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Ethylenediaminetetraacetic acid-induced pseudothrombocytopenia: The story of platelet clumps and report of three cases 乙二胺四乙酸诱发的假性血小板减少症：血小板凝集的故事和三个病例的报告
Journal of Hematology and Allied Sciences Pub Date : 2024-02-07 DOI: 10.25259/jhas_23_2023
Tummidi Santosh, M. Patro
{"title":"Ethylenediaminetetraacetic acid-induced pseudothrombocytopenia: The story of platelet clumps and report of three cases","authors":"Tummidi Santosh, M. Patro","doi":"10.25259/jhas_23_2023","DOIUrl":"https://doi.org/10.25259/jhas_23_2023","url":null,"abstract":"Ethylenediamine tetra-acetic acid (EDTA) induced pseudo-thrombocytopenia is an infrequent phenomenon occurring when samples are processed in an automated analyzer using EDTA as the anticoagulant. We report three cases of Pseudothrombocytopenia wherein peripheral smear evaluation and rerun in separate Haematology analyzers helped us in reaching a conclusion. The widespread use of automated instruments has led to the identification of this phenomenon. However, confirmation of PTCP can only be done under microscopic examination of the slide.","PeriodicalId":499735,"journal":{"name":"Journal of Hematology and Allied Sciences","volume":"96 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139794777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hidden amyloidosis in liver and bone marrow 肝脏和骨髓中的隐性淀粉样变性
Journal of Hematology and Allied Sciences Pub Date : 2024-02-07 DOI: 10.25259/jhas_45_2023
Gayathri Jagadish, M. Archana, K. S. Nataraj, Sandeep Desai, Vishnu Kurpad
{"title":"Hidden amyloidosis in liver and bone marrow","authors":"Gayathri Jagadish, M. Archana, K. S. Nataraj, Sandeep Desai, Vishnu Kurpad","doi":"10.25259/jhas_45_2023","DOIUrl":"https://doi.org/10.25259/jhas_45_2023","url":null,"abstract":"Primary amyloidosis and multiple myeloma (MM) involve clonal plasma cell proliferation. Approximately 10–15% of patients with amyloidosis have MM. Characteristic apple-green birefringence using Congo red staining on polarized microscopy confirms amyloid. MM is prevalent at ages from 60 to 70 years. Amyloidosis commonly affects the heart, kidneys, gastrointestinal tract/liver and peripheral or autonomic nervous system predicting a poor prognosis due to organ deterioration. This case highlights the importance of diagnosing amyloidosis in a 60-year-old female where plasma cells were present in the liver and bone marrow along with amyloid deposits and for early initiation of intense chemotherapy.","PeriodicalId":499735,"journal":{"name":"Journal of Hematology and Allied Sciences","volume":"35 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139855251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ethylenediaminetetraacetic acid-induced pseudothrombocytopenia: The story of platelet clumps and report of three cases 乙二胺四乙酸诱发的假性血小板减少症：血小板凝集的故事和三个病例的报告
Journal of Hematology and Allied Sciences Pub Date : 2024-02-07 DOI: 10.25259/jhas_23_2023
Tummidi Santosh, M. Patro
{"title":"Ethylenediaminetetraacetic acid-induced pseudothrombocytopenia: The story of platelet clumps and report of three cases","authors":"Tummidi Santosh, M. Patro","doi":"10.25259/jhas_23_2023","DOIUrl":"https://doi.org/10.25259/jhas_23_2023","url":null,"abstract":"Ethylenediamine tetra-acetic acid (EDTA) induced pseudo-thrombocytopenia is an infrequent phenomenon occurring when samples are processed in an automated analyzer using EDTA as the anticoagulant. We report three cases of Pseudothrombocytopenia wherein peripheral smear evaluation and rerun in separate Haematology analyzers helped us in reaching a conclusion. The widespread use of automated instruments has led to the identification of this phenomenon. However, confirmation of PTCP can only be done under microscopic examination of the slide.","PeriodicalId":499735,"journal":{"name":"Journal of Hematology and Allied Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139854891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RNA therapeutics in hematology 血液学中的 RNA 疗法
Journal of Hematology and Allied Sciences Pub Date : 2024-02-07 DOI: 10.25259/jhas_5_2024
P. Mandal
{"title":"RNA therapeutics in hematology","authors":"P. Mandal","doi":"10.25259/jhas_5_2024","DOIUrl":"https://doi.org/10.25259/jhas_5_2024","url":null,"abstract":"","PeriodicalId":499735,"journal":{"name":"Journal of Hematology and Allied Sciences","volume":"55 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139855755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combined factor VIII and IX deficiency: An exceptional case 第八因子和第九因子合并缺乏症：一个特殊病例
Journal of Hematology and Allied Sciences Pub Date : 2024-02-07 DOI: 10.25259/jhas_35_2023
Iffat Jamal, Ahmed Kamran Jeelani
{"title":"Combined factor VIII and IX deficiency: An exceptional case","authors":"Iffat Jamal, Ahmed Kamran Jeelani","doi":"10.25259/jhas_35_2023","DOIUrl":"https://doi.org/10.25259/jhas_35_2023","url":null,"abstract":"Familial multiple coagulation factor deficiencies are a group of rare inherited disorders that are characterized by the simultaneous decrease in the levels of two or more coagulation factors. Common synchronous deficiencies are factors VIII and IX and combined deficiency of Vitamin K-dependent coagulation factors (factors II, VII, IX, and X). Here, we report a case of synchronous dual deficiency of factor VIII and IX, which is an extremely rare occurrence and no case report has been mentioned so far to the best of our knowledge. Recognizing such a dual deficiency is very important for proper management of patients.","PeriodicalId":499735,"journal":{"name":"Journal of Hematology and Allied Sciences","volume":"16 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139795888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Atypical presentation of chronic myeloid leukemia as extreme thrombocytosis 慢性髓性白血病的非典型表现为血小板极度增多
Journal of Hematology and Allied Sciences Pub Date : 2024-02-07 DOI: 10.25259/jhas_43_2023
S. J. Manjula, Kanya Kumari Makal
{"title":"Atypical presentation of chronic myeloid leukemia as extreme thrombocytosis","authors":"S. J. Manjula, Kanya Kumari Makal","doi":"10.25259/jhas_43_2023","DOIUrl":"https://doi.org/10.25259/jhas_43_2023","url":null,"abstract":"Chronic myeloid leukemia (CML) is a type of myeloproliferative neoplasm which typically presents with leukocytosis but rarely presents with extreme thrombocytosis with no/mild increase in leukocytes. Here, we describe a unique case of 42-year-old female with peripheral blood smear features that were favoring essential thrombocythemia (ET). However, further studies such as bone marrow and cytogenetic study were suggestive of CML in chronic phase. In some cases, CML mimics ET and cytogenetic study is the confirmatory test. ET and CML have different therapeutics and prognosis, and it is always necessary to consider CML as a differential diagnosis in cases of isolated thrombocytosis/extreme thrombocytosis cases.","PeriodicalId":499735,"journal":{"name":"Journal of Hematology and Allied Sciences","volume":"7 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139854574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Atypical presentation of chronic myeloid leukemia as extreme thrombocytosis 慢性髓性白血病的非典型表现为血小板极度增多
Journal of Hematology and Allied Sciences Pub Date : 2024-02-07 DOI: 10.25259/jhas_43_2023
S. J. Manjula, Kanya Kumari Makal
{"title":"Atypical presentation of chronic myeloid leukemia as extreme thrombocytosis","authors":"S. J. Manjula, Kanya Kumari Makal","doi":"10.25259/jhas_43_2023","DOIUrl":"https://doi.org/10.25259/jhas_43_2023","url":null,"abstract":"Chronic myeloid leukemia (CML) is a type of myeloproliferative neoplasm which typically presents with leukocytosis but rarely presents with extreme thrombocytosis with no/mild increase in leukocytes. Here, we describe a unique case of 42-year-old female with peripheral blood smear features that were favoring essential thrombocythemia (ET). However, further studies such as bone marrow and cytogenetic study were suggestive of CML in chronic phase. In some cases, CML mimics ET and cytogenetic study is the confirmatory test. ET and CML have different therapeutics and prognosis, and it is always necessary to consider CML as a differential diagnosis in cases of isolated thrombocytosis/extreme thrombocytosis cases.","PeriodicalId":499735,"journal":{"name":"Journal of Hematology and Allied Sciences","volume":"110 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139794664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hidden amyloidosis in liver and bone marrow 肝脏和骨髓中的隐性淀粉样变性
Journal of Hematology and Allied Sciences Pub Date : 2024-02-07 DOI: 10.25259/jhas_45_2023
Gayathri Jagadish, M. Archana, K. S. Nataraj, Sandeep Desai, Vishnu Kurpad
{"title":"Hidden amyloidosis in liver and bone marrow","authors":"Gayathri Jagadish, M. Archana, K. S. Nataraj, Sandeep Desai, Vishnu Kurpad","doi":"10.25259/jhas_45_2023","DOIUrl":"https://doi.org/10.25259/jhas_45_2023","url":null,"abstract":"Primary amyloidosis and multiple myeloma (MM) involve clonal plasma cell proliferation. Approximately 10–15% of patients with amyloidosis have MM. Characteristic apple-green birefringence using Congo red staining on polarized microscopy confirms amyloid. MM is prevalent at ages from 60 to 70 years. Amyloidosis commonly affects the heart, kidneys, gastrointestinal tract/liver and peripheral or autonomic nervous system predicting a poor prognosis due to organ deterioration. This case highlights the importance of diagnosing amyloidosis in a 60-year-old female where plasma cells were present in the liver and bone marrow along with amyloid deposits and for early initiation of intense chemotherapy.","PeriodicalId":499735,"journal":{"name":"Journal of Hematology and Allied Sciences","volume":"21 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139795497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RNA therapeutics in hematology 血液学中的 RNA 疗法
Journal of Hematology and Allied Sciences Pub Date : 2024-02-07 DOI: 10.25259/jhas_5_2024
P. Mandal
{"title":"RNA therapeutics in hematology","authors":"P. Mandal","doi":"10.25259/jhas_5_2024","DOIUrl":"https://doi.org/10.25259/jhas_5_2024","url":null,"abstract":"","PeriodicalId":499735,"journal":{"name":"Journal of Hematology and Allied Sciences","volume":"7 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139795904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinicopathological profile of multiple myeloma at a tertiary care hospital in a resource-poor setting: A retrospective study 资源贫乏地区一家三级医院的多发性骨髓瘤临床病理概况：回顾性研究
Journal of Hematology and Allied Sciences Pub Date : 2024-02-07 DOI: 10.25259/jhas_48_2023
Prapannajeet Biswal, Raghvendra Deo Pandey, Gurmeet Singh
{"title":"Clinicopathological profile of multiple myeloma at a tertiary care hospital in a resource-poor setting: A retrospective study","authors":"Prapannajeet Biswal, Raghvendra Deo Pandey, Gurmeet Singh","doi":"10.25259/jhas_48_2023","DOIUrl":"https://doi.org/10.25259/jhas_48_2023","url":null,"abstract":"\u0000\u0000The objective of this study was to study the clinicopathological profile of multiple myeloma (MM) presenting to Jawaharlal Nehru Hospital and Research Center (JLNH&RC) Bhilai and document the disease in central India.\u0000\u0000\u0000\u0000This was a retrospective observational study using patient data from January 2013 to December 2019. The clinical and radiological findings, laboratory parameters, and bone marrow examination were analyzed.\u0000\u0000\u0000\u0000About 35.38% of patients presented in the 6th decade of life with a male-to-female ratio of 1.3:1. About 91.93% of patients had low backache and bone pain, and 96.92% of patients had Anemia. About 63.01% of patients had serum creatinine >2 mg/dL, and 92.30% of patients had A/G ratio reversal. About 64.70% of patients had serum beta-2 microglobulin (≥3.5 μg/mL). About 80.7% had osteolytic lesions, predominantly in the skull and pelvis. About 46.15% of patients had >50% plasma cells on bone marrow aspirate. About 85.71% exhibited hypercellularity, and 8.92% of patients had grade 2 marrow fibrosis. About 76.92% of patients presented with Durie Salmon stage III disease, and 58.82% presented with international staging system (ISS) stage II disease.\u0000\u0000\u0000\u0000MM has an inconsistent clinical presentation with multiple system involvement. It should be considered as a differential in patients above 50 years of age presenting with normocytic normochromic Anemia and bony pain. Bone marrow study is important in resource-poor settings where specialized laboratory testing is limited. The Durie and Salmon staging and the ISS can be used for the prognosis with equal efficacy.\u0000","PeriodicalId":499735,"journal":{"name":"Journal of Hematology and Allied Sciences","volume":"5 3-4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139856498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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