慢性髓性白血病的非典型表现为血小板极度增多

S. J. Manjula, Kanya Kumari Makal
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摘要

慢性髓性白血病(CML)是一种骨髓增生性肿瘤,通常表现为白细胞增多,但极少出现白细胞不增多或轻度增多但血小板极度增多的情况。这里,我们描述了一例独特的病例,患者为 42 岁女性,外周血涂片特征显示为原发性血小板增多症(ET)。然而,进一步的研究,如骨髓和细胞遗传学研究,均提示为慢性骨髓增生性白血病(CML)。在某些情况下,CML 会模仿 ET,而细胞遗传学研究则是确诊试验。ET 和 CML 有不同的治疗方法和预后,在孤立性血小板增多/极度血小板增多病例中,始终有必要将 CML 作为鉴别诊断。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Atypical presentation of chronic myeloid leukemia as extreme thrombocytosis
Chronic myeloid leukemia (CML) is a type of myeloproliferative neoplasm which typically presents with leukocytosis but rarely presents with extreme thrombocytosis with no/mild increase in leukocytes. Here, we describe a unique case of 42-year-old female with peripheral blood smear features that were favoring essential thrombocythemia (ET). However, further studies such as bone marrow and cytogenetic study were suggestive of CML in chronic phase. In some cases, CML mimics ET and cytogenetic study is the confirmatory test. ET and CML have different therapeutics and prognosis, and it is always necessary to consider CML as a differential diagnosis in cases of isolated thrombocytosis/extreme thrombocytosis cases.
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