Jonathan Olsgård Hansen, Hjalte Christian Reeberg Sass, Niels Cramer West, Per Cayé-Thomasen
{"title":"Methods and clinical outcomes in vestibular implantation - A systematic literature review.","authors":"Jonathan Olsgård Hansen, Hjalte Christian Reeberg Sass, Niels Cramer West, Per Cayé-Thomasen","doi":"10.1177/09574271251332157","DOIUrl":"https://doi.org/10.1177/09574271251332157","url":null,"abstract":"<p><p>BackgroundThe vestibular implant is an experimental device that may provide treatment to patients suffering from bilateral vestibulopathy who do not benefit from standard vestibular rehabilitation.ObjectiveThe objective is to identify the various methodology regarding device designs and surgical approaches in addition to assessing subjective and objective vestibular and clinical outcomes in order to evaluate the future and possible limitations of the vestibular implant.MethodsA systematic search of Medline and Embase was conducted according to the PRISMA guidelines using pre-defined inclusion and exclusion criteria. 350 hits were found, which after 2 rounds of screening by 2 independent reviewers resulted in 21 studies eligible for full-text review.ResultsA total of 36 recipients of a vestibular implant across four centres world-wide were identified. Both surgical approach and devices as well as vestibular and functional outcomes varied greatly across centres and from patient to patient, evaluated using a variety of objective and subjective tests.ConclusionSeveral promising results in vestibular implantation were found using both subjective and objective measurements. However, some questions with regards to hearing preservation and long-term, continuous use of the vestibular implant remain to be answered, and more studies are needed to assess the efficacy and cost-utility of the implant.</p>","PeriodicalId":49960,"journal":{"name":"Journal of Vestibular Research-Equilibrium & Orientation","volume":" ","pages":"9574271251332157"},"PeriodicalIF":2.9,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lien Van Laer, Allison Nogi, Jorge Serrador, Michael C Schubert
{"title":"Effect of viewing distance on dynamic visual acuity.","authors":"Lien Van Laer, Allison Nogi, Jorge Serrador, Michael C Schubert","doi":"10.1177/09574271251327957","DOIUrl":"https://doi.org/10.1177/09574271251327957","url":null,"abstract":"<p><p>BackgroundPatients with dizziness and unsteadiness are commonly prescribed gaze stability exercises at varying target distances to manage vestibular impairments but lack objective tools to monitor progress. Maintaining gaze stability during head motion at near distances demands greater eye velocity relative to head velocity due to vergence and increased translational eye rotation demands.ObjectivesThis study compared dynamic visual acuity (DVA) during yaw and pitch at both near and far distances in patients and healthy controls.MethodsThis study includes individuals with unilateral vestibular deafferentation (UVD), veterans with dizziness yet healthy vestibular function, and healthy controls. The computerized DVA at near (50 cm) and far (200 cm) distances were collected. Data analysis included comparisons of near and far DVA in yaw and pitch planes.ResultsA total of 94 participants (34 UVD, 24 veterans with dizziness, 36 controls) were included. Near-distance DVA was significantly worse than far-distance DVA for the entire sample and within each group (<i>p</i> < 0.001).ConclusionsNear-distance DVA is more challenging than far-distance DVA across populations and planes of head rotation. Near-distance DVA may serve as a robust measure of vestibulo-ocular reflex function and offers a practical means for patients to self-monitor the effects of gaze stability training.</p>","PeriodicalId":49960,"journal":{"name":"Journal of Vestibular Research-Equilibrium & Orientation","volume":" ","pages":"9574271251327957"},"PeriodicalIF":2.9,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Arnaud Petry, Manuela Leuzzi, Claire Thibault, Henri Comtet, Ulker Kilic-Huck, Patrice Bourgin, Anne Charpiot, Elisabeth Ruppert
{"title":"High prevalence of sleep disorders in Ménière's disease: Interplay between vestibular function and sleep.","authors":"Arnaud Petry, Manuela Leuzzi, Claire Thibault, Henri Comtet, Ulker Kilic-Huck, Patrice Bourgin, Anne Charpiot, Elisabeth Ruppert","doi":"10.1177/09574271251328339","DOIUrl":"https://doi.org/10.1177/09574271251328339","url":null,"abstract":"<p><p>BackgroundIn Ménière's disease (MD), impaired sleep worsens the quality of life and triggers episodes, perpetuating a vicious cycle. The intricate connection between vestibular function and sleep regulation is poorly understood.ObjectiveWe aimed to investigate this link by studying sleep in confirmed MD patients.MethodsIn a single-center observational study, 26 consecutive patients with MD were enrolled. Sleep characterization included thorough symptom inquiry, questionnaires (PSQI, ESS, PFS, STOP-Bang, and AAO-HNS), and respiratory polygraphy (RP) or polysomnography (PSG).ResultsDespite 42% of patients reporting overall sleep satisfaction, further inquiry revealed 76% experiencing sleep disturbances per PSQI. STOP-Bang indicated 56% with a moderate-to-severe risk of OSAS. OSAS defined by apnea hypopnea index (AHI) ≥ 5/h was present in 75%. OSAS severity was categorized as mild (5/h ≤ AHI < 15/h, 33%), moderate (15/h ≤ AHI < 30/h, 21%), and severe (AHI ≥ 30/h, 21%). In patients with AAO-HNS score >3, migraines and insomnia were more prevalent. Patients with moderate-to-severe OSAS had poorer hearing. All recently diagnosed patients with moderate-to-severe OSAS had undergone more than one medical treatment compared to others (32%).ConclusionsThe high prevalence of sleep disorders in MD patients underscores the need for thorough screening, even without spontaneous complaints. Instrumental sleep exploration via RP or PSG is essential, as OSAS treatment could aid vestibular function.</p>","PeriodicalId":49960,"journal":{"name":"Journal of Vestibular Research-Equilibrium & Orientation","volume":" ","pages":"9574271251328339"},"PeriodicalIF":2.9,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Seunghee Na, Eun-Ju Jeon, Min-Beom Kim, Jung-Yup Lee, Chang-Hee Kim, Sung Il Nam, Hyun Ah Kim, Hyung Lee, Ji-Soo Kim, Jeong-Yoon Choi, Min-Ku Kim, Ji-Yun Park, Jeon Mi Lee, Eunjin Kwon, Seong-Hae Jeong, Sung-Kwang Hong, Hyo-Jeong Lee, Jae-Yong Byun, Myung Hoon Yoo, Seok Min Hong, Tae-Kyeong Lee, Sangwoo Lee, Yun Ji Lee, Kyu-Sung Kim, Jae-Hyun Seo, Sun-Uk Lee, Eek-Sung Lee, Hong Ju Park
{"title":"Clinical features of secondary BPPV: A nation-wide multicenter study.","authors":"Seunghee Na, Eun-Ju Jeon, Min-Beom Kim, Jung-Yup Lee, Chang-Hee Kim, Sung Il Nam, Hyun Ah Kim, Hyung Lee, Ji-Soo Kim, Jeong-Yoon Choi, Min-Ku Kim, Ji-Yun Park, Jeon Mi Lee, Eunjin Kwon, Seong-Hae Jeong, Sung-Kwang Hong, Hyo-Jeong Lee, Jae-Yong Byun, Myung Hoon Yoo, Seok Min Hong, Tae-Kyeong Lee, Sangwoo Lee, Yun Ji Lee, Kyu-Sung Kim, Jae-Hyun Seo, Sun-Uk Lee, Eek-Sung Lee, Hong Ju Park","doi":"10.1177/09574271251319775","DOIUrl":"https://doi.org/10.1177/09574271251319775","url":null,"abstract":"<p><p>BackgroundBenign paroxysmal positional vertigo (BPPV) is the most common peripheral vestibular disorder, and its prevalence is substantial. While primary BPPV has been well studied, the understanding of secondary BPPV is still limited.ObjectiveTo investigate the prevalence and clinical characteristics of secondary BPPV in a national multicenter retrospective analysis.MethodsThe study involved a retrospective analysis of medical records from 17 institutions across South Korea, between January and June 2022. We evaluated clinical features, presumed etiologies, involvement of semicircular canals, response to canalith repositioning procedures (CRPs), presence of residual dizziness, recurrence, and results of auditory and vestibular function tests for both primary and secondary BPPV cases.ResultsOf the total 1363 BPPV cases, 14.5% (198 patients) were categorized as secondary BPPV. The most prevalent etiology for secondary BPPV was head trauma. Secondary BPPV was associated with a higher prevalence of comorbidities including diabetes and inner ear diseases. Patients with secondary BPPV demonstrated more frequent involvement of multiple semicircular canals, necessitated a greater number of CRPs for resolution, and experienced a higher incidence of residual dizziness compared to primary BPPV cases. Furthermore, secondary BPPV patients exhibited more frequent abnormalities in auditory and vestibular function tests.ConclusionsSecondary BPPV accounts for a significant proportion of BPPV cases, with distinct clinical characteristics compared to primary BPPV.</p>","PeriodicalId":49960,"journal":{"name":"Journal of Vestibular Research-Equilibrium & Orientation","volume":" ","pages":"9574271251319775"},"PeriodicalIF":2.9,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143631006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Madlien M Al-Omari, Sawsan M Abuzaid, Hamzeh J Khair, Haidzir Manaf, Alia A Alghwiri
{"title":"The effect of using virtual reality on balance in people with persistent postural-perceptual dizziness: A randomized controlled trial.","authors":"Madlien M Al-Omari, Sawsan M Abuzaid, Hamzeh J Khair, Haidzir Manaf, Alia A Alghwiri","doi":"10.1177/09574271251326587","DOIUrl":"https://doi.org/10.1177/09574271251326587","url":null,"abstract":"<p><p>BackgroundPersistent postural-perceptual dizziness (PPPD) represents a relatively new vestibular diagnosis that has garnered attention within the medical community. Consequently, there is a pressing demand for efficacious management strategies.ObjectiveTo assess the comparative effectiveness of virtual reality (VR) versus vestibular rehabilitation therapy (VRT) in improving PPPD symptoms.MethodsWe randomly assigned a cohort of 42 individuals conclusively diagnosed with PPPD to two distinct groups. The experimental group included 21 participants who received a combination of VR and optokinetic stimulation in addition to VRT, while the control group, also made up of 21 individuals, only received optokinetic stimulation in conjunction with VRT. We administered the intervention sessions twice weekly over a span of 6 weeks, resulting in a total of 10-intervention sessions. Additionally, baseline, post-intervention, and follow-up assessments were conducted.ResultsOur analysis revealed that participants in both groups significantly improved with no significant differences between the groups. Individuals undergoing VR interventions demonstrated marked improvements across all of the assessed parameters including the primary outcome measure that were reduced from 41.55 (11.87) to 23.40 (14.17) (<i>p</i><0.001). Moreover, participants in the control group also displayed notable enhancements in select outcome measures post-intervention including the primary outcome measure that were reduced from 43.60 (12.75) to 26.10 (16.25) (<i>p</i> = 0.001). All participants in both groups maintained significant improvement in the severity of PPPD after 1 year of the. However, the study cannot determine if this change was definitely from the treatment because there was no non-treatment control group.ConclusionsThe study found that the addition of VR to a well-structured VRT did not significantly improve clinical outcomes, indicating a need for further investigation into more effective approaches to yield meaningful clinical benefits. Moreover, adding a control group with no intervention would help revealing a real effect of the intervention.</p>","PeriodicalId":49960,"journal":{"name":"Journal of Vestibular Research-Equilibrium & Orientation","volume":" ","pages":"9574271251326587"},"PeriodicalIF":2.9,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143631007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Microsaccades during video head impulse test in normal subjects.","authors":"Mingwei Xu, Qin Zhang, Yuan Yao, Qiong Wu, Jun Yang, Yulian Jin, Qing Zhang","doi":"10.1177/09574271241299310","DOIUrl":"10.1177/09574271241299310","url":null,"abstract":"<p><p>ObjectiveThis study aimed to quantitatively analyze the characteristics of saccades in normal subjects during video head impulse test (vHIT), to establish a reference for clinical practice.MethodsA cohort of 20 healthy individuals (40 ears) was recruited and compared with a matched group of 20 patients (20 ears) suffering from vestibular neuritis (VN), utilizing vHIT to evaluate the functionality of all three semicircular canals (SCCs). This study analyzed the quantitative characteristics of saccades observed in healthy individuals and patients with VN.ResultsSignificant differences were observed between both groups in terms of lateral saccade frequency, latency, peak velocity, and duration for both the first and second saccades (all <i>p</i> < 0.05, with age as a covariate). Similarly, significant differences were found in vertical SCCs between groups for the frequency, latency, peak velocity, and duration of the first saccade (all <i>p</i> < 0.05, with age as a covariate). However, no significant differences were found in Perez-Rey (PR) scores either in lateral (<i>p</i> = 0.259) or vertical (<i>p</i> = 0.102) SCCs. Within the healthy group, significant differences were observed in the frequency, peak velocity, and duration of the first saccade in lateral and vertical SCCs (all <i>p</i> < 0.05). However, the latency (<i>p</i> = 0.827) and PR scores (<i>p</i> = 0.552) exhibited no significant variation.ConclusionsMicrosaccades characterized by prolonged latency and reduced amplitude can occur in healthy individuals during vHIT and are distinct from the saccades seen in patients with VN due to vestibular impairment. This highlights the need to carefully identify and interpret relevant saccades during clinical assessments.</p>","PeriodicalId":49960,"journal":{"name":"Journal of Vestibular Research-Equilibrium & Orientation","volume":" ","pages":"64-72"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Test-retest reliability of the video ocular counter roll test (vOCR) in healthy young adult.","authors":"Asya Fatma Men, Ayşenur Küçük Ceyhan","doi":"10.1177/09574271241307580","DOIUrl":"10.1177/09574271241307580","url":null,"abstract":"<p><p>BackgroundThe ocular counter roll (OCR) is a component of the vestibulo-ocular reflex (VOR) characterized by torsional eye movements in the opposite direction of the head during head tilt.ObjectiveThis study aimed to determine the test-retest reliability of the video ocular counter-roll (vOCR) test, based on video-oculography (VOG) measurements, in assessing otolith function.MethodsThe study included 40 healthy participants (25 females and 15 males) aged 18-44 years. Each participant underwent the vOCR test twice in 300 lateral head tilt positions 1 week apart. Test-retest reliability was assessed using intraclass correlation coefficients (ICCs), and paired t-tests and Wilcoxon signed-rank tests were used to compare the mean values of the measurements.ResultsThere were no significant differences between the initial and retest measurements (<i>p</i>>0.05). The ICC for left head tilt was 85.2%, and for right head tilt was 79.3%, both indicating excellent reliability (<i>p</i><0.01). The ICC for vOCR asymmetry was 50.7%, indicating moderate reliability (<i>p</i><0.05).ConclusionsThe vOCR test demonstrated high reliability for lateral head tilts and was found to be a reliable tool for evaluating otolith function, supporting its use in the diagnosis and treatment of vestibular disorders.</p>","PeriodicalId":49960,"journal":{"name":"Journal of Vestibular Research-Equilibrium & Orientation","volume":" ","pages":"56-63"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The impact of weak inertial stimulation on visual-vestibular bimodal heading perception.","authors":"Yue Wei, Beisheng Bao, Jingyi Xie, Richard Hy So","doi":"10.1177/09574271241305019","DOIUrl":"10.1177/09574271241305019","url":null,"abstract":"<p><p>Perception of self-motion involves the integration of visual and vestibular sensory information. Currently, there is limited research exploring visual-vestibular interactions under weak vestibular stimulation. This study investigates the impact of weak inertial stimulation on visual-vestibular bimodal heading perception. A translational XY-axis motion platform equipped with a 46-inch LCD TV was utilized to generate synchronized visual and inertial stimuli. The heading perception was examined under visual-only, vestibular-only, and bimodal conditions using three levels of inertial stimuli (9 mg, 14 mg, and 19 mg). In each condition, participants were tested at nine angles (±16°, ±9.2°, ±3°, ±1.7°, and 0° where 0° represents forward movement), to discern left-forward or right-forward motion. The heading discrimination threshold (HDT) was derived from participants' rightward response proportions across all angles. Our findings reveal that the HDT under 14 mg bimodal conditions is significantly higher than that under visual-only conditions (with marginal significance in the 9 mg and 19 mg conditions), indicating that the presence of weak vestibular signals might decrease the precision of bimodal heading discrimination. These results contradict the prediction of Bayesian model theory that perception is more precise under bimodal compared with unimodal conditions. The results may be explained by neurological biases during Bayesian integration, the \"reduced visual precision\" theory, or increased task complexity in bimodal heading discrimination. Further research with larger sample size, extending the study to varied inertial stimuli and visual coherence levels, will be beneficial for clarifying its underlying mechanisms.</p>","PeriodicalId":49960,"journal":{"name":"Journal of Vestibular Research-Equilibrium & Orientation","volume":" ","pages":"45-55"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marco Tramontano, Gianluca Paolocci, Diego Piatti, Giuseppe Attanasio, Laura Casagrande Conti, Elena Bergamini, Leonardo Manzari, Francesco Lacquaniti, Jeffrey P Staab, Gianfranco Bosco, Iole Indovina
{"title":"Dynamic postural stability, symmetry, and smoothness of gait in patients with persistent postural-perceptual dizziness.","authors":"Marco Tramontano, Gianluca Paolocci, Diego Piatti, Giuseppe Attanasio, Laura Casagrande Conti, Elena Bergamini, Leonardo Manzari, Francesco Lacquaniti, Jeffrey P Staab, Gianfranco Bosco, Iole Indovina","doi":"10.1177/09574271241295615","DOIUrl":"10.1177/09574271241295615","url":null,"abstract":"<p><p>BackgroundPatients with persistent postural-perceptual dizziness (PPPD) exhibit altered postural and gait dynamics, but development of these changes following precipitating illnesses is poorly understood.ObjectiveTo compare posture and gait metrics in patients with PPPD or subacute unilateral vestibulopathies (sAUVP) to healthy controls (HC).MethodsTen patients with sAUVP, nine with PPPD, and eleven HC completed the 10 Meters Walk Test (10MWT) (an eyes open task) and Fukuda Stepping Test (FST) (an eyes closed task). Gait stability, symmetry, and smoothness were compared among groups and correlated with Dizziness Handicap Inventory (DHI) scores.Results10MWT - Patients with PPPD had lower pelvis stability and gait symmetry than HCs. Patients with sAUVP had only lower pelvis stability. FST - Patients with PPPD and sAUVP had lower gait smoothness than HCs. Patients with sAUVP also had lower gait symmetry. Among patients with PPPD, DHI scores correlated positively with head stability.ConclusionsPPPD and sAUVP caused abnormal pelvis stability when walking and gait smoothness when stepping but differed in effects on gait symmetry with the presence/absence of visual inputs. For PPPD, visual stimuli had destabilizing effects, whereas for sAUVP vision aided stability. Symptom severity in patients with PPPD was related to head stability.</p>","PeriodicalId":49960,"journal":{"name":"Journal of Vestibular Research-Equilibrium & Orientation","volume":" ","pages":"82-90"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Julia Sjögren, Per-Anders Fransson, Måns Magnusson, Mikael Karlberg, Fredrik Tjernström
{"title":"Acute unilateral vestibulopathy and corticosteroid treatment - A randomized placebo-controlled double-blind trial.","authors":"Julia Sjögren, Per-Anders Fransson, Måns Magnusson, Mikael Karlberg, Fredrik Tjernström","doi":"10.1177/09574271241307649","DOIUrl":"10.1177/09574271241307649","url":null,"abstract":"<p><p>BackgroundThe efficacy of corticosteroids for treating acute vestibular neuritis, or acute unilateral vestibulopathy (AUVP), remains controversial.ObjectiveThis study aimed to evaluate whether corticosteroids improve vestibular function and reduce symptoms in both acute and chronic phases of AUVP.MethodsThis randomized, placebo-controlled, double-blind trial included patients with AUVP (ages 18-80) from emergency departments at three sites in southern Sweden. Patients were randomly assigned to one of three groups: placebo, 3-day or 10-day corticosteroid treatment. The steroid groups received intravenous betamethasone followed by oral steroids, while the placebo group received intravenous saline followed by oral placebo. The primary outcome was canal paresis (%) after 12 months, measured via caloric testing. Secondary outcomes included vHIT gain, Diary Vertigo score, Dizziness Handicap Inventory, and Hospital Anxiety and Depression Scale. Analyses were conducted on an intention-to-treat basis. The trial was registered with the EU Clinical Trials Register (EudraCT Number: 2014-005484-32) and ClinicalTrials.gov (NCT00802529).ResultsFrom December 2015 to March 2021, 350 patients were screened, and 69 were included: 23 in the 10-day corticosteroid group, 22 in the 3-day corticosteroid group, and 24 in the placebo group. All groups showed significant improvement in caloric function over time (<i>p</i> = .002), with no significant differences between groups at any time point (<i>p</i> = .629). Change in caloric asymmetry from baseline to 12 months did not differ between the treatment groups and the placebo group: mean difference -8.34 (95% CI -25.93 to 9.26; <i>p</i> = .347) in the 10-day steroid group and -6.61 (-24.67 to 11.45; <i>p</i> = .467) in the 3-day steroid group, compared with placebo. Secondary outcomes showed no significant differences between groups. Corticosteroid treatments were well tolerated with no safety concerns.ConclusionsCorticosteroid treatment does not significantly improve caloric recovery, vHIT gain recovery, or subjective well-being in patients with AUVP.</p>","PeriodicalId":49960,"journal":{"name":"Journal of Vestibular Research-Equilibrium & Orientation","volume":" ","pages":"91-101"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}