{"title":"Low skeletal muscle density assessed by abdominal computerized tomography predicts outcome in children with chronic kidney disease.","authors":"Meiqiu Wang, Zijian Chen, Tingting Yu, Lianghui You, Yingchao Peng, Huangyu Chen, Pei Zhang, Zhuo Shi, Xiang Fang, LiLi Jia, Zhengkun Xia, Chenbo Ji, Hao Tang, Chunlin Gao","doi":"10.1053/j.jrn.2024.11.003","DOIUrl":"https://doi.org/10.1053/j.jrn.2024.11.003","url":null,"abstract":"<p><strong>Objective: </strong>Skeletal muscle loss and abnormal fat distribution are predictors of poor clinical outcomes in adults with chronic kidney disease (CKD). However, the relationship between body composition (muscle mass and adipose tissue) and prognosis in children with CKD has not been well elucidated.</p><p><strong>Methods: </strong>The retrospective single-center study enrolled children with CKD and healthy group who underwent an abdominal Computerized tomography (CT) examination and compared the body composition of the third lumbar spine (L3) between the two groups. We defined the primary outcome as hemodialysis, peritoneal dialysis, kidney transplantation, or death. Logistic regression analysis was applied to assess the connection between low skeletal muscle density (SMD) and clinical and demographic variables. Multivariate Cox regression analysis was used to evaluate the risk factors for progression to the primary outcome. Kaplan-Meier survival analysis was performed to compare the effect of different body composition on event-free survival rate.</p><p><strong>Results: </strong>32 patients with CKD [eGFR: 14.89(8.86, 29.88) (mL/min/1.73m<sup>2</sup>)] and 66 heathy subjects [eGFR: 135.72(121.70, 161.29) (mL/min/1.73m<sup>2</sup>)] were recruited in our study. From the assessment of body composition assessed by CT, skeletal muscle area, SMD and skeletal muscle index (SMI) in CKD group was lower than those in healthy group (P<0.05). On the other hand, visceral fat area and visceral fat index in CKD group were significantly higher than those in healthy group (P<0.05). In logistic regression analysis, triglyceride (OR: 8.635, 95%CI: 1.153-64.687) was independently associated with low SMD. After adjusting clinical data and body composition, high serum albumin (HR: 0.873, 95%CI: 0.798-0.955) and high SMD (HR: 0.895, 95%CI: 0.822-0.974) were protective factors for delaying renal failure. Based on the Kaplan-Meier analysis, only the group with low SMD had lower event-free survival in comparison to the reference group (P<0.05).</p><p><strong>Conclusions: </strong>These findings suggest that there is significant skeletal muscle loss and decrease in SMD in CKD children. Notably, low SMD is indicative of poor prognosis in CKD children.</p>","PeriodicalId":50066,"journal":{"name":"Journal of Renal Nutrition","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142645110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Comparison between Severity-dependent Protocol and Fixed Dose Regimen of Oral Vitamin D Supplementation on Correction of Hypovitaminosis D among Dialysis Patients.","authors":"Piyawan Kittiskulnam, Saranchana Jiampochaman, Piyatida Chuengsaman, Talerngsak Kanjanabuch, Paweena Susantitaphong, Kanda Sriudom, Sirarat Katesomboon, Kamonchanok Metta, Somchai Eiam-Ong","doi":"10.1053/j.jrn.2024.11.002","DOIUrl":"https://doi.org/10.1053/j.jrn.2024.11.002","url":null,"abstract":"<p><strong>Background: </strong>Low vitamin D status is associated with either low muscle mass or impaired muscle function in dialysis patients. However, there is no consensus on how best to correct hypovitaminosis D, defined as serum 25-hydroxyvitamin D [25(OH)D] level <30 ng/mL, in patients with end-stage kidney disease (ESKD). This study investigated the effect of different vitamin D supplementation regimens on sarcopenia outcomes in dialysis patients.</p><p><strong>Methods: </strong>This was a prospective randomized controlled trial. ESKD patients treated with maintenance hemodialysis (HD) or peritoneal dialysis (PD) with low vitamin D status on a ratio of 1:1, randomized to either receive oral ergocalciferol utilizing a severity-dependent treatment protocol for low vitamin D status suggested by the K/DOQI as a control group, or a fixed-dose regimen of 20,000 international units (IU)/week. The changes in muscle mass were measured by bioimpedance spectroscopy (BIS), muscle strength was assessed by a hand grip dynamometer, physical performance was determined by gait speed, and muscle-related biomarkers were examined.</p><p><strong>Results: </strong>A total of 76 dialysis patients were randomized (HD=43.4%). Baseline characteristics, including age, dialysis vintage, and muscle parameters were similar. After supplementation, the average serum 25(OH)D levels in the severity-dependent and fixed-dose groups were significantly elevated from 14.5±7.3 to 27.2±13.2 ng/mL, p<0.001 and from 15.1±6.4 to 28.8±11.5 ng/mL, p<0.001, respectively, and did not differ between groups at six months (p=0.60). Despite comparable energy and protein intake, the mean BIS-derived total-body muscle mass normalized to height squared was significantly increased at six months in the fixed-dose group (14.5±3.3 to 15.3±3.0 kg/m<sup>2</sup>, p=0.03) compared with the severity-dependent protocol (13.5±2.7 to 13.7±2.9 kg/m<sup>2</sup>, p=0.58). In the subgroup analysis, muscle mass improvement was statistically elevated in PD patients (p=0.01) while unaltered among HD patients (p=0.88) in the fixed-dose group. Muscle strength, gait speed, and serum insulin-like growth factor-1 level, as the mediators of muscle cell growth, were not different between the two groups at six months (p>0.05). Neither hypercalcemia nor hyperphosphatemia was found throughout the study.</p><p><strong>Conclusion: </strong>A fixed-dose ergocalciferol supplementation demonstrates similar performance in the correction of low vitamin D status but better muscle mass improvement than a severity-dependent protocol among ESKD patients. Regular dosing intervals of weekly vitamin D supplementation appear to be a promising treatment for sarcopenia among patients undergoing dialysis.</p>","PeriodicalId":50066,"journal":{"name":"Journal of Renal Nutrition","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142645109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hongjun Zhao, Yanchen Wang, Lihui Guan, Yaofei Sun
{"title":"Association between magnesium intake and chronic kidney diseases and kidney stones in adults aged 50 years and older: dose-response analysis of a nationally representative population-based study.","authors":"Hongjun Zhao, Yanchen Wang, Lihui Guan, Yaofei Sun","doi":"10.1053/j.jrn.2024.11.004","DOIUrl":"https://doi.org/10.1053/j.jrn.2024.11.004","url":null,"abstract":"<p><strong>Objective: </strong>Higher serum magnesium concentrations have been linked to reduced risk of chronic kidney diseases (CKD). However, the dose-response relationships between magnesium intake and CKD and kidney stones in the general population remain unknown. This study aimed to quantitatively assess the dose-response relationships between magnesium intake and CKD and kidney stones.</p><p><strong>Methods: </strong>Adult participants (≥50 years) from the 2007-2018 National Health and Nutrition Examination Survey were included. Magnesium intake from diet and supplements were determined with structured dietary recalls. Patients with kidney stones were identified using a standard questionnaire. CKD was defined as estimated glomerular filtration rate <60 mL/min/1.73 m<sup>2</sup>. The non-linear relationships were explored with restricted cubic splines. Stratified analyses by sex were conducted.</p><p><strong>Results: </strong>The weighted prevalence of CKD and kidney stones was 12.16% and 13.13%, respectively. A non-linear relationship between magnesium intake and CKD (P<sub>for non-linearity</sub><0.01) and kidney stones (P<sub>for non-linearity</sub>=0.02) was found. There was an initial steep decrease in odds of CKD and kidney stones with increasing intakes of magnesium, and then a platform or weaker decrease in odds of CKD and kidney stones was observed beyond 350 mg/day of magnesium intake[odds ratio (95% confidence interval) for CKD: 0.60 (0.46-0.78), 0.77 (0.61-0.98) for kidney stones]. Higher magnesium intake was inversely associated with odds of CKD in both males and females, while the inverse association between higher magnesium intake and odds of kidney stones was only statistically significant in females.</p><p><strong>Conclusions: </strong>Higher magnesium intake was non-linearly associated with lower odds of kidney stones and CKD, and a threshold level of 350 mg/day of magnesium intake was observed in adults aged 50 years and older. These findings deserve to be confirmed by prospective cohort studies.</p>","PeriodicalId":50066,"journal":{"name":"Journal of Renal Nutrition","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142640143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mai Tanaka, Michihiro Hosojima, Hideyuki Kabasawa, Shin Goto, Ichiei Narita
{"title":"Association between Potential Renal Acid Load and 10-Year Mortality in Patients on Hemodialysis.","authors":"Mai Tanaka, Michihiro Hosojima, Hideyuki Kabasawa, Shin Goto, Ichiei Narita","doi":"10.1053/j.jrn.2024.11.001","DOIUrl":"https://doi.org/10.1053/j.jrn.2024.11.001","url":null,"abstract":"<p><strong>Objective: </strong>Higher dietary acid load (DAL) has been linked to elevated incidence and progression of chronic kidney disease. However, the association between DAL and mortality in patients on maintenance hemodialysis (MHD) has not been evaluated.</p><p><strong>Methods: </strong>We retrospectively analyzed baseline laboratory data, self-administered diet history questionnaire results, and 10-year mortality rates in 44 patients (26 men, 67.9±10.4 years) on MHD who participated in a randomized, double-blind, crossover pilot trial of rice endosperm protein supplementation which was conducted in 2013. DAL was estimated from nutrition intake using potential renal acid load (PRAL), and patients were divided into tertiles using this score.</p><p><strong>Results: </strong>During the 10-year observation period, 19 patients (43%) died. A higher PRAL score was significantly associated with higher all-cause mortality. The multivariable-adjusted hazard ratio for all-cause mortality in the highest tertile of PRAL versus the lowest tertile was 3.88 (95% confidence interval [CI], 1.10-13.61). Multiple logistic regression analysis showed a significant association between higher PRAL and lower intake of green and yellow vegetables (odds ratio, 5.40; 95% CI, 1.37-21.26) and fruits (odds ratio, 4.76; 95% CI, 1.30-16.76).</p><p><strong>Conclusion: </strong>Higher PRAL is positively associated with all-cause mortality, and these associations might be affected by a lower intake of fruits and vegetables in Japanese patients on MHD.</p>","PeriodicalId":50066,"journal":{"name":"Journal of Renal Nutrition","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142640144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mariana Mazzei Caiado Bressan, Elisa de Albuquerque Sampaio, Ricardo de Castro Cintra Sesso, Jocemir Ronaldo Lugon
{"title":"Serum phosphate levels and mortality in incident hemodialysis patients: a national retrospective cohort study.","authors":"Mariana Mazzei Caiado Bressan, Elisa de Albuquerque Sampaio, Ricardo de Castro Cintra Sesso, Jocemir Ronaldo Lugon","doi":"10.1053/j.jrn.2024.10.003","DOIUrl":"https://doi.org/10.1053/j.jrn.2024.10.003","url":null,"abstract":"","PeriodicalId":50066,"journal":{"name":"Journal of Renal Nutrition","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142591633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Josiah Thule BSA , Xue Yu MS , Maria E. Montez-Rath PhD , Glenn M. Chertow MD, MPH
{"title":"MyPlate Awareness and Engagement and Perceived and Objective Diet Quality in US Adults With Chronic Kidney Disease","authors":"Josiah Thule BSA , Xue Yu MS , Maria E. Montez-Rath PhD , Glenn M. Chertow MD, MPH","doi":"10.1053/j.jrn.2024.04.007","DOIUrl":"10.1053/j.jrn.2024.04.007","url":null,"abstract":"<div><h3>Objective</h3><div>Awareness of federal dietary guidelines has been associated with better perceived and objective diet quality. Little is known about the awareness of federal dietary recommendations among persons with chronic kidney disease (CKD) and the associations between recognition of guidelines, perception of diet quality, and objective quality of the diet in this population.</div></div><div><h3>Design and Methods</h3><div>We compared awareness of, and engagement with, MyPlate (a representation of 5 food groups from the US Department of Agriculture) along with perceived and objective diet quality, the latter assessed via Dietary Approaches to Stop Hypertension index scores, among US adults with and without CKD during 2017-2020.</div></div><div><h3>Results</h3><div>Among noninstitutionalized adults in the United States, 8.3% had albuminuria with normal or near-normal kidney function, 4.0% had estimated glomerular filtration rate 45-59 mL/minute/1.73 m<sup>2</sup> (CKD stage G3a) and 1.6% had estimated glomerular filtration rate <45 mL/minute/1.73 m<sup>2</sup> (CKD stages G3b/G4/G5). MyPlate awareness was lower among persons with CKD compared with those without CKD (19.6% vs. 26.4%, <em>P</em> < .001) and was lower among persons with more advanced CKD stages: 20.8%, 18.2%, and 16.3% in persons with CKD stages G1/G2, G3a, and G3b/G4/G5, respectively (trend <em>P</em> < .001). Among persons aware of MyPlate, a numerically higher proportion with CKD attempted to follow MyPlate recommendations (43.9% vs. 32.3%, <em>P</em> = .10); the proportion was highest among persons with moderate-to-advanced CKD (41.9%, 42.9%, and 56.9% among persons with CKD stages G1/G2, G3a, and G3b/G4/G5, respectively (trend <em>P</em> < .001)). Perceived and objective dietary quality (the latter based on concordance with the Dietary Approaches to Stop Hypertension diet) were slightly higher among persons with CKD relative to those without CKD.</div></div><div><h3>Conclusions</h3><div>Adults with CKD have lower MyPlate awareness than adults without CKD. Enhancing diet education to persons with CKD could improve diet quality and potentially ameliorate CKD-associated complications.</div></div>","PeriodicalId":50066,"journal":{"name":"Journal of Renal Nutrition","volume":"34 6","pages":"Pages 493-499"},"PeriodicalIF":3.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140916830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Joyce Marcley Vergili EdD, RDN, CSR, CDN, CDCES, FAND
{"title":"Opportunity to Submit Comments to the Food and Drug Administration on Phosphate Food Additive Safety Through December 6, 2024","authors":"Joyce Marcley Vergili EdD, RDN, CSR, CDN, CDCES, FAND","doi":"10.1053/j.jrn.2024.09.003","DOIUrl":"10.1053/j.jrn.2024.09.003","url":null,"abstract":"","PeriodicalId":50066,"journal":{"name":"Journal of Renal Nutrition","volume":"34 6","pages":"Pages 475-476"},"PeriodicalIF":3.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142378529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Emergence of Artificial Intelligence in Renal Nutrition Applications","authors":"Linda W. Moore PhD, RDN, Giacomo Garibotto MD","doi":"10.1053/j.jrn.2024.10.002","DOIUrl":"10.1053/j.jrn.2024.10.002","url":null,"abstract":"","PeriodicalId":50066,"journal":{"name":"Journal of Renal Nutrition","volume":"34 6","pages":"Pages 473-474"},"PeriodicalIF":3.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142512025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marvery P. Duarte MSc , Fábio A. Vieira PT , Victor M. Baião MSc , Jacqueline S. Monteiro MD , Aparecido P. Ferreira PhD , Antônio J. Inda-Filho MD, PhD , Otávio T. Nóbrega PhD , Heitor S. Ribeiro PhD
{"title":"The 10-Item Physical Function Scale as a Sarcopenia Screening Tool for Patients on Hemodialysis","authors":"Marvery P. Duarte MSc , Fábio A. Vieira PT , Victor M. Baião MSc , Jacqueline S. Monteiro MD , Aparecido P. Ferreira PhD , Antônio J. Inda-Filho MD, PhD , Otávio T. Nóbrega PhD , Heitor S. Ribeiro PhD","doi":"10.1053/j.jrn.2024.05.012","DOIUrl":"10.1053/j.jrn.2024.05.012","url":null,"abstract":"<div><h3>Objective</h3><div><span>We investigated the accuracy of the 10-item Physical Function (PF-10) questions of the SF-36 quality of life questionnaire as a </span>sarcopenia<span> screening tool among patients on hemodialysis.</span></div></div><div><h3>Methods</h3><div><span><span>A cross-sectional, multicenter study that included adult patients on hemodialysis. The revised European Working Group on Sarcopenia in Older People was used to diagnose </span>sarcopenia. The 10 questions about daily activities from the SF-36 quality of life questionnaire were used to appoint the PF-10, where the final score could range from 10 to 30, and the lower the worse the physical function. The PF-10 accuracy to identify confirmed sarcopenia (low muscle strength + low muscle mass) was assessed through a receiver operating characteristic curve and the cutoff was calculated using the </span>Youden index.</div></div><div><h3>Results</h3><div>One hundred eighty-five patients were included (median 59 years; 45% female). Prevalence of confirmed sarcopenia was 31.4%. The median PF-10 score was 23 (interquartile range: 17–27) and a significant association with all sarcopenia measurements was found (all <em>P</em> < .05). The best cutoff calculated from the receiver operating characteristic curve was ≤26 points (area under the curve = 0.69, 95% confidence interval 0.61-0.77) with sensitivity and specificity of 96.6% and 71.0%, respectively. Moreover, patients with ≤26 points (n = 133, 72%) had a higher prevalence of low muscle strength by handgrip (53 vs. 19%; P < .001) and 5-time sit-to-stand (41 vs. 10%; P < .001), low gait speed (44 vs. 19%; P = .002), confirmed sarcopenia (39 vs. 11%; P < .001), and severe sarcopenia (26 vs. 4%; P = .001), but not low muscle mass (49 vs. 35%; P = .08), in comparison with those >26 points (n = 52, 28%).</div></div><div><h3>Conclusion</h3><div>The PF-10 may be a useful physical dysfunction and sarcopenia screening tool in patients on hemodialysis. A PF-10 threshold of around 26 points appeared to display the fairest accuracy for diagnosing sarcopenia.</div></div>","PeriodicalId":50066,"journal":{"name":"Journal of Renal Nutrition","volume":"34 6","pages":"Pages 546-551"},"PeriodicalIF":3.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141288846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sahar Amin MD , Barry M. Wall MD , Fridtjof Thomas PhD , Kamyar Kalantar-Zadeh MD, PhD, MPH , Keiichi Sumida MD, PhD, MPH , Csaba P. Kovesdy MD
{"title":"Change Over Time in Pre–End-Stage Renal Disease 24-Hour Urine Creatinine as Muscle Mass Surrogate and Post–End-Stage Renal Disease Mortality","authors":"Sahar Amin MD , Barry M. Wall MD , Fridtjof Thomas PhD , Kamyar Kalantar-Zadeh MD, PhD, MPH , Keiichi Sumida MD, PhD, MPH , Csaba P. Kovesdy MD","doi":"10.1053/j.jrn.2024.03.002","DOIUrl":"10.1053/j.jrn.2024.03.002","url":null,"abstract":"<div><h3>Objective</h3><div><span>Loss of muscle mass and sarcopenia<span> are common in chronic kidney disease<span> (CKD) and end-stage renal disease (ESRD), and sarcopenia can worsen insidiously in patients with advancing CKD. The temporal dynamics of sarcopenia in patients with progressive loss of </span></span></span>kidney function, and its association with future outcomes, is unclear.</div></div><div><h3>Methods</h3><div>In a contemporary national cohort of incident ESRD US veterans, we selected 661 patients who had at least 2 24-hour urine creatinine<span> (24hrUC) measurements, a surrogate of muscle mass, performed during the 3-year prelude period prior to ESRD transition. We estimated 24hrUC slopes in mixed effects models. To assess the temporal dynamics of pre-ESRD changes in 24hrUC and its association with changing eGFR<span><span>, we separately fitted in mixed effects models a penalized spline regression of 24hrUC on time and on eGFR. We examined the association of 24hrUC slopes with postdialysis all-cause mortality using </span>Cox models adjusted for confounders.</span></span></div></div><div><h3>Results</h3><div>The mean slope of 24hrUC versus time was −78 mg/year (95% confidence interval: −102 to −54), with a steeper decline noted in the last year prior to ESRD. More severe decreases in 24hrUC were associated with higher all-cause mortality: a 100 mg/year decrease in 24hrUC was associated with a multivariable adjusted death hazard ratio of 1.41 (95% confidence interval: 1.00-1.98, <em>P</em> = .05).</div></div><div><h3>Conclusion</h3><div>Patients with advanced CKD lose a substantial proportion of their muscle mass each year during pre-ESRD prelude. Loss of muscle mass accelerates near ESRD transition, and more loss of muscle mass is associated with higher mortality after ESRD transition.</div></div>","PeriodicalId":50066,"journal":{"name":"Journal of Renal Nutrition","volume":"34 6","pages":"Pages 500-508"},"PeriodicalIF":3.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140186189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}