Journal of Vestibular Research-Equilibrium & Orientation最新文献

{"title":"Identification of blood-based inflammatory biomarkers for vestibular neuritis using a proximity extension assay.","authors":"Eun Hye Oh, Hyun Sung Kim, Jin-Ok Lee, Seo Young Choi, Kwang-Dong Choi, Jae-Hwan Choi","doi":"10.1177/09574271261418550","DOIUrl":"10.1177/09574271261418550","url":null,"abstract":"<p><p>ObjectiveThe present study aimed to identify blood-based inflammatory biomarkers that would help investigate the underlying pathogenesis in vestibular neuritis (VN) using a proximity extension assay (PEA).MethodsIn this single-center prospective study, we enrolled both a cross-sectional (acute VN vs normal controls) and a longitudinal (acute phase vs recovery phase) cohorts. We quantified 92 plasma inflammatory proteins using the Olink PEA and identified differentially expressed proteins (DEPs) in each cohort using t-tests. The clinical utility and predictive value of each DEP were evaluated using the Pearson correlation test and receiver operating characteristic (ROC) curve analysis, respectively.ResultsIn the cross-sectional cohort, there were 17 DEPs identified between acute VN (<i>n</i> = 35) and normal controls (<i>n</i> = 35), of which Flt3L was the only downregulated DEP that showed longitudinal changes congruent with clinical disease activity in the longitudinal cohort (<i>n</i> = 18). The correlation analysis revealed that the expression level of CXCL5 was significantly related to the absolute gain and gain asymmetry of the horizontal vestibulo-ocular reflex, while five DEPs (OSM, Flt3L, IFN-γ, MCP-1, and uPA) were negatively correlated with the hospitalization period. ROC curves showed that CXCL1 and Flt3L were upregulated and downregulated DEPs with high predictive values, respectively.ConclusionsThis study shows that the high-throughput PEA technology can be used to identify blood-based inflammatory biomarkers for VN. Our findings highlight the potential value of Flt3L and CXCL1/CXCL5 as objective VN markers that may correlate with disease activity.</p>","PeriodicalId":49960,"journal":{"name":"Journal of Vestibular Research-Equilibrium & Orientation","volume":" ","pages":"452-461"},"PeriodicalIF":1.2,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145999631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Head tilt-induced spatial orientation errors associated with functional vestibular disorders and motion sickness susceptibility during non-driving activities in a moving vehicle.","authors":"Youngmin Na, Euncheon Lim, Seonghyeon Kim, Jaesik Yang, Jayce Woojin Baek, Sung Kwang Hong","doi":"10.1177/09574271261430593","DOIUrl":"10.1177/09574271261430593","url":null,"abstract":"<p><p>BackgroundPersistent postural-perceptual dizziness (PPPD) and motion sickness (MS) are associated with disturbances in spatial orientation related to altered multisensory integration. Impaired perception of upright orientation during head tilt may therefore occur in these conditions. Subjective visual vertical (SVV) and subjective visual horizontal (SVH) testing under head-tilted conditions provide quantitative measures of such perceptual errors. We hypothesized that headtilt-induced perceptual errors would be associated with PPPD and with susceptibility to clinically significant MS during non-driving tasks.Methods80 participants were enrolled: 27 healthy controls, 36 individuals with high Motion Sickness Susceptibility Questionnaire scores who reported MS during real-world driving, and 17 patients with PPPD diagnosed according to the Bárány Society criteria. SVV and SVH were measured at ±30° and ±60° head-roll tilts in a virtual environment. Perceptual error was defined as the signed deviation from the true vertical or horizontal orientation. Diagnostic accuracy was assessed using receiver operating characteristic analysis.ResultsSVV and SVH errors under head-tilt conditions differed significantly between groups, with healthy controls showing contraversive deviations and both individuals with high-MS and patients with PPPD exhibiting ipsiversive deviations, particularly at ±60° roll tilts, whereas errors in the upright (0°) position were negligible. Several tilt conditions demonstrated excellent diagnostic accuracy (AUC ≥ 0.90). Real-world MS severity correlated with ipsiversive SVV errors but not with questionnaire-based susceptibility scores.ConclusionsBased on the present findings, further methodological refinement may allow head-tilt SVV/SVH testing to serve as a rapid and sensitive tool for detecting perceptual alterations underlying functional dizziness, with translational potential for MS risk screening in future autonomous vehicle environments.</p>","PeriodicalId":49960,"journal":{"name":"Journal of Vestibular Research-Equilibrium & Orientation","volume":" ","pages":"392-403"},"PeriodicalIF":1.2,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147373463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The molecular and genetic mechanisms of the vestibular disorders: A mini review.","authors":"Xiaoge Jiang, Dong Liu, Fuping Qian","doi":"10.1177/09574271261417617","DOIUrl":"10.1177/09574271261417617","url":null,"abstract":"<p><p>The vestibular disorders, which generally manifest themselves as nausea, vomiting, and dizziness or vertigo, have troubled many people. Increasing evidence suggests that certain vestibular disorders are hereditary, and gene variants contribute to the onset and susceptibility of these disorders. This review summarizes the latest research progress, especially the molecular and genetic aspects of several common vestibular disorders, including Meniere's disease, vestibular migraine, benign paroxysmal positional vertigo, and motion sickness, with the aim of encouraging more fundamental research and enhancing our understanding of the molecular and genetic mechanisms underlying vestibular disorders.</p>","PeriodicalId":49960,"journal":{"name":"Journal of Vestibular Research-Equilibrium & Orientation","volume":" ","pages":"355-364"},"PeriodicalIF":1.2,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145960689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The six-item visual vertigo analogue scale: A modified questionnaire for assessment of visual vertigo.","authors":"Carrie W Hoppes, Pamela M Dunlap, Patrick J Sparto, Kefah M Alshebber, Brooke N Klatt, Karen H Lambert, Joseph M Furman, Theodore J Huppert, Susan L Whitney","doi":"10.1177/09574271261435448","DOIUrl":"10.1177/09574271261435448","url":null,"abstract":"<p><p>BackgroundIndividuals with vestibular disorders often describe symptoms of dizziness, disorientation, and impaired balance induced by visual stimuli, commonly referred to as visual vertigo.ObjectiveThe purpose of this study was to improve assessment of visually induced symptoms by modifying the original, nine-item Visual Vertigo Analogue Scale (VVAS) to produce a more robust, interpretable, and clinically useful measure of visual vertigo. We also aimed to establish a cut-off score for identifying patients with vestibular disorders and low- versus high-severity visual vertigo.MethodsPatients with vestibular disorders (<i>n</i> = 199) and controls (<i>n</i> = 107) completed the modified VVAS (mVVAS). Exploratory factor analysis was conducted to develop a shorter scale and internal consistency analyses were performed. A K-means cluster analysis was used to determine a cut-off score for identifying low- and high-severity groups.ResultsA reduced six-item scale (VVAS-6), which included three items from the VVAS and three items from the mVVAS, had excellent internal consistency (Cronbach's α = 0.93). We identified four concepts within the VVAS-6 (walking with visual stimulation, visual stimulation only, escalator, car). A cut-off score of 37 was able to identify patients with vestibular disorders and high severity of visual vertigo.ConclusionsThe use of a cut-off score of 37 for the VVAS-6 scale resulted in an improvement in correctly identifying patients with vestibular disorders and high severity of visual vertigo from controls.</p>","PeriodicalId":49960,"journal":{"name":"Journal of Vestibular Research-Equilibrium & Orientation","volume":" ","pages":"425-434"},"PeriodicalIF":1.2,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147464160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of vestibular physical therapy on balance and dizziness in people with multiple sclerosis: A systematic review and meta-analysis.","authors":"Diego Piatti, Gianluca Paolocci, Daniel Hector Verdecchia, Maria Grazia Grasso, Gianfranco Bosco, Iole Indovina, Marco Tramontano","doi":"10.1177/09574271261444952","DOIUrl":"10.1177/09574271261444952","url":null,"abstract":"<p><p>Multiple Sclerosis (MS) is a chronic, inflammatory, and degenerative disease of the central nervous system. Balance impairments are very common symptoms among people with MS (PwMS). Vestibular physical therapy (VPT) is an evidence-based approach aimed at managing and improving gaze and balance stability, which could be used to mitigate balance disorders in MS. The objective of this systematic review with meta-analysis is to evaluate the effects of VPT in managing balance and dizziness in PwMS.Electronic databases were searched in February 2025 (PubMed, Scopus and Cochrane) and screened by two blind reviewers. Risk of Bias was assessed using PEDro Scale. A meta-analysis was conducted to evaluate, across multiple studies, the effect sizes for two clinical outcomes: the Dizziness Handicap Inventory (DHI) and the Activities-specific Balance Confidence Scale (ABC).After screening, 16 articles were included in the review, mostly comparing VPT with other conventional approaches. Analysis of the Risk of bias showed quality deficiencies in these studied with respect to the blinding of participants, assessor and physiotherapist. The meta-analysis showed significant efficacy of VPT against control using the DHI as outcome measure (Hedges' g = 1.451, CI [0.190, 2.713]).In conclusion, VPT is a safe approach in reducing dizziness-related disability of PwMS. Further studies are needed to refine assessment methods and explore individualized approaches.</p>","PeriodicalId":49960,"journal":{"name":"Journal of Vestibular Research-Equilibrium & Orientation","volume":" ","pages":"378-391"},"PeriodicalIF":1.2,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13672864/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147845521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic accuracy of the vestibular activities and participation measure subscales to detect severe handicap in individuals with vestibular dysfunction.","authors":"Maria das Graças de Araújo Lira, Lucas Barbosa de Araújo, Juliana Cirilo Soares de Souza, Susan L Whitney, Karyna Myrelly Oliveira Bezerra de Figueiredo Ribeiro","doi":"10.1177/09574271261446597","DOIUrl":"10.1177/09574271261446597","url":null,"abstract":"<p><p>IntroductionThe subscales of the Vestibular Activities and Participation measure (VAP) assess the impact of vestibular dysfunction on activity and participation; however, no diagnostic accuracy studies have evaluated their ability to identify severe handicap in individuals with vestibular disorders.ObjectiveTo evaluate the diagnostic accuracy of the VAP subscales in detecting severe handicap in individuals with vestibular dysfunction.MethodsThe diagnostic accuracy study included individuals with vestibular dysfunction who were ≥18 years. The diagnostic accuracy of the VAP subscales (VAP1-BR and VAP2-BR) was analyzed using Receiver Operating Characteristic (ROC) curves, with the Dizziness Handicap Inventory serving as the reference test. The area under the curve (AUC), cutoff points, sensitivity, specificity, and 95% confidence intervals were determined. Statistical analysis was performed using MedCalc® software, with a significance level of <i>p</i> < 0.05.ResultsThe VAP1-BR showed an AUC of 0.83 (95% CI: 0.744-0.899; <i>p</i> < 0.001), a cutoff point ≥9.37, sensitivity of 69%, and specificity of 84%. The VAP2-BR yielded an AUC of 0.80 (95% CI: 0.710-0.875; <i>p</i> < 0.001), a cutoff point ≥7.71, sensitivity of 68%, and specificity of 83%.ConclusionThe VAP subscales adequately identify severe handicap in individuals with vestibular dysfunction.</p>","PeriodicalId":49960,"journal":{"name":"Journal of Vestibular Research-Equilibrium & Orientation","volume":" ","pages":"435-442"},"PeriodicalIF":1.2,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13672923/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148310068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The forgotten piece of a complex jigsaw: Vestibular assessment is a blind spot for England's NHS falls services.","authors":"Ed Tank","doi":"10.1177/09574271261430436","DOIUrl":"10.1177/09574271261430436","url":null,"abstract":"<p><p>BackgroundFalls remain a major healthcare burden from an individual to societal level. Vestibular disorders are recognised as a significant risk factor for falls in older adults, but identification and assessment of such conditions has only recently been included in national and international guidance. The extent to which National Health Service (NHS) falls services in England are including vestibular assessment is not well known.MethodA freedom-of-information request was sent to 117 Falls Services run by NHS Trusts in England to identify if they included vestibular assessment/management, if so which professions were providing this and whether Trusts planned to develop this aspect.Results115 out of the 117 identified Trusts replied. 39/115 (33.9%) of Trusts reported that their falls prevention services included staff trained to assess and treat vestibular dysfunction. Physiotherapists were the most common profession delivering this. Despite the lack of provision, just 23/115 (20%) of Trusts reported this was an area of their service they were planning to develop.DiscussionThese results show a significant lack of vestibular management in falls services. Accordingly, in their current offering, a majority of NHS Trust falls services will not be able to fully implement recently updated NICE guidance (NG249) or World Falls Guidelines for falls prevention. Given the extensive burden of falls in older adults, steps to close this gap would appear important.</p>","PeriodicalId":49960,"journal":{"name":"Journal of Vestibular Research-Equilibrium & Orientation","volume":" ","pages":"404-411"},"PeriodicalIF":1.2,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147349801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative interventions to improve clinical results in patients with vestibular schwannoma: A systematic review.","authors":"Albert Torrents Torrero, Àngela Callejo Castillo, David Parés Martínez, Maria José Durà Mata","doi":"10.1177/09574271261420125","DOIUrl":"10.1177/09574271261420125","url":null,"abstract":"<p><p>ObjectiveTo assess whether preoperative vestibular rehabilitation and/or intratympanic gentamicin (ITG) improve vestibular compensation and postoperative functional outcomes in patients undergoing vestibular schwannoma surgery.DesignSystematic review conducted in accordance with the PRISMA 2020 statement.Study sampleTwelve original studies were identified through PubMed, Web of Science, and Google Scholar. Eligible designs included clinical trials, cohort, case-control, and case-series studies evaluating preoperative vestibular rehabilitation and/or ITG before surgery. Methodological quality was assessed using the Joanna Briggs Institute (JBI) critical appraisal checklists and the RoB 2 tool.ResultsThree studies implemented ITG alone, whereas nine integrated ITG and/or structured vestibular rehabilitation within multimodal prehabilitation protocols. Rehabilitation components ranged from supervised physiotherapy to home-based or hybrid programs. A Bayesian random-effects meta-analysis of three studies evaluating hospital length of stay (LOS) yielded a small-to-moderate pooled effect favouring prehabilitation (μ = 0.28; 95% CrI -0.37 to 1.00), with moderate heterogeneity and wide uncertainty. Other outcomes such as posturography and dizziness handicap could not be meta-analysed due to methodological heterogeneity. Overall risk of bias was moderate-to-high.ConclusionsPreoperative prehabilitation may support postoperative recovery, particularly when tailored to residual vestibular function and delivered through supervised or hybrid formats. Larger, high-quality randomized trials using standardized outcomes are warranted.</p>","PeriodicalId":49960,"journal":{"name":"Journal of Vestibular Research-Equilibrium & Orientation","volume":" ","pages":"365-377"},"PeriodicalIF":1.2,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146107678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical features and influencing factors of sleep disturbance in vestibular migraine patients: A multi-center cross-sectional study.","authors":"Qingchun Pan, Lei Wang, Bei Li, Kai Zou","doi":"10.1177/09574271261426885","DOIUrl":"10.1177/09574271261426885","url":null,"abstract":"<p><p>BackgroundVestibular migraine (VM) is frequently complicated by sleep disorders, potentially involving abnormalities in vestibular-brainstem neural pathways. This study aimed to analyze sleep characteristics and influencing factors in VM patients through a multicenter cross-sectional survey, explore associations with symptoms like vertigo and headache, and provide a basis for precise interventions.ObjectiveTo profile the sleep characteristics and clinical features of patients with vestibular migraine (VM), and to explore the influencing factors of sleep disturbance in VM patients.MethodsIn this multi-center cross-sectional study, we recruited VM patients who were treated in otolaryngology department and neurology department of 5 hospitals in Sichuan Province from June 2022 to June 2024 as experimental group (including two subgroups divided based on PSQI score: poor sleep quality (PSQI > 5) and good sleep quality (PSQI ≤ 5)), Meanwhile, the control group was composed of non-VM volunteers matching clinical characteristics of experimental group. After clinical data organization, participants were subjected to sleep quality assessment using the Pittsburgh Sleep Quality Index (PSQI). A multivariate Logistic regression was employed to outline factors influencing sleep disturbance in VM patients. In addition, Spearman correlation coefficient was used as a criterion to identify the correlation of sleep disturbance with headache, vertigo and hearing and other clinical features in VM patients.ResultsWith 530 VM patients included, 332 patients had poor sleep quality (PSQI > 5) (62.64%), 198 patients had good sleep quality (PSQI ≤ 5) (37.36%), and 50 patients were selected as the control. VM group had higher total and individual scores of PSQI (<i>p</i> < 0.05). PSQI in VM patients was correlated with VAS and DHI positively (r = 0.797, <i>p</i> < 0.05; r = 0.834, <i>p</i> < 0.05), but PSQI had no correlation with pure tone hearing (r = 0.324, <i>p</i> = 0.167). Moreover, female, age ≥60 years, living alone, duration of disease ≥3 months, motion sickness history, and HADS-A were independent influencing factors for VM patients with poor sleep quality (<i>p</i> < 0.05).ConclusionSleep disturbance is a major interfering factor in VM patients, and patients may experience more severe headache and vertigo when sleep disorder aggravates. VM patients who are female, ≥60 years old, live alone, have a disease course ≥3 months, have a history of motion sickness, and have anxiety should undergo sleep assessment to determine whether there is poor sleep quality, so as to provide a theoretical basis for VM intervention precisely.</p>","PeriodicalId":49960,"journal":{"name":"Journal of Vestibular Research-Equilibrium & Orientation","volume":" ","pages":"443-451"},"PeriodicalIF":1.2,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146208438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional overload and adaptive failure during dual-tasking in Ménière's disease.","authors":"Mehmet Can, Soner Türüdü, Zehra Aydoğan, Ozan Bağış Özgürsoy","doi":"10.1177/09574271261418549","DOIUrl":"10.1177/09574271261418549","url":null,"abstract":"<p><p>BackgroundMénière's disease (MD) impairs cognitive function, yet the dynamics of cognitive-motor interference are not well understood. This study investigated dual-task performance in MD, hypothesizing a greater performance cost for patients compared to healthy controls under combined cognitive and postural loads.MethodTwenty-nine patients with MD and 29 healthy controls participated in a dual-task paradigm that combined computerized dynamic posturography (CDP) with a cognitive battery assessing visuospatial, executive, and working memory functions. Performance was measured across Sensory Organization Test (SOT) conditions of increasing difficulty and analyzed using mixed-effects models.ResultsSignificant dual-task interference was found in the MD group only for reaction times on two cognitive tasks (Mental Rotation and Shifting Attention), where increasing postural difficulty disproportionately slowed performance relative to controls. No dual-task effects were found in the other four cognitive tasks (Visual Stroop Task, Backward Digit Span Task, Corsi Block Task, and Symbol Digit Coding Task). Importantly, concurrent cognitive tasks did not significantly impair postural stability in either group. Patients also exhibited baseline deficits specifically on visuospatial working memory tasks.ConclusionIndividuals with MD demonstrate selective cognitive-motor interference in demanding visuospatial and executive tasks, without concomitant deterioration in postural control under dual-task conditions. This suggests a posture first strategy and highlights a quantifiable, task-specific cognitive burden that is a clinically relevant feature of the disorder. Dual-task paradigms provide a sensitive method for assessing this impact, with clear implications for comprehensive patient evaluation and management.</p>","PeriodicalId":49960,"journal":{"name":"Journal of Vestibular Research-Equilibrium & Orientation","volume":" ","pages":"412-424"},"PeriodicalIF":1.2,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13672953/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145999644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}