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451 Outcomes of patients with unresectable hepatocellular carcinoma who developed an infection while receiving Atezolizumab 451例不可切除肝细胞癌患者在接受Atezolizumab治疗时发生感染的结果
Regular and Young Investigator Award Abstracts Pub Date : 2023-11-01 DOI: 10.1136/jitc-2023-sitc2023.0451
Jiaqiong Xu, Ethan Burns, Kelly Gee, Catherine Wiechmann, Yuqi Zhang, Ryan Kieser, Godsfavour Umoru, Shivan Shah, Kai Sun, Maen Abdelrahim, Abdullah Esmail
{"title":"451 Outcomes of patients with unresectable hepatocellular carcinoma who developed an infection while receiving Atezolizumab","authors":"Jiaqiong Xu, Ethan Burns, Kelly Gee, Catherine Wiechmann, Yuqi Zhang, Ryan Kieser, Godsfavour Umoru, Shivan Shah, Kai Sun, Maen Abdelrahim, Abdullah Esmail","doi":"10.1136/jitc-2023-sitc2023.0451","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.0451","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135216909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
1482 Spatial characterization of pro-inflammatory pathways in the pathogenesis of IBD-associated colorectal cancer 1482 . ibd相关结直肠癌发病过程中促炎通路的空间特征
Regular and Young Investigator Award Abstracts Pub Date : 2023-11-01 DOI: 10.1136/jitc-2023-sitc2023.1482
Kirsteen Maclean, Anna Juncker-Jensen, Qinqin Zha, Lakshmi Chandramohan
{"title":"1482 Spatial characterization of pro-inflammatory pathways in the pathogenesis of IBD-associated colorectal cancer","authors":"Kirsteen Maclean, Anna Juncker-Jensen, Qinqin Zha, Lakshmi Chandramohan","doi":"10.1136/jitc-2023-sitc2023.1482","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.1482","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135216924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
959 Multiomic characterization of the tumor microenvironment in FFPE tissue by simultaneous protein and gene expression profiling 959通过同时进行蛋白和基因表达谱分析的FFPE组织中肿瘤微环境的多组学表征
Regular and Young Investigator Award Abstracts Pub Date : 2023-11-01 DOI: 10.1136/jitc-2023-sitc2023.0959
Jun Chiang, Ace Santiago, Alexander Hermes, Anuj Patel, Benton Veire, David Sukovich, Hardeep Singh, Lauren Gutgesell, Stephen Williams, Augusto Tentori
{"title":"959 Multiomic characterization of the tumor microenvironment in FFPE tissue by simultaneous protein and gene expression profiling","authors":"Jun Chiang, Ace Santiago, Alexander Hermes, Anuj Patel, Benton Veire, David Sukovich, Hardeep Singh, Lauren Gutgesell, Stephen Williams, Augusto Tentori","doi":"10.1136/jitc-2023-sitc2023.0959","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.0959","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135216963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
836 A novel PD-L1 antibody-IL10 fusion protein, PTL011, exhibits synergized therapeutic effect in hepatocellular carcinoma mouse model 一种新的PD-L1抗体- il10融合蛋白PTL011在肝细胞癌小鼠模型中显示出协同治疗作用
Regular and Young Investigator Award Abstracts Pub Date : 2023-11-01 DOI: 10.1136/jitc-2023-sitc2023.0836
Chin-Hsien Tsai, Sheue-Fen Tzeng, Yi-Ru Yu, Huey-Wen Hsiao, Jaeoh Park, Pandelakis Koni, Hung-Kai Chen, Lana Kandalaft, Claudia Lengerke, Ping-Chih Ho
{"title":"836 A novel PD-L1 antibody-IL10 fusion protein, PTL011, exhibits synergized therapeutic effect in hepatocellular carcinoma mouse model","authors":"Chin-Hsien Tsai, Sheue-Fen Tzeng, Yi-Ru Yu, Huey-Wen Hsiao, Jaeoh Park, Pandelakis Koni, Hung-Kai Chen, Lana Kandalaft, Claudia Lengerke, Ping-Chih Ho","doi":"10.1136/jitc-2023-sitc2023.0836","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.0836","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135216966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
81 Optimizing ex vivo CAR-T cell­­­-mediated cytotoxicity assay through multimodality imaging 81通过多模态成像优化体外CAR-T细胞介导的细胞毒性试验
Regular and Young Investigator Award Abstracts Pub Date : 2023-11-01 DOI: 10.1136/jitc-2023-sitc2023.0081
John G Foulke, Luping Chen, Hyeyoun Chang, Kevin M Tyo, Fang Tian, Zhizhan Gu
{"title":"81 Optimizing ex vivo CAR-T cell­­­-mediated cytotoxicity assay through multimodality imaging","authors":"John G Foulke, Luping Chen, Hyeyoun Chang, Kevin M Tyo, Fang Tian, Zhizhan Gu","doi":"10.1136/jitc-2023-sitc2023.0081","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.0081","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135217001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
1067 A three stage immune targeted immuno-cytokine platform that delivers inflammatory signals to the tumor microenvironment 1067一个向肿瘤微环境传递炎症信号的三期免疫靶向免疫细胞因子平台
Regular and Young Investigator Award Abstracts Pub Date : 2023-11-01 DOI: 10.1136/jitc-2023-sitc2023.1067
Brian Rabinovich, Xueyuan Zhou, Jeffrey Takimoto, Nikhita Khanna, Sunny Yoon, Evren Alici
{"title":"1067 A three stage immune targeted immuno-cytokine platform that delivers inflammatory signals to the tumor microenvironment","authors":"Brian Rabinovich, Xueyuan Zhou, Jeffrey Takimoto, Nikhita Khanna, Sunny Yoon, Evren Alici","doi":"10.1136/jitc-2023-sitc2023.1067","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.1067","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135217003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
1315 Identification and generalization of tissue structures with spatial cellular graph partitioning (SCGP) 1315基于空间细胞图划分(SCGP)的组织结构识别与概化
Regular and Young Investigator Award Abstracts Pub Date : 2023-11-01 DOI: 10.1136/jitc-2023-sitc2023.1315
Zhenqin Wu, James Zou, Aaron Mayer, Alexandro E Trevino
{"title":"1315 Identification and generalization of tissue structures with spatial cellular graph partitioning (SCGP)","authors":"Zhenqin Wu, James Zou, Aaron Mayer, Alexandro E Trevino","doi":"10.1136/jitc-2023-sitc2023.1315","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.1315","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135217012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
259 Discovery of synthetic signaling pathway receptors that increase the potency of CAR-T cells through optimized STAT activity 259发现通过优化STAT活性提高CAR-T细胞效力的合成信号通路受体
Regular and Young Investigator Award Abstracts Pub Date : 2023-11-01 DOI: 10.1136/jitc-2023-sitc2023.0259
Thomas J Gardner, Beatriz Millare, Anzhi Yao, Lan Chen, Ashley Cass, Suchismita Mohanty, Jeremy Chen, Alma Gomez, David DeTomaso, Manching Ku, Lionel Berthoin, Meng Lim, Azalea Ong, Vince Thomas, Nicholas Quant, Brian Hsu, Amy-Jo Casbon, Natalie Bezman, Aaron Cooper, Levi Gray-Rupp, Angela Boroughs, W Nicholas Haining
{"title":"259 Discovery of synthetic signaling pathway receptors that increase the potency of CAR-T cells through optimized STAT activity","authors":"Thomas J Gardner, Beatriz Millare, Anzhi Yao, Lan Chen, Ashley Cass, Suchismita Mohanty, Jeremy Chen, Alma Gomez, David DeTomaso, Manching Ku, Lionel Berthoin, Meng Lim, Azalea Ong, Vince Thomas, Nicholas Quant, Brian Hsu, Amy-Jo Casbon, Natalie Bezman, Aaron Cooper, Levi Gray-Rupp, Angela Boroughs, W Nicholas Haining","doi":"10.1136/jitc-2023-sitc2023.0259","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.0259","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135217211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
1494 Role of gain of function p53 mutations in macrophage polarization and myeloid-derived suppressor cells in head and neck squamous cell carcinoma 1494功能获得p53突变在头颈部鳞状细胞癌中巨噬细胞极化和髓源性抑制细胞中的作用
Regular and Young Investigator Award Abstracts Pub Date : 2023-11-01 DOI: 10.1136/jitc-2023-sitc2023.1494
Alanis Rodriguez Rosario, Fabio Henrique Brasil Da Costa, Nicholas Balbin, Roberto Rangel, Abdullah A Osman, Jeffrey N Myers, Andrew Sikora, Roberto Rangel
{"title":"1494 Role of gain of function p53 mutations in macrophage polarization and myeloid-derived suppressor cells in head and neck squamous cell carcinoma","authors":"Alanis Rodriguez Rosario, Fabio Henrique Brasil Da Costa, Nicholas Balbin, Roberto Rangel, Abdullah A Osman, Jeffrey N Myers, Andrew Sikora, Roberto Rangel","doi":"10.1136/jitc-2023-sitc2023.1494","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.1494","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135217232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
640 The combination of COM701 + nivolumab demonstrates preliminary antitumor activity in patients with metastatic breast cancer COM701 + nivolumab联合应用在转移性乳腺癌患者中显示出初步的抗肿瘤活性
Regular and Young Investigator Award Abstracts Pub Date : 2023-11-01 DOI: 10.1136/jitc-2023-sitc2023.0640
Ecaterina Dumbrava, Bartosz Chmielowski, Dale Shepard, Daniel Vaena, Drew Rasco, Manish Sharma, Erika Hamilton, Kyriakos P Papadopoulos, Judy S Wang, Eran Ophir, Pierre Ferre, Inbal Barbiro, Gady Cojocaru, Adeboye H Adewoye, Manish Patel
{"title":"640 The combination of COM701 + nivolumab demonstrates preliminary antitumor activity in patients with metastatic breast cancer","authors":"Ecaterina Dumbrava, Bartosz Chmielowski, Dale Shepard, Daniel Vaena, Drew Rasco, Manish Sharma, Erika Hamilton, Kyriakos P Papadopoulos, Judy S Wang, Eran Ophir, Pierre Ferre, Inbal Barbiro, Gady Cojocaru, Adeboye H Adewoye, Manish Patel","doi":"10.1136/jitc-2023-sitc2023.0640","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.0640","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135217276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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