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Biosimilars Versus Originators in Children With Juvenile Idiopathic Arthritis: A Real-World Experience. 生物仿制药与原研药在青少年特发性关节炎患儿中的应用：真实世界的经验。
IF 2.5 4区 医学
Journal of Pediatric Health Care Pub Date : 2025-01-01 Epub Date: 2024-08-30 DOI: 10.1016/j.pedhc.2024.08.003
Maria Francesca Gicchino, Giusy Capasso, Alessia Amodio, Emanuele Miraglia Del Giudice, Alma Nunzia Olivieri, Anna Di Sessa
{"title":"Biosimilars Versus Originators in Children With Juvenile Idiopathic Arthritis: A Real-World Experience.","authors":"Maria Francesca Gicchino, Giusy Capasso, Alessia Amodio, Emanuele Miraglia Del Giudice, Alma Nunzia Olivieri, Anna Di Sessa","doi":"10.1016/j.pedhc.2024.08.003","DOIUrl":"10.1016/j.pedhc.2024.08.003","url":null,"abstract":"<p><strong>Introduction: </strong>We aimed to evaluate the efficacy, safety, and immunogenicity profile of Etanercept (ETA) and Adalimumab (ADA) biosimilars (BIOs) compared to their originators in children with juvenile idiopathic arthritis (JIA).</p><p><strong>Method: </strong>Eighty-one JIA children treated with ETA or ADA originators or BIOs were examined at baseline (T0) and after 3- (T1), 6- (T2), 12- (T3), and 24-(T4) months after starting treatment.</p><p><strong>Results: </strong>Lower Juvenile Arthritis Disease Activity Score 10 (JADAS-10) scores were reported at T1, T2, T3, and T4 in JIA children treated with BIOs than originators (all p < 0.05). At T1 and T3, anti-drugs antibodies levels were lower in children receiving BIOs than originators (p = 0.04 and p = 0.0007, respectively), even after adjustments (both p < 0.05). Relapses were lower for BIOs compared to originators (p < 0.001). Safety profile was comparable between the groups (p > 0.05).</p><p><strong>Discussion: </strong>A better overall profile of BIOs than originators was demonstrated in JIA children, but larger confirmatory studies are needed.</p>","PeriodicalId":50094,"journal":{"name":"Journal of Pediatric Health Care","volume":" ","pages":"88-92"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142114307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Burnout and Mental Health in Working Parents: Risk Factors and Practice Implications. 在职父母的职业倦怠与心理健康：风险因素和实践意义。
IF 2.5 4区 医学
Journal of Pediatric Health Care Pub Date : 2025-01-01 Epub Date: 2024-09-17 DOI: 10.1016/j.pedhc.2024.07.014
Kate Sustersic Gawlik, Bernadette Mazurek Melnyk, Alai Tan
{"title":"Burnout and Mental Health in Working Parents: Risk Factors and Practice Implications.","authors":"Kate Sustersic Gawlik, Bernadette Mazurek Melnyk, Alai Tan","doi":"10.1016/j.pedhc.2024.07.014","DOIUrl":"10.1016/j.pedhc.2024.07.014","url":null,"abstract":"<p><strong>Introduction: </strong>Burnout and mental health disorders in parents can have significant implications for families. Little is known about these conditions in working parents. The purpose of this study was to identify the prevalence and mental health risk factors for working parent burnout.</p><p><strong>Method: </strong>De-identified data were collected on a convenience sample of 1285 working parents through an online survey.</p><p><strong>Results: </strong>Sixty-five percent of working parents reported burnout. Depression, anxiety, attention deficient hyperactivity disorder, abuse, or history of a mental health disorder in the parent were significantly correlated with parental burnout. Anxiety, attention deficient hyperactivity disorder, presence of a mental health disorder in the child, or if parents thought their child might have a mental health disorder were significantly correlated with parent burnout. Parental burnout was significantly associated with greater risk of child maltreatment.</p><p><strong>Discussion: </strong>This study provides insight into the prevalence and mental health risk factors for parental burnout specific to the working parent.</p>","PeriodicalId":50094,"journal":{"name":"Journal of Pediatric Health Care","volume":" ","pages":"41-50"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142299703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Uncommon Organisms in Neonatal Meningitis: Two Case Reports. 新生儿脑膜炎中的不常见病原体：两例报告
IF 2.5 4区 医学
Journal of Pediatric Health Care Pub Date : 2025-01-01 Epub Date: 2024-09-28 DOI: 10.1016/j.pedhc.2024.08.011
Mary Jean Ohns
{"title":"Uncommon Organisms in Neonatal Meningitis: Two Case Reports.","authors":"Mary Jean Ohns","doi":"10.1016/j.pedhc.2024.08.011","DOIUrl":"10.1016/j.pedhc.2024.08.011","url":null,"abstract":"<p><p>These case reports describe two neonates, born at term, diagnosed with bacterial meningitis and septicemia caused by uncommon organisms. The clinical presentation, diagnostic reasoning, national guidelines, hospital course, and follow-up are discussed. Meningitis is among the differential diagnoses when there is a concern for neonatal sepsis. Concern for sepsis can arise from a variety of antepartum, intrapartum, and postpartum risk factors and present with a variety of symptoms. Neonatal sepsis is a significant cause of mortality, with 750,000 infant deaths annually. Effective treatment of neonatal sepsis requires timely diagnosis and tailored antimicrobial therapy that targets the causative pathogens.</p>","PeriodicalId":50094,"journal":{"name":"Journal of Pediatric Health Care","volume":" ","pages":"93-100"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142331433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influence of Feeding Practices on Intestinal Microbiota Composition in Healthy Chinese Infants: A Prospective Cohort Study. 喂养方式对中国健康婴儿肠道微生物群组成的影响：前瞻性队列研究
IF 2.5 4区 医学
Journal of Pediatric Health Care Pub Date : 2025-01-01 Epub Date: 2024-09-16 DOI: 10.1016/j.pedhc.2024.06.015
Kris Yw Lok, Jade Ll Teng, Jordan Yh Fong, Ye Peng, Heidi Sl Fan, Yuanchao Ma, Tsz Tuen Li, Susanna Kp Lau, Patsy Ph Chau, Hani El-Nezami, Patrick Ip, Marie Tarrant, Hein M Tun, Patrick Cy Woo
{"title":"Influence of Feeding Practices on Intestinal Microbiota Composition in Healthy Chinese Infants: A Prospective Cohort Study.","authors":"Kris Yw Lok, Jade Ll Teng, Jordan Yh Fong, Ye Peng, Heidi Sl Fan, Yuanchao Ma, Tsz Tuen Li, Susanna Kp Lau, Patsy Ph Chau, Hani El-Nezami, Patrick Ip, Marie Tarrant, Hein M Tun, Patrick Cy Woo","doi":"10.1016/j.pedhc.2024.06.015","DOIUrl":"10.1016/j.pedhc.2024.06.015","url":null,"abstract":"<p><strong>Introduction: </strong>This study investigates the impact of different feeding methods (direct breastfeeding, expressed milk feeding, formula feeding) on the infant microbiota at 6 weeks of age.</p><p><strong>Methods: </strong>A total of 217 healthy infants stool samples were collected from Hong Kong between August 2018 and December 2019.</p><p><strong>Results: </strong>Various microbial taxa, including the genera Enterobacter and Raoultella were identified in the expressed breast milk feeding group. The richness and composition of the major bacterial phyla showed similar abundance between direct breastfeeding and expressed breast milk.</p><p><strong>Discussion: </strong>These findings suggests that these bacteria may have colonized the milk during expression or could be introduced from other external sources. The mode of breastfeeding did not significantly alter microbiota parameters in the infant gut at 6 weeks.</p>","PeriodicalId":50094,"journal":{"name":"Journal of Pediatric Health Care","volume":" ","pages":"14-21"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142299708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Failure Modes and Effects Analysis to Evaluate Discharge Delays of Postoperative Tonsillectomy Patients From the Medical-Surgical PICU. 评估扁桃体切除术术后患者从内外科 PICU 出院延迟的故障模式和影响分析。
IF 2.5 4区 医学
Journal of Pediatric Health Care Pub Date : 2025-01-01 Epub Date: 2024-10-10 DOI: 10.1016/j.pedhc.2024.09.007
Emily R Hamilton, Marketa Rejtar, Michele DeGrazia, Youyang Yang
{"title":"Failure Modes and Effects Analysis to Evaluate Discharge Delays of Postoperative Tonsillectomy Patients From the Medical-Surgical PICU.","authors":"Emily R Hamilton, Marketa Rejtar, Michele DeGrazia, Youyang Yang","doi":"10.1016/j.pedhc.2024.09.007","DOIUrl":"10.1016/j.pedhc.2024.09.007","url":null,"abstract":"<p><strong>Background: </strong>Discharge delays of Medical-Surgical Pediatric Intensive Care Unit (PICU) patients with Obstructive Sleep Apnea (OSA) following tonsillectomy or tonsillectomy with adenoidectomy (T&A) negatively impact hospital bed availability.</p><p><strong>Aim statement: </strong>This project identified process improvements to reduce discharge delays and increase PICU bed availability.</p><p><strong>Methods: </strong>A Failure Modes and Effects Analysis (FMEA) was implemented to identify care and process failures that result in discharge delays.</p><p><strong>Intervention: </strong>Through the FMEA, failure risk profile numbers with the highest impact were recognized for improvement (Institute for Healthcare Improvement, 2017; VHA National Center for Patient Safety, 2023).</p><p><strong>Results: </strong>Forty failure modes were identified. High-impact failures included not administering dexamethasone early for patient pain or desaturation, intervening for desaturations consistent with the patient's baseline, and not anticipating family needs for discharge.</p><p><strong>Conclusions: </strong>The FMEA identified several actionable changes that if implemented, could promote timely discharge of patients with OSA following tonsillectomy or T&A.</p>","PeriodicalId":50094,"journal":{"name":"Journal of Pediatric Health Care","volume":" ","pages":"58-68"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142479390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Health Equity and Children With Medical Complexity/Children and Youth With Special Health Care Needs: A Scoping Review.
IF 2.5 4区 医学
Journal of Pediatric Health Care Pub Date : 2025-01-01 Epub Date: 2024-11-30 DOI: 10.1016/j.pedhc.2024.11.008
Elizabeth A Flasch
{"title":"Health Equity and Children With Medical Complexity/Children and Youth With Special Health Care Needs: A Scoping Review.","authors":"Elizabeth A Flasch","doi":"10.1016/j.pedhc.2024.11.008","DOIUrl":"10.1016/j.pedhc.2024.11.008","url":null,"abstract":"","PeriodicalId":50094,"journal":{"name":"Journal of Pediatric Health Care","volume":" ","pages":"140-146"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142773763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Case Presentation of a Neuroglial Cyst Causing Acute Hydrocephalus. 神经胶质细胞囊肿导致急性脑积水的病例介绍。
IF 2.5 4区 医学
Journal of Pediatric Health Care Pub Date : 2025-01-01 Epub Date: 2024-06-21 DOI: 10.1016/j.pedhc.2024.05.003
Elizabeth M Byrd, James M Johnston
{"title":"Case Presentation of a Neuroglial Cyst Causing Acute Hydrocephalus.","authors":"Elizabeth M Byrd, James M Johnston","doi":"10.1016/j.pedhc.2024.05.003","DOIUrl":"10.1016/j.pedhc.2024.05.003","url":null,"abstract":"<p><p>Neuroglial cysts are rare congenital cysts that seldom require surgical treatment. This case highlights a rare instance when a neurolglial cyst caused acute hydrocephalus in a 10-year old boy. Originally diagnosed and managed as pediatric-onset migraines, the patient presented to the emergency department with nausea, vomiting, and ataxia without clear pathology on neuroradiology. The neurosurgical team took him to the operating room based on his clinical picture and history and the cyst was discovered there. The pathology was benign, and he has had a complete resolution of symptoms.</p>","PeriodicalId":50094,"journal":{"name":"Journal of Pediatric Health Care","volume":" ","pages":"83-87"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141433253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Screening for Adverse Childhood Experiences in Adolescents Using the Bright Futures Previsit Questionnaire. 使用 "光明未来 "预访问卷筛查青少年的不良童年经历。
IF 2.5 4区 医学
Journal of Pediatric Health Care Pub Date : 2025-01-01 Epub Date: 2024-07-15 DOI: 10.1016/j.pedhc.2024.06.018
Janel M Draxler, Todd M Ruppar, Julie A Carbray, Kathleen R Delaney
{"title":"Screening for Adverse Childhood Experiences in Adolescents Using the Bright Futures Previsit Questionnaire.","authors":"Janel M Draxler, Todd M Ruppar, Julie A Carbray, Kathleen R Delaney","doi":"10.1016/j.pedhc.2024.06.018","DOIUrl":"10.1016/j.pedhc.2024.06.018","url":null,"abstract":"<p><p>In pediatric primary care, incorporation of existing practice tools into screening for adverse childhood experiences (ACEs) may reduce screening barriers, promoting timely intervention on negative health impacts from childhood trauma. One such screening tool is the Bright Futures Previsit Questionnaire (PVQ). To evaluate the extent to which the PVQ may be used to screen for ACEs, this research aimed to map items related to ACEs from adolescent PVQs against adverse events historically identified as conventional and expanded ACEs. The adolescent PVQs mapped effectively to nine ACEs: adverse neighborhood experiences, bullying, emotional neglect, friend or family substance misuse, household safety, intimate partner violence, interpersonal violence, physical neglect, and sexual abuse. Universal ACE screening can be conducted using adolescent PVQs; however, issues remain regarding the reliability and validity of using the PVQs to identify ACEs, and some ACEs are not effectively assessed using adolescent PVQs.</p>","PeriodicalId":50094,"journal":{"name":"Journal of Pediatric Health Care","volume":" ","pages":"76-82"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141635562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Congenital Nasal Pyriform Aperture Stenosis and the Significance of McGovern Nipple. 先天性鼻梨状孔狭窄与麦戈文乳头的意义
IF 2.5 4区 医学
Journal of Pediatric Health Care Pub Date : 2025-01-01 Epub Date: 2024-09-21 DOI: 10.1016/j.pedhc.2024.06.017
Amanda Esperas, Rachel Marlow, Danielle Sebbens
{"title":"Congenital Nasal Pyriform Aperture Stenosis and the Significance of McGovern Nipple.","authors":"Amanda Esperas, Rachel Marlow, Danielle Sebbens","doi":"10.1016/j.pedhc.2024.06.017","DOIUrl":"10.1016/j.pedhc.2024.06.017","url":null,"abstract":"<p><p>Congenital nasal pyriform aperture stenosis (CNPAS) is a rare but potentially life-threatening cause of upper airway obstruction in infants. It was first described in 1988 and 1989 in the radiology and otolaryngology literature. Congenital airway obstruction affects up to 1 in 5,000 infants, and many of these obstructions result from choanal atresia. CNPAS is estimated to occur 1 in 25,000 live births. This case report describes a neonate with acute respiratory distress and obstructive breathing pattern relieved by opening her oral airway and maintained with the McGovern nipple decreasing ventilator days during hospitalization with viral bronchiolitis.</p>","PeriodicalId":50094,"journal":{"name":"Journal of Pediatric Health Care","volume":" ","pages":"e1-e4"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142299705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relationships Among Stress, Diabetes Distress, and Biomarkers in Children with Type 1 Diabetes Mellitus from Diverse Income and Racial Backgrounds. 来自不同收入和种族背景的 1 型糖尿病患儿的压力、糖尿病困扰和生物标志物之间的关系。
IF 2.5 4区 医学
Journal of Pediatric Health Care Pub Date : 2025-01-01 Epub Date: 2024-10-10 DOI: 10.1016/j.pedhc.2024.08.012
Sara L Davis, Sarah S Jaser, Nataliya Ivankova, Marti Rice
{"title":"Relationships Among Stress, Diabetes Distress, and Biomarkers in Children with Type 1 Diabetes Mellitus from Diverse Income and Racial Backgrounds.","authors":"Sara L Davis, Sarah S Jaser, Nataliya Ivankova, Marti Rice","doi":"10.1016/j.pedhc.2024.08.012","DOIUrl":"10.1016/j.pedhc.2024.08.012","url":null,"abstract":"<p><strong>Introduction: </strong>The purpose of this quantitative study was to consider factors that may negatively impact glycemic levels in Black and White children 8-12 years old with a diagnosis of type 1 diabetes mellitus.</p><p><strong>Method: </strong>Perceived stress, diabetes distress, morning and afternoon salivary cortisol, inflammatory biomarkers, and hemoglobin A1c (HbA1c) were measured in this quantitative, cross-sectional phase of a larger, mixed methods study. Thirty-four children and their parents completed self-report surveys, and children provided blood and salivary samples, to examine effect sizes of relationships among variables of interest.</p><p><strong>Results: </strong>Most children did not meet ADA recommendations for HbA1c. HbA1c was higher in Black children. Medium-to-large effects were noted between perceived stress and HbA1c. Cortisol and IL-8 may mediate the relationship between perceived stress and HbA1c in children.</p><p><strong>Discussion: </strong>Understanding causes of elevated glycemic levels in children, especially from low-income and underrepresented populations, may help tailor diabetes management interventions to improve health outcomes.</p>","PeriodicalId":50094,"journal":{"name":"Journal of Pediatric Health Care","volume":" ","pages":"5-13"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11646180/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142479392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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