Laeknabladid最新文献_第6页

[Ventricular Assist Devices in Iceland - A New Milestone in the Treatment of End-Stage Heart Failure]. [冰岛心室辅助装置-终末期心力衰竭治疗的新里程碑]。

IF 0.6 4区医学

Laeknabladid Pub Date : 2025-01-01 DOI: 10.17992/lbl.2025.10.855

Inga Jona Ingimarsdottir

引用次数: 0

[Pregnancy and childbirth of women with epilepsy on antiepileptic treatment in Iceland]. 【冰岛癫痫患者接受抗癫痫治疗后的妊娠和分娩】。

IF 0.6 4区医学

Laeknabladid Pub Date : 2025-01-01 DOI: 10.17992/lbl.2025.10.857

Brynhildur K Asgeirsdottir, Sigridur Margret Thorbergsdottir, Haukur Hjaltason, Agust Hilmarsson, Thora Steingrimsdottir

{"title":"[Pregnancy and childbirth of women with epilepsy on antiepileptic treatment in Iceland].","authors":"Brynhildur K Asgeirsdottir, Sigridur Margret Thorbergsdottir, Haukur Hjaltason, Agust Hilmarsson, Thora Steingrimsdottir","doi":"10.17992/lbl.2025.10.857","DOIUrl":"https://doi.org/10.17992/lbl.2025.10.857","url":null,"abstract":"Introduction: Epilepsy is one of the most common chronic illnesses among women of childbearing age, and it is known that antiepileptic drugs can be teratogenic. Recommendations for the treatment of women with epilepsy during pregnancy focus on minimizing the risk of seizures and fetal damage. In general, changes in antiepileptic treatment are not recommended, except to avoid the use of valproate, and the use of high-dose folic acid is advised before and during pregnancy. This article describes the results of a study on the outcomes of pregnancy and childbirth in women with epilepsy on anti-epileptic treatment in Iceland from 2011 to 2020.Materials and methods: A retrospective, matched case-control study over a 10-year period. Data were obtained from the Icelandic Medical Birth Registry and the Prescription Database of the Directorate of Health. Statistical analysis was based on t-tests, Wilcoxon tests, chi-square tests, and Fisher test, and a linear mixed model was used in cases where adjustment was made for confounding factors.Results: The study group included 107 births, and 202 in the control group. Women with epilepsy attended more frequent antenatal visits and had higher rates of labor induction, cesarean section and use of anesthesia during labor. There was no difference in mean gestational age, mean labor duration, mean blood loss during labor, or median Apgar score between the groups. Use of antiepileptic medication was lower during pregnancy than before, mainly due to reduced use of valproate.Conclusions: Pregnancy and delivery outcomes of women with epilepsy were generally favorable. There was no increased risk of serious complications in pregnancy and labor, nor congenital anomalies or deviations in the newborns. We consider our results important for women with epilepsy in Iceland, as well as for doctors and other health care professionals providing their care.","PeriodicalId":49924,"journal":{"name":"Laeknabladid","volume":"111 10","pages":"414-420"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Severe hidradenitis suppurativa treated with acellular fish skin - A case report and discussion of the disorder]. [无细胞鱼皮治疗严重化脓性汗腺炎1例报告及讨论]。

IF 0.6 4区医学

Laeknabladid Pub Date : 2025-01-01 DOI: 10.17992/lbl.2025.11.864

Audur Gunnarsdottir, Elsa Bjork Valsdottir

引用次数: 0

[Ventricular assist devices in Iceland 2010-2024]. [2010-2024年冰岛心室辅助装置]。

IF 0.6 4区医学

Laeknabladid Pub Date : 2025-01-01 DOI: 10.17992/lbl.2025.10.858

Magnus Ari Brynleifsson, Aevar Orn Ulfarsson, Martin Ingi Sigurdsson

{"title":"[Ventricular assist devices in Iceland 2010-2024].","authors":"Magnus Ari Brynleifsson, Aevar Orn Ulfarsson, Martin Ingi Sigurdsson","doi":"10.17992/lbl.2025.10.858","DOIUrl":"https://doi.org/10.17992/lbl.2025.10.858","url":null,"abstract":"Introduction: Ventricular assist devices are increasingly used as a treatment option for patients with advanced heart failure, however, there is a lack of information about the number of patients, indications, and outcomes of this patient population in Iceland.Methods and materials: A retrospective study covering the period 01.01.2020 - 31.12.2024. The study population consisted of individuals who had received a ventricular assist device and had received treatment or follow-up care in Iceland either before or after implantation of the ventricular assist device. Clinical data were obtained from electronic medical records, and variables were collected before and after implantation.Results: Between 2010 and 2024, six individuals received a ventricular assist device (VAD), all of whom were male. The age at implantation ranged from 17 to 66 years. Indications for VAD implantation were equally divided between bridge to transplantation (3/6) and bridge to candidacy (3/6). The underlying causes of heart failure were dilated cardiomyopathy (5/6) and ischemic cardiomyopathy (1/6). Four patients received a left ventricular assist device, while two received a biventricular assist device. Four patients subsequently underwent heart transplantation, one died while on VAD support, and one remained on VAD therapy at the end of the study period. The mean time from VAD implantation to heart transplantation was 249 days. Throughout the study period, there were a total of 1704 days on which at least one patient with a VAD was located in Iceland, corresponding to 31% of the study period. Four complications were documented in three patients: driveline infection, ventricular tachycardia, gastrointestinal bleeding and subarachnoid hemorrhage due to syncope.Conclusions: Patients with VADs were effectively managed in Iceland, and the results imply that the use of VADs possibly represents a currently underutilized therapeutic option for advanced heart failure in Iceland.","PeriodicalId":49924,"journal":{"name":"Laeknabladid","volume":"111 10","pages":"421-427"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[The Nobel prize in medicine - microRNA and gene regulation]. [诺贝尔医学奖- microRNA和基因调控]。

IF 0.4 4区医学

Laeknabladid Pub Date : 2024-12-01 DOI: 10.17992/lbl.2024.12.816

Eirikur Steingrimsson, Magnus Karl Magnusson

引用次数: 0

[Food as migraine trigger]. [食物引发偏头痛]。

IF 0.4 4区医学

Laeknabladid Pub Date : 2024-12-01 DOI: 10.17992/lbl.2024.12.818

Hadda Margret Haraldsdottir, Ingibjorg Gunnarsdottir, Arora Ros Ingadottir, Olafur Sveinsson

{"title":"[Food as migraine trigger].","authors":"Hadda Margret Haraldsdottir, Ingibjorg Gunnarsdottir, Arora Ros Ingadottir, Olafur Sveinsson","doi":"10.17992/lbl.2024.12.818","DOIUrl":"https://doi.org/10.17992/lbl.2024.12.818","url":null,"abstract":"Background and aims: Migraine is a neurological disorder that is characterized by severe headaches and temporary motor and sensory disturbances. Migraine triggers are internal or external factors that can increase the likelihood of a migraine attack. Some individuals with migraine associate their attacks with the consumption of certain types of food, but no have been conducted in Iceland. The aim of the study was to estimate the proportion of individuals with migraine in Iceland who associate their symptoms with consuming certain types of food.Methods: An electronic questionnaire was submitted to two groups (≥18 years old), members of the Icelandic Facebook group 'Migreni' (n=395 and to patients being treated by a neurologist (n=108), with the question if they thought certain foods could trigger migraine attacks. A total of 503 opened the survey (19.6% in the Facebook group and 65% managed by a neurologist). Response options were never/rarely, sometimes, often, or always. Other questions included types of migraine, medication use and background.Results: Out of 466 participants, 354 individuals (76%) claimed that food often or always triggered their migraine. The proportion was higher in the Facebook group than in the neurologist group (78% vs. 66%, p=0.007). Red wine and skipping meals (hunger) were the most common food-related triggers, reported as triggers often or always by >50%. Other common food triggers included white wine, liquorice, and smoked meat; they were reported as triggers by 20-50% of participants.Conclusion: Food seems to be a common migraine trigger, and the main food-related triggers were similar to those reported in other studies. However, previous studies have not shown liquorice as a common food trigger for migraines, and smoked meat was found to be a more common trigger than seen in other studies.","PeriodicalId":49924,"journal":{"name":"Laeknabladid","volume":"110 12","pages":"564-570"},"PeriodicalIF":0.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[New treatment perspectives in chronic kidney disease]. [慢性肾脏疾病治疗的新观点]。

IF 0.4 4区医学

Laeknabladid Pub Date : 2024-12-01 DOI: 10.17992/lbl.2024.12.815

Fjolnir Elvarsson

引用次数: 0

[SGLT2 inhibitors - A novel treatment for congestive heart failure and chronic kidney disease]. [SGLT2抑制剂-一种治疗充血性心力衰竭和慢性肾脏疾病的新方法]。

IF 0.4 4区医学

Laeknabladid Pub Date : 2024-12-01 DOI: 10.17992/lbl.2024.12.817

Sigridur Birna Eliasdottir

{"title":"[SGLT2 inhibitors - A novel treatment for congestive heart failure and chronic kidney disease].","authors":"Sigridur Birna Eliasdottir","doi":"10.17992/lbl.2024.12.817","DOIUrl":"https://doi.org/10.17992/lbl.2024.12.817","url":null,"abstract":"SGLT2 inhibitors increase renal excretion of sodium and glucose by blocking the SGLT2 transporters in the proximal tubule. Not only do they lower blood sugars levels but also have positive effects on blood pressure and weight. They lead to more efficient energy metabolism in the heart and kidneys, increase the production of red blood cells and decrease fibrosis and inflammation in the heart and the kidneys. Large double blind randomized trials have shown both cardiac and renal protective effects. Patient with heart failure, both with reduced and preserved ejection fraction have shown to benefit from treatment with SGLT2 inhibitors. They have lower risk of death due to cardiovascular causes and decreased risk of hospitalization because of heart failure compared to patient treated with placebo both with and without diabetes type 2. SGLT2 inhibitors are shown to decrease risk of chronic kidney disease stage 5 and dialysis, death due of cardiovascular events and doubling of serum creatinine in patients with chronic kidney disease both with and without diabetes type 2. They are now recommended for treatment of heart failure and chronic kidney disease with the highest evidence grade. SGLT2 inhibitors do not increase risk of hypoglycemia or acute kidney injury but do have a serious uncommon adverse effect that are normoglycemic ketoacidosis and Fournier's gangrene that physicians need to be alert to.","PeriodicalId":49924,"journal":{"name":"Laeknabladid","volume":"110 12","pages":"558-563"},"PeriodicalIF":0.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Anyone can contract HIV but no one should get AIDS]. 任何人都可能感染艾滋病毒，但不应该得艾滋病。

IF 0.6 4区医学

Laeknabladid Pub Date : 2024-11-01 DOI: 10.17992/lbl.2024.11.813

Katrin Holmgrimsdottir, Saemundur Rognvaldsson, Telma Huld Ragnarsdottir, Erna Milunka Kojic

引用次数: 0

[Meckel's diverticulitis with perforation - a case report and discussion of the disorder]. [梅克尔憩室炎伴穿孔-一例报告及疾病讨论]。

IF 0.6 4区医学

Laeknabladid Pub Date : 2024-11-01 DOI: 10.17992/lbl.2024.11.814

Gudrun Margret Vidarsdottir, Hulda Maria Einarsdottir, Jon Gunnlaugur Jonasson, Pall Helgi Moller

引用次数: 0