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1390 A Fc-optimized B7-H3 antibody for induction of NK cell reactivity against acute myeloid leukemia 1390a fc优化的B7-H3抗体诱导NK细胞对急性髓性白血病的反应性
Regular and Young Investigator Award Abstracts Pub Date : 2023-11-01 DOI: 10.1136/jitc-2023-sitc2023.1390
Sylwia A Stefanczyk, Ilona Hagelstein, Martina S Lutz, Stefanie Müller, Latifa Zekri, Jonas S Heitmann, Helmut R Salih, Melanie Märklin
{"title":"1390 A Fc-optimized B7-H3 antibody for induction of NK cell reactivity against acute myeloid leukemia","authors":"Sylwia A Stefanczyk, Ilona Hagelstein, Martina S Lutz, Stefanie Müller, Latifa Zekri, Jonas S Heitmann, Helmut R Salih, Melanie Märklin","doi":"10.1136/jitc-2023-sitc2023.1390","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.1390","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135216402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
76 Customizable polymer-based synthetic cells for imaging flow cytometry 用于成像流式细胞术的可定制聚合物合成细胞
Regular and Young Investigator Award Abstracts Pub Date : 2023-11-01 DOI: 10.1136/jitc-2023-sitc2023.0076
Martina de Geus, Daixuan Zhang, Juan Armas
{"title":"76 Customizable polymer-based synthetic cells for imaging flow cytometry","authors":"Martina de Geus, Daixuan Zhang, Juan Armas","doi":"10.1136/jitc-2023-sitc2023.0076","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.0076","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135216425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
1288 Characterization of tertiary lymphoid structure in pancreatic ductal adenocarcinoma tumors: insights from gene expression and pathology images, and identification using a deep learning approach 1288胰腺导管腺癌肿瘤的三级淋巴结构特征:来自基因表达和病理图像的见解，以及使用深度学习方法的识别
Regular and Young Investigator Award Abstracts Pub Date : 2023-11-01 DOI: 10.1136/jitc-2023-sitc2023.1288
Meijian Guan, Anantharaman Muthuswamy, Susan Sun, Clifton Drew, Jenny Kaufmann, Merzu Belete, Sriram Sridhar, Brandon Higgs, Han Si
{"title":"1288 Characterization of tertiary lymphoid structure in pancreatic ductal adenocarcinoma tumors: insights from gene expression and pathology images, and identification using a deep learning approach","authors":"Meijian Guan, Anantharaman Muthuswamy, Susan Sun, Clifton Drew, Jenny Kaufmann, Merzu Belete, Sriram Sridhar, Brandon Higgs, Han Si","doi":"10.1136/jitc-2023-sitc2023.1288","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.1288","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135216432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
119 Uncovering spatial biology of mouse tumor immune microenvironment using imaging mass cytometry 119利用成像细胞术揭示小鼠肿瘤免疫微环境的空间生物学
Regular and Young Investigator Award Abstracts Pub Date : 2023-11-01 DOI: 10.1136/jitc-2023-sitc2023.0119
Qanber Raza, Liang Lim, Thomas D Pfister, Christina Loh
{"title":"119 Uncovering spatial biology of mouse tumor immune microenvironment using imaging mass cytometry","authors":"Qanber Raza, Liang Lim, Thomas D Pfister, Christina Loh","doi":"10.1136/jitc-2023-sitc2023.0119","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.0119","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135216476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
1053 Preclinical pharmacodynamic characterization of STK-026: a novel IL-12 partial agonist for cancer with maintained CD8 T cell activity, reduced NK-mediated toxicity and an improved therapeutic window STK-026的临床前药效学特征:一种新的IL-12部分激动剂，具有维持CD8 T细胞活性，降低nk介导的毒性和改善的治疗窗口
Regular and Young Investigator Award Abstracts Pub Date : 2023-11-01 DOI: 10.1136/jitc-2023-sitc2023.1053
Zhenya Koliesnik, Michael Totagrande, Ryan Burgess, Kim Q Tran, Michele Bauer, Bharghavi Jayaraman, Cindy Buffone, Priyanka Balasubrahmanyam, Jan Emmerich, Deepti Chaturvedi, Deepti Rokkam, Rene De Waal Malefyt, Heiko Greb, Navneet Ratti, Sandro Vivona, Robert Kastelein, Patrick Lupardus, Luis Zuniga, David B Rosen, Martin Oft
{"title":"1053 Preclinical pharmacodynamic characterization of STK-026: a novel IL-12 partial agonist for cancer with maintained CD8 T cell activity, reduced NK-mediated toxicity and an improved therapeutic window","authors":"Zhenya Koliesnik, Michael Totagrande, Ryan Burgess, Kim Q Tran, Michele Bauer, Bharghavi Jayaraman, Cindy Buffone, Priyanka Balasubrahmanyam, Jan Emmerich, Deepti Chaturvedi, Deepti Rokkam, Rene De Waal Malefyt, Heiko Greb, Navneet Ratti, Sandro Vivona, Robert Kastelein, Patrick Lupardus, Luis Zuniga, David B Rosen, Martin Oft","doi":"10.1136/jitc-2023-sitc2023.1053","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.1053","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135216510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
994 Functional assays on the single cell level: advantages and applications for NK killing assays 单细胞水平的功能测定:NK杀伤测定的优势和应用
Regular and Young Investigator Award Abstracts Pub Date : 2023-11-01 DOI: 10.1136/jitc-2023-sitc2023.0994
Nora Fekete-Drimusz, Alessia Dunst, Bas Lievaart, Jannis Naehring, Robin Krüger
{"title":"994 Functional assays on the single cell level: advantages and applications for NK killing assays","authors":"Nora Fekete-Drimusz, Alessia Dunst, Bas Lievaart, Jannis Naehring, Robin Krüger","doi":"10.1136/jitc-2023-sitc2023.0994","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.0994","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135216659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
1449 NCG-M is a triple immunodeficient mouse with increased reconstitution of human myeloid cell populations for use in immunotherapy preclinical research 1449 NCG-M是一种三重免疫缺陷小鼠，具有增加的人髓细胞群重构，用于免疫治疗临床前研究
Regular and Young Investigator Award Abstracts Pub Date : 2023-11-01 DOI: 10.1136/jitc-2023-sitc2023.1449
Steven Bronson, Jenny Rowe, Christoph Eberle, Robert Mihalek, Ann Fiore, Stephen Festin
{"title":"1449 NCG-M is a triple immunodeficient mouse with increased reconstitution of human myeloid cell populations for use in immunotherapy preclinical research","authors":"Steven Bronson, Jenny Rowe, Christoph Eberle, Robert Mihalek, Ann Fiore, Stephen Festin","doi":"10.1136/jitc-2023-sitc2023.1449","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.1449","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135216677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
606 IMpower110: Tertiary lymphoid structures (TLS) and clinical outcomes in advanced non-small cell lung cancer (NSCLC) treated with first-line atezolizumab or chemotherapy 606 IMpower110:一线atezolizumab或化疗治疗晚期非小细胞肺癌(NSCLC)的三级淋巴样结构(TLS)和临床结果
Regular and Young Investigator Award Abstracts Pub Date : 2023-11-01 DOI: 10.1136/jitc-2023-sitc2023.0606
Minu K Srivastava, Velimir Gayevskiy, Vy Ma, Ivette Estay, Miguel Lopez de Rodas, Barani Kumar Rajendran, Tien Hoang, Marcus Ballinger, Reena Amin, Roy S Herbst, Filippo de Marinis, Giuseppe Giaccone, Jacek Jassem, David R Spigel, Kurt Schalper, Hartmut Koeppen, David S Shames, Robert Johnston, Jennifer M Giltnane, Barzin Y Nabet
{"title":"606 IMpower110: Tertiary lymphoid structures (TLS) and clinical outcomes in advanced non-small cell lung cancer (NSCLC) treated with first-line atezolizumab or chemotherapy","authors":"Minu K Srivastava, Velimir Gayevskiy, Vy Ma, Ivette Estay, Miguel Lopez de Rodas, Barani Kumar Rajendran, Tien Hoang, Marcus Ballinger, Reena Amin, Roy S Herbst, Filippo de Marinis, Giuseppe Giaccone, Jacek Jassem, David R Spigel, Kurt Schalper, Hartmut Koeppen, David S Shames, Robert Johnston, Jennifer M Giltnane, Barzin Y Nabet","doi":"10.1136/jitc-2023-sitc2023.0606","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.0606","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135216729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
1313 UltiStacker™: easy to use multimodal image co-registration with sub-cellular accuracy 1313 UltiStacker™:易于使用的多模态图像共配准与亚细胞精度
Regular and Young Investigator Award Abstracts Pub Date : 2023-11-01 DOI: 10.1136/jitc-2023-sitc2023.1313
Douglas Wood, Gourab Chatterjee, Angela Vasaturo
{"title":"1313 UltiStacker™: easy to use multimodal image co-registration with sub-cellular accuracy","authors":"Douglas Wood, Gourab Chatterjee, Angela Vasaturo","doi":"10.1136/jitc-2023-sitc2023.1313","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.1313","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135216735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
440 Preclinical safety assessment for specificity of biotherapeutics using the membrane proteome array 440利用膜蛋白质组阵列对生物治疗药物特异性进行临床前安全性评估
Regular and Young Investigator Award Abstracts Pub Date : 2023-11-01 DOI: 10.1136/jitc-2023-sitc2023.0440
Tabb Sullivan, Carmen Navia, Rona Wilf, Rachel Fong, Benjamin Doranz
{"title":"440 Preclinical safety assessment for specificity of biotherapeutics using the membrane proteome array","authors":"Tabb Sullivan, Carmen Navia, Rona Wilf, Rachel Fong, Benjamin Doranz","doi":"10.1136/jitc-2023-sitc2023.0440","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.0440","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135216752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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