Zhenya Koliesnik, Michael Totagrande, Ryan Burgess, Kim Q Tran, Michele Bauer, Bharghavi Jayaraman, Cindy Buffone, Priyanka Balasubrahmanyam, Jan Emmerich, Deepti Chaturvedi, Deepti Rokkam, Rene De Waal Malefyt, Heiko Greb, Navneet Ratti, Sandro Vivona, Robert Kastelein, Patrick Lupardus, Luis Zuniga, David B Rosen, Martin Oft
{"title":"STK-026的临床前药效学特征:一种新的IL-12部分激动剂,具有维持CD8 T细胞活性,降低nk介导的毒性和改善的治疗窗口","authors":"Zhenya Koliesnik, Michael Totagrande, Ryan Burgess, Kim Q Tran, Michele Bauer, Bharghavi Jayaraman, Cindy Buffone, Priyanka Balasubrahmanyam, Jan Emmerich, Deepti Chaturvedi, Deepti Rokkam, Rene De Waal Malefyt, Heiko Greb, Navneet Ratti, Sandro Vivona, Robert Kastelein, Patrick Lupardus, Luis Zuniga, David B Rosen, Martin Oft","doi":"10.1136/jitc-2023-sitc2023.1053","DOIUrl":null,"url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":"79 2","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"1053 Preclinical pharmacodynamic characterization of STK-026: a novel IL-12 partial agonist for cancer with maintained CD8 T cell activity, reduced NK-mediated toxicity and an improved therapeutic window\",\"authors\":\"Zhenya Koliesnik, Michael Totagrande, Ryan Burgess, Kim Q Tran, Michele Bauer, Bharghavi Jayaraman, Cindy Buffone, Priyanka Balasubrahmanyam, Jan Emmerich, Deepti Chaturvedi, Deepti Rokkam, Rene De Waal Malefyt, Heiko Greb, Navneet Ratti, Sandro Vivona, Robert Kastelein, Patrick Lupardus, Luis Zuniga, David B Rosen, Martin Oft\",\"doi\":\"10.1136/jitc-2023-sitc2023.1053\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"\",\"PeriodicalId\":500964,\"journal\":{\"name\":\"Regular and Young Investigator Award Abstracts\",\"volume\":\"79 2\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Regular and Young Investigator Award Abstracts\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1136/jitc-2023-sitc2023.1053\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Regular and Young Investigator Award Abstracts","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1136/jitc-2023-sitc2023.1053","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
1053 Preclinical pharmacodynamic characterization of STK-026: a novel IL-12 partial agonist for cancer with maintained CD8 T cell activity, reduced NK-mediated toxicity and an improved therapeutic window