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Comment on “Effect of Protein Supplementation on Health-Related Quality of Life in Individuals With Advanced Chronic Kidney Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials” 对“补充蛋白质对晚期慢性肾病患者健康相关生活质量的影响:随机对照试验的系统回顾和荟萃分析”的评论。
IF 3.2 3区 医学
Journal of Renal Nutrition Pub Date : 2026-05-01 Epub Date: 2025-12-12 DOI: 10.1053/j.jrn.2025.09.007
Yang Li MD, Lingling Niu MD, Nana Luo BD, Xiang Li MD, Yafen Wang MD
{"title":"Comment on “Effect of Protein Supplementation on Health-Related Quality of Life in Individuals With Advanced Chronic Kidney Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials”","authors":"Yang Li MD, Lingling Niu MD, Nana Luo BD, Xiang Li MD, Yafen Wang MD","doi":"10.1053/j.jrn.2025.09.007","DOIUrl":"10.1053/j.jrn.2025.09.007","url":null,"abstract":"","PeriodicalId":50066,"journal":{"name":"Journal of Renal Nutrition","volume":"36 3","pages":"Pages 533-534"},"PeriodicalIF":3.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145759268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predicted Lean Body Mass and the Risk of Adverse Kidney Outcomes in Men 男性预测瘦体重和不良肾脏结局的风险。
IF 3.2 3区 医学
Journal of Renal Nutrition Pub Date : 2026-05-01 Epub Date: 2026-01-16 DOI: 10.1053/j.jrn.2026.01.001
Yuta Suzuki PhD , Hidehiro Kaneko MD, PhD , Tatsuhiko Azegami MD, PhD , Akira Okada MD, PhD , Toshiyuki Ko MD, PhD , Katsuhito Fujiu MD, PhD , Norifumi Takeda MD, PhD , Hiroyuki Morita MD, PhD , Takashi Yokoo MD, PhD , Koichi Node MD, PhD , Kaori Hayashi MD, PhD , Issei Komuro MD, PhD , Hideo Yasunaga MD, PhD , Masaomi Nangaku MD, PhD , Norihiko Takeda MD, PhD
{"title":"Predicted Lean Body Mass and the Risk of Adverse Kidney Outcomes in Men","authors":"Yuta Suzuki PhD ,&nbsp;Hidehiro Kaneko MD, PhD ,&nbsp;Tatsuhiko Azegami MD, PhD ,&nbsp;Akira Okada MD, PhD ,&nbsp;Toshiyuki Ko MD, PhD ,&nbsp;Katsuhito Fujiu MD, PhD ,&nbsp;Norifumi Takeda MD, PhD ,&nbsp;Hiroyuki Morita MD, PhD ,&nbsp;Takashi Yokoo MD, PhD ,&nbsp;Koichi Node MD, PhD ,&nbsp;Kaori Hayashi MD, PhD ,&nbsp;Issei Komuro MD, PhD ,&nbsp;Hideo Yasunaga MD, PhD ,&nbsp;Masaomi Nangaku MD, PhD ,&nbsp;Norihiko Takeda MD, PhD","doi":"10.1053/j.jrn.2026.01.001","DOIUrl":"10.1053/j.jrn.2026.01.001","url":null,"abstract":"<div><h3>Objective</h3><div>There are limited clinical data on whether low lean body mass is a risk factor for adverse kidney outcomes. We aimed to investigate the association between lean body mass, derived from a simple formula, and adverse kidney outcomes in men.</div></div><div><h3>Methods</h3><div>This cohort study utilized nationwide data from the DeSC database, encompassing a total of 468,597 men. The components for predicting lean body mass include age, height, body weight, waist circumference, and ethnicity. The primary outcome was a decrease in estimated glomerular filtration rate (eGFR) ≥ 40% from the baseline measurement.</div></div><div><h3>Results</h3><div>During a mean follow-up of 4.0 years, a decrease in eGFR of ≥40% was observed in 2,047 individuals. Individuals in tertile 1 of predicted lean body mass had a higher risk of a decrease in eGFR of ≥40% than those in tertile 3 (hazard ratio, 1.54; 95% confidence interval, 1.33-1.78). In cubic spline analysis, the hazard ratio was observed to decrease progressively with higher predicted lean body mass up to the median level, after which it plateaued. The significant association between lower predicted lean body mass and the risk of eGFR of ≥40% was generally consistent across subgroups stratified by baseline characteristics, including eGFR levels.</div></div><div><h3>Conclusion</h3><div>Men with lower predicted lean body mass had a higher risk of adverse kidney outcome. Our results suggest the clinical importance of lean body mass assessment for kidney disease risk stratification.</div></div>","PeriodicalId":50066,"journal":{"name":"Journal of Renal Nutrition","volume":"36 3","pages":"Pages 464-472"},"PeriodicalIF":3.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146000427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diet, Dietary Guideline Adherence, and Clinical Determinants of Diet in Kidney Transplant Recipients: Results of the Active Care After Transplantation Study 肾移植受者的饮食、饮食指南依从性和饮食的临床决定因素:移植后积极护理研究的结果
IF 3.2 3区 医学
Journal of Renal Nutrition Pub Date : 2026-05-01 Epub Date: 2025-10-24 DOI: 10.1053/j.jrn.2025.10.008
Caecilia S.E. Doorenbos MD , Tim J. Knobbe MD, PhD , Daan Kremer MD, PhD , Davide Brunello MSc , Desie Dijkema RD, MSc , Iris M.Y. van Vliet RD, PhD , Frederike J. Bemelman MD, PhD , Stefan P. Berger MD, PhD , Gerjan Navis MD, PhD , Stephan J.L. Bakker MD, PhD , Eva Corpeleijn PhD
{"title":"Diet, Dietary Guideline Adherence, and Clinical Determinants of Diet in Kidney Transplant Recipients: Results of the Active Care After Transplantation Study","authors":"Caecilia S.E. Doorenbos MD ,&nbsp;Tim J. Knobbe MD, PhD ,&nbsp;Daan Kremer MD, PhD ,&nbsp;Davide Brunello MSc ,&nbsp;Desie Dijkema RD, MSc ,&nbsp;Iris M.Y. van Vliet RD, PhD ,&nbsp;Frederike J. Bemelman MD, PhD ,&nbsp;Stefan P. Berger MD, PhD ,&nbsp;Gerjan Navis MD, PhD ,&nbsp;Stephan J.L. Bakker MD, PhD ,&nbsp;Eva Corpeleijn PhD","doi":"10.1053/j.jrn.2025.10.008","DOIUrl":"10.1053/j.jrn.2025.10.008","url":null,"abstract":"<div><h3>Objective</h3><div>Diet-related morbidity is high in kidney transplant recipients (KTR), but detailed dietary assessments are limited. In this study, we evaluated diet and dietary guideline adherence in KTR compared to the general population and identified KTR-specific dietary determinants.</div></div><div><h3>Methods</h3><div>Cross-sectional dietary data from KTR (&lt;1 year posttransplantation), obtained using 3-day food diaries at baseline in the Active Care after Transplantation Study in 4 study centers throughout the Netherlands, were analyzed. Food group and nutrient intake were evaluated using Dutch food–based dietary guidelines and Dutch Dietary Reference Values. The results were compared to the national Food Consumption Survey data from the general population. Associations of clinical characteristics with dietary intake were assessed using linear regression.</div></div><div><h3>Results</h3><div>Dietary assessments of 167 KTR (40% female, age 51.9 ± 13.5 years, 147 [94-227] days posttransplantation) showed low dietary guideline adherence for intake of fruits (recommendation: &gt;200 g/day, 22% adherent, median intake [interquartile range]: 110 [41-190] g/day), vegetables (recommendation: &gt;200 g/day, 28% adherent, intake: 137 [83-211] g/day), fiber (recommendation: &gt;25 g/day, 26% adherent, intake: 20.5 [16.3-25.8] g/day), and plant-to-total protein ratio (recommendation: &gt;0.50, 12% adherent, intake: 0.37 [0.31-0.45]). Diet of KTR was largely similar to that of the general population and slightly healthier in some aspects, including lower intake of salt, red meat, sugary beverages and soft drinks, and higher soft fat intake. Deceased donor status was associated with lower vegetable intake (st.β [95% confidence interval] = −0.45 [−0.75, −0.14], <em>P</em> = .004). Polypharmacy (≥5 daily medications) was associated with a lower plant-to-total protein ratio (st.β [95% confidence interval] = −0.43 [−0.82, −0.05], <em>P</em> = .03).</div></div><div><h3>Conclusion</h3><div>Dietary guideline adherence in KTR was low, and diet was comparable to that of the general population. Considering the high diet–related morbidity burden in KTR, dietary adherence deserves priority as a prevention target in this population, especially in patients with a deceased donor or polypharmacy.</div></div>","PeriodicalId":50066,"journal":{"name":"Journal of Renal Nutrition","volume":"36 3","pages":"Pages 341-352"},"PeriodicalIF":3.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148104023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Association Between Circadian Eating Behaviors and Diabetic Kidney Disease in Diabetes Mellitus Patients: A Cross-Sectional Analysis 糖尿病患者昼夜节律饮食行为与糖尿病肾病之间的关系:一项横断面分析
IF 3.2 3区 医学
Journal of Renal Nutrition Pub Date : 2026-05-01 Epub Date: 2025-11-20 DOI: 10.1053/j.jrn.2025.10.016
Haoran Tao MD , Shanshan Chen MMed , Weicong Zeng MD , Lili You MD , Jin Xu BSc , Phei Er Saw PhD , Li Yan MD , Meng Ren MD
{"title":"The Association Between Circadian Eating Behaviors and Diabetic Kidney Disease in Diabetes Mellitus Patients: A Cross-Sectional Analysis","authors":"Haoran Tao MD ,&nbsp;Shanshan Chen MMed ,&nbsp;Weicong Zeng MD ,&nbsp;Lili You MD ,&nbsp;Jin Xu BSc ,&nbsp;Phei Er Saw PhD ,&nbsp;Li Yan MD ,&nbsp;Meng Ren MD","doi":"10.1053/j.jrn.2025.10.016","DOIUrl":"10.1053/j.jrn.2025.10.016","url":null,"abstract":"<div><h3>Objective(s)</h3><div>Recent studies have suggested that circadian eating behaviors play a significant role in metabolic diseases and their related complications. However, the impact of daily eating frequency (DEF) and nighttime fasting duration (NFD) on diabetic kidney disease remains poorly understood. This study aims to investigate the potential association between DEF and NFD with the development of diabetic kidney disease.</div></div><div><h3>Methods</h3><div>Data from the NHANES dataset (1999-2018) were collected to obtain information on diabetes and circadian eating behaviors. Using the recorded start and end times of each meal throughout the day, we calculated the NFD. And the frequency of eating episodes was used to evaluate DEF. Meanwhile, diabetic kidney disease was diagnosed in diabetic patients according to the criteria of impaired estimated glomerular filtration rate (&lt;60 mL/min/1.73 m<sup>2</sup>) and/or the presence of albuminuria (urinary albumin to urinary creatinine ratio &gt;30 mg/g). Weighted logistic regression models were used to assess the associations between DEF and NFD in relation to the diabetic kidney disease.</div></div><div><h3>Results</h3><div>Our study encompassed a total of 7,336 adult participants. We found that the prevalence of diabetic kidney disease has a nonlinear relationship with DEF and NFD, plateauing at 3 meals per day and minimizing when NFD is between 10 and 11. Based on this result, the entire population was divided into 5 subgroups according to the quantiles of DEF and NFD. Compared to DEF at 3 times, participants with DEF fewer than 3 times had a higher diabetic kidney disease prevalence even after adjusting for covariates (odds ratio [OR] = 1.59, 95% confidence interval [CI]: 1.16-2.18). Furthermore, participants with an NFD exceeding 12 hours demonstrated a higher prevalence of diabetic kidney disease (12-13.5 hours OR = 1.30, 95% CI: 1.04,1.65); &gt;14 h: OR = 1.45, 95% CI: 1.09, 1.91), compared to those with an NFD of 10 to 11 hours.</div></div><div><h3>Conclusion(s)</h3><div>Our findings indicate that a DEF of fewer than 3 times per day and an NFD of more than 12 hours are associated with an increased prevalence of diabetic kidney disease. Modifying circadian eating patterns may hold potential for improving renal outcomes in individuals with diabetes.</div></div>","PeriodicalId":50066,"journal":{"name":"Journal of Renal Nutrition","volume":"36 3","pages":"Pages 454-463"},"PeriodicalIF":3.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145582840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Requiem for a Standardized Calculation of Ideal Body Weight in Chronic Kidney Disease? 慢性肾病患者理想体重标准计算的安魂曲?
IF 3.2 3区 医学
Journal of Renal Nutrition Pub Date : 2026-05-01 Epub Date: 2026-01-15 DOI: 10.1053/j.jrn.2025.12.007
Claudia D'Alessandro , Massimo Torreggiani MD, PhD , Francoise Lippi , Carla Avesani PhD , Adamasco Cupisti MD , Giorgina Barbara Piccoli MD
{"title":"A Requiem for a Standardized Calculation of Ideal Body Weight in Chronic Kidney Disease?","authors":"Claudia D'Alessandro ,&nbsp;Massimo Torreggiani MD, PhD ,&nbsp;Francoise Lippi ,&nbsp;Carla Avesani PhD ,&nbsp;Adamasco Cupisti MD ,&nbsp;Giorgina Barbara Piccoli MD","doi":"10.1053/j.jrn.2025.12.007","DOIUrl":"10.1053/j.jrn.2025.12.007","url":null,"abstract":"<div><div>Defining a patient's body weight in order to calculate their protein and energy prescription is an important step for physicians and dietitians working in the field of kidney diseases. Ideal body weight embraces 2 concepts. It is defined both as “the goal weight at which nutritional requirements are met” and “the body weight associated with the lowest mortality for a given height, age, gender, and frame size”. Both definitions are not generalizable to people living with chronic kidney disease (CKD), and there is no agreed method for how to define ideal body weight in CKD. The epidemiology of CKD patients is continuously changing; recent years have seen a sharp increase in patients' average age and the prevalence of obesity. This paper critically examines the different ways to calculate a “reference” body weight that can be used to estimate and prescribe a patient's intake of energy and nutrients (proteins in particular) and offers some practical suggestions on how this should be done, particularly those who are overweight or obese.</div></div>","PeriodicalId":50066,"journal":{"name":"Journal of Renal Nutrition","volume":"36 3","pages":"Pages 373-380"},"PeriodicalIF":3.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145994764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Food Assistance to Financially Insecure Children and Adolescents With Chronic Kidney Disease: Impact on Disease Progression 对患有慢性肾病的经济不安全儿童和青少年的粮食援助:对疾病进展的影响。
IF 3.2 3区 医学
Journal of Renal Nutrition Pub Date : 2026-05-01 Epub Date: 2026-01-16 DOI: 10.1053/j.jrn.2025.12.005
Anoosh Moin MD, MPH , Michael F. Schneider MS , Matthew B. Matheson MS , Bradley A. Warady MD , Susan Furth MD, PhD , Oleh Akchurin MD, PhD , Chronic Kidney Disease in Children (CKiD) Study Investigators
{"title":"Food Assistance to Financially Insecure Children and Adolescents With Chronic Kidney Disease: Impact on Disease Progression","authors":"Anoosh Moin MD, MPH ,&nbsp;Michael F. Schneider MS ,&nbsp;Matthew B. Matheson MS ,&nbsp;Bradley A. Warady MD ,&nbsp;Susan Furth MD, PhD ,&nbsp;Oleh Akchurin MD, PhD ,&nbsp;Chronic Kidney Disease in Children (CKiD) Study Investigators","doi":"10.1053/j.jrn.2025.12.005","DOIUrl":"10.1053/j.jrn.2025.12.005","url":null,"abstract":"<div><h3>Objectives</h3><div>In North American children with chronic kidney disease (CKD), poverty correlates with faster disease progression. As an aspect of poverty, food insecurity is common among these children, yet its impact on CKD progression is underexplored. The purpose of this study was to assess the impact of food assistance (FA) on CKD progression by comparing the cumulative incidence and the hazard of kidney replacement therapy (KRT) initiation in those who reported receiving FA to those who did not.</div></div><div><h3>Design and Methods</h3><div>This study included longitudinal data collected over 10 years of follow-up from a subset of 266 participants from the Chronic Kidney Disease in Children prospective cohort study whose annual household income was ≤$36,000 to assess the association between FA and KRT initiation.</div></div><div><h3>Results</h3><div>Over 388 person-years in which FA was reported, 21 KRT events occurred (KRT incidence rate of 5.4 per 100 person-years and estimated 10-year cumulative incidence of KRT of 41%), while during 592 person-years with no FA, 44 KRT events occurred (KRT incidence rate of 7.4 per 100 person-years and estimated 10-year cumulative incidence of KRT of 55%). FA recipients showed a trend toward a lower hazard of KRT initiation over 10 years of follow-up than those not receiving FA.</div></div><div><h3>Conclusion</h3><div>Our findings suggest that sustained FA participation may mitigate CKD progression. The study contributes to the growing body of evidence on the potential role of food security, including FA, in mitigating CKD outcomes among children.</div></div>","PeriodicalId":50066,"journal":{"name":"Journal of Renal Nutrition","volume":"36 3","pages":"Pages 520-523"},"PeriodicalIF":3.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146000374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Single-Site Teaching Kitchen Project Increases Confidence for Dietary Interventions Aimed at Prevention of Kidney Stones in Known Stone Formers: A Pilot Study 单站点教学厨房项目增加了针对已知结石患者预防肾结石的饮食干预的信心:一项试点研究。
IF 3.2 3区 医学
Journal of Renal Nutrition Pub Date : 2026-05-01 Epub Date: 2025-11-21 DOI: 10.1053/j.jrn.2025.10.017
Ellie Mehrara BS , Ava Mousavi MD, MPH , Sapna Thaker BS , Karan Thaker BS , Kyle Zuniga MD , Shelby Yaceczko DCN, RDN-AP, CNSC , Lynn Stothers MD, MHS , Kymora B. Scotland MD, PhD
{"title":"Single-Site Teaching Kitchen Project Increases Confidence for Dietary Interventions Aimed at Prevention of Kidney Stones in Known Stone Formers: A Pilot Study","authors":"Ellie Mehrara BS ,&nbsp;Ava Mousavi MD, MPH ,&nbsp;Sapna Thaker BS ,&nbsp;Karan Thaker BS ,&nbsp;Kyle Zuniga MD ,&nbsp;Shelby Yaceczko DCN, RDN-AP, CNSC ,&nbsp;Lynn Stothers MD, MHS ,&nbsp;Kymora B. Scotland MD, PhD","doi":"10.1053/j.jrn.2025.10.017","DOIUrl":"10.1053/j.jrn.2025.10.017","url":null,"abstract":"<div><h3>Objective(s)</h3><div>Patterns of dietary intake are known risk factors for both kidney stone formation and recurrence. Dietary recommendations such as the Dietary Approaches To Stop Hypertension diet can reduce risk, but patients may lack knowledge or a practical understanding on implementing these diet patterns. Virtual teaching kitchens have proven effective in improving dietary practices in other populations, but have not been applied to patients with kidney stones. This study assessed the effectiveness of virtual teaching kitchen sessions in enhancing dietary confidence and practices for kidney stone prevention.</div></div><div><h3>Methods</h3><div>Eligible adults, aged 18 years and older, with a history of recurrent kidney stones were recruited to participate in one of two virtual teaching kitchen sessions. Pre-intervention surveys were administered to participants assessing individual cooking habits and dietary confidence. Post-intervention surveys assessed changes in cooking attitudes, dietary confidence, and program satisfaction.</div></div><div><h3>Results</h3><div>Forty-six participants completed both preintervention and postintervention surveys. Results showed significant improvements in enjoyment of trying new recipes, reduced frustration with cooking, and perceptions of home-cooked meals as both affordable and healthy. Participants also reported finding cooking less tiring and increased confidence in adopting key dietary practices, including reducing added sugar intake, choosing lean proteins, using spices instead of salt, consuming more fruits and vegetables, and controlling portion sizes (all <em>P</em> &lt; .05).</div></div><div><h3>Conclusions</h3><div>The virtual teaching kitchen intervention significantly improved participants’ confidence and attitudes toward adopting dietary practices essential for kidney stone prevention, highlighting its promise as an educational tool for patients.</div></div>","PeriodicalId":50066,"journal":{"name":"Journal of Renal Nutrition","volume":"36 3","pages":"Pages 524-528"},"PeriodicalIF":3.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145592719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prebiotic Administration to Chronic Kidney Disease Patients Modifies Their Fecal Microbiome and Host Metabolism 给CKD患者服用益生元可改变其微生物组和代谢。
IF 3.2 3区 医学
Journal of Renal Nutrition Pub Date : 2026-05-01 Epub Date: 2025-11-21 DOI: 10.1053/j.jrn.2025.10.015
Dominic S. Raj MD , Bei Gao PhD , Michael B. Sohn PhD , Christopher Brydges , Anvesha Srivastava PhD , Hamid Rabb MD , Alfred K. Cheung MD , Oliver Fiehn PhD , Cynthia Kendrick BS , Jennifer J. Gassman PhD , Anam Tariq MHS , Tamara Isakova MD , Linda F. Fried MD , Myles Wolf MD , Kalani L. Raphael MD , John P. Middleton MD , Yoosif Abdalla MD , Pilot Studies in CKD Consortium
{"title":"Prebiotic Administration to Chronic Kidney Disease Patients Modifies Their Fecal Microbiome and Host Metabolism","authors":"Dominic S. Raj MD ,&nbsp;Bei Gao PhD ,&nbsp;Michael B. Sohn PhD ,&nbsp;Christopher Brydges ,&nbsp;Anvesha Srivastava PhD ,&nbsp;Hamid Rabb MD ,&nbsp;Alfred K. Cheung MD ,&nbsp;Oliver Fiehn PhD ,&nbsp;Cynthia Kendrick BS ,&nbsp;Jennifer J. Gassman PhD ,&nbsp;Anam Tariq MHS ,&nbsp;Tamara Isakova MD ,&nbsp;Linda F. Fried MD ,&nbsp;Myles Wolf MD ,&nbsp;Kalani L. Raphael MD ,&nbsp;John P. Middleton MD ,&nbsp;Yoosif Abdalla MD ,&nbsp;Pilot Studies in CKD Consortium","doi":"10.1053/j.jrn.2025.10.015","DOIUrl":"10.1053/j.jrn.2025.10.015","url":null,"abstract":"<div><h3>Objective(s)</h3><div>Prebiotics are believed to improve gut microbial dysbiosis and dysmetabolism in chronic kidney disease (CKD) patients. However, impact of prebiotics on gut microbial metagenome and dynamic changes in metabolome has not been clearly defined.</div></div><div><h3>Methods</h3><div>We conducted a nonrandomized, open-label, three-phase pilot trial to investigate the effect of daily oral prebiotic, oligofructose-enriched inulin (p-inulin), on stool functional metagenome and changes in plasma, urine, and stool metabolites in 13 CKD patients. The study comprised a pretreatment phase (8 weeks), p-inulin treatment phase (12 weeks), and post-treatment phase (8 weeks).</div></div><div><h3>Results</h3><div>During treatment phase, there was a significant increase in the abundance of <em>Bifidobacterium adolescentis</em>, <em>Bifidobacterium longum</em>, and <em>Lachnospiraceae</em> species. Microbial pathways related to carbohydrate degradation and amino acid biosynthesis were enriched during the treatment phase, but urea biosynthetic pathway was attenuated. In plasma, metabolic biosynthetic pathways for valine, leucine, and isoleucine were activated during the treatment phase. Microbial genes related to lipid metabolism were enriched during post-treatment. Abundance of several polar and nonpolar lipids were altered in plasma and stool samples during treatment and post-treatment phases. Pathway analysis for lipids indicated suppression of triglyceride biosynthesis in plasma and enhanced triglyceride degradation in stool during the treatment phase. Secondary bile acid levels in plasma, urine, and stool were significantly reduced during p-inulin consumption. Urine levels of indoxyl sulfate and p-cresol sulfate were reduced during treatment phase.</div></div><div><h3>Conclusion(s)</h3><div>P-inulin administration to CKD patients resulted in a distinct shift in toxin-generating proteolysis to amino acid biosynthesis and favorable changes in lipid metabolism.</div></div>","PeriodicalId":50066,"journal":{"name":"Journal of Renal Nutrition","volume":"36 3","pages":"Pages 419-429"},"PeriodicalIF":3.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145592712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Response to Comment on “Effect of Protein Supplementation on Health-Related Quality of Life With Advanced Chronic Kidney Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials” 对“补充蛋白质对晚期慢性肾病患者健康相关生活质量的影响:随机对照试验的系统回顾和荟萃分析”评论的回应。
IF 3.2 3区 医学
Journal of Renal Nutrition Pub Date : 2026-05-01 Epub Date: 2025-12-12 DOI: 10.1053/j.jrn.2025.12.003
Yasmin Iman BSc, Krista Rossum MD, MSc, Amanda Krueger RD, Favian Co BSc, Makan Pourmasoumi PhD(C), Ruth Ewhrudjakpor BSc (Hons), Nicole Askin MLIS, Rebecca C. Mollard PhD, Clara Bohm MD, MPH
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引用次数: 0
Letter to the Editor: “The Acute Effect of Dark Chocolate on Blood Pressure and Renal Hemodynamics as Assessed With Doppler Ultrasound in Healthy Volunteers” 致编辑的信:“健康志愿者用多普勒超声评估黑巧克力对血压和肾脏血流动力学的急性影响。”
IF 3.2 3区 医学
Journal of Renal Nutrition Pub Date : 2026-05-01 Epub Date: 2025-12-08 DOI: 10.1053/j.jrn.2025.08.006
Parth Aphale PhD, Shashank Dokania BHMS, Himanshu Shekhar BHMS
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引用次数: 0
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