Korean Journal of Parasitology最新文献

Leishmania Vaccines: the Current Situation with Its Promising Aspect for the Future. 利什曼病疫苗：现状与未来前景。

IF 1.4 4区医学

Korean Journal of Parasitology Pub Date : 2022-12-01 Epub Date: 2022-12-22 DOI: 10.3347/kjp.2022.60.6.379

Rasit Dinc

{"title":"Leishmania Vaccines: the Current Situation with Its Promising Aspect for the Future.","authors":"Rasit Dinc","doi":"10.3347/kjp.2022.60.6.379","DOIUrl":"10.3347/kjp.2022.60.6.379","url":null,"abstract":"Leishmaniasis is a serious parasitic disease caused by Leishmania spp. transmitted through sandfly bites. This disease is a major public health concern worldwide. It can occur in 3 different clinical forms: cutaneous, mucocutaneous, and visceral Leishmaniasis (CL, MCL, and VL, respectively), caused by different Leishmania spp. Currently, licensed vaccines are unavailable for the treatment of human Leishmaniasis. The treatment and prevention of this disease rely mainly on chemotherapeutics, which are highly toxic and have an increasing resistance problem. The development of a safe, effective, and affordable vaccine for all forms of vector-borne disease is urgently needed to block transmission of the parasite between the host and vector. Immunological mechanisms in the pathogenesis of Leishmaniasis are complex. IL-12-driven Th1-type immune response plays a crucial role in host protection. The essential purpose of vaccination is to establish a protective immune response. To date, numerous vaccine studies have been conducted using live/attenuated/killed parasites, fractionated parasites, subunits, recombinant or DNA technology, delivery systems, and chimeric peptides. Most of these studies were limited to animals. In addition, standardization has not been achieved in these studies due to the differences in the virulence dynamics of the Leishmania spp. and the feasibility of the adjuvants. More studies are needed to develop a safe and effective vaccine, which is the most promising approach against Leishmania infection.","PeriodicalId":49938,"journal":{"name":"Korean Journal of Parasitology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/bd/1d/kjp-60-6-379.PMC9806502.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9549755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Imaging Manifestations and Misdiagnosis Analysis of Six Cases of Bone Hydatid Disease. 骨包虫病6例影像学表现及误诊分析。

4区医学

Korean Journal of Parasitology Pub Date : 2022-12-01 DOI: 10.3347/kjp.2022.60.6.413

Yanqiu Sun, Chunlong Yan, Dengfeng Tian, Chenhong Zhang, Qiang Zhang

{"title":"Imaging Manifestations and Misdiagnosis Analysis of Six Cases of Bone Hydatid Disease.","authors":"Yanqiu Sun, Chunlong Yan, Dengfeng Tian, Chenhong Zhang, Qiang Zhang","doi":"10.3347/kjp.2022.60.6.413","DOIUrl":"https://doi.org/10.3347/kjp.2022.60.6.413","url":null,"abstract":"We retrospectively evaluated the clinical and imaging features of 6 patients with bone hydatid disease confirmed by surgery and pathological examination. Among the 6 patients, 2 were infected with Echinococcosis granulosus metacestode and 4 were infected with E. multilocularis metacestode. The 2 cases with cystic echinococcosis were diagnosed by computed tomographic (CT) examination, and other 4 cases were diagnosed by magnetic resonance (MR) imaging. On the initial evaluation, 1 case each was misdiagnosed as a giant cell tumor or neurogenic tumor, and 2 were misdiagnosed as tuberculosis. The imaging manifestations of bone hydatid disease are complex, but most common findings include expansive osteolytic bone destruction, which may be associated with sclerosing edges or dead bone formation, localized soft tissue masses, and vertebral lesions with wedge-shaped changes and spinal stenosis. Combining imaging findings with the patient’s epidemiological history and immunological examinations is of great help in improving the diagnosis and differential diagnosis of bone hydatid disease.","PeriodicalId":49938,"journal":{"name":"Korean Journal of Parasitology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/85/8d/kjp-60-6-413.PMC9806501.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10869831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Demodex Blepharitis: An Analysis of Nine Patients. 蠕形螨性睑炎9例分析。

4区医学

Korean Journal of Parasitology Pub Date : 2022-12-01 DOI: 10.3347/kjp.2022.60.6.429

Young Il Lee, Min Seo, Kyong Jin Cho

引用次数: 1

In Vitro Evaluation of Two Novel Antimalarial Derivatives of SKM13: SKM13-MeO and SKM13-F. 两种新型SKM13抗疟衍生物SKM13- meo和SKM13- f的体外评价

4区医学

Korean Journal of Parasitology Pub Date : 2022-12-01 DOI: 10.3347/kjp.2022.60.6.401

Thuy-Tien Thi Trinh, Young-Ah Kim, Hyelee Hong, Linh Thi Thuy Le, Hayoung Jang, Soon-Ai Kim, Hyun Park, Hak Sung Kim, Seon-Ju Yeo

{"title":"In Vitro Evaluation of Two Novel Antimalarial Derivatives of SKM13: SKM13-MeO and SKM13-F.","authors":"Thuy-Tien Thi Trinh, Young-Ah Kim, Hyelee Hong, Linh Thi Thuy Le, Hayoung Jang, Soon-Ai Kim, Hyun Park, Hak Sung Kim, Seon-Ju Yeo","doi":"10.3347/kjp.2022.60.6.401","DOIUrl":"https://doi.org/10.3347/kjp.2022.60.6.401","url":null,"abstract":"Antimalarial drugs play an important role in the control and treatment of malaria, a deadly disease caused by the protozoan parasite Plasmodium spp. The development of novel antimalarial agents effective against drug-resistant malarial parasites is urgently needed. The novel derivatives, SKM13-MeO and SKM13-F, were designed based on an SKM13 template by replacing the phenyl group with electron-donating (-OMe) or electron-withdrawing groups (-F), respectively, to reverse the electron density. A colorimetric assay was used to quantify cytotoxicity, and in vitro inhibition assays were performed on 3 different blood stages (ring, trophozoite, and schizonts) of P. falciparum 3D7 and the ring/mixed stage of D6 strain after synchronization. The in vitro cytotoxicity analysis showed that 2 new SKM13 derivatives reduced the cytotoxicity of the SKM13 template. SKM13 maintained the IC50 at the ring and trophozoite stages but not at the schizont stage. The IC50 values for both the trophozoite stage of P. falciparum 3D7 and ring/mixed stages of D6 demonstrated that 2 SKM13 derivatives had decreased antimalarial efficacy, particularly for the SKM13-F derivative. SKM13 may be comparably effective in ring and trophozoite, and electron-donating groups (-OMe) may be better maintain the antimalarial activity than electron-withdrawing groups (-F) in SKM13 modification.","PeriodicalId":49938,"journal":{"name":"Korean Journal of Parasitology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/08/9f/kjp-60-6-401.PMC9806497.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10869838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Ocular Sparganosis in China: Episode of Migration from Muscle Cone to Subconjunctiva. 中国的一例眼球海绵体病：从肌锥到结膜下的移行发作。

IF 1.4 4区医学

Korean Journal of Parasitology Pub Date : 2022-12-01 Epub Date: 2022-12-22 DOI: 10.3347/kjp.2022.60.6.419

Xinyuan Chen, Yanyuan Fang, Liming Tao, Miao Liu, Kun Liang

{"title":"A Case of Ocular Sparganosis in China: Episode of Migration from Muscle Cone to Subconjunctiva.","authors":"Xinyuan Chen, Yanyuan Fang, Liming Tao, Miao Liu, Kun Liang","doi":"10.3347/kjp.2022.60.6.419","DOIUrl":"10.3347/kjp.2022.60.6.419","url":null,"abstract":"To improve our understanding of the migration of sparganum in humans, we report a case of ocular sparganosis having the migratory episode from the muscle cone to the subconjunctiva. A 34-year-old woman was admitted to the Hospital of Anhui Medical University (Hefei, China), in December 2019. She presented with conjunctival hemorrhage and recurrent pain in the left eye. A foreign body was found in the muscle cone of the eye. Two months later, a ribbon-like white material was found under the conjunctiva on slit-lamp examination. A long and slender, actively moving parasite was extracted by surgery. The extracted worm was approximately 8 cm long and 2 mm wide. The worm was whitish, wrinkled, ribbon shaped, and had a slightly enlarged scolex. The worm sample was morphologically identified as a plerocercoid larva (sparganum) of the Spirometra tapeworm. Her conjunctival blood suffusion and eye pain ceased within 1 week after operation. She has been in good health without any symptoms during the 2-year follow-up. A case of ocular sparganosis, in which larval worm migrated from the muscle cone to the subconjunctiva is reported from China.","PeriodicalId":49938,"journal":{"name":"Korean Journal of Parasitology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b3/f5/kjp-60-6-419.PMC9806500.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10869834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Two Cases of Mange Mite (Sarcoptes scabiei) Infestation in Long-Tailed Goral (Naemorhedus caudatus) in Republic of Korea. 韩国长尾舌螨(尾尾舌螨)侵染2例。

4区医学

Korean Journal of Parasitology Pub Date : 2022-12-01 DOI: 10.3347/kjp.2022.60.6.423

Da Som Park, Jin Choi, Hee-Jong Kim, Jin-Yong Kim, Min-Han Kim, Jin-Young Lee, Jeong Chan Moon, Hee-Bok Park, KyungMin Park, Jun Hee Yun, Yeonsu Oh, Seongjun Choe, Ki-Jeong Na, Jongmin Yoon

{"title":"Two Cases of Mange Mite (Sarcoptes scabiei) Infestation in Long-Tailed Goral (Naemorhedus caudatus) in Republic of Korea.","authors":"Da Som Park, Jin Choi, Hee-Jong Kim, Jin-Yong Kim, Min-Han Kim, Jin-Young Lee, Jeong Chan Moon, Hee-Bok Park, KyungMin Park, Jun Hee Yun, Yeonsu Oh, Seongjun Choe, Ki-Jeong Na, Jongmin Yoon","doi":"10.3347/kjp.2022.60.6.423","DOIUrl":"https://doi.org/10.3347/kjp.2022.60.6.423","url":null,"abstract":"The long-tailed goral, Naemorhedus caudatus (Mammalia: Bovidae), is one of the endangered animals in the Republic of Korea (Korea). Sarcoptic mange mites infested in diverse species of mammals, including humans, but no case has been reported in long-tailed gorals. We report 2 cases of mange mite, Sarcoptes scabiei, infestation in long-tailed gorals. Mange mites were sampled in the skin legions of the 2 long-tailed gorals, which were rescued in 2 different regions, Uljin-gun, Gyeongsangbuk-do and Cheorwon-gun, Gangwon-do, Korea. Our results showed that the ectoparasite was the itch mite that burrowed into skin and caused scabies on the morphological inspection and placed within the phylogenetic relations of the species. The present study confirmed for the first time in Korea that mange mites are pathogenic scabies of long-tailed goral. Closer surveillance of this pathogenic ectoparasite in zoonotic and infectious ecosystems is warranted.","PeriodicalId":49938,"journal":{"name":"Korean Journal of Parasitology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f4/d3/kjp-60-6-423.PMC9806499.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10869833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ectopic Schistosomiasis Involving Axillary Lymph Nodes. 异位血吸虫病累及腋窝淋巴结。

4区医学

Korean Journal of Parasitology Pub Date : 2022-12-01 DOI: 10.3347/kjp.2022.60.6.409

Xia Chen, Nian'an He

引用次数: 0

Genetic Diversity and Clustering of the Rhoptry Associated Protein-1 of Plasmodium knowlesi from Peninsular Malaysia and Malaysian Borneo. 马来西亚半岛和马来西亚婆罗洲诺氏疟原虫花环相关蛋白-1的遗传多样性和聚类。

4区医学

Korean Journal of Parasitology Pub Date : 2022-12-01 DOI: 10.3347/kjp.2022.60.6.393

Ummi Wahidah Azlan, Yee Ling Lau, Mun Yik Fong

{"title":"Genetic Diversity and Clustering of the Rhoptry Associated Protein-1 of Plasmodium knowlesi from Peninsular Malaysia and Malaysian Borneo.","authors":"Ummi Wahidah Azlan, Yee Ling Lau, Mun Yik Fong","doi":"10.3347/kjp.2022.60.6.393","DOIUrl":"https://doi.org/10.3347/kjp.2022.60.6.393","url":null,"abstract":"Human infection with simian malaria Plasmodium knowlesi is a cause for concern in Southeast Asian countries, especially in Malaysia. A previous study on Peninsular Malaysia P. knowlesi rhoptry associated protein-1 (PkRAP1) gene has discovered the existence of dimorphism. In this study, genetic analysis of PkRAP1 in a larger number of P. knowlesi samples from Malaysian Borneo was conducted. The PkRAP1 of these P. knowlesi isolates was PCR-amplified and sequenced. The newly obtained PkRAP1 gene sequences (n = 34) were combined with those from the previous study (n = 26) and analysed for polymorphism and natural selection. Sequence analysis revealed a higher genetic diversity of PkRAP1 compared to the previous study. Exon II of the gene had higher diversity (π = 0.0172) than exon I (π = 0.0128). The diversity of the total coding region (π = 0.0167) was much higher than those of RAP1 orthologues such as PfRAP-1 (π = 0.0041) and PvRAP1 (π = 0.00088). Z-test results indicated that the gene was under purifying selection. Phylogenetic tree and haplotype network showed distinct clustering of Peninsular Malaysia and Malaysian Borneo PkRAP1 haplotypes. This geographical-based clustering of PkRAP1 haplotypes provides further evidence of the dimorphism of the gene and possible existence of 2 distinct P. knowlesi lineages in Malaysia.","PeriodicalId":49938,"journal":{"name":"Korean Journal of Parasitology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/57/84/kjp-60-6-393.PMC9806503.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10869836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Erratum: Toxoplasma gondii Induces Apoptosis via Endoplasmic Reticulum Stress-Derived Mitochondrial Pathway in Human Small Intestinal Epithelial Cell-Line. 勘误:刚地弓形虫通过内质网应激衍生的线粒体途径诱导人小肠上皮细胞凋亡。

4区医学

Korean Journal of Parasitology Pub Date : 2022-10-01 Epub Date: 2022-10-21 DOI: 10.3347/kjp.2022.60.5.371

引用次数: 0

Treatment with Extracellular Vesicles from Giardia lamblia Alleviates Dextran Sulfate Sodium-Induced Colitis in C57BL/6 Mice. 蓝氏贾第鞭毛虫细胞外囊泡治疗可减轻硫酸葡聚糖钠诱导的C57BL/6小鼠结肠炎。

4区医学

Korean Journal of Parasitology Pub Date : 2022-10-01 Epub Date: 2022-10-21 DOI: 10.3347/kjp.2022.60.5.309

Hyun Jung Kim, Young-Ju Lee, Seon-Ok Back, Shin-Hyeong Cho, Hee-Il Lee, Myoung-Ro Lee

{"title":"Treatment with Extracellular Vesicles from Giardia lamblia Alleviates Dextran Sulfate Sodium-Induced Colitis in C57BL/6 Mice.","authors":"Hyun Jung Kim, Young-Ju Lee, Seon-Ok Back, Shin-Hyeong Cho, Hee-Il Lee, Myoung-Ro Lee","doi":"10.3347/kjp.2022.60.5.309","DOIUrl":"https://doi.org/10.3347/kjp.2022.60.5.309","url":null,"abstract":"Inflammatory bowel disease (IBD) is a chronic and recurrent illness of the gastrointestinal tract. Treatment of IBD traditionally involves the use of aminosalicylic acid and steroids, while these drugs has been associated with untoward effects and refractoriness. The absence of effective treatment regimen against IBD has led to the exploration of new targets. Parasites are promising as an alternative therapy for IBD. Recent studies have highlighted the use of parasite-derived substances, such as excretory secretory products, extracellular vesicles (EVs), and exosomes, for the treatment of IBD. In this report, we examined whether EVs secreted by Giardia lamblia could prevent colitis in a mouse model. G. lamblia EVs (GlEVs) were prepared from in vitro cultures of Giardia trophozoites. Clinical signs, microscopic colon tissue inflammation, and cytokine expression levels were detected to assess the effect of GlEV treatment on dextran sulfate sodium (DSS)-induced experimental murine colitis. The administration of GlEVs prior to DSS challenge reduced the expression levels of pro-inflammatory cytokines, including tumor necrosis factor alpha, interleukin 1 beta, and interferon gamma. Our results indicate that GlEV can exert preventive effects and possess therapeutic properties against DSS-induced colitis.","PeriodicalId":49938,"journal":{"name":"Korean Journal of Parasitology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/be/03/kjp-60-5-309.PMC9633160.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40675328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4