Changes in proximal colon on intestinal ultrasound indicate the efficacy of induction therapy for active ulcerative colitis.

IF 2.1 4区医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Journal of Medical Ultrasonics Pub Date : 2025-06-16 DOI:10.1007/s10396-025-01554-z

Koichi Izumikawa, Tomoki Inaba, Eriko Yasutomi, Sakuma Takahashi, Hugh Shunsuke Colvin, Ichiro Sakakihara, Kumiko Yamamoto, Shigetomi Tanaka, Shigenao Ishikawa, Masaki Wato

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引用次数: 0

Abstract

Purpose: This study aimed to elucidate the effectiveness of intestinal ultrasound (IUS) in assessing induction therapy for active ulcerative colitis (UC).

Methods: Thirty-two patients (12 with severe colitis and 20 with moderate colitis) were analyzed. Disease activity was assessed using the Mayo endoscopic score (MES) obtained via colonoscopy. Ultrasound (US) grade and bowel wall thickness (BWT) before induction therapy were compared in terms of MES. Changes in US grade and BWT from pre-treatment to clinical improvement were analyzed at the most inflamed segments, oral side, and anal side.

Results: A correlation coefficient of 0.58 (p < 0.01) indicated a strong correlation between US grade and MES. US grade and BWT decreased at the most inflamed segments, oral side, and anal side for clinical improvement in all cases (p < 0.01, p < 0.01, respectively). However, changes in US grade were significantly greater on the oral side than the most inflamed segments or the anal side (p = 0.008 and p = 0.039, respectively).

Conclusion: IUS is an effective method for assessing the efficacy of induction therapy for active UC. The assessment should be performed at the proximal part of the colon, rather than solely at the site of the most pronounced inflammation.

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肠超声显示近端结肠改变提示诱导治疗活动性溃疡性结肠炎的疗效。

目的：本研究旨在阐明肠超声（IUS）在评估活动性溃疡性结肠炎（UC）诱导治疗中的有效性。方法：对32例患者的临床资料进行分析，其中重度结肠炎12例，中度结肠炎20例。使用结肠镜检查获得的Mayo内镜评分（MES）评估疾病活动性。比较诱导治疗前超声（US）分级和肠壁厚度（BWT）的MES。从治疗前到临床改善，我们分析了最炎症节段、口腔侧和肛门侧的US分级和BWT的变化。结果：相关系数为0.58 (p)。结论：IUS是评价诱导治疗活动性UC疗效的有效方法。评估应在结肠近端进行，而不是仅仅在最明显的炎症部位进行。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Medical Ultrasonics 医学-核医学

CiteScore

3.30

自引率

11.10%

发文量

102

审稿时长

>12 weeks

期刊介绍： The Journal of Medical Ultrasonics is the official journal of the Japan Society of Ultrasonics in Medicine. The main purpose of the journal is to provide forum for the publication of papers documenting recent advances and new developments in the entire field of ultrasound in medicine and biology, encompassing both the medical and the engineering aspects of the science.The journal welcomes original articles, review articles, images, and letters to the editor.The journal also provides state-of-the-art information such as announcements from the boards and the committees of the society.