medRxiv - Nutrition最新文献_第8页

Inflammatory dietary potential is associated with vitamin depletion and gut microbial dysbiosis in early pregnancy 妊娠早期的炎症性饮食可能与维生素消耗和肠道微生物失调有关

medRxiv - Nutrition Pub Date : 2023-12-03 DOI: 10.1101/2023.12.02.23299325

Suzanne Alvernaz, Elizabeth Wenzel, Unnathi Nagelli, Lacey Pezley, Bazil LaBomascus, Jack Gilbert, Pauline Maki, Lisa Tussing-Humphreys, Beatriz Penalver Bernabe

{"title":"Inflammatory dietary potential is associated with vitamin depletion and gut microbial dysbiosis in early pregnancy","authors":"Suzanne Alvernaz, Elizabeth Wenzel, Unnathi Nagelli, Lacey Pezley, Bazil LaBomascus, Jack Gilbert, Pauline Maki, Lisa Tussing-Humphreys, Beatriz Penalver Bernabe","doi":"10.1101/2023.12.02.23299325","DOIUrl":"https://doi.org/10.1101/2023.12.02.23299325","url":null,"abstract":"Background: Pregnancy alters many physiological systems, including the maternal gut microbiota. Diet is a key regulator of this system and can alter host inflammation. Multiple perinatal disorders have been associated with inflammation, maternal metabolic alterations, and gut microbiota dysbiosis, including gestational diabetes mellitus, preeclampsia, preterm birth, and mood disorders. However, the effects of high inflammatory diets on the gut microbiota during pregnancy has yet to be fully explored. Objective: To use a systems-based approach to characterize associations among dietary inflammatory potential, a measure of diet quality, and the gut microbiome during pregnancy. Methods: Forty-nine pregnant persons were recruited prior to 16 weeks of gestation. Participants completed a food frequency questionnaire (FFQ) and provided fecal samples. Dietary inflammatory potential was assessed using the Dietary Inflammatory Index (DII) from FFQ data. Fecal samples were analyzed using 16S rRNA amplicon sequencing. Differential taxa abundance with respect to DII score were identified, and microbial metabolic potential was predicted using PICRUSt2. Results: Inflammatory diets were associated with decreased vitamin and mineral intake and dysbiotic gut microbiome structure and metabolism. Gut microbial compositional differences revealed a decrease in short chain fatty acid producers such as g_Faecalibacterium, upregulation of vitamin B12 synthesis, methylglyoxal detoxification, galactose metabolism and multi drug efflux systems in pregnant individuals with increased DII scores. Conclusions: Dietary inflammatory potential was associated with depletion of vitamins & minerals and gut microbiota metabolic dysregulation.","PeriodicalId":501073,"journal":{"name":"medRxiv - Nutrition","volume":" 35","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138494389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A healthful plant-based diet is associated with higher physical and mental well-being among older adults independent of circulating CRP 健康的植物性饮食与独立于循环CRP的老年人更高的身心健康有关

medRxiv - Nutrition Pub Date : 2023-11-30 DOI: 10.1101/2023.11.30.23299231

Kerstin Schorr, Marian Beekman, Venetka Agayn, Jeanne H.M. de Vries, Lisette C.P.G.M. De Groot, P. Eline Slagboom

{"title":"A healthful plant-based diet is associated with higher physical and mental well-being among older adults independent of circulating CRP","authors":"Kerstin Schorr, Marian Beekman, Venetka Agayn, Jeanne H.M. de Vries, Lisette C.P.G.M. De Groot, P. Eline Slagboom","doi":"10.1101/2023.11.30.23299231","DOIUrl":"https://doi.org/10.1101/2023.11.30.23299231","url":null,"abstract":"Plant-based diets (PBD) have been found to be environmentally sustainable as well as beneficial for health. Observational research showed that higher plant-based diet quality improves well-being in adult women, however this is unclear for older adults. This association may be due to anti-inflammatory properties of PBD. Older adults, often suffering from chronic inflammation, may therefore profit from a more PBD. Therefore, we investigated the relation between PBD and well-being in older adults of both genders and tested whether the effects are influenced by circulating high-senstivity C-reactive protein (hsCRP) levels. We used the data of the population-based Lifelines Cohort Study (n=6,635, mean age=65.2 years) and a subsample in which hsCRP was measured (n=2,251, mean age=65.2 years). We applied a plant-based diet index measuring adherence to a healthful (hPDI) and an unhealthful (uPDI) plant-based diet based on food frequency questionnaires. The RAND-36 questionnaire was applied as measure of quality of life, from which we derived physical (PCS) and mental component scores (MCS). Older adults with the highest adherence to a healthful plant-based diet had respectively 14% and 12% greater odds for high physical well-being and mental well-being. Meanwhile, higher adherence to uPDI was associated with respectively 19% and 14% lower odds for high physical and mental well-being. We observed an additive but no mediating effect of hsCRP on the association between plant-based diets and well-being. We conclude that in older men and women, adherence to a healthful plant-based diet and circulating levels of inflammation are independently associated with physical and mental well-being.","PeriodicalId":501073,"journal":{"name":"medRxiv - Nutrition","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138516420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling Vulnerabilities in Maternal-Child Health amidst COVID-19: A Cross-Sectional Study on Food Insecurity and Socio-Demographic Disparities in the U.S. 揭示COVID-19期间母婴健康的脆弱性:美国粮食不安全和社会人口差异的横断面研究

medRxiv - Nutrition Pub Date : 2023-11-29 DOI: 10.1101/2023.11.28.23299080

Zoe Henkes, Maria J. Romo-Palafox

引用次数: 0

Changes in household purchasing of soft drinks following the UK Soft Drinks Industry Levy by household income and composition: controlled interrupted time series analysis, March 2014 to November 2019 2014年3月至2019年11月，按家庭收入和组成划分的英国软饮料行业征税后家庭购买软饮料的变化:受控中断时间序列分析

medRxiv - Nutrition Pub Date : 2023-11-28 DOI: 10.1101/2023.11.27.23299070

Nina T. Rogers, Steven Cummins, David Pell, Harry Rutter, Stephen J. Sharp, Richard Smith, Martin White, Jean Adams

引用次数: 0

Effects of Maternal Fortified Balanced Energy-Protein Supplementation on the Mother-Infant Gut Microbiome: A Sub-Study of the MISAME-III Randomized Controlled Trial 母体强化平衡能量蛋白补充对母婴肠道微生物组的影响:MISAME-III随机对照试验的一项亚研究

medRxiv - Nutrition Pub Date : 2023-11-27 DOI: 10.1101/2023.11.24.23298964

Lishi Deng, Steff Taelman, Matthew R. Olm, Laéticia Céline Toé, Eva Balini, Lionel Ouédraogo, Yuri Bastos-Moreira, Alemayehu Argaw, Kokeb Tesfamariam, Erica D. Sonnenburg, Moctar Ouédraogo, Rasmané Ganaba, Wim van Criekinge, Patrick Kolsteren, Michiel Stock, Carl Lachat, Justin L. Sonnenburg, Trenton Dailey-Chwalibóg

{"title":"Effects of Maternal Fortified Balanced Energy-Protein Supplementation on the Mother-Infant Gut Microbiome: A Sub-Study of the MISAME-III Randomized Controlled Trial","authors":"Lishi Deng, Steff Taelman, Matthew R. Olm, Laéticia Céline Toé, Eva Balini, Lionel Ouédraogo, Yuri Bastos-Moreira, Alemayehu Argaw, Kokeb Tesfamariam, Erica D. Sonnenburg, Moctar Ouédraogo, Rasmané Ganaba, Wim van Criekinge, Patrick Kolsteren, Michiel Stock, Carl Lachat, Justin L. Sonnenburg, Trenton Dailey-Chwalibóg","doi":"10.1101/2023.11.24.23298964","DOIUrl":"https://doi.org/10.1101/2023.11.24.23298964","url":null,"abstract":"Biological pathways, including individual gut microbiome are potential barriers for maternal nutritional supplementation to improvement in infant growth. We evaluated the impact of balanced energy-protein (BEP) supplementation during pregnancy and the first six months of lactation on the composition and functionality of gut microbiome in mothers and their infants in rural Burkina Faso. Our findings reveal that BEP supplementation led to a significant increase in microbiome diversity during pregnancy. In the second trimester, there was a notable decrease in the abundance of an <em>Oscillospiraceae</em> species, while postpartum, the abundance of <em>Bacteroides fragilis</em> increased. We identified concerted enriched or depleted microbial pathways associated with BEP supplementation, including the phosphotransferase system, a critical mechanism for bacterial carbohydrates uptake, which exhibited enrichment in infants born to BEP-supplemented mothers. Despite these observations, the intricate biological connections with other omics necessitate further analysis to fully elucidate the underlying comprehensive biological pathways.","PeriodicalId":501073,"journal":{"name":"medRxiv - Nutrition","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138516419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long chain omega-3 fatty acid intake in pregnancy and risk of type 1 diabetes in the offspring: Two large Scandinavian pregnancy cohorts – MoBa and DNBC 妊娠期摄入长链omega-3脂肪酸和后代患1型糖尿病的风险:两个大型斯堪的纳维亚妊娠队列- MoBa和DNBC

medRxiv - Nutrition Pub Date : 2023-11-24 DOI: 10.1101/2023.11.23.23297665

Nicolai A. Lund-Blix, Anne A. Bjerregaard, German Tapia, Ketil Størdal, Anne Lise Brantsæter, Marin Strøm, Thorhallur I. Halldorsson, Charlotta Granstrøm, Jannet Svensson, Geir Joner, Torild Skrivarhaug, Pål R. Njølstad, Sjurdur F. Olsen, Lars C. Stene

引用次数: 0

Exogenous ketosis attenuates acute mountain sickness and mitigates high-altitude hypoxemia 外源性酮症可减轻急性高山病和高原低氧血症

medRxiv - Nutrition Pub Date : 2023-11-22 DOI: 10.1101/2023.11.21.23298762

Myrthe Stalmans, Domen Tominec, Wout Lauriks, Ruben Robberechts, Tadej Debevec, Chiel Poffé

引用次数: 0

Prenatal multiple micronutrient-fortified balanced energy-protein supplementation and newborn telomere length and mitochondrial DNA content: a randomized controlled efficacy trial in rural Burkina Faso 产前多种微量营养素强化平衡能量蛋白补充和新生儿端粒长度和线粒体DNA含量:布基纳法索农村的随机对照疗效试验

medRxiv - Nutrition Pub Date : 2023-11-22 DOI: 10.1101/2023.11.22.23298825

Giles T. Hanley-Cook, Yuri Bastos-Moreira, Dries S. Martens, Trenton Dailey-Chwalibóg, Laeticia Celine Toe, Brenda de Kok, Lionel Ouédraogo, Alemayehu Argaw, Kokeb Tesfamariam, Patrick Kolsteren, Lieven Huybregts, Tim S. Nawrot, Sarah De Saeger, Marthe De Boevre, Carl Lachat

引用次数: 0

Decreases in purchases of energy, sodium, sugar, and saturated fat three years after implementation of the Chilean Food Labelling and Marketing Law 《智利食品标签和营销法》实施三年后，能源、钠、糖和饱和脂肪的购买量减少

medRxiv - Nutrition Pub Date : 2023-11-22 DOI: 10.1101/2023.11.21.23298789

Lindsey Smith Taillie, Maxime Bercholz, Barry Popkin, Natalia Rebolledo, Marcela Reyes, M. Camila Corvalán

引用次数: 0

FooDOxS: A Database of Oxidized Sterols Content in Foods 食品中氧化甾醇含量数据库

medRxiv - Nutrition Pub Date : 2023-11-18 DOI: 10.1101/2023.11.15.23298592

Ilce Gabriela Medina-Meza, Yashasvi Vaidya, Carlo Barnaba

引用次数: 0