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762 A first-in-human phase 1 clinical study evaluating safety, tolerability, pharmacokinetics, pharmacodynamics and efficacy of the EDB+FN targeting ADC PYX-201 in participants with advanced solid tumors 762一项针对晚期实体瘤患者的EDB+FN靶向ADC PYX-201的安全性、耐受性、药代动力学、药效学和疗效的人体i期临床研究
Regular and Young Investigator Award Abstracts Pub Date : 2023-11-01 DOI: 10.1136/jitc-2023-sitc2023.0762
Sharon Wilks, Benedito Carneiro, Gregory Cote, Jason Henry, Shiraj Sen, Alexander I Spira, Frank Yung-Chin Tsai, Judy S Wang, Marsha Crochiere, Shui He, Sondra Smyrnios, Dipali Unadkat, Bin Zhang, Anthony W Tolcher
{"title":"762 A first-in-human phase 1 clinical study evaluating safety, tolerability, pharmacokinetics, pharmacodynamics and efficacy of the EDB+FN targeting ADC PYX-201 in participants with advanced solid tumors","authors":"Sharon Wilks, Benedito Carneiro, Gregory Cote, Jason Henry, Shiraj Sen, Alexander I Spira, Frank Yung-Chin Tsai, Judy S Wang, Marsha Crochiere, Shui He, Sondra Smyrnios, Dipali Unadkat, Bin Zhang, Anthony W Tolcher","doi":"10.1136/jitc-2023-sitc2023.0762","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.0762","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135217285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
1022 Sex-biased T cell exhaustion drives differential immune responses in glioblastoma 性别偏倚的T细胞衰竭驱动胶质母细胞瘤的差异免疫反应
Regular and Young Investigator Award Abstracts Pub Date : 2023-11-01 DOI: 10.1136/jitc-2023-sitc2023.1022
Juyeun Lee, Michael Nicosia, Ellen Hong, Daniel Silver, Cathy Li, Justin Lathia
{"title":"1022 Sex-biased T cell exhaustion drives differential immune responses in glioblastoma","authors":"Juyeun Lee, Michael Nicosia, Ellen Hong, Daniel Silver, Cathy Li, Justin Lathia","doi":"10.1136/jitc-2023-sitc2023.1022","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.1022","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135217289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
1287 Comparison of multiplex immunofluorescence and H&E-based approaches for characterization of the tumor microenvironment 1287多重免疫荧光与基于H&amp的肿瘤微环境表征方法的比较
Regular and Young Investigator Award Abstracts Pub Date : 2023-11-01 DOI: 10.1136/jitc-2023-sitc2023.1287
Fredrick D Gootkind, Xinwei Sher, Keith Steele, Florent Peyraud, Jean-Philippe Guégan, Antoine Italiano, Guy T Clifton, Laura A Dillon
{"title":"1287 Comparison of multiplex immunofluorescence and H&E-based approaches for characterization of the tumor microenvironment","authors":"Fredrick D Gootkind, Xinwei Sher, Keith Steele, Florent Peyraud, Jean-Philippe Guégan, Antoine Italiano, Guy T Clifton, Laura A Dillon","doi":"10.1136/jitc-2023-sitc2023.1287","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.1287","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135217295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
212 Investigating cancer and immune cell interactions in the tumour microenvironment with MERFISH 利用MERFISH研究肿瘤微环境中癌症和免疫细胞的相互作用
Regular and Young Investigator Award Abstracts Pub Date : 2023-11-01 DOI: 10.1136/jitc-2023-sitc2023.0212
Leiam Colbert, Nicolas Fernandez, Hao Wang, Benjamin Patterson, Justin He, Jiang He
{"title":"212 Investigating cancer and immune cell interactions in the tumour microenvironment with MERFISH","authors":"Leiam Colbert, Nicolas Fernandez, Hao Wang, Benjamin Patterson, Justin He, Jiang He","doi":"10.1136/jitc-2023-sitc2023.0212","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.0212","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135217466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
820 ANV600 is a novel PD-1 targeted IL-2Rβ/γ agonist that is combinable with therapeutic PD-1 inhibitors 820 ANV600是一种新型PD-1靶向IL-2Rβ/γ激动剂，可与治疗性PD-1抑制剂联合使用
Regular and Young Investigator Award Abstracts Pub Date : 2023-11-01 DOI: 10.1136/jitc-2023-sitc2023.0820
Patrizia Murer, Ulisse Salazar, Nicole Egli, Laetitia Petersen, Pia Neubert, Christian Stocker, Alexander Rau, Kirsten Richter, Andreas Katopodis, Christoph Huber
{"title":"820 ANV600 is a novel PD-1 targeted IL-2Rβ/γ agonist that is combinable with therapeutic PD-1 inhibitors","authors":"Patrizia Murer, Ulisse Salazar, Nicole Egli, Laetitia Petersen, Pia Neubert, Christian Stocker, Alexander Rau, Kirsten Richter, Andreas Katopodis, Christoph Huber","doi":"10.1136/jitc-2023-sitc2023.0820","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.0820","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135217478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
516 CD47 x B7-H3 bispecific antibody offers a new strategy for treating B7-H3+/CD47+tumors 516 CD47 x B7-H3双特异性抗体为治疗B7-H3+/CD47+肿瘤提供了新的策略
Regular and Young Investigator Award Abstracts Pub Date : 2023-11-01 DOI: 10.1136/jitc-2023-sitc2023.0516
Xinhua Wang, Oi Kwan Wong, Lei Shi, Qi Fei, Leonard Post, Xiaocheng Chen
{"title":"516 CD47 x B7-H3 bispecific antibody offers a new strategy for treating B7-H3<sup>+</sup>/CD47<sup>+</sup>tumors","authors":"Xinhua Wang, Oi Kwan Wong, Lei Shi, Qi Fei, Leonard Post, Xiaocheng Chen","doi":"10.1136/jitc-2023-sitc2023.0516","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.0516","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135217482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
1068 Evaluation of the innate and adaptive immune modulatory properties and anti-tumor activity of CD38-targeted interferon alpha [68] cd38靶向干扰素α的先天和适应性免疫调节特性及抗肿瘤活性的评价
Regular and Young Investigator Award Abstracts Pub Date : 2023-11-01 DOI: 10.1136/jitc-2023-sitc2023.1068
James F Sampson, Hong Zhang, Tomoya Hara, Dong Mei Zhang, Adam J Hinthorne, Sabrina C Collins, Michael D Curley
{"title":"1068 Evaluation of the innate and adaptive immune modulatory properties and anti-tumor activity of CD38-targeted interferon alpha","authors":"James F Sampson, Hong Zhang, Tomoya Hara, Dong Mei Zhang, Adam J Hinthorne, Sabrina C Collins, Michael D Curley","doi":"10.1136/jitc-2023-sitc2023.1068","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.1068","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135217516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
1023 Cell-intrinsic Tim-3 is required for optimal CD8 response to acute LCMV infection 细胞内固有的Tim-3是CD8对急性LCMV感染的最佳反应所必需的
Regular and Young Investigator Award Abstracts Pub Date : 2023-11-01 DOI: 10.1136/jitc-2023-sitc2023.1023
Priyanka Manandhar, Emily Landy, Lawrence Kane
{"title":"1023 Cell-intrinsic Tim-3 is required for optimal CD8 response to acute LCMV infection","authors":"Priyanka Manandhar, Emily Landy, Lawrence Kane","doi":"10.1136/jitc-2023-sitc2023.1023","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.1023","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135217525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
1324 The effect of antibiotic therapy on immunotherapy outcomes in the treatment of acquired bacterial infections during stage IV cancer treatment 1324 .抗生素治疗对IV期癌症获得性细菌感染治疗免疫治疗结果的影响
Regular and Young Investigator Award Abstracts Pub Date : 2023-11-01 DOI: 10.1136/jitc-2023-sitc2023.1324
Ernest Philon, Daniel Johnson, Wesley Duerson, Graham Unis
{"title":"1324 The effect of antibiotic therapy on immunotherapy outcomes in the treatment of acquired bacterial infections during stage IV cancer treatment","authors":"Ernest Philon, Daniel Johnson, Wesley Duerson, Graham Unis","doi":"10.1136/jitc-2023-sitc2023.1324","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.1324","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135217551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
1138 TGFβ-specific T cells recognize megakaryocyte progenitors in patients with myeloproliferative neoplasms 1138 tgf β特异性T细胞在骨髓增生性肿瘤患者中识别巨核细胞祖细胞
Regular and Young Investigator Award Abstracts Pub Date : 2023-11-01 DOI: 10.1136/jitc-2023-sitc2023.1138
Thomas Lisle, Maria Perez Penco, Morten Orebo Holmström, Josephine Hallundbæk Ruders, Jacob Handlos Grauslund, Vibe Skov, Lasse Kjær, Hans Hasselbalch, Mads Andersen
{"title":"1138 TGFβ-specific T cells recognize megakaryocyte progenitors in patients with myeloproliferative neoplasms","authors":"Thomas Lisle, Maria Perez Penco, Morten Orebo Holmström, Josephine Hallundbæk Ruders, Jacob Handlos Grauslund, Vibe Skov, Lasse Kjær, Hans Hasselbalch, Mads Andersen","doi":"10.1136/jitc-2023-sitc2023.1138","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.1138","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135217558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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