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Regular and Young Investigator Award Abstracts最新文献

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1451 The implantation site impacts the tumour growth kinetics and tumour immune infiltrate in EO771 and 4T1 syngeneic breast cancer models 1451在EO771和4T1同基因乳腺癌模型中，植入部位影响肿瘤生长动力学和肿瘤免疫浸润
Regular and Young Investigator Award Abstracts Pub Date : 2023-11-01 DOI: 10.1136/jitc-2023-sitc2023.1451
Theoni Katopodi, Yin Xin Ho, Charlotte Bell, Lyndsey Hanson, Amy Cantrell, Emily Wright, Nick Moore, Stewart Brown, Lorraine Mooney, Jane Kendrew
{"title":"1451 The implantation site impacts the tumour growth kinetics and tumour immune infiltrate in EO771 and 4T1 syngeneic breast cancer models","authors":"Theoni Katopodi, Yin Xin Ho, Charlotte Bell, Lyndsey Hanson, Amy Cantrell, Emily Wright, Nick Moore, Stewart Brown, Lorraine Mooney, Jane Kendrew","doi":"10.1136/jitc-2023-sitc2023.1451","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.1451","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135216125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
182 Peripheral immunological features as predictors of breast cancer chemoimmunotherapy response 外周血免疫特征作为乳腺癌化学免疫治疗反应的预测因子
Regular and Young Investigator Award Abstracts Pub Date : 2023-11-01 DOI: 10.1136/jitc-2023-sitc2023.0182
Xiaopeng Sun, Brandie C Taylor, Margaret Axelrod, Lamorna Swigart, Laura van ‘t Veer, Gillian Hirst, Justin M Balko
{"title":"182 Peripheral immunological features as predictors of breast cancer chemoimmunotherapy response","authors":"Xiaopeng Sun, Brandie C Taylor, Margaret Axelrod, Lamorna Swigart, Laura van ‘t Veer, Gillian Hirst, Justin M Balko","doi":"10.1136/jitc-2023-sitc2023.0182","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.0182","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135216131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
886 In vitrostudy of the effects of ceralasertib (AZD6738) on the tumor microenvironment cell populations [86] ceralasertib (AZD6738)对肿瘤微环境细胞群影响的体外研究
Regular and Young Investigator Award Abstracts Pub Date : 2023-11-01 DOI: 10.1136/jitc-2023-sitc2023.0886
Luis Vence, Radhika Rayanki, Tao Deng, Mohamed Moustafa, Sonia Iyer, Marta Milo, Lydia Greenlees, Steve Arbitman, Arthur Lambert, Giulia Fabbri, Raffaello Cimbro, Gemma Jones, Douglas C Palmer, Patricia McCoon
{"title":"886 <i>In vitro</i>study of the effects of ceralasertib (AZD6738) on the tumor microenvironment cell populations","authors":"Luis Vence, Radhika Rayanki, Tao Deng, Mohamed Moustafa, Sonia Iyer, Marta Milo, Lydia Greenlees, Steve Arbitman, Arthur Lambert, Giulia Fabbri, Raffaello Cimbro, Gemma Jones, Douglas C Palmer, Patricia McCoon","doi":"10.1136/jitc-2023-sitc2023.0886","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.0886","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135216136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
1186 Engineering bispecific dual-antagonist antibodies for novel cancer therapies 1186工程双特异性双拮抗剂抗体用于新的癌症治疗
Regular and Young Investigator Award Abstracts Pub Date : 2023-11-01 DOI: 10.1136/jitc-2023-sitc2023.1186
Ankita Srivastava, Tracy Charlton, Ranveer Jayani, Omer Keinan, Arvin Akoopie, Jonah Rainey, Jacek Ostrowski
{"title":"1186 Engineering bispecific dual-antagonist antibodies for novel cancer therapies","authors":"Ankita Srivastava, Tracy Charlton, Ranveer Jayani, Omer Keinan, Arvin Akoopie, Jonah Rainey, Jacek Ostrowski","doi":"10.1136/jitc-2023-sitc2023.1186","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.1186","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135216155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
143 Correlating RNA-seq detection and IHC staining of potential antibody-drug conjugate (ADC) targets: HER3, HER2, TROP2, Nectin4, and aFLR 潜在抗体-药物偶联(ADC)靶点:HER3、HER2、TROP2、Nectin4和aFLR的相关RNA-seq检测和免疫组化染色
Regular and Young Investigator Award Abstracts Pub Date : 2023-11-01 DOI: 10.1136/jitc-2023-sitc2023.0143
Vladimir Kushnarev, Danil Stupichev, Kirill Kryukov, Suren Davitavyan, Monique Johnson, Basavaraja Uddajjara Shanthappa, Zhongmin Xiang, Krystle Nomie, Ekaterina Postovalova, Alexander Bagaev, Nathan Fowler, Funda Meric-Bernstam
{"title":"143 Correlating RNA-seq detection and IHC staining of potential antibody-drug conjugate (ADC) targets: HER3, HER2, TROP2, Nectin4, and aFLR","authors":"Vladimir Kushnarev, Danil Stupichev, Kirill Kryukov, Suren Davitavyan, Monique Johnson, Basavaraja Uddajjara Shanthappa, Zhongmin Xiang, Krystle Nomie, Ekaterina Postovalova, Alexander Bagaev, Nathan Fowler, Funda Meric-Bernstam","doi":"10.1136/jitc-2023-sitc2023.0143","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.0143","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135216158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
745 Immune cell profiling of advanced-stage solid tumors patients treated with an oncolytic adenovirus encoding for TNF-a and IL-2 (TILT-123) 编码TNF-a和IL-2的溶瘤腺病毒(TILT-123)治疗晚期实体瘤患者的免疫细胞谱分析
Regular and Young Investigator Award Abstracts Pub Date : 2023-11-01 DOI: 10.1136/jitc-2023-sitc2023.0745
Dafne CA Quixabeira, Santeri A Pakola, James Clubb, Lyna Haybout, Elise Jirovec, Tatiana Kudling, Joao Santos, Victor Cervera-Carrascon, Katriina Peltola, Tuomo Alanko, Jorma Sormunen, Riitta Korpisaari, Marjut Jaakkola, Juha Kononen, Susanna Juteau, Claudia Kistler, Suvi Sorsa, Riikka Havunen, Akseli Hemminki
{"title":"745 Immune cell profiling of advanced-stage solid tumors patients treated with an oncolytic adenovirus encoding for TNF-a and IL-2 (TILT-123)","authors":"Dafne CA Quixabeira, Santeri A Pakola, James Clubb, Lyna Haybout, Elise Jirovec, Tatiana Kudling, Joao Santos, Victor Cervera-Carrascon, Katriina Peltola, Tuomo Alanko, Jorma Sormunen, Riitta Korpisaari, Marjut Jaakkola, Juha Kononen, Susanna Juteau, Claudia Kistler, Suvi Sorsa, Riikka Havunen, Akseli Hemminki","doi":"10.1136/jitc-2023-sitc2023.0745","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.0745","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135216174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
362 Allelic variants of MR1 drive cancer and allo-reactivity by MR1-restricted T cells MR1的362个等位变异驱动癌症和MR1限制性T细胞的同种异体反应性
Regular and Young Investigator Award Abstracts Pub Date : 2023-11-01 DOI: 10.1136/jitc-2023-sitc2023.0362
Duncan Howie, Terri V Cornforth, Nathifa Moyo, Suzanne Cole, Emily Lam, Tatiana Lobry, Ron Wolchinsky, Angharad Lloyd, Katarzyna Ward, Eleanor M Denham, Gurdyal S Besra, Patricia Illing, Bruce MacLachlan, Julian Vivian, Jeremy Raynes, Jerome Le Nours, Anthony Purcell, Samit Kundu, Jonathan D Silk, Luke Williams, Sophie Papa, Jamie Rossjohn, Joseph Dukes
{"title":"362 Allelic variants of MR1 drive cancer and allo-reactivity by MR1-restricted T cells","authors":"Duncan Howie, Terri V Cornforth, Nathifa Moyo, Suzanne Cole, Emily Lam, Tatiana Lobry, Ron Wolchinsky, Angharad Lloyd, Katarzyna Ward, Eleanor M Denham, Gurdyal S Besra, Patricia Illing, Bruce MacLachlan, Julian Vivian, Jeremy Raynes, Jerome Le Nours, Anthony Purcell, Samit Kundu, Jonathan D Silk, Luke Williams, Sophie Papa, Jamie Rossjohn, Joseph Dukes","doi":"10.1136/jitc-2023-sitc2023.0362","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.0362","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135216176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
117 Ultrahigh-plex to high-throughput spatial phenotyping: an integrated pathway from discovery to translational and clinical studies 117超高plex到高通量空间表型:从发现到转化和临床研究的综合途径
Regular and Young Investigator Award Abstracts Pub Date : 2023-11-01 DOI: 10.1136/jitc-2023-sitc2023.0117
Aditya Pratapa, Ning Ma, Lorcan Sherry, Matthew MacFarlane, Gabriel Reines March, Niyati Jhaveri, Najiba Mammadova
{"title":"117 Ultrahigh-plex to high-throughput spatial phenotyping: an integrated pathway from discovery to translational and clinical studies","authors":"Aditya Pratapa, Ning Ma, Lorcan Sherry, Matthew MacFarlane, Gabriel Reines March, Niyati Jhaveri, Najiba Mammadova","doi":"10.1136/jitc-2023-sitc2023.0117","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.0117","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135216180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
190 Utilizing a peptide-based approach to target and evaluate novel biomarker Neu5Gc Sialyl Lewis A in cancer 利用基于肽的方法靶向和评估新的生物标志物Neu5Gc Sialyl Lewis a在癌症中的作用
Regular and Young Investigator Award Abstracts Pub Date : 2023-11-01 DOI: 10.1136/jitc-2023-sitc2023.0190
Shelby Knoche, Indu Venugopal, Michael J McGuire, Kathlynn C Brown
{"title":"190 Utilizing a peptide-based approach to target and evaluate novel biomarker Neu5Gc Sialyl Lewis A in cancer","authors":"Shelby Knoche, Indu Venugopal, Michael J McGuire, Kathlynn C Brown","doi":"10.1136/jitc-2023-sitc2023.0190","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.0190","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135216199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
1396 TriTCE CPI: a novel trispecifc T cell engager platform with integrated PD-1/PD-L1 checkpoint inhibition engineered for the treatment of immunosuppressed tumors 1396 TriTCE CPI:一种新型的三特异性T细胞参与平台，集成了PD-1/PD-L1检查点抑制，用于治疗免疫抑制肿瘤
Regular and Young Investigator Award Abstracts Pub Date : 2023-11-01 DOI: 10.1136/jitc-2023-sitc2023.1396
Meghan M Verstraete, Maya Poffenberger, Matteo Zago, Veronica Luu, Brenda Ma, Nichole Escalante, Janessa Li, Diego Perez Escanda, Siran Cao, Edward Meier, Sifa Arrafi, Yun Peng, Anna Von Rossum, Genevieve Desjardins, Nina Weisser, Thomas Spreter von Kreudenstein
{"title":"1396 TriTCE CPI: a novel trispecifc T cell engager platform with integrated PD-1/PD-L1 checkpoint inhibition engineered for the treatment of immunosuppressed tumors","authors":"Meghan M Verstraete, Maya Poffenberger, Matteo Zago, Veronica Luu, Brenda Ma, Nichole Escalante, Janessa Li, Diego Perez Escanda, Siran Cao, Edward Meier, Sifa Arrafi, Yun Peng, Anna Von Rossum, Genevieve Desjardins, Nina Weisser, Thomas Spreter von Kreudenstein","doi":"10.1136/jitc-2023-sitc2023.1396","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.1396","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135216372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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