad (IFP) is a source of pain in patients with knee osteoarthritis (OA). Changes in pressure due to knee joint movement may increase IFP stiffness and potentially cause pain. This study aimed to investigate changes in IFP stiffness during knee flexion in knee OA patients.</p><p><strong>Methods: </strong>Sixteen patients with knee OA and 14 healthy elderly controls participated in this study. IFP stiffness was measured with the patient in the supine position at maximum knee extension, 45°, 90°, and maximum flexion using ultrasound elastography. Stiffness was measured at the superficial layer of the IFP, located beneath the patellar tendon. Additionally, the knee pain score for knee OA patients was assessed using the numeric rating scale and the Intermittent and Constant Osteoarthritis Pain (ICOAP).</p><p><strong>Results: </strong>Two-way analysis of variance showed a significant main effect for group and joint angle, as well as an interaction effect. IFP stiffness increased with knee flexion. Knee OA patients exhibited significantly higher IFP stiffness at both maximum knee extension and flexion than the control group. A significant correlation was found between IFP stiffness in knee OA patients at 45°, 90°, and maximum knee flexion and ICOAP intermittent pain.</p><p><strong>Conclusion: </strong>These results suggest that knee movement affects IFP stiffness, with increased stiffness observed in knee OA patients. Increased stiffness in OA patients may contribute to knee pain, particularly at mid-to-deep flexion angles.</p>","PeriodicalId":50130,"journal":{"name":"Journal of Medical Ultrasonics","volume":" ","pages":"209-215"},"PeriodicalIF":2.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145276429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multicenter study of fetal crown-rump length measurement using 3D ultrasound in assisted reproductive technology pregnancies.","authors":"Ritsuko K Pooh, Megumi Machida, Kohtaro Uenishi, Takahito Miyake, Toshiyuki Hata, Rikikazu Sugiyama, Masahide Shiotani, Kenji Furui, Tetsunori Mukaida, Atsumi Yoshida, Fumitoshi Koga, Motowo Nabeta, Koichi Kyono, Yoshiharu Morimoto","doi":"10.1007/s10396-026-01626-8","DOIUrl":"https://doi.org/10.1007/s10396-026-01626-8","url":null,"abstract":"<p><strong>Purpose: </strong>Accurate crown-rump length (CRL) measurement is fundamental for pregnancy dating and first-trimester screening. The Japanese standards established in 2003 using two-dimensional (2D) ultrasound require updating with modern imaging technology. This study aimed to establish new CRL reference standards for Japanese fetuses using three-dimensional (3D) ultrasound in precisely dated assisted reproductive technology (ART) pregnancies.</p><p><strong>Methods: </strong>We conducted a multicenter retrospective cohort study of singleton ART pregnancies from 11 Japanese fertility centers (2020-2023), with pregnancy outcomes documented in 2024. Inclusion required term delivery (≥ 37 weeks) and birth weight within the mean ± 1.5 SD. CRL measurements were performed centrally using standardized 3D ultrasound protocols. Polynomial regression models were used to generate reference equations.</p><p><strong>Results: </strong>Of 2,356 datasets, 1,598 pregnancies met inclusion criteria. The mean maternal age was 36.3 ± 4.2 years. Reproducibility was excellent [intra- and inter-observer intraclass correlation coefficients (ICC) > 0.990]. No significant differences were found among ART methods in maternal age, gestational age at delivery, birth weight, or CRL growth pattern (p > 0.01). Third-degree polynomial regression produced reference curves for the 10th, 50th, and 90th percentiles. Compared with 2003 standards, CRL values were consistently larger (p < 0.001), and the growth trajectory showed no significant difference from the INTERGROWTH-21st international curve. Birth weights aligned with national standards, supporting general applicability.</p><p><strong>Conclusion: </strong>These updated 3D ultrasound-based CRL reference standards for ART pregnancies modernize Japanese practice and establish a refined framework for accurate gestational dating and first-trimester screening.</p>","PeriodicalId":50130,"journal":{"name":"Journal of Medical Ultrasonics","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147522520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of breast ultrasound image classification accuracy between convolutional neural networks and human experts using multicenter external validation cohort data.","authors":"Makoto Yamakawa, Tsuyoshi Shiina, Toshikazu Ito, Sadako-Tanaka Akashi, Kouzou Murakami, Takanori Watanabe, Hirotaka Morishima, Koichiro Tsugawa, Takayoshi Uematsu, Naoshi Nishida, Masatoshi Kudo","doi":"10.1007/s10396-026-01631-x","DOIUrl":"https://doi.org/10.1007/s10396-026-01631-x","url":null,"abstract":"<p><strong>Purpose: </strong>In recent years, much research has been conducted on ultrasound diagnosis of breast tumors using convolutional neural networks (CNNs). While many CNNs for breast tumor classification have been investigated, previous studies have evaluated them using data from the same institution that provided the CNN training data. This may have biased the accuracy of the CNNs. To perform a fairer evaluation, we compared the accuracy of CNNs with that of human experts using a multicenter external validation cohort. Additionally, previous studies used fewer than about 2000 images to train CNNs, whereas this study used 16,530 images.</p><p><strong>Methods: </strong>We trained a 2-class (benign, malignant) classification CNN and a 4-class (breast cancer, fibroadenoma, simple cyst, and other benign tumors) classification CNN using 16,530 images. Using data from a multicenter external validation cohort, we compared the classification accuracy of the developed CNNs to that of human experts.</p><p><strong>Results: </strong>The 2-class classification CNN achieved an accuracy of 88.1%. The benign/malignant classification from the 4-class classification CNN achieved an accuracy of 86.3%. Human experts achieved an accuracy of 83.2%. Thus, the 2-class classification CNN was slightly more accurate than the benign/malignant classification from the 4-class classification CNN. Both developed CNNs were more accurate than human experts.</p><p><strong>Conclusion: </strong>The CNNs developed using a large-scale breast ultrasound image database achieved higher accuracy than that of human experts in evaluation using multicenter external validation cohort data.</p>","PeriodicalId":50130,"journal":{"name":"Journal of Medical Ultrasonics","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147522576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fiducial marker placement for hepatocellular carcinoma using magnetic resonance imaging-ultrasound fusion guidance: targeting accuracy and determinants of error (with video).","authors":"Katsuhiko Tsutsumi, Kenta Yamamoto, Yumi Oie, Takayuki Miyachi, Yutaka Kato, Kentaro Yamao, Takuya Ishikawa, Yoji Ishizu, Takashi Honda, Hiroki Kawashima","doi":"10.1007/s10396-026-01624-w","DOIUrl":"https://doi.org/10.1007/s10396-026-01624-w","url":null,"abstract":"<p><strong>Purpose: </strong>Stereotactic body radiation therapy (SBRT) is effective for hepatocellular carcinoma (HCC), and accurate fiducial marker placement is essential for motion-compensated tracking. We assessed the targeting accuracy and safety achieved with magnetic resonance imaging-ultrasound (MRI-US) fusion guidance and explored factors associated with placement error.</p><p><strong>Methods: </strong>In this single-center cohort, 44 patients with HCC underwent SBRT with percutaneous fiducial placement under Gd-EOB-DTPA-enhanced MRI-US fusion. A region of interest (ROI) adjacent to the tumor was defined during planning, and the distance difference |A-B| between the planned tumor-ROI distance (A) and the post-procedure tumor-marker distance (B) was used as the targeting error. Predictors of error > 5 mm were explored using a random-forest model.</p><p><strong>Results: </strong>Median targeting error was 6.79 mm (range: 4.06-13.19 mm). In the exploratory model, a longer ROI-tumor distance appeared to have relatively higher feature-importance values for errors > 5 mm, whereas tumor depth and sonographic visibility contributed minimally. During follow-up, four local recurrences and twenty intrahepatic metastases occurred. The cumulative incidence of intrahepatic metastasis was 14.2%, 16.7%, and 24.1% at 180, 360, and 540 days, respectively. Two patients (7.4%) progressed from Child-Pugh class A to B at 6 months.</p><p><strong>Conclusions: </strong>MRI-US fusion guidance enabled sub-centimeter fiducial placement accuracy in this cohort. A shorter tumor-ROI distance may be associated with smaller targeting error, although this remains exploratory. Tumor depth and visibility showed limited influence on placement accuracy.</p>","PeriodicalId":50130,"journal":{"name":"Journal of Medical Ultrasonics","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147515895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}