Journal of Voice最新文献

{"title":"Comparison of Botulinum Toxin Versus Steroid Injection for Recurrent Laryngeal Contact Granuloma.","authors":"Shufang Zhang, Jie Shan, Qian Nie, Mingjie Zhang, Mengjun Wang, Cancan Wu, Yaru Sang","doi":"10.1016/j.jvoice.2026.09.053","DOIUrl":"https://doi.org/10.1016/j.jvoice.2026.09.053","url":null,"abstract":"<p><strong>Objectives: </strong>To compare the efficacy of botulinum toxin injection versus steroid injection in the treatment of patients with recurrent laryngeal contact granuloma.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on clinical data from 44 patients with recurrent laryngeal contact granuloma who received either botulinum toxin injection or steroid injection between August 2021 and April 2026. Patients were divided into a botulinum toxin injection group and a steroid injection group. The cure rate, recurrence rate, and time to cure were compared between the two groups to determine the optimal treatment for patients with recurrent lesions.</p><p><strong>Results: </strong>In patients with recurrent granulomas, the botulinum toxin injection group demonstrated a higher cure rate (90%) and a lower recurrence rate (0%) compared with the steroid injection group (cure rate: 76.47%; recurrence rate: 11.54%), although the differences were not statistically significant (P > 0.05). The time to cure in the steroid injection group was significantly longer than that in the botulinum toxin injection group (P < 0.01).</p><p><strong>Conclusion: </strong>In patients with recurrent laryngeal contact granuloma, botulinum toxin injection was associated with a shorter time to cure compared with steroid injection. Botulinum toxin injection is an effective treatment for recurrent granulomas.</p>","PeriodicalId":49954,"journal":{"name":"Journal of Voice","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149168948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of Life Trajectories After Partial Laryngectomy Versus Total Laryngectomy Stratified by Voice Rehabilitation Success.","authors":"Sang Hoo Park, Younghac Kim, Eun-Hye Kim, Taek Yoon Cheong, Man Ki Chung, Han-Sin Jeong, Young-Ik Son, Nayeon Choi","doi":"10.1016/j.jvoice.2026.09.026","DOIUrl":"https://doi.org/10.1016/j.jvoice.2026.09.026","url":null,"abstract":"<p><strong>Background: </strong>Although partial laryngectomy (PL) is often preferred for functional preservation, long-term quality-of-life (QoL) outcomes after total laryngectomy (TL) may vary according to voice rehabilitation success. We compared five-year longitudinal QoL trajectories among PL, TL with successful voice rehabilitation (TL-S), and TL with failed rehabilitation (TL-F).</p><p><strong>Methods: </strong>Ninety-two patients were categorized into PL (n = 52), TL-S (n = 21), and TL-F (n = 19). QoL was assessed from baseline to 5 years postoperatively using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) and Head and Neck Cancer-Specific Module (EORTC QLQ-H&N35) at multiple intervals (pre-op, 1 month, 3 months, 1 year, 2 years, and 5 years). Longitudinal patterns were evaluated across multiple functional and symptom domains. Longitudinal within-group changes were analyzed using generalized estimating equations, and supplementary between-group comparisons at each time point were performed using the Kruskal-Wallis test.</p><p><strong>Results: </strong>By 5 years, the TL-S group showed a Summary Score comparable to that of the PL group, whereas global health status/QoL remained higher in the PL group. The TL-S group also showed more favorable Speech scores at 5 years, with swallowing outcomes approaching those of the PL group at later time points. In contrast, the TL-F group showed persistently higher swallowing-related burden, with broader symptom burden, including Social Contact problems and Financial Difficulties, remaining more pronounced over time.</p><p><strong>Conclusions: </strong>Voice rehabilitation status may be associated with long-term QoL patterns after laryngeal cancer surgery. Successful rehabilitation after TL may be associated with more favorable long-term QoL patterns, with outcomes in selected domains approaching those of the PL group, whereas unsuccessful rehabilitation may be associated with persistently poorer outcomes.</p>","PeriodicalId":49954,"journal":{"name":"Journal of Voice","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149170836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laryngology Patient-Reported Outcome Measures and Demographics as Predictors of Dysphonia-Related Procedures.","authors":"Adam Beucler, Aditya Mahesh, Ohad Cohen, Meredith Tabangin, Rebecca J Howell, Aaron D Friedman","doi":"10.1016/j.jvoice.2026.09.044","DOIUrl":"https://doi.org/10.1016/j.jvoice.2026.09.044","url":null,"abstract":"<p><strong>Objectives: </strong>Patient-Reported Outcome Measures (PROMs) are popular in laryngology clinics. We hypothesized that certain PROMs and demographic data might identify which dysphonic patients are more likely to require a procedure by a laryngologist prior to initial examination.</p><p><strong>Methods: </strong>This study took place at one academic medical center laryngology clinic from September 2021 to October 2023. A prospectively collected new laryngology patient database was queried for a chief complaint inclusive of dysphonia; Vocal Handicap Index-10 (VHI-10), Reflux Symptom Index, and Glottal Function Index (GFI) scores; and a poststroboscopy diagnosis. A retrospective chart review was performed for patient age at presentation, sex, and subsequent dysphonia-related procedures (DRPs) (operating room or office). T tests /Wilcoxon rank sums/ Chi-square tests compared characteristics between patients having a DRP within 1 year of their first visit (DRP+) and patients who did not. Logistic regression models were used to identify predictors of procedure, and accuracy was assessed with receiver operator characteristic curves.</p><p><strong>Results: </strong>Five hundred seventy-seven dysphonic patients were identified; 174 (30.1%) were DRP+. This population was statistically significantly older, more likely to be male, more likely to have a chief complaint of only dysphonia (CCOD), and had greater VHI-10 and GFI scores. Multivariable analysis revealed that the VHI-10 score, the presence (versus absence) of CCOD, and patient sex maximized the area under the curve (0.74; 95% CI: 0.70-0.78).</p><p><strong>Conclusion: </strong>Higher VHI-10 scores, CCOD, and male sex may be predictive of the need for subsequent voice-related procedures in new dysphonia patients. These data may be useful for initial visit screening and triage in resource-constrained voice clinics.</p>","PeriodicalId":49954,"journal":{"name":"Journal of Voice","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149170032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proposed Classification System for Office-based Blue Laser Tissue Effect in Reinke's Edema.","authors":"Abdul-Latif Hamdan, Jerome R Lechien, Patrick Abou Raji Feghali, Robert T Sataloff","doi":"10.1016/j.jvoice.2026.08.046","DOIUrl":"https://doi.org/10.1016/j.jvoice.2026.08.046","url":null,"abstract":"<p><strong>Objective: </strong>To describe a new classification system for blue laser-induced tissue effect in Reinke's edema (RE).</p><p><strong>Method: </strong>All video recordings of patients with RE who had undergone office-based blue laser therapy between October 2022 and May 2026 were reviewed, and a total of 16 video clips were selected to include the different types of tissue effects observed. Each video clip included a short segment showing part of the laser procedure and the immediate posttreatment tissue effect. The compiled video recordings were blindly rated by three board-certified laryngologists based on a 4-point proposed classification; Blanching of the mucosa with or without angiolysis (RE-BLL1); Blanching of the mucosa with epithelial disruption or violation (RE-BLL2); Epithelial disruption with submucosal tissue ablation/evaporation (RE-BLL3), and Epithelial disruption with submucosal tissue extraction/removal (RE-BLL4).</p><p><strong>Results: </strong>The overall agreement in rating among the three reviewers was 96.7% (58 of 60 ratings). The agreement in rating RE-BLL1 tokens was 100% (15 of 15 ratings), 93.3% for RE-BLL2 tokens (14 of 15 ratings), 93.3% for RE-BLL3 tokens (14 of 15 ratings), and 100% for RE-BLL4 tokens (15 of 15 ratings). All reviewers demonstrated 100% intra-rater agreement with their own classification of the unidentified repeated recordings. Inter-rater reliability among the three blinded reviewers was excellent. Using a two-way mixed-effects model with absolute agreement, the single-measure ICC was 0.975 (95% CI: 0.948-0.989), indicating excellent reliability of an individual reviewer's grading. The average-measure ICC was 0.991 (95% CI: 0.982-0.996), indicating excellent reliability when the three reviewers' scores were considered together.</p><p><strong>Conclusion: </strong>The proposed 4-point classification system for tissue effects of blue laser treatment of RE had an excellent inter-rater and intra-rater reliability. By standardizing the description of the blue laser-induced tissue effect in RE, this classification could help improve consistent communication among laryngologists and other voice care providers.</p>","PeriodicalId":49954,"journal":{"name":"Journal of Voice","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149139055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the Effects of Amateur Singing on Speaking Voice Quality, Function, and Motor Control Across Adulthood.","authors":"Amélie Nadeau, Pascale Tremblay, Maude Desjardins","doi":"10.1016/j.jvoice.2026.09.019","DOIUrl":"https://doi.org/10.1016/j.jvoice.2026.09.019","url":null,"abstract":"<p><strong>Objectives: </strong>Singing is an accessible activity that may promote vocal health, including vocal function, quality, and motor control. However, evidence remains limited and heterogeneous, as some studies have shown an association between singing practice and dysphonia-related complaints in certain populations. This study investigated whether amateur singing practice influences adult speaking voice outcomes related to function, quality, and motor control, and whether it may moderate age-related vocal changes.</p><p><strong>Methods: </strong>Participants were 143 French-speaking adults (20-98 years; 72 singers, 71 non-singers). Amateur singers were defined as individuals singing in a choir for at least two years with a minimal weekly practice of 60 minutes. Vocal function and quality were assessed using the Dysphonia Severity Index, Acoustic Voice Quality Index, speaking habitual intensity, and perceptual judgment of overall severity. Voice Onset Time (VOT) and its variability during a diadochokinetic task were used as proxies for vocal motor control. Linear and mixed-effects regression models tested the main effects of group (singers/non-singers), age, and their interaction, while controlling for relevant variables.</p><p><strong>Results: </strong>Singers exhibited higher harmonic-to-noise ratios and lower shimmer values than non-singers. Age predicted lower maximal fundamental frequency values, independent of singing status. A moderating effect of singing was found for overall severity ratings, showing a trend toward better perceptual vocal quality in younger and middle-aged singers, but not in older singers, resulting in a steeper association between age and overall severity among singers. Interactions also revealed differential associations between VOT and age in singers compared to non-singers for specific consonants, suggesting potential differences in laryngeal-articulatory coordination between groups.</p><p><strong>Conclusion: </strong>Findings suggest that amateur singing is associated with specific acoustic and perceptual benefits, although some of these associations may not be found in older adults. Longitudinal studies are needed to clarify the potential benefits of amateur singing.</p>","PeriodicalId":49954,"journal":{"name":"Journal of Voice","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149149031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-Validation of Acoustic Roughness Index in Korean.","authors":"Geun Hyo Kim, Dong Won Lim, Na Ryung Kim, Beom Yang Shin, Yeon Woo Lee","doi":"10.1016/j.jvoice.2026.09.039","DOIUrl":"https://doi.org/10.1016/j.jvoice.2026.09.039","url":null,"abstract":"<p><strong>Objectives: </strong>The Acoustic Roughness Index (ARI) is a multivariate acoustic measure specifically developed to objectively quantify vocal roughness by integrating multiple acoustic features, including subharmonic phenomena that are difficult to capture using conventional acoustic measures. Because the ARI analyzes concatenated voice samples that include connected speech, its performance may be influenced by language-specific phonetic and prosodic characteristics. Although its clinical utility has been demonstrated in Japanese and German populations, it has not been validated in Korean speakers. Therefore, this study aimed to validate the ARI and establish an optimal diagnostic cutoff for discriminating dysphonic voices from normal voices in Korean speakers.</p><p><strong>Methods: </strong>Voice recordings from 330 native Korean speakers (74 controls and 256 patients with dysphonia) were analyzed. Concatenated voice samples consisting of a sustained vowel and a reading passage were used to calculate ARI scores. Three experienced speech-language pathologists independently rated vocal roughness using a 7-point auditory-perceptual scale, and the mean rating served as the reference standard. Concurrent validity was evaluated using Spearman's rank correlation, and receiver operating characteristic (ROC) curve analysis was performed to determine the optimal diagnostic cutoff.</p><p><strong>Results: </strong>ARI demonstrated a strong positive correlation with auditory-perceptual roughness ratings (Spearman's ρ = 0.804, P < 0.001). ARI scores were significantly higher in the dysphonia group than in the control group (P < 0.001). ROC analysis demonstrated excellent diagnostic accuracy (AUC = 0.923), and the optimal cutoff value was 2.29, yielding a sensitivity of 74.6% and a specificity of 90.5%.</p><p><strong>Conclusions: </strong>The ARI demonstrated strong concurrent validity and excellent diagnostic performance for discriminating dysphonic voices from normal controls in Korean speakers. The proposed cutoff of 2.29 provides clinically useful discrimination and supports the cross-linguistic applicability of the ARI as an objective adjunct to auditory-perceptual voice assessment.</p>","PeriodicalId":49954,"journal":{"name":"Journal of Voice","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149149421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient Selection Trends in Age, Gender, and Voice Severity in Patients with Vocal Fold Paresis.","authors":"Julissa Li, Priya Krishna, Saul Mota, Thomas Murry","doi":"10.1016/j.jvoice.2026.09.018","DOIUrl":"https://doi.org/10.1016/j.jvoice.2026.09.018","url":null,"abstract":"<p><strong>Objectives: </strong>Advances in otolaryngology have led to improved differentiation between vocal fold paresis and paralysis. Treatments for vocal fold paresis include voice therapy and surgical interventions, such as injection augmentation or laryngeal surgery. Limited data exist regarding patient profiles associated with trends in initial treatment selection of voice therapy versus surgical treatment. The purpose of this study was to describe trends in treatment selection for patients with vocal fold paresis.</p><p><strong>Methods: </strong>A retrospective chart review was conducted of 150 adult patients with a clinical diagnosis of \"vocal fold paresis.\" Data collected included age at diagnosis, gender, voice severity assessed using the Voice Handicap Index-10 (VHI-10), and treatment modality options (no treatment, voice therapy, or vocal fold augmentation). Common comorbidities were also collected. Comparisons were made at the initial consultation according to VHI-10 score, age, and gender.</p><p><strong>Results: </strong>This study included 76 females and 74 males. For severity, we found that for every 1 unit increase in VHI-10 score, the odds of receiving no treatment decreased by 8% (sig @ 0.000001) and the odds of receiving vocal fold injection (VFI) increased by 7% (sig @ 0.0004). For every 1 unit of increase in age, the odds of receiving no treatment decreased by 3% (sig @ 0.0082) and the odds of receiving VFI increased by 3% (sig @ 0.0446). Gender was not statistically significant when choosing between no treatment and treatment (P-value = 0.903). Patients who did not receive treatment were more likely to have no major comorbidities, whereas those who received voice therapy or VFI more commonly had at least one.</p><p><strong>Conclusions: </strong>This study provides objective data for describing patient treatment selection following the diagnosis of vocal fold paresis. These results suggest that age and voice severity at the time of diagnosis are factors associated with initial patient treatment selection.</p>","PeriodicalId":49954,"journal":{"name":"Journal of Voice","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149139134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Voice-Related Outcomes Among Patients With Temporomandibular Disorders: A Systematic Review and Narrative Synthesis.","authors":"Patrick Abou Raji Feghali, Abdul-Latif Hamdan","doi":"10.1016/j.jvoice.2026.08.036","DOIUrl":"https://doi.org/10.1016/j.jvoice.2026.08.036","url":null,"abstract":"<p><strong>Background: </strong>Temporomandibular disorders (TMD) may influence voice through effects on mandibular movement and vocal tract configuration. This review synthesized subjective and objective voice-related outcomes among patients with TMD.</p><p><strong>Methods: </strong>A systematic search of MEDLINE via Ovid, PubMed, EMBASE, Scopus, Cochrane Library, and Google Scholar was completed, with no date restrictions. Observational studies were eligible if they included patients with TMD and reported at least one voice-related outcome. Methodological quality was assessed using Joanna Briggs Institute critical appraisal tools. Data were synthesized narratively.</p><p><strong>Results: </strong>The search identified 440 records; after duplicate removal, screening, and review, 10 studies comprising 3,467 TMD participants were included. Study designs, TMD definitions, comparator groups, and voice outcome measures varied substantially. Voice outcomes included symptom-based reporting of dysphonia or voice disorder, Voice Handicap Index, voice-related quality of life questionnaires, auditory-perceptual assessment, acoustic and cepstral analyses, spectrography, and the Dysphonia Severity Index. Symptom-based studies reported dysphonia or voice disorder in 12.6% of a 1,000-patient TMD cohort and in 73.1% of older adults with TMD compared with 29.7% without TMD in the same sample. Patient-reported outcomes were variable, but several studies showed greater voice handicap or poorer voice-related quality of life with increasing TMD severity. Auditory-perceptual assessment showed reduced loudness among patients with severe TMD. Objective measures showed reduced loudness, increased antiresonance, lower cepstral peak prominence values, and lower Dysphonia Severity Index scores in patients with TMD or greater TMD severity. Overall methodological quality was high in three studies, moderate in six, and low in one.</p><p><strong>Conclusion: </strong>Voice symptoms and abnormal voice findings are frequently reported among patients with TMD and may worsen with increasing TMD severity. However, methodological heterogeneity and predominantly cross-sectional designs limit causal inference. Future studies should use standardized TMD definitions, matched controls, and integrated voice assessment methods.</p>","PeriodicalId":49954,"journal":{"name":"Journal of Voice","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149139067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Objective and Subjective Voice Assessment in Children With Attention-Deficit/Hyperactivity Disorder.","authors":"Armon Massoodi, Fatemeh Taghizade Firouzjaii, Akram Ahmadi, Sina Mohammadpour, Hossein-Ali Nikbakht","doi":"10.1016/j.jvoice.2026.09.016","DOIUrl":"https://doi.org/10.1016/j.jvoice.2026.09.016","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this study was to compare acoustic voice measures, auditory-perceptual voice quality, and parent-reported voice handicap between children with attention-deficit/hyperactivity disorder (ADHD) and typically developing (TD) peers.</p><p><strong>Study design: </strong>Case-control study.</p><p><strong>Methods: </strong>Voice assessments including acoustic analysis using Praat, auditory-perceptual assessment using GRBAS, and parent-reported voice handicap using the Persian CVHI-10-P were performed in 88 children with ADHD and 88 age- and sex-matched TD children; CVHI-10-P data were available for 86 children with ADHD and 88 TD children.</p><p><strong>Results: </strong>Acoustic analysis showed that children with ADHD had significantly higher loudness than TD children (P = 0.007), whereas TD children demonstrated significantly higher jitter values (P = 0.001). No significant differences were observed for fundamental frequency (F₀), shimmer, harmonics-to-noise ratio (HNR), and the s/z ratio. In the auditory-perceptual assessment, a significant between-group difference was found only for the Grade (G) component of the GRBAS scale (P = 0.003), while Roughness, Breathiness, Asthenia, and Strain did not differ significantly between groups. Children with ADHD who had dysphonia, based on the overall dysphonia grade of the GRBAS, demonstrated higher jitter and lower HNR than those without dysphonia. Children with ADHD also had significantly higher scores on the Persian CVHI-10-P than TD children (P < 0.001). Overall dysphonia severity was significantly correlated with higher jitter (ρ = 0.493, P < 0.001) and lower HNR (ρ = -0.334, P = 0.002). CVHI-10-P scores were not significantly associated with acoustic measures or overall dysphonia severity (P > 0.05).</p><p><strong>Conclusion: </strong>Although the values of acoustic measurement were mostly similar between children with ADHD and TD group, children with ADHD demonstrated significantly higher parent-perceived voice handicap and worse overall perceptual voice quality. Given that the Persian CVHI-10-P identified dysphonia in 20.93% of children with ADHD, incorporating parent-reported voice handicap measures into routine clinical settings is strongly recommended.</p>","PeriodicalId":49954,"journal":{"name":"Journal of Voice","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149129108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proteomic Stratification Across Human Male Vocal Fold Tissue Layers.","authors":"Aaron M Johnson, Elizabeth Erickson-DiRenzo, Melissa Boersma, Hua Zhou, Mary J Sandage","doi":"10.1016/j.jvoice.2026.09.021","DOIUrl":"https://doi.org/10.1016/j.jvoice.2026.09.021","url":null,"abstract":"<p><strong>Objectives: </strong>To compare relative proteomic abundance across the human true vocal fold cover (epithelium and superficial lamina propria; TVFC), vocal ligament (intermediate and deep lamina propria; VL), and thyroarytenoid muscle (TA), and to characterize shared and distinct molecular pathways.</p><p><strong>Methods: </strong>Cross-sectional exploratory proteomic study using tandem mass tag-based quantitative mass spectrometry on tissue from five human male cadaveric larynges (mean age 56.6 years) obtained from a national tissue bank. Differential protein abundance was assessed using linear mixed modeling, and Gene Ontology (GO) enrichment analysis characterized functional specialization across layers.</p><p><strong>Results: </strong>Of 895 quantified proteins, 554 were detected in all three layers, with 181 jointly detected in the TVFC and VL, and 160 detected only in the TA. Differential expression analysis revealed minimal divergence between TVFC and VL (all FDR > 0.10) but robust separation of TA from both the TVFC and VL (FDR < 0.05). GO enrichment demonstrated that TVFC was enriched for inflammatory and immune processes, VL occupied an intermediate position sharing features with both TVFC and TA, and TA demonstrated contractile specialization.</p><p><strong>Conclusion: </strong>This exploratory study provides an initial descriptive comparison of protein expression across human vocal fold layers, with VL serving as a potential transitional zone between the immunomodulatory cover and contractile muscle. These findings confirm the well-established histological, cellular, and functional differences among these layers, and provide preliminary data to inform future studies of laryngeal biology, pathology, and intervention.</p>","PeriodicalId":49954,"journal":{"name":"Journal of Voice","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149129093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}