Journal of Renal Nutrition最新文献

{"title":"Circulating Concentrations of advanced Glycation end Products, Carboxymethyl Lysine and Methylglyoxal are Associated With Renal Function in Individuals With Diabetes","authors":"Lina Ding MD ,&nbsp;Yanli Hou MD ,&nbsp;Junjun Liu PhD ,&nbsp;Xiaolei Wang PhD ,&nbsp;Zhibin Wang MD ,&nbsp;Wenyu Ding MD ,&nbsp;Ke Zhao MD","doi":"10.1053/j.jrn.2023.09.005","DOIUrl":"10.1053/j.jrn.2023.09.005","url":null,"abstract":"<div><h3>Objective</h3><p>Diabetic kidney disease<span><span> (DKD) is one of the most severe chronic complications of diabetes and is associated with higher level of </span>advanced glycation end products (AGEs). The aim of this study was to investigate the diagnostic potential of combined detection of multiple serum AGEs in diagnosing DKD.</span></p></div><div><h3>Methods</h3><p>Serum AGEs, N^ε-(carboxymethyl) lysine (CML), N^ε<span><span>-(carboxyethyl) lysine, and methylglyoxal<span> (MGO) levels were measured by enzyme-linked immunosorbent assay in 176 individuals with type 2 diabetes. Participants were classified into normoalbuminuria, microalbuminuria, and </span></span>macroalbuminuria<span> group according to their urinary albumin to creatinine ratio (UACR).</span></span></p></div><div><h3>Results</h3><p><span><span>Higher serum AGEs levels were found to be positively correlated with U-Alb, UACR, and blood urea nitrogen in the study of 176 individuals with type 2 diabetes. CML and MGO levels were positively correlated with U-Alb, UACR, blood urea nitrogen, Scr, and </span>uric acid<span>, and negatively correlated with estimated glomerular filtration rate (</span></span><em>P</em><span> &lt; .05). Multivariate logistic regression analysis showed that elevated levels of AGEs, CML, and MGO were independent risk factors for the progression of DKD (odds ratio = 1.861, 1.016, 7.607, </span><em>P</em> &lt; .01). The sensitivity, specificity, and area under receiver operating characteristic curve of combined detection of AGEs, MGO, and CML were higher than those of three individual detections (area under the curve = 0.952, 0.772, 0.868, 0905, respectively, <em>P</em> &lt; .05).</p></div><div><h3>Conclusion</h3><p>The combined detection of AGEs, CML, and MGO may improve the reliability of early diagnosis of DKD.</p></div>","PeriodicalId":50066,"journal":{"name":"Journal of Renal Nutrition","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41150218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Artificial Intelligence to Patient-Targeted Health Information on Kidney Stone Disease","authors":"Reza Kianian ,&nbsp;Matthew Carter ,&nbsp;Ilana Finkelshtein ,&nbsp;Sriram V. Eleswarapu ,&nbsp;Naveen Kachroo","doi":"10.1053/j.jrn.2023.10.002","DOIUrl":"10.1053/j.jrn.2023.10.002","url":null,"abstract":"<div><h3>Objective</h3><p><span>The American Medical Association recommends health information to be written at a 6th grade level reading level. Our aim was to determine whether Artificial Intelligence can outperform the existing health information on kidney stone prevention and </span>treatment.</p></div><div><h3>Methods</h3><p>The top 50 search results for “Kidney Stone Prevention” and “Kidney Stone Treatment” on Google, Bing, and Yahoo were selected. Duplicate webpages, advertisements, pages intended for health professionals such as science articles, links to videos, paid subscription pages, and links nonrelated to kidney stone prevention and/or treatment were excluded. Included pages were categorized into academic, hospital-affiliated, commercial, nonprofit foundations, and other. Quality and readability of webpages were evaluated using validated tools, and the reading level was descriptively compared with ChatGPT generated health information on kidney stone prevention and treatment.</p></div><div><h3>Results</h3><p>50 webpages on kidney stone prevention and 49 on stone treatment were included in this study. The reading level was determined to equate to that of a 10th to 12th grade student. Quality was measured as “fair” with no pages scoring “excellent” and only 20% receiving a “good” quality. There was no significant difference between pages from academic, hospital-affiliated, commercial, and nonprofit foundation publications. The text generated by ChatGPT was considerably easier to understand with readability levels measured as low as 5th grade.</p></div><div><h3>Conclusions</h3><p>The language used in existing information on kidney stone disease is of subpar quality and too complex to understand. Machine learning tools could aid in generating information that is comprehensible by the public.</p></div>","PeriodicalId":50066,"journal":{"name":"Journal of Renal Nutrition","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41240319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietitians Play a Crucial and Expanding Role in Renal Nutrition and Medical Nutrition Therapy","authors":"Brandon Kistler PhD, RD,&nbsp;Carla Maria Avesani PhD,&nbsp;Jerrilynn D. Burrowes PhD, RD, CDN, FNKF,&nbsp;Maria Chan PhD, AdvAPD, FNKF,&nbsp;Lilian Cuppari PhD,&nbsp;Mary Kay Hensley MS, RDN, FAND, FNKF,&nbsp;Tilakavati Karupaiah RnD, PhD,&nbsp;Maria Christina Kilates MA, RD,&nbsp;Denise Mafra PhD,&nbsp;Karen Manley BSc, MHumNutr, GradDipDiet,&nbsp;Marianne Vennegoor BSc,&nbsp;Angela Yee-Moon Wang MD, PhD,&nbsp;Kelly Lambert PhD, Adv APD,&nbsp;Keiichi Sumida MD,&nbsp;Linda W. Moore PhD, RDN,&nbsp;Kamyar Kalantar-Zadeh MD, MPH, PhD,&nbsp;Katrina L. Campbell PhD","doi":"10.1053/j.jrn.2024.02.001","DOIUrl":"10.1053/j.jrn.2024.02.001","url":null,"abstract":"","PeriodicalId":50066,"journal":{"name":"Journal of Renal Nutrition","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139906771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"March Meeting Announcements","authors":"Mary Kay Hensley MS, RDN, FAND","doi":"10.1053/j.jrn.2024.01.004","DOIUrl":"https://doi.org/10.1053/j.jrn.2024.01.004","url":null,"abstract":"","PeriodicalId":50066,"journal":{"name":"Journal of Renal Nutrition","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1051227624000128/pdfft?md5=077eb882b9491ac242973dfcfc27a4e0&pid=1-s2.0-S1051227624000128-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140188008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Proposed Predictive Equation for Energy Expenditure Estimation Among Noncritically Ill Patients With Acute Kidney Injury","authors":"Patharasit Jindapateep MD ,&nbsp;Worawan Sirichana MD ,&nbsp;Nattachai Srisawat MD ,&nbsp;Warradit Srisuwanwattana MD ,&nbsp;Kamonchanok Metta CDT ,&nbsp;Nareerat Sae-eao BSc ,&nbsp;Somchai Eiam-Ong MD ,&nbsp;Piyawan Kittiskulnam MD","doi":"10.1053/j.jrn.2023.09.006","DOIUrl":"10.1053/j.jrn.2023.09.006","url":null,"abstract":"<div><h3>Objective</h3><p>The incidence of acute kidney injury (AKI) is identified more frequently in noncritical compared with intensive care settings. The prognosis of malnourished AKI patients is far worse than those with normal nutritional status. However, a method for estimating the optimal amount of energy required to guide nutritional support among noncritically ill AKI patients is yet to be determined.</p></div><div><h3>Methods</h3><p>We evaluated the performance of weight-based formulas (20-30 kcal/kg/day) with the reference values of energy expenditure (EE) measured by indirect calorimetry (IC) among noncritically ill AKI patients during hospitalization. The statistics for assessing agreement, including total deviation index and accuracy within 10% represent the percentage of estimations falling within the IC value range of ±10%, were tested. Parameters for predicting the EE equation were also developed using a regression analysis model.</p></div><div><h3>Results</h3><p><span>A total of 40 noncritically ill AKI patients were recruited. The mean age of participants was 62.5 ± 16.5 years with 50% being male. The average IC-derived EE was 1,124.6 ± 278.9 kcal/day with respiratory quotients 0.8-1.3, indicating good validity of the IC test. Receiving dialysis, protein catabolic rate, and age was not significantly associated with measured EE. Nearly all weight-based formulas overestimated measured EE. The magnitude of total deviation index values was broad with the proportion of patients achieving an accuracy of 10% being as low as 20%. The proposed equation to predict EE derived from this study was EE (kcal/day) = 618.27 + (8.98 x weight in kg) + 137.0 if diabetes - 199.7 if female (</span><em>r</em>^<em>2</em> = 0.68, <em>P</em> &lt; .001). In the validation study with an independent group of noncritically ill AKI patients, predicted EE using the newly derived equation was also significantly correlated with measured EE by IC (<em>r</em> = 0.69, <em>P</em> = .004).</p></div><div><h3>Conclusion</h3><p>Estimation of EE by weight-based formulas usually overestimated measured EE among noncritically ill AKI patients. In the absence of IC, the proposed predictive equation, specifically for noncritically ill AKI patients might be useful, in addition to weight-based formulas, for guiding caloric dosing in clinical practice.</p></div>","PeriodicalId":50066,"journal":{"name":"Journal of Renal Nutrition","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41162599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association of Frailty and Malnutrition With Dietary Intake and Gastrointestinal Symptoms in People With Kidney Failure: 2-Year Prospective Study","authors":"Cameron McLean MNutDiet ,&nbsp;Ann-Maree Randall BNutDiet ,&nbsp;Michele Ryan BSc, DipNutDiet ,&nbsp;Brendan Smyth PhD ,&nbsp;Max Thomsett BSc ,&nbsp;Mark A. Brown PhD ,&nbsp;Jessica K. Dawson PhD","doi":"10.1053/j.jrn.2023.10.006","DOIUrl":"10.1053/j.jrn.2023.10.006","url":null,"abstract":"<div><h3>Background</h3><p>Frailty<span> and malnutrition are both associated with worsening morbidity and mortality and become more prevalent in the elderly and as kidney function declines. Anorexia and reduced oral intake are common features of both frailty and malnutrition. However, there are sparse data evaluating the impact of other gastrointestinal (GI) symptoms, such as taste changes, on rates of frailty and malnutrition in people with kidney failure. The aim of this study is to describe the prevalence of frailty and malnutrition and their association with dietary intake and nutrition-related symptoms in people with kidney failure.</span></p></div><div><h3>Methods</h3><p>This observational study recruited people with kidney failure who were commencing Conservative Kidney Management or elderly people (aged &gt; 75 years) newly commenced on dialysis from 3 renal units. Participants underwent assessments of frailty, nutritional status, dietary intake, and GI symptom burden when they attended clinic appointments, approximately every 6 months.</p></div><div><h3>Results</h3><p>Of the 85 participants, 57% were assessed as being frail and 33% were assessed as being malnourished. Participants assessed as frail reported more GI symptoms (3 vs. 2, <em>P</em> &lt; .001) that were more severe (1.75 vs. 1.0, <em>P</em> &lt; .001) compared to nonfrail participants. Being malnourished was associated with a 5 times higher chance of being frail (odds ratio 5.8; 95% confidence interval 1.5, 21.8; <em>P</em> = .015) and having more severe symptoms was associated with a 2 times higher chance (odds ratio 2.8; 95% CI 1.1, 7.0; <em>P</em> = .026) of being frail. In addition to experiencing more GI symptoms, that were more severe, participants who were malnourished consumed significantly less energy (1234 kcal vs. 1400 kcal, <em>P</em> = .01) and protein (51 g vs. 74 g, <em>P</em> &lt; .001).</p></div><div><h3>Conclusions</h3><p>Frailty and malnutrition are common and are associated with a higher GI symptom burden and poorer dietary intake. Future research is needed to determine effective interventions targeting frailty and malnutrition, including nutrition-related symptoms and optimal protein intake.</p></div>","PeriodicalId":50066,"journal":{"name":"Journal of Renal Nutrition","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71428531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Frailty With Nutritional Status in Patients With Chronic Kidney Disease","authors":"Pei Wei Tseng MD,&nbsp;Ting-Yun Lin MD,&nbsp;Szu-Chun Hung MD","doi":"10.1053/j.jrn.2023.09.003","DOIUrl":"10.1053/j.jrn.2023.09.003","url":null,"abstract":"<div><h3>Objectives</h3><p>Frailty<span><span> is commonly observed in patients<span> with chronic kidney disease (CKD) and is associated with </span></span>adverse outcomes. Protein-energy wasting (PEW), a state of decreased body stores of protein and energy fuels, may be associated with frailty. However, few data are available on the possible association between frailty and PEW in CKD.</span></p></div><div><h3>Methods</h3><p><span><span>We examined the association between frailty and nutritional status assessed using anthropometric and body composition measurements, </span>serum albumin<span>, handgrip strength, the Malnutrition Inflammation Score (MIS), and dietary protein<span> and calorie intake in a cross-sectional analysis of nondialysis patients with CKD stages 3-5. Body composition was assessed using multifrequency bioelectrical impedance. Frailty was defined as a Clinical Frailty Scale ≥4. We performed </span></span></span>logistic regression<span><span> with different nutrition assessment tools as the main predictors and age, sex, comorbidity, estimated </span>glomerular filtration rate (eGFR), and hemoglobin as covariates.</span></p></div><div><h3>Results</h3><p>A total of 157 patients (93 men and 64 women; mean age 64 years; diabetes prevalence 38.9%) with CKD (eGFR 24.4 ± 13.4 mL/min/1.73 m²<span>) were included. Overall, 29.3% of patients were frail. Patients with frailty were older and had a significantly higher fat tissue index and MIS but a significantly lower lean tissue index, eGFR, hemoglobin value, serum albumin value, handgrip strength value, and dietary protein intake. In multivariate logistic regression analyses, a higher body mass index category (odds ratio [OR], 1.54; 95% confidence interval [CI], 1.03-2.31), higher fat tissue index (OR, 1.15; 95% CI, 1.03-1.28), larger waist circumference (OR, 1.05; 95% CI, 1.01-1.09), reduced handgrip strength (OR, 2.70; 95% CI, 1.17-6.21), PEW defined by MIS ≥5 (OR, 3.49; 95% CI, 1.35-9.01), and dietary protein intake ≤0.8 g/kg/day (OR, 2.70; 95% CI, 1.18-6.19) were associated with higher odds of frailty.</span></p></div><div><h3>Conclusion</h3><p>Frailty is associated with nutritional status in patients with CKD. A comprehensive nutrition assessment may allow the implementation of strategies to prevent or reduce frailty.</p></div>","PeriodicalId":50066,"journal":{"name":"Journal of Renal Nutrition","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41149468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acceptability, Adherence, Safety and Experiences of Low Energy Diets in People With Obesity and Chronic Kidney Disease: A Mixed Methods Study","authors":"Marguerite Conley MNutDiet, BSci(ExSportSci(Hons)) ,&nbsp;Hannah L. Mayr BHsc(Nut&Diet), PhD ,&nbsp;Mikeeley Hoch BNutDiet(Hons) ,&nbsp;David W. Johnson MB BS (Hons, Univ Medal), FRACP, DMed(Res), FASN, FAHMS, PhD ,&nbsp;Andrea K. Viecelli MD FRACP PhD ,&nbsp;Helen MacLaughlin AD","doi":"10.1053/j.jrn.2023.09.004","DOIUrl":"10.1053/j.jrn.2023.09.004","url":null,"abstract":"<div><h3>Objectives</h3><p>Obesity is a modifiable risk factor for chronic kidney disease<span> (CKD) progression. Low energy diets (LEDs) have not been adequately studied in people with CKD. This study aimed to explore acceptability, adherence, safety, and experiences of two LED prescriptions in adults living with obesity and CKD.</span></p></div><div><h3>Design and Methods</h3><p>In a mixed-methods study, obese adults with CKD were prescribed two LEDs (∼800 to 1000 kcal/day each), in a randomised order for 2 weeks each. One diet consisted of four meal replacement products daily (Optifast®, Nestlé Health Science) and the other two pre-prepared frozen meals (Lite n’ Easy®, Mitchell's Quality Foods). Participants received weekly dietitian support, completed daily adherence checklists (converted to % of provided meals/replacements consumed) and participated in post-intervention semi-structured interviews to capture their experience.</p></div><div><h3>Results</h3><p><span>Nine participants were included (mean age 46.5 ± 14.3 years, estimated glomerular filtration rate 64 ± 26 mL/min/1.73 m</span>²<span>, 4/9 male). Mean self-reported adherence was 88 ± 11% and mean 4-week weight change<span> was −7.3 ± 5.6 kg. Two participants withdrew at week two. Most frequently reported side effects were hunger and headaches. Adverse events of interest included one episode each of hyperkalaemia and hypoglycaemia. No serious adverse events occurred. Four overarching themes of patient experiences were identified: strategies used to adapt, disruption to the norm, individual preferences, and influences on acceptability.</span></span></p></div><div><h3>Conclusions</h3><p>LEDs were found to be acceptable and safe with high self-reported adherence rates. Future LED trials should include specialist diabetes management, close monitoring for hyperkalaemia and adequate support to assist with managing side effects and dietary and social adjustments.</p></div>","PeriodicalId":50066,"journal":{"name":"Journal of Renal Nutrition","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41154026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Plant-based Diet and Kidney Function in Adults","authors":"Behrooz Moloudpour MSc ,&nbsp;Samira Arbabi Jam MSc ,&nbsp;Mitra Darbandi MSc ,&nbsp;Ali Janati PhD ,&nbsp;Masoumeh Gholizadeh PhD ,&nbsp;Farid Najafi MD, PhD ,&nbsp;Yahya Pasdar PhD","doi":"10.1053/j.jrn.2023.09.002","DOIUrl":"10.1053/j.jrn.2023.09.002","url":null,"abstract":"<div><h3>Objective</h3><p>A plant-based diet has both antioxidant and anti-inflammatory properties. Therefore, it is hypothesized that adherence to a plant-based diet may have a positive effect on kidney function. The study aimed to determine the association between the plant-based diet index (PDI) and chronic kidney disease (CKD).</p></div><div><h3>Methods</h3><p><span><span><span><span>This cross-sectional analysis used information from the Ravansar noncommunicable diseases </span>cohort study, which included 9,746 participants between the ages of 35 and 65. By measuring the estimation </span>glomerular filtration rate (eGFR) with the modification of diet in the </span>renal disease<span> equation, CKD was determined. Using a food frequency questionnaire, the PDI was computed based on food intake. To determine odds ratios (ORs), multivariable </span></span>logistic regression models were utilized.</p></div><div><h3>Results</h3><p>1,058 (10.86%) participants had CKD (eGFR&lt;60 mL/min/1.73 m²), and the mean PDI was 54.22 ± 6.68. The mean eGFR in the group with a high PDI score was significantly higher than the group with a low PDI score (fourth quartile: 79.20 ± 0.36 vs. first quartile: 72.95 ± 0.31, <em>P</em> &lt; .001). Adherence to a plant-based diet was more prevalent in those with a higher socioeconomic status (<em>P</em> &lt; .001). After adjusting for potential confounders, the odds of CKD in the third and fourth quartiles of PDI were 25% (OR: 0.75; 95% confidence interval: 0.62-0.91) and 39% (OR: 0.61; 95% confidence interval: 0.48-0.78, <em>P</em> trend&lt;.001) lower than the first quartile, respectively.</p></div><div><h3>Conclusions</h3><p>The findings of this study suggest that having a plant-based diet may prevent the prevalent CDK. However, further studies with a cohort design are recommended.</p></div>","PeriodicalId":50066,"journal":{"name":"Journal of Renal Nutrition","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41162600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health-related Quality of Life in 10 years Long-term Survivors of Chronic Kidney Disease: A From-J Study","authors":"Reiko Okubo MD, PhD ,&nbsp;Masahide Kondo MD, MSc, PhD ,&nbsp;Toshiyuki Imasawa MD, PhD ,&nbsp;Chie Saito MD, PhD ,&nbsp;Hirayasu Kai MD, PhD ,&nbsp;Ryoya Tsunoda MD, PhD ,&nbsp;Junichi Hoshino MD, PhD ,&nbsp;Tsuyoshi Watanabe MD, PhD ,&nbsp;Ichiei Narita MD, PhD ,&nbsp;Seiichi Matsuo MD, PhD ,&nbsp;Hirofumi Makino MD, PhD ,&nbsp;Akira Hishida MD, PhD ,&nbsp;Kunihiro Yamagata MD, PhD","doi":"10.1053/j.jrn.2023.10.001","DOIUrl":"10.1053/j.jrn.2023.10.001","url":null,"abstract":"<div><h3>Objective</h3><p><span><span>The Chronic Kidney Disease (CKD) practice facilitation program in the Frontier of Renal Outcome Modifications in Japan study reduced cardiovascular disease (CVD) events </span>in patients with CKD. 10-year long-term survivors with CKD lived with serious complications, including end-stage kidney disease and CVD. This study aimed to measure health-related </span>quality of life in 10-year long-term CKD survivors and examine the predictors and determinants of clinical indices for measured quality of life (QOL) scores.</p></div><div><h3>Methods</h3><p>The EQ-5D-5L, a generic preference-based instrument, was administered to 1,473 CKD survivors enrolled in the Frontier of Renal Outcome Modifications in JapanFrontier of Renal Outcome Modifications in JapanFrontier of Renal Outcome Modifications in Japan study. The 10th-year data collection was performed by either primary care physicians or participants who filled out questionnaires from October 2018 to March 31, 2019.</p></div><div><h3>Results</h3><p><span><span>The response rate was 38.2% (423/1,473). The mean QOL score was 0.893 (95% confidence interval (CI), 0.880–0.906), and the median QOL score was 1.000 (interquartile range (IQR), 0.826–1.000). The mean QOL score in participants with renal replacement therapy was 0.824 (95% CI, 0.767–0.881), and the median was 0.828 (IQR, 0.755–1.000). The mean QOL score in participants with CVD was 0.877 (95% CI, 0.811–0.943), and the median was 1.000 (IQR, 0.723–1.000). The mean QOL score in participants with 50% decline in estimated </span>glomerular filtration was 0.893 (95% CI, 0.860–0.926), and the median was 0.889 (IQR, 0.825–1.000). The decrease in QOL scores with baseline CKD stages was significant according to the Jonckheere–Terpstra test for trend (</span><em>P</em><span> = .002). Baseline age, systolic blood pressure<span>, and history of hyperuricemia were significant predictors of 10th-year QOL scores.</span></span></p></div><div><h3>Conclusion</h3><p>We suggest that CKD complications negatively affect the QOL scores in 10-year long-term survivors with CKD. CKD guideline-based practices, prevention of end-stage kidney disease/CVD and management of hypertension, diabetes and hyperuricemia, might contribute to future health-related quality of life in patients with CKD.</p></div>","PeriodicalId":50066,"journal":{"name":"Journal of Renal Nutrition","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41218080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}